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Protein

Transcription activator of gluconeogenesis ERT1

Gene

ERT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like PCK1. Involved in restriction of Ty1 transposition.2 Publications

Miscellaneous

Present with 85 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 68Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • carbon utilization Source: GO_Central
  • gluconeogenesis Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
  • positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processGluconeogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator of gluconeogenesis ERT1
Alternative name(s):
Ethanol regulator of translation 1
Gene namesi
Name:ERT1
Ordered Locus Names:YBR239C
ORF Names:YBR1622
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR239C.
SGDiS000000443. ERT1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Increases the periodicity of transcriptional and metabolic oscillation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149931 – 529Transcription activator of gluconeogenesis ERT1Add BLAST529

Proteomic databases

MaxQBiP38140.
PRIDEiP38140.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32934. 63 interactors.
DIPiDIP-4432N.
IntActiP38140. 6 interactors.
MINTiMINT-498032.
STRINGi4932.YBR239C.

Structurei

3D structure databases

ProteinModelPortaliP38140.
SMRiP38140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini408 – 480PASPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the ERT1/acuK family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000068325.
InParanoidiP38140.
OMAiGLPHAYA.
OrthoDBiEOG092C2QST.

Family and domain databases

CDDicd00067. GAL4. 1 hit.
cd00130. PAS. 1 hit.
Gene3Di4.10.240.10. 1 hit.
InterProiView protein in InterPro
IPR000014. PAS.
IPR013767. PAS_fold.
IPR001138. Zn2-C6_fun-type_DNA-bd.
PfamiView protein in Pfam
PF00989. PAS. 1 hit.
PF00172. Zn_clus. 1 hit.
SMARTiView protein in SMART
SM00066. GAL4. 1 hit.
SM00091. PAS. 1 hit.
SUPFAMiSSF55785. SSF55785. 1 hit.
SSF57701. SSF57701. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiView protein in PROSITE
PS50112. PAS. 1 hit.
PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P38140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTPDENDYK TSTDPDTSAN TNHTLEKKKR KKRKNTNVAC VNCSRLHVSC
60 70 80 90 100
EAKRPCLRCI SKGLTATCVD APRKKSKYLA GIPNRELPMN IQPDLPPRKI
110 120 130 140 150
MIPIYNNSSN SSLNVNNMGE QQKFTSPQHI VHKAKFLSNA ADSEYSILSN
160 170 180 190 200
IIYQDTLSNK IPIDILYSNT NSTSNSTIGN SSNNSPTGTN TSPEETEMEK
210 220 230 240 250
IRQLYSEQRA NIPPHPYPSS NQNVYSILLG PNSAKIVASQ VNLFANHFPL
260 270 280 290 300
VPVDSADNSL NFKRLLPRDP SEKSSQINWD SSINQYYLNS ETVTFPELAI
310 320 330 340 350
PLKRRKNHLV SVSLESCSPD AANIKSNVEW EHSLRYSTPM EIYTSINAPF
360 370 380 390 400
SHTPGFHHLL VYLKHRFNQQ DLVKMCRSIA EFRPIFIACS VTLTEEDMIF
410 420 430 440 450
MEQCYQRTLL EYVKFIAQIG TPTCIWRRNG QISYVNEEFE ILCGWTREEL
460 470 480 490 500
LNKMTFIVEI MDDESVRDYF KTLSKVAYRD FRGSEKMKVC RLLSPIKGKI
510 520
IHCCCMWTLK RDVSGLPLMI LGNFMPILN
Length:529
Mass (Da):60,311
Last modified:October 1, 1994 - v1
Checksum:i6C89B70CBCCA93D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36108 Genomic DNA. Translation: CAA85202.1.
BK006936 Genomic DNA. Translation: DAA07355.1.
PIRiS46116.
RefSeqiNP_009798.3. NM_001178587.3.

Genome annotation databases

EnsemblFungiiYBR239C; YBR239C; YBR239C.
GeneIDi852541.
KEGGisce:YBR239C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiERT1_YEAST
AccessioniPrimary (citable) accession number: P38140
Secondary accession number(s): D6VQN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 5, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names