Transcription activator of gluconeogenesis ERT1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P38140 (ERT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Transcription activator of gluconeogenesis ERT1

Alternative name(s):
Ethanol regulator of translation 1

Gene names

Name:	ERT1
Ordered Locus Names:	YBR239C
ORF Names:	YBR1622

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like PCK1. Involved in restriction of Ty1 transposition. Ref.6 Ref.7
Subcellular location	Cytoplasm. Nucleus Ref.3.
Disruption phenotype	Increases the periodicity of transcriptional and metabolic oscillation. Ref.5
Miscellaneous	Present with 85 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the ERT1/acuK family. Contains 1 PAS (PER-ARNT-SIM) domain. Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Keywords
Biological process	Gluconeogenesis Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: GOC transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from direct assay Ref.3. Source: SGD nucleus Inferred from direct assay Ref.3. Source: SGD
Molecular_function	sequence-specific DNA binding Inferred from direct assay PubMed 19111667 PubMed 19158363. Source: SGD sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
LSB3	P43603	2	EBI-21048,EBI-22980
RVS167	P39743	2	EBI-21048,EBI-14500
YSC84	P32793	2	EBI-21048,EBI-24460

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 529

529

Transcription activator of gluconeogenesis ERT1

PRO_0000114993

Regions

Domain

408 – 480

PAS

DNA binding

40 – 68

Zn(2)-C6 fungal-type

Sequences

Sequence

Length

Mass (Da)

Tools

P38140 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 6C89B70CBCCA93D8
Show »

FASTA

529

60,311

        10         20         30         40         50         60 
MCTPDENDYK TSTDPDTSAN TNHTLEKKKR KKRKNTNVAC VNCSRLHVSC EAKRPCLRCI 

        70         80         90        100        110        120 
SKGLTATCVD APRKKSKYLA GIPNRELPMN IQPDLPPRKI MIPIYNNSSN SSLNVNNMGE 

       130        140        150        160        170        180 
QQKFTSPQHI VHKAKFLSNA ADSEYSILSN IIYQDTLSNK IPIDILYSNT NSTSNSTIGN 

       190        200        210        220        230        240 
SSNNSPTGTN TSPEETEMEK IRQLYSEQRA NIPPHPYPSS NQNVYSILLG PNSAKIVASQ 

       250        260        270        280        290        300 
VNLFANHFPL VPVDSADNSL NFKRLLPRDP SEKSSQINWD SSINQYYLNS ETVTFPELAI 

       310        320        330        340        350        360 
PLKRRKNHLV SVSLESCSPD AANIKSNVEW EHSLRYSTPM EIYTSINAPF SHTPGFHHLL 

       370        380        390        400        410        420 
VYLKHRFNQQ DLVKMCRSIA EFRPIFIACS VTLTEEDMIF MEQCYQRTLL EYVKFIAQIG 

       430        440        450        460        470        480 
TPTCIWRRNG QISYVNEEFE ILCGWTREEL LNKMTFIVEI MDDESVRDYF KTLSKVAYRD 

       490        500        510        520 
FRGSEKMKVC RLLSPIKGKI IHCCCMWTLK RDVSGLPLMI LGNFMPILN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]	"Evolution of the clock from yeast to man by period-doubling folds in the cellular oscillator." Klevecz R.R., Li C.M. Cold Spring Harb. Symp. Quant. Biol. 72:421-429(2007) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[6]	"Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis." Nyswaner K.M., Checkley M.A., Yi M., Stephens R.M., Garfinkel D.J. Genetics 178:197-214(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Transcriptional regulation of nonfermentable carbon utilization in budding yeast." Turcotte B., Liang X.B., Robert F., Soontorngun N. FEMS Yeast Res. 10:2-13(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z36108 Genomic DNA. Translation: CAA85202.1. BK006936 Genomic DNA. Translation: DAA07355.1.
PIR	S46116.
RefSeq	NP_009798.3. NM_001178587.3.
3D structure databases
ProteinModelPortal	P38140.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4432N.
IntAct	P38140. 6 interactions.
MINT	MINT-498032.
STRING	4932.YBR239C.
Proteomic databases
PaxDb	P38140.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR239C; YBR239C; YBR239C.
GeneID	852541.
KEGG	sce:YBR239C. sce:YBR243C.
Organism-specific databases
CYGD	YBR239c.
SGD	S000000443. ERT1.
Phylogenomic databases
eggNOG	NOG39365.
GeneTree	ENSGT00530000068325.
KO	K01001.
OMA	DIPMLIV.
OrthoDB	EOG44BF9G.
Gene expression databases
Genevestigator	P38140.
GermOnline	YBR239C. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	4.10.240.10. 1 hit.
InterPro	IPR000014. PAS. IPR013767. PAS_fold. IPR001138. Zn2-C6_fun-type_DNA-bd. [Graphical view]
Pfam	PF00989. PAS. 1 hit. PF00172. Zn_clus. 1 hit. [Graphical view]
SMART	SM00066. GAL4. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
SUPFAM	SSF57701. Fungi_TrN. 1 hit.
TIGRFAMs	TIGR00229. sensory_box. 1 hit.
PROSITE	PS50112. PAS. 1 hit. PS00463. ZN2_CY6_FUNGAL_1. 1 hit. PS50048. ZN2_CY6_FUNGAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	971610.

Entry information

Entry name

ERT1_YEAST

Accession

Primary (citable) accession number: P38140
Secondary accession number(s): D6VQN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents