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Protein

Dityrosine transporter 1

Gene

DTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore.1 Publication

GO - Molecular functioni

  • amine transmembrane transporter activity Source: SGD

GO - Biological processi

  • amine transport Source: SGD
  • ascospore wall assembly Source: SGD
  • transmembrane transport Source: SGD

Keywordsi

Biological processSporulation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29124-MONOMER

Protein family/group databases

TCDBi2.A.1.2.40 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Dityrosine transporter 1
Gene namesi
Name:DTR1
Ordered Locus Names:YBR180W
ORF Names:YBR1242
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR180W
SGDiS000000384 DTR1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 110CytoplasmicSequence analysisAdd BLAST110
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 149ExtracellularSequence analysisAdd BLAST18
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 184CytoplasmicSequence analysisAdd BLAST14
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 207ExtracellularSequence analysis2
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 240CytoplasmicSequence analysisAdd BLAST12
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 267ExtracellularSequence analysis6
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 366CytoplasmicSequence analysisAdd BLAST78
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 398ExtracellularSequence analysisAdd BLAST11
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 446CytoplasmicSequence analysisAdd BLAST27
Transmembranei447 – 469HelicalSequence analysisAdd BLAST23
Topological domaini470 – 472ExtracellularSequence analysis3
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 520CytoplasmicSequence analysisAdd BLAST27
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542ExtracellularSequence analysis1
Transmembranei543 – 563HelicalSequence analysisAdd BLAST21
Topological domaini564 – 572CytoplasmicSequence analysis9

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734381 – 572Dityrosine transporter 1Add BLAST572

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP38125
PRIDEiP38125

Expressioni

Inductioni

During sporulation.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi32878, 47 interactors
DIPiDIP-5179N
IntActiP38125, 4 interactors
MINTiP38125
STRINGi4932.YBR180W

Structurei

3D structure databases

ProteinModelPortaliP38125
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 572Required for the localization to the prospore membraneAdd BLAST25

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227
InParanoidiP38125
OMAiETLRCIV
OrthoDBiEOG092C2079

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P38125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEPFQKKN LGLQINSQES GTTRSTFHSL EDLGDDVINE SWDQVNQKRA
60 70 80 90 100
NIDHDVFHEH PDSSPSLSAQ KAKTKEEEVA VKSSNSQSRD PSPDTQAHIP
110 120 130 140 150
YTYFSKDQRL IIFGIIIFIG FLGPMSGNIY IPALPLLQRE YDVSATTINA
160 170 180 190 200
TVSVFMAVFS VGPLFWGALA DFGGRKFLYM VSLSLMLIVN ILLAAVPVNI
210 220 230 240 250
AALFVLRIFQ AFASSSVISL GAGTVTDVVP PKHRGKAIAY FMMGPNMGPI
260 270 280 290 300
IAPIVAGLIL MKGNYWRWLF GFTSIMTGIA LILVTALLPE TLRCIVGNGD
310 320 330 340 350
PKWGDKKDER ENNESPFFEG NKISHRRLFP DIGIRKPVNN DAFFQENFPK
360 370 380 390 400
PPKAGLTLYW KMIKCPPIII TSVSTALLFS SYYAFSVTFS YYLEHDYRFT
410 420 430 440 450
MLEIGAAYVC PGVAMLLGSQ SGGHLSDYLR SRWIKSHPKK KFPAEFRLLL
460 470 480 490 500
NLIGILLTIC GTIGYGWAIF FHYHFVVLLV FSALTAFGMT WCSNTSMTYL
510 520 530 540 550
TELFPKRAAG TVAVSSFFRN VGAAISSAII LQLCNAMGIG WCFTGLGLCS
560 570
SISLIGILYL LIFQRKYTAK EF
Length:572
Mass (Da):63,407
Last modified:October 1, 1994 - v1
Checksum:i8175C30520A266F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36049 Genomic DNA Translation: CAA85141.1
BK006936 Genomic DNA Translation: DAA07294.1
PIRiS46051
RefSeqiNP_009739.1, NM_001178528.1

Genome annotation databases

EnsemblFungiiYBR180W; YBR180W; YBR180W
GeneIDi852478
KEGGisce:YBR180W

Similar proteinsi

Entry informationi

Entry nameiDTR1_YEAST
AccessioniPrimary (citable) accession number: P38125
Secondary accession number(s): D6VQH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health