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Protein

Transcription activator of gluconeogenesis ERT1

Gene

ERT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes like PCK1. Involved in restriction of Ty1 transposition.2 Publications

Miscellaneous

Present with 85 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi40 – 68Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • carbon utilization Source: GO_Central
  • gluconeogenesis Source: UniProtKB-KW
  • negative regulation of transcription by RNA polymerase II Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
  • positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processGluconeogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29170-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator of gluconeogenesis ERT1
Alternative name(s):
Ethanol regulator of translation 1
Gene namesi
Name:ERT1
Ordered Locus Names:YBR239C
ORF Names:YBR1622
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YBR239C
SGDiS000000443 ERT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Increases the periodicity of transcriptional and metabolic oscillation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149931 – 529Transcription activator of gluconeogenesis ERT1Add BLAST529

Proteomic databases

MaxQBiP38140
PaxDbiP38140
PRIDEiP38140

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32934, 64 interactors
DIPiDIP-4432N
IntActiP38140, 7 interactors
MINTiP38140
STRINGi4932.YBR239C

Structurei

3D structure databases

ProteinModelPortaliP38140
SMRiP38140
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini408 – 480PASPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the ERT1/acuK family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000068325
InParanoidiP38140
OMAiGLPHAYA
OrthoDBiEOG092C2QST

Family and domain databases

CDDicd00067 GAL4, 1 hit
cd00130 PAS, 1 hit
InterProiView protein in InterPro
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF00989 PAS, 1 hit
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00066 GAL4, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF55785 SSF55785, 1 hit
SSF57701 SSF57701, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50112 PAS, 1 hit
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTPDENDYK TSTDPDTSAN TNHTLEKKKR KKRKNTNVAC VNCSRLHVSC
60 70 80 90 100
EAKRPCLRCI SKGLTATCVD APRKKSKYLA GIPNRELPMN IQPDLPPRKI
110 120 130 140 150
MIPIYNNSSN SSLNVNNMGE QQKFTSPQHI VHKAKFLSNA ADSEYSILSN
160 170 180 190 200
IIYQDTLSNK IPIDILYSNT NSTSNSTIGN SSNNSPTGTN TSPEETEMEK
210 220 230 240 250
IRQLYSEQRA NIPPHPYPSS NQNVYSILLG PNSAKIVASQ VNLFANHFPL
260 270 280 290 300
VPVDSADNSL NFKRLLPRDP SEKSSQINWD SSINQYYLNS ETVTFPELAI
310 320 330 340 350
PLKRRKNHLV SVSLESCSPD AANIKSNVEW EHSLRYSTPM EIYTSINAPF
360 370 380 390 400
SHTPGFHHLL VYLKHRFNQQ DLVKMCRSIA EFRPIFIACS VTLTEEDMIF
410 420 430 440 450
MEQCYQRTLL EYVKFIAQIG TPTCIWRRNG QISYVNEEFE ILCGWTREEL
460 470 480 490 500
LNKMTFIVEI MDDESVRDYF KTLSKVAYRD FRGSEKMKVC RLLSPIKGKI
510 520
IHCCCMWTLK RDVSGLPLMI LGNFMPILN
Length:529
Mass (Da):60,311
Last modified:October 1, 1994 - v1
Checksum:i6C89B70CBCCA93D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36108 Genomic DNA Translation: CAA85202.1
BK006936 Genomic DNA Translation: DAA07355.1
PIRiS46116
RefSeqiNP_009798.3, NM_001178587.3

Genome annotation databases

EnsemblFungiiYBR239C; YBR239C; YBR239C
GeneIDi852541
KEGGisce:YBR239C

Similar proteinsi

Entry informationi

Entry nameiERT1_YEAST
AccessioniPrimary (citable) accession number: P38140
Secondary accession number(s): D6VQN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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