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Protein

Pachytene checkpoint protein 2

Gene

PCH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the pachytene checkpoint, the meiotic checkpoint that prevents chromosome segregation when defects in recombination and synaptonemal complex formation occurred. Represses meiotic recombination in the rDNA, probably by excluding the meiosis-specific protein HOP1 from the nucleolar region.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi314 – 321ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • meiotic DNA double-strand break formation Source: SGD
  • meiotic recombination checkpoint Source: SGD
  • reciprocal meiotic recombination Source: SGD

Keywordsi

Biological processMeiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29129-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pachytene checkpoint protein 2
Gene namesi
Name:PCH2
Ordered Locus Names:YBR186W
ORF Names:YBR1308
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR186W
SGDiS000000390 PCH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847891 – 564Pachytene checkpoint protein 2Add BLAST564

Proteomic databases

PaxDbiP38126
PRIDEiP38126

Expressioni

Inductioni

Induced at the onset of meiosis I and reaches a maximum level during pachytene (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi32884, 65 interactors
DIPiDIP-4661N
IntActiP38126, 4 interactors
MINTiP38126
STRINGi4932.YBR186W

Structurei

3D structure databases

ProteinModelPortaliP38126
SMRiP38126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. PCH2 subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00390000017432
HOGENOMiHOG000115471
InParanoidiP38126
KOiK22399
OMAiKTTICKA
OrthoDBiEOG092C30NO

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits

Sequencei

Sequence statusi: Complete.

P38126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYIVDLQVR GSSLRVIKCM FREDEQISSL HSGSDSKQNS NKKLGEFLNL
60 70 80 90 100
LKAVVKRKLE SFPKDRLKTS IITGQELMRE GQGSIEIKDP PTEAQQHLIR
110 120 130 140 150
SLAKVLLHQF SSINGKVNTV NEGQDNLFLS LFVKKISIEQ QSTSHVSIKL
160 170 180 190 200
NFHEKINLGQ HIDSILDSEE TNESDTYHMG SVDEFIIYPF CCLEEQDELK
210 220 230 240 250
NGSILSTEFD KIDLELDEDD GFEGETLNNC INSVGNFDIP LSKQTLNLVN
260 270 280 290 300
ISYLPGTTFE GQWESLYFGN NIKERLYSYA TISLKIARFK QTGDSNQEDI
310 320 330 340 350
TTLITNNKLL LVHGPPGTGK TTLCKALCQK LSVRREFSDG SDTIDTNYKG
360 370 380 390 400
IIIELSCARI FSKWFGESSK NISIVFKDIE ELLKVNEGRG IFICLLIDEV
410 420 430 440 450
EAIASSRTNL SSRNESTDGI RVVNTLLTQL DRLKKYHNFL ALATSNLLDS
460 470 480 490 500
LDDAFVDRAD GVFYVGNPTA EGILHILKVC IEEMITSGII LFHARSTGVK
510 520 530 540 550
FFNKYQDILR KIAIKCSTVD ISGRTIRKLP LMCLSEYFRT FPVDDDEFVL
560
ALAMSARKLS AARK
Length:564
Mass (Da):63,460
Last modified:September 5, 2006 - v2
Checksum:i9B40C41368672877
GO

Sequence cautioni

The sequence AAB60280 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA85147 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02073 Genomic DNA Translation: AAB60280.1 Sequence problems.
Z36055 Genomic DNA Translation: CAA85147.1 Sequence problems.
BK006936 Genomic DNA Translation: DAA07301.1
PIRiS46058
RefSeqiNP_009745.2, NM_001178534.1

Genome annotation databases

EnsemblFungiiYBR186W; YBR186W; YBR186W
GeneIDi852484
KEGGisce:YBR186W

Similar proteinsi

Entry informationi

Entry nameiPCH2_YEAST
AccessioniPrimary (citable) accession number: P38126
Secondary accession number(s): D6VQI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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