Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal-coenzyme A synthetase

Gene

PCS60

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Non-essential protein involved in fatty acid metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi190 – 20718AMPBy similarityAdd
BLAST

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • mRNA binding Source: SGD
  • oxalate-CoA ligase activity Source: SGD

GO - Biological processi

  • oxalate catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Enzyme and pathway databases

BioCyciYEAST:G3O-29157-MONOMER.
BRENDAi6.2.1.3. 984.
6.2.1.8. 984.
ReactomeiR-SCE-75105. Fatty Acyl-CoA Biosynthesis.
R-SCE-75876. Synthesis of very long-chain fatty acyl-CoAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal-coenzyme A synthetase (EC:6.-.-.-)
Gene namesi
Name:PCS60
Synonyms:FAT2
Ordered Locus Names:YBR222C
ORF Names:YBR1512
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR222C.
SGDiS000000426. PCS60.

Subcellular locationi

GO - Cellular componenti

  • peroxisomal matrix Source: SGD
  • peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Peroxisomal-coenzyme A synthetasePRO_0000193182Add
BLAST

Proteomic databases

MaxQBiP38137.

Expressioni

Inductioni

By oleic acid.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-6831,EBI-6831

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi32919. 26 interactions.
DIPiDIP-2796N.
IntActiP38137. 10 interactions.
MINTiMINT-618445.

Structurei

3D structure databases

ProteinModelPortaliP38137.
SMRiP38137. Positions 16-537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi541 – 5433Microbody targeting signalSequence analysis

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000119304.
HOGENOMiHOG000229994.
InParanoidiP38137.
OMAiIPRIRFI.
OrthoDBiEOG72RN7X.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAATVTAS FNDTFSVSDN VAVIVPETDT QVTYRDLSHM VGHFQTMFTN
60 70 80 90 100
PNSPLYGAVF RQDTVAISMR NGLEFIVAFL GATMDAKIGA PLNPNYKEKE
110 120 130 140 150
FNFYLNDLKS KAICVPKGTT KLQSSEILKS ASTFGCFIVE LAFDATRFRV
160 170 180 190 200
EYDIYSPEDN YKRVIYRSLN NAKFVNTNPV KFPGFARSSD VALILHTSGT
210 220 230 240 250
TSTPKTVPLL HLNIVRSTLN IANTYKLTPL DRSYVVMPLF HVHGLIGVLL
260 270 280 290 300
STFRTQGSVV VPDGFHPKLF WDQFVKYNCN WFSCVPTISM IMLNMPKPNP
310 320 330 340 350
FPHIRFIRSC SSALAPATFH KLEKEFNAPV LEAYAMTEAS HQMTSNNLPP
360 370 380 390 400
GKRKPGTVGQ PQGVTVVILD DNDNVLPPGK VGEVSIRGEN VTLGYANNPK
410 420 430 440 450
ANKENFTKRE NYFRTGDQGY FDPEGFLVLT GRIKELINRG GEKISPIELD
460 470 480 490 500
GIMLSHPKID EAVAFGVPDD MYGQVVQAAI VLKKGEKMTY EELVNFLKKH
510 520 530 540
LASFKIPTKV YFVDKLPKTA TGKIQRRVIA ETFAKSSRNK SKL
Length:543
Mass (Da):60,489
Last modified:October 1, 1994 - v1
Checksum:i2BA18B77D10D62F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36091 Genomic DNA. Translation: CAA85185.1.
BK006936 Genomic DNA. Translation: DAA07339.1.
PIRiS46098.
RefSeqiNP_009781.3. NM_001178570.3.

Genome annotation databases

EnsemblFungiiYBR222C; YBR222C; YBR222C.
GeneIDi852523.
KEGGisce:YBR222C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36091 Genomic DNA. Translation: CAA85185.1.
BK006936 Genomic DNA. Translation: DAA07339.1.
PIRiS46098.
RefSeqiNP_009781.3. NM_001178570.3.

3D structure databases

ProteinModelPortaliP38137.
SMRiP38137. Positions 16-537.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32919. 26 interactions.
DIPiDIP-2796N.
IntActiP38137. 10 interactions.
MINTiMINT-618445.

Proteomic databases

MaxQBiP38137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR222C; YBR222C; YBR222C.
GeneIDi852523.
KEGGisce:YBR222C.

Organism-specific databases

EuPathDBiFungiDB:YBR222C.
SGDiS000000426. PCS60.

Phylogenomic databases

GeneTreeiENSGT00760000119304.
HOGENOMiHOG000229994.
InParanoidiP38137.
OMAiIPRIRFI.
OrthoDBiEOG72RN7X.

Enzyme and pathway databases

BioCyciYEAST:G3O-29157-MONOMER.
BRENDAi6.2.1.3. 984.
6.2.1.8. 984.
ReactomeiR-SCE-75105. Fatty Acyl-CoA Biosynthesis.
R-SCE-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

PROiP38137.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Identification of a yeast peroxisomal member of the family of AMP-binding proteins."
    Blobel F., Erdmann R.
    Eur. J. Biochem. 240:468-476(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAT2_YEAST
AccessioniPrimary (citable) accession number: P38137
Secondary accession number(s): D6VQL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 6, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8770 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.