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Protein

Mitochondrial carrier protein RIM2

Gene

RIM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. pyrimidine nucleotide transmembrane transporter activity Source: SGD
  2. transporter activity Source: SGD

GO - Biological processi

  1. divalent metal ion transport Source: SGD
  2. mitochondrial genome maintenance Source: SGD
  3. pyrimidine nucleotide transport Source: SGD
  4. regulation of mitochondrial membrane potential Source: UniProtKB
  5. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29134-MONOMER.

Protein family/group databases

TCDBi2.A.29.10.4. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier protein RIM2
Gene namesi
Name:RIM2
Ordered Locus Names:YBR192W
ORF Names:YBR1402
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR192w.
SGDiS000000396. RIM2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei53 – 7321Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei131 – 15121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei347 – 36822Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Mitochondrial carrier protein RIM2PRO_0000090690Add
BLAST

Proteomic databases

MaxQBiP38127.
PaxDbiP38127.

Expressioni

Gene expression databases

GenevestigatoriP38127.

Interactioni

Protein-protein interaction databases

BioGridi32889. 16 interactions.
DIPiDIP-4933N.
MINTiMINT-507683.
STRINGi4932.YBR192W.

Structurei

3D structure databases

ProteinModelPortaliP38127.
SMRiP38127. Positions 53-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 163114Solcar 1Add
BLAST
Repeati173 – 26290Solcar 2Add
BLAST
Repeati286 – 37590Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301650.
GeneTreeiENSGT00550000074670.
HOGENOMiHOG000188210.
InParanoidiP38127.
KOiK15116.
OMAiVEGILQW.
OrthoDBiEOG7N905P.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKKSIEEWE EDAIESVPYL ASDEKGSNYK EATQIPLNLK QSEIENHPTV
60 70 80 90 100
KPWVHFVAGG IGGMAGAVVT CPFDLVKTRL QSDIFLKAYK SQAVNISKGS
110 120 130 140 150
TRPKSINYVI QAGTHFKETL GIIGNVYKQE GFRSLFKGLG PNLVGVIPAR
160 170 180 190 200
SINFFTYGTT KDMYAKAFNN GQETPMIHLM AAATAGWATA TATNPIWLIK
210 220 230 240 250
TRVQLDKAGK TSVRQYKNSW DCLKSVIRNE GFTGLYKGLS ASYLGSVEGI
260 270 280 290 300
LQWLLYEQMK RLIKERSIEK FGYQAEGTKS TSEKVKEWCQ RSGSAGLAKF
310 320 330 340 350
VASIATYPHE VVRTRLRQTP KENGKRKYTG LVQSFKVIIK EEGLFSMYSG
360 370
LTPHLMRTVP NSIIMFGTWE IVIRLLS
Length:377
Mass (Da):42,102
Last modified:October 1, 1994 - v1
Checksum:iA3C61383C3B3743B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21487 Genomic DNA. Translation: CAA79678.1.
Z36061 Genomic DNA. Translation: CAA85154.1.
AY557871 Genomic DNA. Translation: AAS56197.1.
BK006936 Genomic DNA. Translation: DAA07306.1.
PIRiS36081.
RefSeqiNP_009751.1. NM_001178540.1.

Genome annotation databases

EnsemblFungiiYBR192W; YBR192W; YBR192W.
GeneIDi852491.
KEGGisce:YBR192W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21487 Genomic DNA. Translation: CAA79678.1.
Z36061 Genomic DNA. Translation: CAA85154.1.
AY557871 Genomic DNA. Translation: AAS56197.1.
BK006936 Genomic DNA. Translation: DAA07306.1.
PIRiS36081.
RefSeqiNP_009751.1. NM_001178540.1.

3D structure databases

ProteinModelPortaliP38127.
SMRiP38127. Positions 53-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32889. 16 interactions.
DIPiDIP-4933N.
MINTiMINT-507683.
STRINGi4932.YBR192W.

Protein family/group databases

TCDBi2.A.29.10.4. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBiP38127.
PaxDbiP38127.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR192W; YBR192W; YBR192W.
GeneIDi852491.
KEGGisce:YBR192W.

Organism-specific databases

CYGDiYBR192w.
SGDiS000000396. RIM2.

Phylogenomic databases

eggNOGiNOG301650.
GeneTreeiENSGT00550000074670.
HOGENOMiHOG000188210.
InParanoidiP38127.
KOiK15116.
OMAiVEGILQW.
OrthoDBiEOG7N905P.

Enzyme and pathway databases

BioCyciYEAST:G3O-29134-MONOMER.

Miscellaneous databases

NextBioi971477.

Gene expression databases

GenevestigatoriP38127.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif."
    Demolis N., Mallet L., Bussereau F., Jacquet M.
    Yeast 9:645-659(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiRIM2_YEAST
AccessioniPrimary (citable) accession number: P38127
Secondary accession number(s): D6VQI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 4, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.