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P38140

- ERT1_YEAST

UniProt

P38140 - ERT1_YEAST

Protein

Transcription activator of gluconeogenesis ERT1

Gene

ERT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like PCK1. Involved in restriction of Ty1 transposition.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi40 – 6829Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    4. signal transducer activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Gluconeogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29170-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription activator of gluconeogenesis ERT1
    Alternative name(s):
    Ethanol regulator of translation 1
    Gene namesi
    Name:ERT1
    Ordered Locus Names:YBR239C
    ORF Names:YBR1622
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR239c.
    SGDiS000000443. ERT1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Increases the periodicity of transcriptional and metabolic oscillation.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Transcription activator of gluconeogenesis ERT1PRO_0000114993Add
    BLAST

    Proteomic databases

    MaxQBiP38140.
    PaxDbiP38140.

    Expressioni

    Gene expression databases

    GenevestigatoriP38140.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LSB3P436033EBI-21048,EBI-22980
    RVS167P397434EBI-21048,EBI-14500
    YSC84P327934EBI-21048,EBI-24460

    Protein-protein interaction databases

    BioGridi32934. 17 interactions.
    DIPiDIP-4432N.
    IntActiP38140. 6 interactions.
    MINTiMINT-498032.
    STRINGi4932.YBR239C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini408 – 48073PASPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ERT1/acuK family.Curated
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation
    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG39365.
    GeneTreeiENSGT00530000068325.
    OMAiYVGNEFC.
    OrthoDBiEOG70KGZB.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR000014. PAS.
    IPR013767. PAS_fold.
    IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF00989. PAS. 1 hit.
    PF00172. Zn_clus. 1 hit.
    [Graphical view]
    SMARTiSM00066. GAL4. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF55785. SSF55785. 1 hit.
    SSF57701. SSF57701. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50112. PAS. 1 hit.
    PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38140-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCTPDENDYK TSTDPDTSAN TNHTLEKKKR KKRKNTNVAC VNCSRLHVSC    50
    EAKRPCLRCI SKGLTATCVD APRKKSKYLA GIPNRELPMN IQPDLPPRKI 100
    MIPIYNNSSN SSLNVNNMGE QQKFTSPQHI VHKAKFLSNA ADSEYSILSN 150
    IIYQDTLSNK IPIDILYSNT NSTSNSTIGN SSNNSPTGTN TSPEETEMEK 200
    IRQLYSEQRA NIPPHPYPSS NQNVYSILLG PNSAKIVASQ VNLFANHFPL 250
    VPVDSADNSL NFKRLLPRDP SEKSSQINWD SSINQYYLNS ETVTFPELAI 300
    PLKRRKNHLV SVSLESCSPD AANIKSNVEW EHSLRYSTPM EIYTSINAPF 350
    SHTPGFHHLL VYLKHRFNQQ DLVKMCRSIA EFRPIFIACS VTLTEEDMIF 400
    MEQCYQRTLL EYVKFIAQIG TPTCIWRRNG QISYVNEEFE ILCGWTREEL 450
    LNKMTFIVEI MDDESVRDYF KTLSKVAYRD FRGSEKMKVC RLLSPIKGKI 500
    IHCCCMWTLK RDVSGLPLMI LGNFMPILN 529
    Length:529
    Mass (Da):60,311
    Last modified:October 1, 1994 - v1
    Checksum:i6C89B70CBCCA93D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36108 Genomic DNA. Translation: CAA85202.1.
    BK006936 Genomic DNA. Translation: DAA07355.1.
    PIRiS46116.
    RefSeqiNP_009798.3. NM_001178587.3.

    Genome annotation databases

    EnsemblFungiiYBR239C; YBR239C; YBR239C.
    GeneIDi852541.
    KEGGisce:YBR239C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36108 Genomic DNA. Translation: CAA85202.1 .
    BK006936 Genomic DNA. Translation: DAA07355.1 .
    PIRi S46116.
    RefSeqi NP_009798.3. NM_001178587.3.

    3D structure databases

    ProteinModelPortali P38140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32934. 17 interactions.
    DIPi DIP-4432N.
    IntActi P38140. 6 interactions.
    MINTi MINT-498032.
    STRINGi 4932.YBR239C.

    Proteomic databases

    MaxQBi P38140.
    PaxDbi P38140.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR239C ; YBR239C ; YBR239C .
    GeneIDi 852541.
    KEGGi sce:YBR239C.

    Organism-specific databases

    CYGDi YBR239c.
    SGDi S000000443. ERT1.

    Phylogenomic databases

    eggNOGi NOG39365.
    GeneTreei ENSGT00530000068325.
    OMAi YVGNEFC.
    OrthoDBi EOG70KGZB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29170-MONOMER.

    Miscellaneous databases

    NextBioi 971610.

    Gene expression databases

    Genevestigatori P38140.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF00989. PAS. 1 hit.
    PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    SMARTi SM00066. GAL4. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55785. SSF55785. 1 hit.
    SSF57701. SSF57701. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50112. PAS. 1 hit.
    PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Evolution of the clock from yeast to man by period-doubling folds in the cellular oscillator."
      Klevecz R.R., Li C.M.
      Cold Spring Harb. Symp. Quant. Biol. 72:421-429(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    6. "Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis."
      Nyswaner K.M., Checkley M.A., Yi M., Stephens R.M., Garfinkel D.J.
      Genetics 178:197-214(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Transcriptional regulation of nonfermentable carbon utilization in budding yeast."
      Turcotte B., Liang X.B., Robert F., Soontorngun N.
      FEMS Yeast Res. 10:2-13(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiERT1_YEAST
    AccessioniPrimary (citable) accession number: P38140
    Secondary accession number(s): D6VQN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 85 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3