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Protein

Probable mannosyltransferase KTR3

Gene

KTR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible glycosyltransferase that transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei295NucleophileSequence analysis1

GO - Molecular functioni

  • alpha-1,2-mannosyltransferase activity Source: GO_Central
  • mannosyltransferase activity Source: SGD

GO - Biological processi

  • cell wall mannoprotein biosynthetic process Source: GO_Central
  • N-glycan processing Source: SGD
  • protein N-linked glycosylation Source: GO_Central
  • protein O-linked glycosylation Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:G3O-29145-MONOMER
YEAST:G3O-29145-MONOMER

Protein family/group databases

CAZyiGT15 Glycosyltransferase Family 15

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyltransferase KTR3 (EC:2.4.1.-)
Gene namesi
Name:KTR3
Ordered Locus Names:YBR205W
ORF Names:YBR1445
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR205W
SGDiS000000409 KTR3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 44Helical; Signal-anchor for type II membrane proteinAdd BLAST17
Topological domaini45 – 404LumenalSequence analysisAdd BLAST360

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002082441 – 404Probable mannosyltransferase KTR3Add BLAST404

Proteomic databases

MaxQBiP38130
PaxDbiP38130
PRIDEiP38130

Interactioni

Subunit structurei

Interacts with SVP26.1 Publication

Protein-protein interaction databases

BioGridi32902, 64 interactors
DIPiDIP-1723N
IntActiP38130, 17 interactors
MINTiP38130
STRINGi4932.YBR205W

Structurei

3D structure databases

ProteinModelPortaliP38130
SMRiP38130
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 83Stem regionBy similarityAdd BLAST39
Regioni84 – 404CatalyticBy similarityAdd BLAST321

Sequence similaritiesi

Belongs to the glycosyltransferase 15 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000000831
HOGENOMiHOG000160667
InParanoidiP38130
KOiK10967
OMAiDPFVFMQ
OrthoDBiEOG092C3H4I

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002685 Glyco_trans_15
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR31121 PTHR31121, 1 hit
PfamiView protein in Pfam
PF01793 Glyco_transf_15, 1 hit
PIRSFiPIRSF018153 Glyco_trans_15, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

P38130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVHHKKKLM PKSALLIRKY QKGIRSSFIG LIIVLSFLFF MSGSRSPEVP
60 70 80 90 100
IAQGTSVSRV ASKDYLMPFT DKSQGVIHPV DDGKKEKGVM VTLARNSDLW
110 120 130 140 150
NLVKSIRHVE DRFNNRYHYD WVFLNDQPFS DEFKRVTSAL VSGKAKYGTI
160 170 180 190 200
PKDHWSIPSW IDTEKFDEKR LAMGKLDIPY GSSVPYRHMC RFQSGFIWRH
210 220 230 240 250
PLLEEYEWFW RVDTDITLFC DIQYDIFKFL KVNNKKYGFI LSVSEYERTI
260 270 280 290 300
PTLWETTKKF IKKNPKFLHK NNLMKFISND DGDTYNMCHF WTNFEIGSLD
310 320 330 340 350
FFRSDAYREY FDYLDSSGGF FYERWGDAPV HSIAASLFLD KSEIHFFDGL
360 370 380 390 400
GFHHPDFTSC PIEQKIRLQN KCICEPSKDV TWTPDYFCTR KYFSAGNYKL

PPGI
Length:404
Mass (Da):47,482
Last modified:October 1, 1994 - v1
Checksum:i199F184731C4F381
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100W → R in AAT93230 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21487 Genomic DNA Translation: CAA79693.1
Z36074 Genomic DNA Translation: CAA85169.1
AY693211 Genomic DNA Translation: AAT93230.1
BK006936 Genomic DNA Translation: DAA07323.1
PIRiS34031
RefSeqiNP_009764.3, NM_001178553.3

Genome annotation databases

EnsemblFungiiYBR205W; YBR205W; YBR205W
GeneIDi852504
KEGGisce:YBR205W

Similar proteinsi

Entry informationi

Entry nameiKTR3_YEAST
AccessioniPrimary (citable) accession number: P38130
Secondary accession number(s): D6VQK3, E9P931
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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