Reviewed,
UniProtKB/Swiss-Prot P38130 (KTR3_YEAST)
Last modified
February 9, 2010.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable mannosyltransferase KTR3 EC=2.4.1.131 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 404 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Possible glycosyltransferase. |
| Catalytic activity | Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. |
| Subunit structure | Interacts with SVP26. Ref.4 |
| Subcellular location | Membrane; Single-pass type II membrane protein Probable. |
| Miscellaneous | Present with 704 molecules/cell in log phase SD medium. Ref.3 |
| Sequence similarities | Belongs to the glycosyltransferase 15 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fungal-type cell wall organization Inferred from mutant phenotype. Source: SGD protein amino acid N-linked glycosylationInferred from mutant phenotype. Source: SGD protein amino acid O-linked glycosylationInferred from mutant phenotype. Source: SGD |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | glycolipid 2-alpha-mannosyltransferase activity Inferred from electronic annotation. Source: EC protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 404 | 404 | Probable mannosyltransferase KTR3 | PRO_0000208244 | |||||
Regions | |||||||||
| Topological domain | 1 – 27 | 27 | Cytoplasmic Potential | ||||||
| Transmembrane | 28 – 44 | 17 | Signal-anchor for type II membrane protein | ||||||
| Topological domain | 45 – 404 | 360 | Lumenal Potential | ||||||
| Region | 45 – 83 | 39 | Stem region By similarity | ||||||
| Region | 84 – 404 | 321 | Catalytic By similarity | ||||||
Sites | |||||||||
| Active site | 295 | 1 | Nucleophile Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes." Bussereau F., Mallet L., Gaillon L., Jacquet M. Yeast 9:797-806(1993) [PubMed: 8368014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [2] | "Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. Kleine K.EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [3] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [4] | "Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments." Inadome H., Noda Y., Adachi H., Yoda K. Mol. Cell. Biol. 25:7696-7710(2005) [PubMed: 16107716] [Abstract] Cited for: INTERACTION WITH SVP26. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z21487 Genomic DNA. Translation: CAA79693.1. Z36074 Genomic DNA. Translation: CAA85169.1. |
| PIR | S34031. |
| RefSeq | NP_009764.1. |
3D structure databases | |
| SMR | P38130. Positions 75-403. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-1723N. |
| IntAct | P38130. 26 interactions. |
| STRING | P38130. |
Protein family/group databases | |
| CAZy | GT15. Glycosyltransferase Family 15. |
Proteomic databases | |
| PeptideAtlas | P38130. |
Genome annotation databases | |
| Ensembl | YBR205W; YBR205W; YBR205W; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 852504. |
| KEGG | sce:YBR205W. |
| NMPDR | fig|4932.3.peg.475. |
Organism-specific databases | |
| CYGD | YBR205w. |
| SGD | S000000409. KTR3. |
Phylogenomic databases | |
| eggNOG | fuNOG04371. |
| HOGENOM | HBG396033. |
| OMA | MKFISND. |
| OrthoDB | EOG9S7M66. |
| PhylomeDB | P38130. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.131. 250. |
Gene expression databases | |
| ArrayExpress | P38130. |
| Genevestigator | P38130. |
| GermOnline | YBR205W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR002685. Glyco_trans_15. [Graphical view] |
| Pfam | PF01793. Glyco_transf_15. 1 hit. [Graphical view] |
| PIRSF | PIRSF018153. Glyco_trans_15. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 971516. |
Entry information
| Entry name | KTR3_YEAST | ||||||||
| Accession | Primary (citable) accession number: P38130 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome II Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names |

Clusters with


