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P38140 (ERT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription activator of gluconeogenesis ERT1
Alternative name(s):
Ethanol regulator of translation 1
Gene names
Name:ERT1
Ordered Locus Names:YBR239C
ORF Names:YBR1622
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like PCK1. Involved in restriction of Ty1 transposition. Ref.6 Ref.7

Subcellular location

Cytoplasm. Nucleus Ref.3.

Disruption phenotype

Increases the periodicity of transcriptional and metabolic oscillation. Ref.5

Miscellaneous

Present with 85 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ERT1/acuK family.

Contains 1 PAS (PER-ARNT-SIM) domain.

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Transcription activator of gluconeogenesis ERT1
PRO_0000114993

Regions

Domain408 – 48073PAS
DNA binding40 – 6829Zn(2)-C6 fungal-type

Sequences

Sequence LengthMass (Da)Tools
P38140 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 6C89B70CBCCA93D8

FASTA52960,311
        10         20         30         40         50         60 
MCTPDENDYK TSTDPDTSAN TNHTLEKKKR KKRKNTNVAC VNCSRLHVSC EAKRPCLRCI 

        70         80         90        100        110        120 
SKGLTATCVD APRKKSKYLA GIPNRELPMN IQPDLPPRKI MIPIYNNSSN SSLNVNNMGE 

       130        140        150        160        170        180 
QQKFTSPQHI VHKAKFLSNA ADSEYSILSN IIYQDTLSNK IPIDILYSNT NSTSNSTIGN 

       190        200        210        220        230        240 
SSNNSPTGTN TSPEETEMEK IRQLYSEQRA NIPPHPYPSS NQNVYSILLG PNSAKIVASQ 

       250        260        270        280        290        300 
VNLFANHFPL VPVDSADNSL NFKRLLPRDP SEKSSQINWD SSINQYYLNS ETVTFPELAI 

       310        320        330        340        350        360 
PLKRRKNHLV SVSLESCSPD AANIKSNVEW EHSLRYSTPM EIYTSINAPF SHTPGFHHLL 

       370        380        390        400        410        420 
VYLKHRFNQQ DLVKMCRSIA EFRPIFIACS VTLTEEDMIF MEQCYQRTLL EYVKFIAQIG 

       430        440        450        460        470        480 
TPTCIWRRNG QISYVNEEFE ILCGWTREEL LNKMTFIVEI MDDESVRDYF KTLSKVAYRD 

       490        500        510        520 
FRGSEKMKVC RLLSPIKGKI IHCCCMWTLK RDVSGLPLMI LGNFMPILN 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Evolution of the clock from yeast to man by period-doubling folds in the cellular oscillator."
Klevecz R.R., Li C.M.
Cold Spring Harb. Symp. Quant. Biol. 72:421-429(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[6]"Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis."
Nyswaner K.M., Checkley M.A., Yi M., Stephens R.M., Garfinkel D.J.
Genetics 178:197-214(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Transcriptional regulation of nonfermentable carbon utilization in budding yeast."
Turcotte B., Liang X.B., Robert F., Soontorngun N.
FEMS Yeast Res. 10:2-13(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z36108 Genomic DNA. Translation: CAA85202.1.
BK006936 Genomic DNA. Translation: DAA07355.1.
PIRS46116.
RefSeqNP_009798.3. NM_001178587.3.

3D structure databases

ProteinModelPortalP38140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32934. 17 interactions.
DIPDIP-4432N.
IntActP38140. 6 interactions.
MINTMINT-498032.
STRING4932.YBR239C.

Proteomic databases

MaxQBP38140.
PaxDbP38140.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR239C; YBR239C; YBR239C.
GeneID852541.
KEGGsce:YBR239C.

Organism-specific databases

CYGDYBR239c.
SGDS000000443. ERT1.

Phylogenomic databases

eggNOGNOG39365.
GeneTreeENSGT00530000068325.
OMAYVGNEFC.
OrthoDBEOG70KGZB.

Enzyme and pathway databases

BioCycYEAST:G3O-29170-MONOMER.

Gene expression databases

GenevestigatorP38140.

Family and domain databases

Gene3D4.10.240.10. 1 hit.
InterProIPR000014. PAS.
IPR013767. PAS_fold.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamPF00989. PAS. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMSSF55785. SSF55785. 1 hit.
SSF57701. SSF57701. 1 hit.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50112. PAS. 1 hit.
PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio971610.

Entry information

Entry nameERT1_YEAST
AccessionPrimary (citable) accession number: P38140
Secondary accession number(s): D6VQN5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families