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P38125

- DTR1_YEAST

UniProt

P38125 - DTR1_YEAST

Protein

Dityrosine transporter 1

Gene

DTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore.1 Publication

    GO - Molecular functioni

    1. amine transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. amine transport Source: SGD
    2. ascospore wall assembly Source: SGD
    3. transmembrane transport Source: SGD

    Keywords - Biological processi

    Sporulation, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29124-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.2.40. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dityrosine transporter 1
    Gene namesi
    Name:DTR1
    Ordered Locus Names:YBR180W
    ORF Names:YBR1242
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR180w.
    SGDiS000000384. DTR1.

    Subcellular locationi

    Prospore membrane 5 Publications; Multi-pass membrane protein 5 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. prospore membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Dityrosine transporter 1PRO_0000173438Add
    BLAST

    Post-translational modificationi

    Phosphorylated.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Inductioni

    During sporulation.1 Publication

    Gene expression databases

    GenevestigatoriP38125.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CHS3P294651EBI-20904,EBI-4632

    Protein-protein interaction databases

    BioGridi32878. 17 interactions.
    DIPiDIP-5179N.
    IntActiP38125. 3 interactions.
    MINTiMINT-540134.
    STRINGi4932.YBR180W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38125.
    SMRiP38125. Positions 133-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 110110CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini132 – 14918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini171 – 18414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini206 – 2072ExtracellularSequence Analysis
    Topological domaini229 – 24012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 2676ExtracellularSequence Analysis
    Topological domaini289 – 36678CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini388 – 39811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini420 – 44627CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini470 – 4723ExtracellularSequence Analysis
    Topological domaini494 – 52027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini542 – 5421ExtracellularSequence Analysis
    Topological domaini564 – 5729CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei447 – 46923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei473 – 49321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei543 – 56321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni548 – 57225Required for the localization to the prospore membraneAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00620000088227.
    OMAiFGMTWVF.
    OrthoDBiEOG7HXD0V.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38125-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSEPFQKKN LGLQINSQES GTTRSTFHSL EDLGDDVINE SWDQVNQKRA    50
    NIDHDVFHEH PDSSPSLSAQ KAKTKEEEVA VKSSNSQSRD PSPDTQAHIP 100
    YTYFSKDQRL IIFGIIIFIG FLGPMSGNIY IPALPLLQRE YDVSATTINA 150
    TVSVFMAVFS VGPLFWGALA DFGGRKFLYM VSLSLMLIVN ILLAAVPVNI 200
    AALFVLRIFQ AFASSSVISL GAGTVTDVVP PKHRGKAIAY FMMGPNMGPI 250
    IAPIVAGLIL MKGNYWRWLF GFTSIMTGIA LILVTALLPE TLRCIVGNGD 300
    PKWGDKKDER ENNESPFFEG NKISHRRLFP DIGIRKPVNN DAFFQENFPK 350
    PPKAGLTLYW KMIKCPPIII TSVSTALLFS SYYAFSVTFS YYLEHDYRFT 400
    MLEIGAAYVC PGVAMLLGSQ SGGHLSDYLR SRWIKSHPKK KFPAEFRLLL 450
    NLIGILLTIC GTIGYGWAIF FHYHFVVLLV FSALTAFGMT WCSNTSMTYL 500
    TELFPKRAAG TVAVSSFFRN VGAAISSAII LQLCNAMGIG WCFTGLGLCS 550
    SISLIGILYL LIFQRKYTAK EF 572
    Length:572
    Mass (Da):63,407
    Last modified:October 1, 1994 - v1
    Checksum:i8175C30520A266F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36049 Genomic DNA. Translation: CAA85141.1.
    BK006936 Genomic DNA. Translation: DAA07294.1.
    PIRiS46051.
    RefSeqiNP_009739.1. NM_001178528.1.

    Genome annotation databases

    EnsemblFungiiYBR180W; YBR180W; YBR180W.
    GeneIDi852478.
    KEGGisce:YBR180W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36049 Genomic DNA. Translation: CAA85141.1 .
    BK006936 Genomic DNA. Translation: DAA07294.1 .
    PIRi S46051.
    RefSeqi NP_009739.1. NM_001178528.1.

    3D structure databases

    ProteinModelPortali P38125.
    SMRi P38125. Positions 133-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32878. 17 interactions.
    DIPi DIP-5179N.
    IntActi P38125. 3 interactions.
    MINTi MINT-540134.
    STRINGi 4932.YBR180W.

    Protein family/group databases

    TCDBi 2.A.1.2.40. the major facilitator superfamily (mfs).

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR180W ; YBR180W ; YBR180W .
    GeneIDi 852478.
    KEGGi sce:YBR180W.

    Organism-specific databases

    CYGDi YBR180w.
    SGDi S000000384. DTR1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00620000088227.
    OMAi FGMTWVF.
    OrthoDBi EOG7HXD0V.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29124-MONOMER.

    Miscellaneous databases

    NextBioi 971444.

    Gene expression databases

    Genevestigatori P38125.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Dtrlp, a multidrug resistance transporter of the major facilitator superfamily, plays an essential role in spore wall maturation in Saccharomyces cerevisiae."
      Felder T., Bogengruber E., Tenreiro S., Ellinger A., Sa-Correia I., Briza P.
      Eukaryot. Cell 1:799-810(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, FUNCTION, SUBCELLULAR LOCATION.
    4. "Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis."
      Iwamoto M.A., Fairclough S.R., Rudge S.A., Engebrecht J.
      Eukaryot. Cell 4:536-544(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    5. "Phospholipase D and the SNARE Sso1p are necessary for vesicle fusion during sporulation in yeast."
      Nakanishi H., Morishita M., Schwartz C.L., Coluccio A., Engebrecht J., Neiman A.M.
      J. Cell Sci. 119:1406-1415(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. "Snc1p v-SNARE transport to the prospore membrane during yeast sporulation is dependent on endosomal retrieval pathways."
      Morishita M., Mendonsa R., Wright J., Engebrecht J.
      Traffic 8:1231-1245(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "Sorting signals within the Saccharomyces cerevisiae sporulation-specific dityrosine transporter, Dtr1p, C terminus promote Golgi-to-prospore membrane transport."
      Morishita M., Engebrecht J.
      Eukaryot. Cell 7:1674-1684(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.

    Entry informationi

    Entry nameiDTR1_YEAST
    AccessioniPrimary (citable) accession number: P38125
    Secondary accession number(s): D6VQH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3