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P38141

- THI2_YEAST

UniProt

P38141 - THI2_YEAST

Protein

Thiamine biosynthesis regulatory protein

Gene

THI2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Positive regulator of thiamine biosynthesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi30 – 5728Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: SGD
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of thiamine biosynthetic process Source: SGD
    2. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    3. thiamine biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Thiamine biosynthesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29171-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiamine biosynthesis regulatory protein
    Gene namesi
    Name:THI2
    Synonyms:PHO6
    Ordered Locus Names:YBR240C
    ORF Names:YBR1624
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR240c.
    SGDiS000000444. THI2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Thiamine biosynthesis regulatory proteinPRO_0000114984Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP38141.

    Interactioni

    Protein-protein interaction databases

    BioGridi32935. 12 interactions.
    DIPiDIP-5362N.
    IntActiP38141. 1 interaction.
    MINTiMINT-556210.
    STRINGi4932.YBR240C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38141.
    SMRiP38141. Positions 26-59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG68468.
    OrthoDBiEOG72ZCQ3.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF00172. Zn_clus. 1 hit.
    [Graphical view]
    SMARTiSM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38141-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNSKRQQRS KKVASSSKVP PTKGRTFTGC WACRFKKRRC DENRPICSLC    50
    AKHGDNCSYD IRLMWLEENI YKVRKHSLIS SLQARKSKSK PLCQKISKSR 100
    FKQMTHFRQL SPPTSDCEDS VHEASKETTL PNDNTFTISV RRLKIYNNAV 150
    ASVFGSMTNR DYTQKRIDKK LDELLNMVEN DISVVNLNCS KHGPYSVFRA 200
    NPAAVTSALT DQLPSPGHSM SSAEETTTAA LSSPPEDSTS LIDIIQGKIF 250
    GILWFNCYGN MILNRQEYTT WFINKMRNSL TTEFIRFLGK IIDDPDINMA 300
    SCLFKECIAR WSCVDWQSIA ITMLVIIHGY TCPNLTKLLR VWFLQQKLLR 350
    FSMYPLVNFI INNTQDLDVL YHCNGLLGNA DLFEDPYQDE LTSELHVLVT 400
    ERLVNSWKDT ILQQLCSCQD TTLSCSQLRY WQLQLKCNQQ FYKDVYAMQD 450
    Length:450
    Mass (Da):51,823
    Last modified:October 1, 1994 - v1
    Checksum:i1A8B1627EC66FD93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D32073 Genomic DNA. Translation: BAA22093.1.
    Z36109 Genomic DNA. Translation: CAA85203.1.
    BK006936 Genomic DNA. Translation: DAA07356.1.
    PIRiS46117.
    RefSeqiNP_009799.3. NM_001178588.3.

    Genome annotation databases

    EnsemblFungiiYBR240C; YBR240C; YBR240C.
    GeneIDi852542.
    KEGGisce:YBR240C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D32073 Genomic DNA. Translation: BAA22093.1 .
    Z36109 Genomic DNA. Translation: CAA85203.1 .
    BK006936 Genomic DNA. Translation: DAA07356.1 .
    PIRi S46117.
    RefSeqi NP_009799.3. NM_001178588.3.

    3D structure databases

    ProteinModelPortali P38141.
    SMRi P38141. Positions 26-59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32935. 12 interactions.
    DIPi DIP-5362N.
    IntActi P38141. 1 interaction.
    MINTi MINT-556210.
    STRINGi 4932.YBR240C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR240C ; YBR240C ; YBR240C .
    GeneIDi 852542.
    KEGGi sce:YBR240C.

    Organism-specific databases

    CYGDi YBR240c.
    SGDi S000000444. THI2.

    Phylogenomic databases

    eggNOGi NOG68468.
    OrthoDBi EOG72ZCQ3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29171-MONOMER.

    Miscellaneous databases

    NextBioi 971613.

    Gene expression databases

    Genevestigatori P38141.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    SMARTi SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Nishimura H., Nosaka K., Kaneko Y., Iwashima A.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / GRF88.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiTHI2_YEAST
    AccessioniPrimary (citable) accession number: P38141
    Secondary accession number(s): D6VQN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3