Reviewed, UniProtKB/Swiss-Prot P38125 (YB30_YEAST)

Names and origin

Protein names

Recommended name:
    Uncharacterized transporter YBR180W

Gene names

Ordered Locus Names:	YBR180W
ORF Names:	YBR1242

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the major facilitator superfamily. CAR1 family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amine transport Inferred from mutant phenotype. Source: SGD ascospore wall assembly Inferred from mutant phenotype. Source: SGD transmembrane transport Inferred from mutant phenotype. Source: SGD
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell prospore membrane Inferred from direct assay. Source: SGD
Molecular function	amine transmembrane transporter activity Inferred from mutant phenotype. Source: SGD protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CHS3	P29465	1	EBI-20904,EBI-4632

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 572	572	Uncharacterized transporter YBR180W		PRO_0000173438
Regions
	Topological domain	1 – 110	110	Cytoplasmic Potential
	Transmembrane	111 – 131	21	Potential
	Topological domain	132 – 149	18	Extracellular Potential
	Transmembrane	150 – 170	21	Potential
	Topological domain	171 – 184	14	Cytoplasmic Potential
	Transmembrane	185 – 205	21	Potential
	Topological domain	206 – 207	2	Extracellular Potential
	Transmembrane	208 – 228	21	Potential
	Topological domain	229 – 240	12	Cytoplasmic Potential
	Transmembrane	241 – 261	21	Potential
	Topological domain	262 – 267	6	Extracellular Potential
	Transmembrane	268 – 288	21	Potential
	Topological domain	289 – 366	78	Cytoplasmic Potential
	Transmembrane	367 – 387	21	Potential
	Topological domain	388 – 398	11	Extracellular Potential
	Transmembrane	399 – 419	21	Potential
	Topological domain	420 – 446	27	Cytoplasmic Potential
	Transmembrane	447 – 469	23	Potential
	Topological domain	470 – 472	3	Extracellular Potential
	Transmembrane	473 – 493	21	Potential
	Topological domain	494 – 520	27	Cytoplasmic Potential
	Transmembrane	521 – 541	21	Potential
	Topological domain	542	1	Extracellular Potential
	Transmembrane	543 – 563	21	Potential
	Topological domain	564 – 572	9	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P38125-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 8175C30520A266F4	FASTA	572	63,407
	10 20 30 40 50 60 MGSEPFQKKN LGLQINSQES GTTRSTFHSL EDLGDDVINE SWDQVNQKRA NIDHDVFHEH 70 80 90 100 110 120 PDSSPSLSAQ KAKTKEEEVA VKSSNSQSRD PSPDTQAHIP YTYFSKDQRL IIFGIIIFIG 130 140 150 160 170 180 FLGPMSGNIY IPALPLLQRE YDVSATTINA TVSVFMAVFS VGPLFWGALA DFGGRKFLYM 190 200 210 220 230 240 VSLSLMLIVN ILLAAVPVNI AALFVLRIFQ AFASSSVISL GAGTVTDVVP PKHRGKAIAY 250 260 270 280 290 300 FMMGPNMGPI IAPIVAGLIL MKGNYWRWLF GFTSIMTGIA LILVTALLPE TLRCIVGNGD 310 320 330 340 350 360 PKWGDKKDER ENNESPFFEG NKISHRRLFP DIGIRKPVNN DAFFQENFPK PPKAGLTLYW 370 380 390 400 410 420 KMIKCPPIII TSVSTALLFS SYYAFSVTFS YYLEHDYRFT MLEIGAAYVC PGVAMLLGSQ 430 440 450 460 470 480 SGGHLSDYLR SRWIKSHPKK KFPAEFRLLL NLIGILLTIC GTIGYGWAIF FHYHFVVLLV 490 500 510 520 530 540 FSALTAFGMT WCSNTSMTYL TELFPKRAAG TVAVSSFFRN VGAAISSAII LQLCNAMGIG 550 560 570 WCFTGLGLCS SISLIGILYL LIFQRKYTAK EF

References

[1]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z36049 Genomic DNA. Translation: CAA85141.1.
PIR	S46051.
RefSeq	NP_009739.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5179N.
IntAct	P38125. 4 interactions.
STRING	P38125.
Genome annotation databases
Ensembl	YBR180W; YBR180W; YBR180W; Saccharomyces cerevisiae. [Genome view]
GeneID	852478.
KEGG	sce:YBR180W.
NMPDR	fig|4932.3.peg.445.
Organism-specific databases
CYGD	YBR180w.
SGD	S000000384. DTR1.
Phylogenomic databases
HOGENOM	P38125.
OMA	WASWADY
OrthoDB	EOG9W9KM2
Gene expression databases
ArrayExpress	P38125.
Genevestigator	P38125.
GermOnline	YBR180W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR011701. MFS_1. IPR016196. MFS_general_subst_transpt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	971444.

Entry information

Entry name

YB30_YEAST

Accession

Primary (citable) accession number: P38125

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 24, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)