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P38140

- ERT1_YEAST

UniProt

P38140 - ERT1_YEAST

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Protein

Transcription activator of gluconeogenesis ERT1

Gene

ERT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like PCK1. Involved in restriction of Ty1 transposition.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi40 – 6829Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: SGD
  2. sequence-specific DNA binding Source: SGD
  3. signal transducer activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. negative regulation of transcription from RNA polymerase II promoter Source: SGD
  3. negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
  4. positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  5. positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Gluconeogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator of gluconeogenesis ERT1
Alternative name(s):
Ethanol regulator of translation 1
Gene namesi
Name:ERT1
Ordered Locus Names:YBR239C
ORF Names:YBR1622
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR239c.
SGDiS000000443. ERT1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Increases the periodicity of transcriptional and metabolic oscillation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Transcription activator of gluconeogenesis ERT1PRO_0000114993Add
BLAST

Proteomic databases

MaxQBiP38140.
PaxDbiP38140.

Expressioni

Gene expression databases

GenevestigatoriP38140.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSB3P436033EBI-21048,EBI-22980
RVS167P397434EBI-21048,EBI-14500
YSC84P327934EBI-21048,EBI-24460

Protein-protein interaction databases

BioGridi32934. 18 interactions.
DIPiDIP-4432N.
IntActiP38140. 6 interactions.
MINTiMINT-498032.
STRINGi4932.YBR239C.

Structurei

3D structure databases

ProteinModelPortaliP38140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini408 – 48073PASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ERT1/acuK family.Curated
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG39365.
GeneTreeiENSGT00530000068325.
InParanoidiP38140.
OMAiYVGNEFC.
OrthoDBiEOG70KGZB.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR000014. PAS.
IPR013767. PAS_fold.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF55785. SSF55785. 1 hit.
SSF57701. SSF57701. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50112. PAS. 1 hit.
PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38140-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCTPDENDYK TSTDPDTSAN TNHTLEKKKR KKRKNTNVAC VNCSRLHVSC
60 70 80 90 100
EAKRPCLRCI SKGLTATCVD APRKKSKYLA GIPNRELPMN IQPDLPPRKI
110 120 130 140 150
MIPIYNNSSN SSLNVNNMGE QQKFTSPQHI VHKAKFLSNA ADSEYSILSN
160 170 180 190 200
IIYQDTLSNK IPIDILYSNT NSTSNSTIGN SSNNSPTGTN TSPEETEMEK
210 220 230 240 250
IRQLYSEQRA NIPPHPYPSS NQNVYSILLG PNSAKIVASQ VNLFANHFPL
260 270 280 290 300
VPVDSADNSL NFKRLLPRDP SEKSSQINWD SSINQYYLNS ETVTFPELAI
310 320 330 340 350
PLKRRKNHLV SVSLESCSPD AANIKSNVEW EHSLRYSTPM EIYTSINAPF
360 370 380 390 400
SHTPGFHHLL VYLKHRFNQQ DLVKMCRSIA EFRPIFIACS VTLTEEDMIF
410 420 430 440 450
MEQCYQRTLL EYVKFIAQIG TPTCIWRRNG QISYVNEEFE ILCGWTREEL
460 470 480 490 500
LNKMTFIVEI MDDESVRDYF KTLSKVAYRD FRGSEKMKVC RLLSPIKGKI
510 520
IHCCCMWTLK RDVSGLPLMI LGNFMPILN
Length:529
Mass (Da):60,311
Last modified:October 1, 1994 - v1
Checksum:i6C89B70CBCCA93D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36108 Genomic DNA. Translation: CAA85202.1.
BK006936 Genomic DNA. Translation: DAA07355.1.
PIRiS46116.
RefSeqiNP_009798.3. NM_001178587.3.

Genome annotation databases

EnsemblFungiiYBR239C; YBR239C; YBR239C.
GeneIDi852541.
KEGGisce:YBR239C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36108 Genomic DNA. Translation: CAA85202.1 .
BK006936 Genomic DNA. Translation: DAA07355.1 .
PIRi S46116.
RefSeqi NP_009798.3. NM_001178587.3.

3D structure databases

ProteinModelPortali P38140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32934. 18 interactions.
DIPi DIP-4432N.
IntActi P38140. 6 interactions.
MINTi MINT-498032.
STRINGi 4932.YBR239C.

Proteomic databases

MaxQBi P38140.
PaxDbi P38140.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR239C ; YBR239C ; YBR239C .
GeneIDi 852541.
KEGGi sce:YBR239C.

Organism-specific databases

CYGDi YBR239c.
SGDi S000000443. ERT1.

Phylogenomic databases

eggNOGi NOG39365.
GeneTreei ENSGT00530000068325.
InParanoidi P38140.
OMAi YVGNEFC.
OrthoDBi EOG70KGZB.

Enzyme and pathway databases

BioCyci YEAST:G3O-29170-MONOMER.

Miscellaneous databases

NextBioi 971610.

Gene expression databases

Genevestigatori P38140.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR000014. PAS.
IPR013767. PAS_fold.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF00989. PAS. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view ]
SMARTi SM00066. GAL4. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF55785. SSF55785. 1 hit.
SSF57701. SSF57701. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50112. PAS. 1 hit.
PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Evolution of the clock from yeast to man by period-doubling folds in the cellular oscillator."
    Klevecz R.R., Li C.M.
    Cold Spring Harb. Symp. Quant. Biol. 72:421-429(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  6. "Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis."
    Nyswaner K.M., Checkley M.A., Yi M., Stephens R.M., Garfinkel D.J.
    Genetics 178:197-214(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Transcriptional regulation of nonfermentable carbon utilization in budding yeast."
    Turcotte B., Liang X.B., Robert F., Soontorngun N.
    FEMS Yeast Res. 10:2-13(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiERT1_YEAST
AccessioniPrimary (citable) accession number: P38140
Secondary accession number(s): D6VQN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 85 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3