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P38130

- KTR3_YEAST

UniProt

P38130 - KTR3_YEAST

Protein

Probable mannosyltransferase KTR3

Gene

KTR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Possible glycosyltransferase.

    Catalytic activityi

    Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei295 – 2951NucleophileSequence Analysis

    GO - Molecular functioni

    1. mannosyltransferase activity Source: SGD

    GO - Biological processi

    1. mannosylation Source: GOC
    2. N-glycan processing Source: SGD
    3. protein O-linked glycosylation Source: SGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29145-MONOMER.

    Protein family/group databases

    CAZyiGT15. Glycosyltransferase Family 15.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mannosyltransferase KTR3 (EC:2.4.1.-)
    Gene namesi
    Name:KTR3
    Ordered Locus Names:YBR205W
    ORF Names:YBR1445
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR205w.
    SGDiS000000409. KTR3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Probable mannosyltransferase KTR3PRO_0000208244Add
    BLAST

    Proteomic databases

    MaxQBiP38130.
    PaxDbiP38130.
    PeptideAtlasiP38130.

    Expressioni

    Gene expression databases

    GenevestigatoriP38130.

    Interactioni

    Subunit structurei

    Interacts with SVP26.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RPL4AP106643EBI-9987,EBI-15390

    Protein-protein interaction databases

    BioGridi32902. 50 interactions.
    DIPiDIP-1723N.
    IntActiP38130. 15 interactions.
    MINTiMINT-391567.
    STRINGi4932.YBR205W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38130.
    SMRiP38130. Positions 85-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini45 – 404360LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4417Helical; Signal-anchor for type II membrane proteinAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni45 – 8339Stem regionBy similarityAdd
    BLAST
    Regioni84 – 404321CatalyticBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyltransferase 15 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5020.
    GeneTreeiENSGT00390000000831.
    HOGENOMiHOG000160667.
    KOiK10967.
    OMAiMRKWERI.
    OrthoDBiEOG779P83.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR002685. Glyco_trans_15.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01793. Glyco_transf_15. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018153. Glyco_trans_15. 1 hit.
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P38130-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVHHKKKLM PKSALLIRKY QKGIRSSFIG LIIVLSFLFF MSGSRSPEVP    50
    IAQGTSVSRV ASKDYLMPFT DKSQGVIHPV DDGKKEKGVM VTLARNSDLW 100
    NLVKSIRHVE DRFNNRYHYD WVFLNDQPFS DEFKRVTSAL VSGKAKYGTI 150
    PKDHWSIPSW IDTEKFDEKR LAMGKLDIPY GSSVPYRHMC RFQSGFIWRH 200
    PLLEEYEWFW RVDTDITLFC DIQYDIFKFL KVNNKKYGFI LSVSEYERTI 250
    PTLWETTKKF IKKNPKFLHK NNLMKFISND DGDTYNMCHF WTNFEIGSLD 300
    FFRSDAYREY FDYLDSSGGF FYERWGDAPV HSIAASLFLD KSEIHFFDGL 350
    GFHHPDFTSC PIEQKIRLQN KCICEPSKDV TWTPDYFCTR KYFSAGNYKL 400
    PPGI 404
    Length:404
    Mass (Da):47,482
    Last modified:October 1, 1994 - v1
    Checksum:i199F184731C4F381
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1001W → R in AAT93230. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21487 Genomic DNA. Translation: CAA79693.1.
    Z36074 Genomic DNA. Translation: CAA85169.1.
    AY693211 Genomic DNA. Translation: AAT93230.1.
    BK006936 Genomic DNA. Translation: DAA07323.1.
    PIRiS34031.
    RefSeqiNP_009764.3. NM_001178553.3.

    Genome annotation databases

    EnsemblFungiiYBR205W; YBR205W; YBR205W.
    GeneIDi852504.
    KEGGisce:YBR205W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21487 Genomic DNA. Translation: CAA79693.1 .
    Z36074 Genomic DNA. Translation: CAA85169.1 .
    AY693211 Genomic DNA. Translation: AAT93230.1 .
    BK006936 Genomic DNA. Translation: DAA07323.1 .
    PIRi S34031.
    RefSeqi NP_009764.3. NM_001178553.3.

    3D structure databases

    ProteinModelPortali P38130.
    SMRi P38130. Positions 85-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32902. 50 interactions.
    DIPi DIP-1723N.
    IntActi P38130. 15 interactions.
    MINTi MINT-391567.
    STRINGi 4932.YBR205W.

    Protein family/group databases

    CAZyi GT15. Glycosyltransferase Family 15.

    Proteomic databases

    MaxQBi P38130.
    PaxDbi P38130.
    PeptideAtlasi P38130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR205W ; YBR205W ; YBR205W .
    GeneIDi 852504.
    KEGGi sce:YBR205W.

    Organism-specific databases

    CYGDi YBR205w.
    SGDi S000000409. KTR3.

    Phylogenomic databases

    eggNOGi COG5020.
    GeneTreei ENSGT00390000000831.
    HOGENOMi HOG000160667.
    KOi K10967.
    OMAi MRKWERI.
    OrthoDBi EOG779P83.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29145-MONOMER.

    Miscellaneous databases

    NextBioi 971516.

    Gene expression databases

    Genevestigatori P38130.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR002685. Glyco_trans_15.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01793. Glyco_transf_15. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018153. Glyco_trans_15. 1 hit.
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes."
      Bussereau F., Mallet L., Gaillon L., Jacquet M.
      Yeast 9:797-806(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
      Inadome H., Noda Y., Adachi H., Yoda K.
      Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SVP26.

    Entry informationi

    Entry nameiKTR3_YEAST
    AccessioniPrimary (citable) accession number: P38130
    Secondary accession number(s): D6VQK3, E9P931
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 704 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3