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P38130 (KTR3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mannosyltransferase KTR3

EC=2.4.1.-
Gene names
Name:KTR3
Ordered Locus Names:YBR205W
ORF Names:YBR1445
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possible glycosyltransferase.

Catalytic activity

Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Subunit structure

Interacts with SVP26. Ref.6

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the glycosyltransferase 15 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RPL4AP106643EBI-9987,EBI-15390

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Probable mannosyltransferase KTR3
PRO_0000208244

Regions

Topological domain1 – 2727Cytoplasmic Potential
Transmembrane28 – 4417Helical; Signal-anchor for type II membrane protein
Topological domain45 – 404360Lumenal Potential
Region45 – 8339Stem region By similarity
Region84 – 404321Catalytic By similarity

Sites

Active site2951Nucleophile Potential

Experimental info

Sequence conflict1001W → R in AAT93230. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P38130 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 199F184731C4F381

FASTA40447,482
        10         20         30         40         50         60 
MSVHHKKKLM PKSALLIRKY QKGIRSSFIG LIIVLSFLFF MSGSRSPEVP IAQGTSVSRV 

        70         80         90        100        110        120 
ASKDYLMPFT DKSQGVIHPV DDGKKEKGVM VTLARNSDLW NLVKSIRHVE DRFNNRYHYD 

       130        140        150        160        170        180 
WVFLNDQPFS DEFKRVTSAL VSGKAKYGTI PKDHWSIPSW IDTEKFDEKR LAMGKLDIPY 

       190        200        210        220        230        240 
GSSVPYRHMC RFQSGFIWRH PLLEEYEWFW RVDTDITLFC DIQYDIFKFL KVNNKKYGFI 

       250        260        270        280        290        300 
LSVSEYERTI PTLWETTKKF IKKNPKFLHK NNLMKFISND DGDTYNMCHF WTNFEIGSLD 

       310        320        330        340        350        360 
FFRSDAYREY FDYLDSSGGF FYERWGDAPV HSIAASLFLD KSEIHFFDGL GFHHPDFTSC 

       370        380        390        400 
PIEQKIRLQN KCICEPSKDV TWTPDYFCTR KYFSAGNYKL PPGI 

« Hide

References

« Hide 'large scale' references
[1]"A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes."
Bussereau F., Mallet L., Gaillon L., Jacquet M.
Yeast 9:797-806(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
Inadome H., Noda Y., Adachi H., Yoda K.
Mol. Cell. Biol. 25:7696-7710(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SVP26.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z21487 Genomic DNA. Translation: CAA79693.1.
Z36074 Genomic DNA. Translation: CAA85169.1.
AY693211 Genomic DNA. Translation: AAT93230.1.
BK006936 Genomic DNA. Translation: DAA07323.1.
PIRS34031.
RefSeqNP_009764.3. NM_001178553.3.

3D structure databases

ProteinModelPortalP38130.
SMRP38130. Positions 85-395.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32902. 48 interactions.
DIPDIP-1723N.
IntActP38130. 15 interactions.
MINTMINT-391567.
STRING4932.YBR205W.

Protein family/group databases

CAZyGT15. Glycosyltransferase Family 15.

Proteomic databases

PaxDbP38130.
PeptideAtlasP38130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR205W; YBR205W; YBR205W.
GeneID852504.
KEGGsce:YBR205W.

Organism-specific databases

CYGDYBR205w.
SGDS000000409. KTR3.

Phylogenomic databases

eggNOGCOG5020.
GeneTreeENSGT00390000000831.
HOGENOMHOG000160667.
KOK10967.
OMAMRKWERI.
OrthoDBEOG779P83.

Enzyme and pathway databases

BioCycYEAST:G3O-29145-MONOMER.

Gene expression databases

GenevestigatorP38130.

Family and domain databases

InterProIPR002685. Glyco_trans_15.
[Graphical view]
PfamPF01793. Glyco_transf_15. 1 hit.
[Graphical view]
PIRSFPIRSF018153. Glyco_trans_15. 1 hit.
ProtoNetSearch...

Other

NextBio971516.

Entry information

Entry nameKTR3_YEAST
AccessionPrimary (citable) accession number: P38130
Secondary accession number(s): D6VQK3, E9P931
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families