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P38130

- KTR3_YEAST

UniProt

P38130 - KTR3_YEAST

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Protein
Probable mannosyltransferase KTR3
Gene
KTR3, YBR205W, YBR1445
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possible glycosyltransferase.

Catalytic activityi

Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei295 – 2951Nucleophile Reviewed prediction

GO - Molecular functioni

  1. mannosyltransferase activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. N-glycan processing Source: SGD
  2. mannosylation Source: GOC
  3. protein O-linked glycosylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-29145-MONOMER.

Protein family/group databases

CAZyiGT15. Glycosyltransferase Family 15.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyltransferase KTR3 (EC:2.4.1.-)
Gene namesi
Name:KTR3
Ordered Locus Names:YBR205W
ORF Names:YBR1445
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR205w.
SGDiS000000409. KTR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei28 – 4417Helical; Signal-anchor for type II membrane protein
Add
BLAST
Topological domaini45 – 404360Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Probable mannosyltransferase KTR3
PRO_0000208244Add
BLAST

Proteomic databases

MaxQBiP38130.
PaxDbiP38130.
PeptideAtlasiP38130.

Expressioni

Gene expression databases

GenevestigatoriP38130.

Interactioni

Subunit structurei

Interacts with SVP26.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RPL4AP106643EBI-9987,EBI-15390

Protein-protein interaction databases

BioGridi32902. 50 interactions.
DIPiDIP-1723N.
IntActiP38130. 15 interactions.
MINTiMINT-391567.
STRINGi4932.YBR205W.

Structurei

3D structure databases

ProteinModelPortaliP38130.
SMRiP38130. Positions 85-395.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni45 – 8339Stem region By similarity
Add
BLAST
Regioni84 – 404321Catalytic By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5020.
GeneTreeiENSGT00390000000831.
HOGENOMiHOG000160667.
KOiK10967.
OMAiMRKWERI.
OrthoDBiEOG779P83.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR002685. Glyco_trans_15.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFiPIRSF018153. Glyco_trans_15. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P38130-1 [UniParc]FASTAAdd to Basket

« Hide

MSVHHKKKLM PKSALLIRKY QKGIRSSFIG LIIVLSFLFF MSGSRSPEVP    50
IAQGTSVSRV ASKDYLMPFT DKSQGVIHPV DDGKKEKGVM VTLARNSDLW 100
NLVKSIRHVE DRFNNRYHYD WVFLNDQPFS DEFKRVTSAL VSGKAKYGTI 150
PKDHWSIPSW IDTEKFDEKR LAMGKLDIPY GSSVPYRHMC RFQSGFIWRH 200
PLLEEYEWFW RVDTDITLFC DIQYDIFKFL KVNNKKYGFI LSVSEYERTI 250
PTLWETTKKF IKKNPKFLHK NNLMKFISND DGDTYNMCHF WTNFEIGSLD 300
FFRSDAYREY FDYLDSSGGF FYERWGDAPV HSIAASLFLD KSEIHFFDGL 350
GFHHPDFTSC PIEQKIRLQN KCICEPSKDV TWTPDYFCTR KYFSAGNYKL 400
PPGI 404
Length:404
Mass (Da):47,482
Last modified:October 1, 1994 - v1
Checksum:i199F184731C4F381
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001W → R in AAT93230. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21487 Genomic DNA. Translation: CAA79693.1.
Z36074 Genomic DNA. Translation: CAA85169.1.
AY693211 Genomic DNA. Translation: AAT93230.1.
BK006936 Genomic DNA. Translation: DAA07323.1.
PIRiS34031.
RefSeqiNP_009764.3. NM_001178553.3.

Genome annotation databases

EnsemblFungiiYBR205W; YBR205W; YBR205W.
GeneIDi852504.
KEGGisce:YBR205W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21487 Genomic DNA. Translation: CAA79693.1 .
Z36074 Genomic DNA. Translation: CAA85169.1 .
AY693211 Genomic DNA. Translation: AAT93230.1 .
BK006936 Genomic DNA. Translation: DAA07323.1 .
PIRi S34031.
RefSeqi NP_009764.3. NM_001178553.3.

3D structure databases

ProteinModelPortali P38130.
SMRi P38130. Positions 85-395.
ModBasei Search...

Protein-protein interaction databases

BioGridi 32902. 50 interactions.
DIPi DIP-1723N.
IntActi P38130. 15 interactions.
MINTi MINT-391567.
STRINGi 4932.YBR205W.

Protein family/group databases

CAZyi GT15. Glycosyltransferase Family 15.

Proteomic databases

MaxQBi P38130.
PaxDbi P38130.
PeptideAtlasi P38130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR205W ; YBR205W ; YBR205W .
GeneIDi 852504.
KEGGi sce:YBR205W.

Organism-specific databases

CYGDi YBR205w.
SGDi S000000409. KTR3.

Phylogenomic databases

eggNOGi COG5020.
GeneTreei ENSGT00390000000831.
HOGENOMi HOG000160667.
KOi K10967.
OMAi MRKWERI.
OrthoDBi EOG779P83.

Enzyme and pathway databases

BioCyci YEAST:G3O-29145-MONOMER.

Miscellaneous databases

NextBioi 971516.

Gene expression databases

Genevestigatori P38130.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR002685. Glyco_trans_15.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01793. Glyco_transf_15. 1 hit.
[Graphical view ]
PIRSFi PIRSF018153. Glyco_trans_15. 1 hit.
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes."
    Bussereau F., Mallet L., Gaillon L., Jacquet M.
    Yeast 9:797-806(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
    Inadome H., Noda Y., Adachi H., Yoda K.
    Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SVP26.

Entry informationi

Entry nameiKTR3_YEAST
AccessioniPrimary (citable) accession number: P38130
Secondary accession number(s): D6VQK3, E9P931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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