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P38125

- DTR1_YEAST

UniProt

P38125 - DTR1_YEAST

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Protein

Dityrosine transporter 1

Gene

DTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore.1 Publication

GO - Molecular functioni

  1. amine transmembrane transporter activity Source: SGD

GO - Biological processi

  1. amine transport Source: SGD
  2. ascospore wall assembly Source: SGD
  3. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sporulation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29124-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.40. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Dityrosine transporter 1
Gene namesi
Name:DTR1
Ordered Locus Names:YBR180W
ORF Names:YBR1242
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR180w.
SGDiS000000384. DTR1.

Subcellular locationi

Prospore membrane 5 Publications; Multi-pass membrane protein 5 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 110110CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Topological domaini132 – 14918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Topological domaini171 – 18414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei185 – 20521HelicalSequence AnalysisAdd
BLAST
Topological domaini206 – 2072ExtracellularSequence Analysis
Transmembranei208 – 22821HelicalSequence AnalysisAdd
BLAST
Topological domaini229 – 24012CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Topological domaini262 – 2676ExtracellularSequence Analysis
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Topological domaini289 – 36678CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence AnalysisAdd
BLAST
Topological domaini388 – 39811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST
Topological domaini420 – 44627CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei447 – 46923HelicalSequence AnalysisAdd
BLAST
Topological domaini470 – 4723ExtracellularSequence Analysis
Transmembranei473 – 49321HelicalSequence AnalysisAdd
BLAST
Topological domaini494 – 52027CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST
Topological domaini542 – 5421ExtracellularSequence Analysis
Transmembranei543 – 56321HelicalSequence AnalysisAdd
BLAST
Topological domaini564 – 5729CytoplasmicSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. prospore membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Dityrosine transporter 1PRO_0000173438Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

During sporulation.1 Publication

Gene expression databases

GenevestigatoriP38125.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CHS3P294651EBI-20904,EBI-4632

Protein-protein interaction databases

BioGridi32878. 17 interactions.
DIPiDIP-5179N.
IntActiP38125. 3 interactions.
MINTiMINT-540134.
STRINGi4932.YBR180W.

Structurei

3D structure databases

ProteinModelPortaliP38125.
SMRiP38125. Positions 133-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni548 – 57225Required for the localization to the prospore membraneAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088227.
InParanoidiP38125.
OMAiFGMTWVF.
OrthoDBiEOG7HXD0V.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38125-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSEPFQKKN LGLQINSQES GTTRSTFHSL EDLGDDVINE SWDQVNQKRA
60 70 80 90 100
NIDHDVFHEH PDSSPSLSAQ KAKTKEEEVA VKSSNSQSRD PSPDTQAHIP
110 120 130 140 150
YTYFSKDQRL IIFGIIIFIG FLGPMSGNIY IPALPLLQRE YDVSATTINA
160 170 180 190 200
TVSVFMAVFS VGPLFWGALA DFGGRKFLYM VSLSLMLIVN ILLAAVPVNI
210 220 230 240 250
AALFVLRIFQ AFASSSVISL GAGTVTDVVP PKHRGKAIAY FMMGPNMGPI
260 270 280 290 300
IAPIVAGLIL MKGNYWRWLF GFTSIMTGIA LILVTALLPE TLRCIVGNGD
310 320 330 340 350
PKWGDKKDER ENNESPFFEG NKISHRRLFP DIGIRKPVNN DAFFQENFPK
360 370 380 390 400
PPKAGLTLYW KMIKCPPIII TSVSTALLFS SYYAFSVTFS YYLEHDYRFT
410 420 430 440 450
MLEIGAAYVC PGVAMLLGSQ SGGHLSDYLR SRWIKSHPKK KFPAEFRLLL
460 470 480 490 500
NLIGILLTIC GTIGYGWAIF FHYHFVVLLV FSALTAFGMT WCSNTSMTYL
510 520 530 540 550
TELFPKRAAG TVAVSSFFRN VGAAISSAII LQLCNAMGIG WCFTGLGLCS
560 570
SISLIGILYL LIFQRKYTAK EF
Length:572
Mass (Da):63,407
Last modified:October 1, 1994 - v1
Checksum:i8175C30520A266F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36049 Genomic DNA. Translation: CAA85141.1.
BK006936 Genomic DNA. Translation: DAA07294.1.
PIRiS46051.
RefSeqiNP_009739.1. NM_001178528.1.

Genome annotation databases

EnsemblFungiiYBR180W; YBR180W; YBR180W.
GeneIDi852478.
KEGGisce:YBR180W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36049 Genomic DNA. Translation: CAA85141.1 .
BK006936 Genomic DNA. Translation: DAA07294.1 .
PIRi S46051.
RefSeqi NP_009739.1. NM_001178528.1.

3D structure databases

ProteinModelPortali P38125.
SMRi P38125. Positions 133-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32878. 17 interactions.
DIPi DIP-5179N.
IntActi P38125. 3 interactions.
MINTi MINT-540134.
STRINGi 4932.YBR180W.

Protein family/group databases

TCDBi 2.A.1.2.40. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR180W ; YBR180W ; YBR180W .
GeneIDi 852478.
KEGGi sce:YBR180W.

Organism-specific databases

CYGDi YBR180w.
SGDi S000000384. DTR1.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00620000088227.
InParanoidi P38125.
OMAi FGMTWVF.
OrthoDBi EOG7HXD0V.

Enzyme and pathway databases

BioCyci YEAST:G3O-29124-MONOMER.

Miscellaneous databases

NextBioi 971444.

Gene expression databases

Genevestigatori P38125.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Dtrlp, a multidrug resistance transporter of the major facilitator superfamily, plays an essential role in spore wall maturation in Saccharomyces cerevisiae."
    Felder T., Bogengruber E., Tenreiro S., Ellinger A., Sa-Correia I., Briza P.
    Eukaryot. Cell 1:799-810(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, FUNCTION, SUBCELLULAR LOCATION.
  4. "Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis."
    Iwamoto M.A., Fairclough S.R., Rudge S.A., Engebrecht J.
    Eukaryot. Cell 4:536-544(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. "Phospholipase D and the SNARE Sso1p are necessary for vesicle fusion during sporulation in yeast."
    Nakanishi H., Morishita M., Schwartz C.L., Coluccio A., Engebrecht J., Neiman A.M.
    J. Cell Sci. 119:1406-1415(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Snc1p v-SNARE transport to the prospore membrane during yeast sporulation is dependent on endosomal retrieval pathways."
    Morishita M., Mendonsa R., Wright J., Engebrecht J.
    Traffic 8:1231-1245(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Sorting signals within the Saccharomyces cerevisiae sporulation-specific dityrosine transporter, Dtr1p, C terminus promote Golgi-to-prospore membrane transport."
    Morishita M., Engebrecht J.
    Eukaryot. Cell 7:1674-1684(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.

Entry informationi

Entry nameiDTR1_YEAST
AccessioniPrimary (citable) accession number: P38125
Secondary accession number(s): D6VQH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3