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Protein

Probable metabolite transport protein YBR241C

Gene

YBR241C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • substrate-specific transmembrane transporter activity Source: SGD

GO - Biological processi

  • transmembrane transport Source: SGD
  • transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29172-MONOMER.
ReactomeiR-SCE-189200. Hexose transport.
R-SCE-196836. Vitamin C (ascorbate) metabolism.
R-SCE-422356. Regulation of insulin secretion.
R-SCE-428776. Class II GLUTs.
R-SCE-428790. Facilitative Na+-independent glucose transporters.
R-SCE-5653890. Lactose synthesis.
R-SCE-70153. Glucose transport.

Protein family/group databases

TCDBi2.A.1.1.96. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable metabolite transport protein YBR241C
Gene namesi
Ordered Locus Names:YBR241C
ORF Names:YBR1625
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR241C.
SGDiS000000445. YBR241C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence analysisAdd
BLAST
Transmembranei19 – 3921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini40 – 8748VacuolarSequence analysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini109 – 12113CytoplasmicSequence analysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini143 – 1464VacuolarSequence analysis
Transmembranei147 – 16721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini168 – 17811CytoplasmicSequence analysisAdd
BLAST
Transmembranei179 – 19820Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini199 – 2046VacuolarSequence analysis
Transmembranei205 – 22521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini226 – 29974CytoplasmicSequence analysisAdd
BLAST
Transmembranei300 – 32021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini321 – 3222VacuolarSequence analysis
Transmembranei323 – 33715Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini338 – 3447CytoplasmicSequence analysis
Transmembranei345 – 36420Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini365 – 39026VacuolarSequence analysisAdd
BLAST
Transmembranei391 – 41121Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini412 – 4198CytoplasmicSequence analysis
Transmembranei420 – 44223Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini443 – 4464VacuolarSequence analysis
Transmembranei447 – 46317Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini464 – 48825CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Probable metabolite transport protein YBR241CPRO_0000050463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi32936. 13 interactions.
DIPiDIP-5363N.
IntActiP38142. 10 interactions.
MINTiMINT-552773.

Structurei

3D structure databases

ProteinModelPortaliP38142.
SMRiP38142. Positions 20-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119022.
HOGENOMiHOG000199277.
InParanoidiP38142.
OrthoDBiEOG71P2M5.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETERLMPN GGSRETKPLI TGHLILGTIV ACLGSIQYGY HIAELNAPQE
60 70 80 90 100
FLSCSRFEAP DENISYDDTW VGQHGLKQCI ALTDSQYGAI TSIFSIGGLF
110 120 130 140 150
GSYYAGNWAN RYGRKYVSMG ASAMCMVSSL LLFFSNSYLQ LLFGRFLVGM
160 170 180 190 200
SCGTAIVITP LFINEIAPVE WRGAMGSMNQ VSINLGILLT QTLALKYADS
210 220 230 240 250
YNWRWLLFSG SVIAVANILA WLKVDESPRW LVSHGFVSEA ETALFKLRPG
260 270 280 290 300
TYQQAKQEIQ DWQRSHGHNR DPESSEETHS GPTLWQYVTD PSYKKPRTVI
310 320 330 340 350
LAILSCQQFC GINSIIFYGV KVIGKILPDY SIQVNFAISI LNVVVTLAAS
360 370 380 390 400
AIIDHVGRRP LLLASTTVMT AMSLLISVGL TLSVSFLLVT ATFVYIAAFA
410 420 430 440 450
IGLGPIPFLI IGELSYPQDA ATAQSFGTVC NWLATFIVGY LFPIGHGLMG
460 470 480
GYVFAIFAAI AAMFATYVYK RVPETKGKTT YSEVWAGY
Length:488
Mass (Da):53,526
Last modified:October 1, 1994 - v1
Checksum:iF74A2E3676363BE5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti438 – 4381V → A in AAT92614 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36110 Genomic DNA. Translation: CAA85204.1.
AY692595 Genomic DNA. Translation: AAT92614.1.
BK006936 Genomic DNA. Translation: DAA07357.1.
PIRiS46118.
RefSeqiNP_009800.1. NM_001178589.1.

Genome annotation databases

EnsemblFungiiYBR241C; YBR241C; YBR241C.
GeneIDi852543.
KEGGisce:YBR241C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36110 Genomic DNA. Translation: CAA85204.1.
AY692595 Genomic DNA. Translation: AAT92614.1.
BK006936 Genomic DNA. Translation: DAA07357.1.
PIRiS46118.
RefSeqiNP_009800.1. NM_001178589.1.

3D structure databases

ProteinModelPortaliP38142.
SMRiP38142. Positions 20-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32936. 13 interactions.
DIPiDIP-5363N.
IntActiP38142. 10 interactions.
MINTiMINT-552773.

Protein family/group databases

TCDBi2.A.1.1.96. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR241C; YBR241C; YBR241C.
GeneIDi852543.
KEGGisce:YBR241C.

Organism-specific databases

EuPathDBiFungiDB:YBR241C.
SGDiS000000445. YBR241C.

Phylogenomic databases

GeneTreeiENSGT00760000119022.
HOGENOMiHOG000199277.
InParanoidiP38142.
OrthoDBiEOG71P2M5.

Enzyme and pathway databases

BioCyciYEAST:G3O-29172-MONOMER.
ReactomeiR-SCE-189200. Hexose transport.
R-SCE-196836. Vitamin C (ascorbate) metabolism.
R-SCE-422356. Regulation of insulin secretion.
R-SCE-428776. Class II GLUTs.
R-SCE-428790. Facilitative Na+-independent glucose transporters.
R-SCE-5653890. Lactose synthesis.
R-SCE-70153. Glucose transport.

Miscellaneous databases

PROiP38142.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiYB91_YEAST
AccessioniPrimary (citable) accession number: P38142
Secondary accession number(s): D6VQN7, Q6B2Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.