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Protein

Dityrosine transporter 1

Gene

DTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore.1 Publication

GO - Molecular functioni

  • amine transmembrane transporter activity Source: SGD

GO - Biological processi

  • amine transport Source: SGD
  • ascospore wall assembly Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sporulation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29124-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.40. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Dityrosine transporter 1
Gene namesi
Name:DTR1
Ordered Locus Names:YBR180W
ORF Names:YBR1242
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR180W.
SGDiS000000384. DTR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 110CytoplasmicSequence analysisAdd BLAST110
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 149ExtracellularSequence analysisAdd BLAST18
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 184CytoplasmicSequence analysisAdd BLAST14
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 207ExtracellularSequence analysis2
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 240CytoplasmicSequence analysisAdd BLAST12
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 267ExtracellularSequence analysis6
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 366CytoplasmicSequence analysisAdd BLAST78
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 398ExtracellularSequence analysisAdd BLAST11
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 446CytoplasmicSequence analysisAdd BLAST27
Transmembranei447 – 469HelicalSequence analysisAdd BLAST23
Topological domaini470 – 472ExtracellularSequence analysis3
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 520CytoplasmicSequence analysisAdd BLAST27
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542ExtracellularSequence analysis1
Transmembranei543 – 563HelicalSequence analysisAdd BLAST21
Topological domaini564 – 572CytoplasmicSequence analysis9

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • prospore membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734381 – 572Dityrosine transporter 1Add BLAST572

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP38125.

Expressioni

Inductioni

During sporulation.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi32878. 18 interactors.
DIPiDIP-5179N.
IntActiP38125. 3 interactors.
MINTiMINT-540134.

Structurei

3D structure databases

ProteinModelPortaliP38125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 572Required for the localization to the prospore membraneAdd BLAST25

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227.
InParanoidiP38125.
OMAiFGMTWVF.
OrthoDBiEOG092C2079.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEPFQKKN LGLQINSQES GTTRSTFHSL EDLGDDVINE SWDQVNQKRA
60 70 80 90 100
NIDHDVFHEH PDSSPSLSAQ KAKTKEEEVA VKSSNSQSRD PSPDTQAHIP
110 120 130 140 150
YTYFSKDQRL IIFGIIIFIG FLGPMSGNIY IPALPLLQRE YDVSATTINA
160 170 180 190 200
TVSVFMAVFS VGPLFWGALA DFGGRKFLYM VSLSLMLIVN ILLAAVPVNI
210 220 230 240 250
AALFVLRIFQ AFASSSVISL GAGTVTDVVP PKHRGKAIAY FMMGPNMGPI
260 270 280 290 300
IAPIVAGLIL MKGNYWRWLF GFTSIMTGIA LILVTALLPE TLRCIVGNGD
310 320 330 340 350
PKWGDKKDER ENNESPFFEG NKISHRRLFP DIGIRKPVNN DAFFQENFPK
360 370 380 390 400
PPKAGLTLYW KMIKCPPIII TSVSTALLFS SYYAFSVTFS YYLEHDYRFT
410 420 430 440 450
MLEIGAAYVC PGVAMLLGSQ SGGHLSDYLR SRWIKSHPKK KFPAEFRLLL
460 470 480 490 500
NLIGILLTIC GTIGYGWAIF FHYHFVVLLV FSALTAFGMT WCSNTSMTYL
510 520 530 540 550
TELFPKRAAG TVAVSSFFRN VGAAISSAII LQLCNAMGIG WCFTGLGLCS
560 570
SISLIGILYL LIFQRKYTAK EF
Length:572
Mass (Da):63,407
Last modified:October 1, 1994 - v1
Checksum:i8175C30520A266F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36049 Genomic DNA. Translation: CAA85141.1.
BK006936 Genomic DNA. Translation: DAA07294.1.
PIRiS46051.
RefSeqiNP_009739.1. NM_001178528.1.

Genome annotation databases

EnsemblFungiiYBR180W; YBR180W; YBR180W.
GeneIDi852478.
KEGGisce:YBR180W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36049 Genomic DNA. Translation: CAA85141.1.
BK006936 Genomic DNA. Translation: DAA07294.1.
PIRiS46051.
RefSeqiNP_009739.1. NM_001178528.1.

3D structure databases

ProteinModelPortaliP38125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32878. 18 interactors.
DIPiDIP-5179N.
IntActiP38125. 3 interactors.
MINTiMINT-540134.

Protein family/group databases

TCDBi2.A.1.2.40. the major facilitator superfamily (mfs).

Proteomic databases

PRIDEiP38125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR180W; YBR180W; YBR180W.
GeneIDi852478.
KEGGisce:YBR180W.

Organism-specific databases

EuPathDBiFungiDB:YBR180W.
SGDiS000000384. DTR1.

Phylogenomic databases

GeneTreeiENSGT00620000088227.
InParanoidiP38125.
OMAiFGMTWVF.
OrthoDBiEOG092C2079.

Enzyme and pathway databases

BioCyciYEAST:G3O-29124-MONOMER.

Miscellaneous databases

PROiP38125.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDTR1_YEAST
AccessioniPrimary (citable) accession number: P38125
Secondary accession number(s): D6VQH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.