P38127 (RIM2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial carrier protein RIM2

Gene names

Name:	RIM2
Ordered Locus Names:	YBR192W
ORF Names:	YBR1402

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial genome maintenance Inferred from genetic interaction PubMed 7891656. Source: SGD
Cellular_component	integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 16823961PubMed 7891656. Source: SGD
Molecular_function	pyrimidine nucleotide transmembrane transporter activity Inferred from direct assay PubMed 16194150. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Mitochondrial carrier protein RIM2		PRO_0000090690
Regions
	Transmembrane	53 – 73	21	Helical; Name=1; Potential
	Transmembrane	131 – 151	21	Helical; Name=2; Potential
	Transmembrane	179 – 199	21	Helical; Name=3; Potential
	Transmembrane	238 – 258	21	Helical; Name=4; Potential
	Transmembrane	286 – 306	21	Helical; Name=5; Potential
	Transmembrane	347 – 368	22	Helical; Name=6; Potential
	Repeat	50 – 163	114	Solcar 1
	Repeat	173 – 262	90	Solcar 2
	Repeat	286 – 375	90	Solcar 3

Sequences

	Sequence		Length	Mass (Da)
	P38127 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: A3C61383C3B3743B	FASTA	377	42,102
	10 20 30 40 50 60 MPKKSIEEWE EDAIESVPYL ASDEKGSNYK EATQIPLNLK QSEIENHPTV KPWVHFVAGG 70 80 90 100 110 120 IGGMAGAVVT CPFDLVKTRL QSDIFLKAYK SQAVNISKGS TRPKSINYVI QAGTHFKETL 130 140 150 160 170 180 GIIGNVYKQE GFRSLFKGLG PNLVGVIPAR SINFFTYGTT KDMYAKAFNN GQETPMIHLM 190 200 210 220 230 240 AAATAGWATA TATNPIWLIK TRVQLDKAGK TSVRQYKNSW DCLKSVIRNE GFTGLYKGLS 250 260 270 280 290 300 ASYLGSVEGI LQWLLYEQMK RLIKERSIEK FGYQAEGTKS TSEKVKEWCQ RSGSAGLAKF 310 320 330 340 350 360 VASIATYPHE VVRTRLRQTP KENGKRKYTG LVQSFKVIIK EEGLFSMYSG LTPHLMRTVP 370 NSIIMFGTWE IVIRLLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif." Demolis N., Mallet L., Bussereau F., Jacquet M. Yeast 9:645-659(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z21487 Genomic DNA. Translation: CAA79678.1. Z36061 Genomic DNA. Translation: CAA85154.1. AY557871 Genomic DNA. Translation: AAS56197.1. BK006936 Genomic DNA. Translation: DAA07306.1.
PIR	S36081.
RefSeq	NP_009751.1. NM_001178540.1.
3D structure databases
ProteinModelPortal	P38127.
SMR	P38127. Positions 53-376.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4933N.
MINT	MINT-507683.
STRING	4932.YBR192W.
Protein family/group databases
TCDB	2.A.29.10.4. mitochondrial carrier (MC) family.
Proteomic databases
PaxDb	P38127.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR192W; YBR192W; YBR192W.
GeneID	852491.
KEGG	sce:YBR192W.
Organism-specific databases
CYGD	YBR192w.
SGD	S000000396. RIM2.
Phylogenomic databases
eggNOG	NOG301650.
GeneTree	ENSGT00550000074670.
HOGENOM	HOG000188210.
KO	K15116.
OMA	CLKMILE.
OrthoDB	EOG4XKZH2.
Enzyme and pathway databases
BioCyc	YEAST:G3O-29134-MONOMER.
Gene expression databases
Genevestigator	P38127.
GermOnline	YBR192W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002067. Mit_carrier. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00926. MITOCARRIER.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	971477.

Entry information

Entry name

RIM2_YEAST

Accession

Primary (citable) accession number: P38127
Secondary accession number(s): D6VQI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 29, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program