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Protein

Tyrosine-protein kinase etk

Gene

etk

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein tyrosine kinase activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11826-MONOMER.
ECOL316407:JW0964-MONOMER.
MetaCyc:EG11826-MONOMER.
BRENDAi2.7.10.1. 2026.

Protein family/group databases

TCDBi8.A.3.3.1. the cytoplasmic membrane-periplasmic auxiliary-1 (mpa1) protein with cytoplasmic (c) domain (mpa1-c or mpa1+c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase etk (EC:2.7.10.-)
Gene namesi
Name:etk
Synonyms:yccC
Ordered Locus Names:b0981, JW0964
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11826. etk.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 424PeriplasmicSequence analysisAdd BLAST371
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Topological domaini446 – 726CytoplasmicSequence analysisAdd BLAST281

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002123491 – 726Tyrosine-protein kinase etkAdd BLAST726

Post-translational modificationi

Autophosphorylated. Dephosphorylated by etp.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP38134.
PaxDbiP38134.
PRIDEiP38134.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-562015,EBI-562015

Protein-protein interaction databases

BioGridi4261406. 386 interactors.
DIPiDIP-9526N.
IntActiP38134. 2 interactors.
MINTiMINT-6743651.
STRINGi511145.b0981.

Structurei

Secondary structure

1726
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi457 – 460Combined sources4
Turni461 – 463Combined sources3
Beta strandi466 – 471Combined sources6
Helixi475 – 478Combined sources4
Helixi502 – 505Combined sources4
Helixi510 – 525Combined sources16
Beta strandi533 – 543Combined sources11
Helixi545 – 558Combined sources14
Beta strandi563 – 567Combined sources5
Turni570 – 572Combined sources3
Helixi575 – 578Combined sources4
Beta strandi584 – 586Combined sources3
Helixi587 – 591Combined sources5
Helixi597 – 600Combined sources4
Beta strandi602 – 604Combined sources3
Turni605 – 608Combined sources4
Beta strandi609 – 612Combined sources4
Helixi621 – 625Combined sources5
Helixi628 – 640Combined sources13
Beta strandi642 – 647Combined sources6
Turni651 – 653Combined sources3
Helixi656 – 660Combined sources5
Helixi661 – 663Combined sources3
Beta strandi665 – 672Combined sources8
Turni673 – 675Combined sources3
Helixi680 – 690Combined sources11
Beta strandi698 – 702Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CIOX-ray2.50A/D452-726[»]
ProteinModelPortaliP38134.
SMRiP38134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38134.

Family & Domainsi

Sequence similaritiesi

Belongs to the etk/wzc family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D75. Bacteria.
COG0489. LUCA.
COG3206. LUCA.
HOGENOMiHOG000153997.
InParanoidiP38134.
KOiK16692.
OMAiNEIGRQY.
PhylomeDBiP38134.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR032807. GNVR.
IPR003856. LipoPS_biosynth.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
PF13807. GNVR. 1 hit.
PF02706. Wzz. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

P38134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTKNMNTPP GSTQENEIDL LRLVGELWDH RKFIISVTAL FTLIAVAYSL
60 70 80 90 100
LSTPIYQADT LVQVEQKQGN AILSGLSDMI PNSSPESAPE IQLLQSRMIL
110 120 130 140 150
GKTIAELNLR DIVEQKYFPI VGRGWARLTK EKPGELAISW MHIPQLNGQD
160 170 180 190 200
QQLTLTVGEN GHYTLEGEEF TVNGMVGQRL EKDGVALTIA DIKAKPGTQF
210 220 230 240 250
VLSQRTELEA INALQETFTV SERSKESGML ELTMTGDDPQ LITRILNSIA
260 270 280 290 300
NNYLQQNIAR QAAQDSQSLE FLQRQLPEVR SELDQAEEKL NVYRQQRDSV
310 320 330 340 350
DLNLEAKAVL EQIVNVDNQL NELTFREAEI SQLYKKDHPT YRALLEKRQT
360 370 380 390 400
LEQERKRLNK RVSAMPSTQQ EVLRLSRDVE AGRAVYLQLL NRQQELSISK
410 420 430 440 450
SSAIGNVRII DPAVTQPQPV KPKKALNVVL GFILGLFISV GAVLARAMLR
460 470 480 490 500
RGVEAPEQLE EHGISVYATI PMSEWLDKRT RLRKKNLFSN QQRHRTKNIP
510 520 530 540 550
FLAVDNPADS AVEAVRALRT SLHFAMMETE NNILMITGAT PDSGKTFVSS
560 570 580 590 600
TLAAVIAQSD QKVLFIDADL RRGYSHNLFT VSNEHGLSEY LAGKDELNKV
610 620 630 640 650
IQHFGKGGFD VITRGQVPPN PSELLMRDRM RQLLEWANDH YDLVIVDTPP
660 670 680 690 700
MLAVSDAAVV GRSVGTSLLV ARFGLNTAKE VSLSMQRLEQ AGVNIKGAIL
710 720
NGVIKRASTA YSYGYNYYGY SYSEKE
Length:726
Mass (Da):81,242
Last modified:November 1, 1997 - v2
Checksum:iBAA060F59680DA22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti726E → EEN (PubMed:8905232).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74066.1.
AP009048 Genomic DNA. Translation: BAA35746.1.
M58708 Genomic DNA. No translation available.
PIRiC64839.
RefSeqiNP_415501.1. NC_000913.3.
WP_000208650.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74066; AAC74066; b0981.
BAA35746; BAA35746; BAA35746.
GeneIDi947409.
KEGGiecj:JW0964.
eco:b0981.
PATRICi32117185. VBIEscCol129921_1016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74066.1.
AP009048 Genomic DNA. Translation: BAA35746.1.
M58708 Genomic DNA. No translation available.
PIRiC64839.
RefSeqiNP_415501.1. NC_000913.3.
WP_000208650.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CIOX-ray2.50A/D452-726[»]
ProteinModelPortaliP38134.
SMRiP38134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261406. 386 interactors.
DIPiDIP-9526N.
IntActiP38134. 2 interactors.
MINTiMINT-6743651.
STRINGi511145.b0981.

Protein family/group databases

TCDBi8.A.3.3.1. the cytoplasmic membrane-periplasmic auxiliary-1 (mpa1) protein with cytoplasmic (c) domain (mpa1-c or mpa1+c) family.

Proteomic databases

EPDiP38134.
PaxDbiP38134.
PRIDEiP38134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74066; AAC74066; b0981.
BAA35746; BAA35746; BAA35746.
GeneIDi947409.
KEGGiecj:JW0964.
eco:b0981.
PATRICi32117185. VBIEscCol129921_1016.

Organism-specific databases

EchoBASEiEB1773.
EcoGeneiEG11826. etk.

Phylogenomic databases

eggNOGiENOG4105D75. Bacteria.
COG0489. LUCA.
COG3206. LUCA.
HOGENOMiHOG000153997.
InParanoidiP38134.
KOiK16692.
OMAiNEIGRQY.
PhylomeDBiP38134.

Enzyme and pathway databases

BioCyciEcoCyc:EG11826-MONOMER.
ECOL316407:JW0964-MONOMER.
MetaCyc:EG11826-MONOMER.
BRENDAi2.7.10.1. 2026.

Miscellaneous databases

EvolutionaryTraceiP38134.
PROiP38134.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR005702. EPS_synthesis.
IPR032807. GNVR.
IPR003856. LipoPS_biosynth.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13614. AAA_31. 1 hit.
PF13807. GNVR. 1 hit.
PF02706. Wzz. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01007. eps_fam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiETK_ECOLI
AccessioniPrimary (citable) accession number: P38134
Secondary accession number(s): P75879
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Seems to be expressed only in enteropathogenic E.coli strains; in E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.