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Protein

Thiamine biosynthesis regulatory protein

Gene

THI2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Positive regulator of thiamine biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 57Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

  • positive regulation of thiamine biosynthetic process Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • thiamine biosynthetic process Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processThiamine biosynthesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29171-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine biosynthesis regulatory protein
Gene namesi
Name:THI2
Synonyms:PHO6
Ordered Locus Names:YBR240C
ORF Names:YBR1624
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR240C
SGDiS000000444 THI2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149841 – 450Thiamine biosynthesis regulatory proteinAdd BLAST450

Proteomic databases

PaxDbiP38141
PRIDEiP38141

Interactioni

Protein-protein interaction databases

BioGridi32935, 30 interactors
DIPiDIP-5362N
IntActiP38141, 1 interactor
MINTiP38141
STRINGi4932.YBR240C

Structurei

3D structure databases

ProteinModelPortaliP38141
SMRiP38141
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP38141
OMAiTFTGCWA
OrthoDBiEOG092C22Z9

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSKRQQRS KKVASSSKVP PTKGRTFTGC WACRFKKRRC DENRPICSLC
60 70 80 90 100
AKHGDNCSYD IRLMWLEENI YKVRKHSLIS SLQARKSKSK PLCQKISKSR
110 120 130 140 150
FKQMTHFRQL SPPTSDCEDS VHEASKETTL PNDNTFTISV RRLKIYNNAV
160 170 180 190 200
ASVFGSMTNR DYTQKRIDKK LDELLNMVEN DISVVNLNCS KHGPYSVFRA
210 220 230 240 250
NPAAVTSALT DQLPSPGHSM SSAEETTTAA LSSPPEDSTS LIDIIQGKIF
260 270 280 290 300
GILWFNCYGN MILNRQEYTT WFINKMRNSL TTEFIRFLGK IIDDPDINMA
310 320 330 340 350
SCLFKECIAR WSCVDWQSIA ITMLVIIHGY TCPNLTKLLR VWFLQQKLLR
360 370 380 390 400
FSMYPLVNFI INNTQDLDVL YHCNGLLGNA DLFEDPYQDE LTSELHVLVT
410 420 430 440 450
ERLVNSWKDT ILQQLCSCQD TTLSCSQLRY WQLQLKCNQQ FYKDVYAMQD
Length:450
Mass (Da):51,823
Last modified:October 1, 1994 - v1
Checksum:i1A8B1627EC66FD93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32073 Genomic DNA Translation: BAA22093.1
Z36109 Genomic DNA Translation: CAA85203.1
BK006936 Genomic DNA Translation: DAA07356.1
PIRiS46117
RefSeqiNP_009799.3, NM_001178588.3

Genome annotation databases

EnsemblFungiiYBR240C; YBR240C; YBR240C
GeneIDi852542
KEGGisce:YBR240C

Similar proteinsi

Entry informationi

Entry nameiTHI2_YEAST
AccessioniPrimary (citable) accession number: P38141
Secondary accession number(s): D6VQN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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