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P38141 (THI2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiamine biosynthesis regulatory protein
Gene names
Name:THI2
Synonyms:PHO6
Ordered Locus Names:YBR240C
ORF Names:YBR1624
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Positive regulator of thiamine biosynthesis.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Thiamine biosynthesis regulatory protein
PRO_0000114984

Regions

DNA binding30 – 5728Zn(2)-C6 fungal-type

Sequences

Sequence LengthMass (Da)Tools
P38141 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 1A8B1627EC66FD93

FASTA45051,823
        10         20         30         40         50         60 
MVNSKRQQRS KKVASSSKVP PTKGRTFTGC WACRFKKRRC DENRPICSLC AKHGDNCSYD 

        70         80         90        100        110        120 
IRLMWLEENI YKVRKHSLIS SLQARKSKSK PLCQKISKSR FKQMTHFRQL SPPTSDCEDS 

       130        140        150        160        170        180 
VHEASKETTL PNDNTFTISV RRLKIYNNAV ASVFGSMTNR DYTQKRIDKK LDELLNMVEN 

       190        200        210        220        230        240 
DISVVNLNCS KHGPYSVFRA NPAAVTSALT DQLPSPGHSM SSAEETTTAA LSSPPEDSTS 

       250        260        270        280        290        300 
LIDIIQGKIF GILWFNCYGN MILNRQEYTT WFINKMRNSL TTEFIRFLGK IIDDPDINMA 

       310        320        330        340        350        360 
SCLFKECIAR WSCVDWQSIA ITMLVIIHGY TCPNLTKLLR VWFLQQKLLR FSMYPLVNFI 

       370        380        390        400        410        420 
INNTQDLDVL YHCNGLLGNA DLFEDPYQDE LTSELHVLVT ERLVNSWKDT ILQQLCSCQD 

       430        440        450 
TTLSCSQLRY WQLQLKCNQQ FYKDVYAMQD 

« Hide

References

« Hide 'large scale' references
[1]Nishimura H., Nosaka K., Kaneko Y., Iwashima A.
Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / GRF88.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D32073 Genomic DNA. Translation: BAA22093.1.
Z36109 Genomic DNA. Translation: CAA85203.1.
BK006936 Genomic DNA. Translation: DAA07356.1.
PIRS46117.
RefSeqNP_009799.3. NM_001178588.3.

3D structure databases

ProteinModelPortalP38141.
SMRP38141. Positions 26-59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32935. 12 interactions.
DIPDIP-5362N.
IntActP38141. 1 interaction.
MINTMINT-556210.
STRING4932.YBR240C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR240C; YBR240C; YBR240C.
GeneID852542.
KEGGsce:YBR240C.

Organism-specific databases

CYGDYBR240c.
SGDS000000444. THI2.

Phylogenomic databases

eggNOGNOG68468.
OrthoDBEOG72ZCQ3.

Enzyme and pathway databases

BioCycYEAST:G3O-29171-MONOMER.

Gene expression databases

GenevestigatorP38141.

Family and domain databases

Gene3D4.10.240.10. 1 hit.
InterProIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMSSF57701. SSF57701. 1 hit.
PROSITEPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio971613.

Entry information

Entry nameTHI2_YEAST
AccessionPrimary (citable) accession number: P38141
Secondary accession number(s): D6VQN6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families