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P38125 (DTR1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dityrosine transporter 1
Gene names
Name:DTR1
Ordered Locus Names:YBR180W
ORF Names:YBR1242
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore. Ref.3

Subcellular location

Prospore membrane; Multi-pass membrane protein Ref.3 Ref.4 Ref.5 Ref.7 Ref.8.

Induction

During sporulation. Ref.3

Post-translational modification

Phosphorylated. Ref.8

Sequence similarities

Belongs to the major facilitator superfamily. CAR1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CHS3P294651EBI-20904,EBI-4632

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Dityrosine transporter 1
PRO_0000173438

Regions

Topological domain1 – 110110Cytoplasmic Potential
Transmembrane111 – 13121Helical; Potential
Topological domain132 – 14918Extracellular Potential
Transmembrane150 – 17021Helical; Potential
Topological domain171 – 18414Cytoplasmic Potential
Transmembrane185 – 20521Helical; Potential
Topological domain206 – 2072Extracellular Potential
Transmembrane208 – 22821Helical; Potential
Topological domain229 – 24012Cytoplasmic Potential
Transmembrane241 – 26121Helical; Potential
Topological domain262 – 2676Extracellular Potential
Transmembrane268 – 28821Helical; Potential
Topological domain289 – 36678Cytoplasmic Potential
Transmembrane367 – 38721Helical; Potential
Topological domain388 – 39811Extracellular Potential
Transmembrane399 – 41921Helical; Potential
Topological domain420 – 44627Cytoplasmic Potential
Transmembrane447 – 46923Helical; Potential
Topological domain470 – 4723Extracellular Potential
Transmembrane473 – 49321Helical; Potential
Topological domain494 – 52027Cytoplasmic Potential
Transmembrane521 – 54121Helical; Potential
Topological domain5421Extracellular Potential
Transmembrane543 – 56321Helical; Potential
Topological domain564 – 5729Cytoplasmic Potential
Region548 – 57225Required for the localization to the prospore membrane

Sequences

Sequence LengthMass (Da)Tools
P38125 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 8175C30520A266F4

FASTA57263,407
        10         20         30         40         50         60 
MGSEPFQKKN LGLQINSQES GTTRSTFHSL EDLGDDVINE SWDQVNQKRA NIDHDVFHEH 

        70         80         90        100        110        120 
PDSSPSLSAQ KAKTKEEEVA VKSSNSQSRD PSPDTQAHIP YTYFSKDQRL IIFGIIIFIG 

       130        140        150        160        170        180 
FLGPMSGNIY IPALPLLQRE YDVSATTINA TVSVFMAVFS VGPLFWGALA DFGGRKFLYM 

       190        200        210        220        230        240 
VSLSLMLIVN ILLAAVPVNI AALFVLRIFQ AFASSSVISL GAGTVTDVVP PKHRGKAIAY 

       250        260        270        280        290        300 
FMMGPNMGPI IAPIVAGLIL MKGNYWRWLF GFTSIMTGIA LILVTALLPE TLRCIVGNGD 

       310        320        330        340        350        360 
PKWGDKKDER ENNESPFFEG NKISHRRLFP DIGIRKPVNN DAFFQENFPK PPKAGLTLYW 

       370        380        390        400        410        420 
KMIKCPPIII TSVSTALLFS SYYAFSVTFS YYLEHDYRFT MLEIGAAYVC PGVAMLLGSQ 

       430        440        450        460        470        480 
SGGHLSDYLR SRWIKSHPKK KFPAEFRLLL NLIGILLTIC GTIGYGWAIF FHYHFVVLLV 

       490        500        510        520        530        540 
FSALTAFGMT WCSNTSMTYL TELFPKRAAG TVAVSSFFRN VGAAISSAII LQLCNAMGIG 

       550        560        570 
WCFTGLGLCS SISLIGILYL LIFQRKYTAK EF 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Dtrlp, a multidrug resistance transporter of the major facilitator superfamily, plays an essential role in spore wall maturation in Saccharomyces cerevisiae."
Felder T., Bogengruber E., Tenreiro S., Ellinger A., Sa-Correia I., Briza P.
Eukaryot. Cell 1:799-810(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, FUNCTION, SUBCELLULAR LOCATION.
[4]"Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis."
Iwamoto M.A., Fairclough S.R., Rudge S.A., Engebrecht J.
Eukaryot. Cell 4:536-544(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[5]"Phospholipase D and the SNARE Sso1p are necessary for vesicle fusion during sporulation in yeast."
Nakanishi H., Morishita M., Schwartz C.L., Coluccio A., Engebrecht J., Neiman A.M.
J. Cell Sci. 119:1406-1415(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[7]"Snc1p v-SNARE transport to the prospore membrane during yeast sporulation is dependent on endosomal retrieval pathways."
Morishita M., Mendonsa R., Wright J., Engebrecht J.
Traffic 8:1231-1245(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[8]"Sorting signals within the Saccharomyces cerevisiae sporulation-specific dityrosine transporter, Dtr1p, C terminus promote Golgi-to-prospore membrane transport."
Morishita M., Engebrecht J.
Eukaryot. Cell 7:1674-1684(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z36049 Genomic DNA. Translation: CAA85141.1.
BK006936 Genomic DNA. Translation: DAA07294.1.
PIRS46051.
RefSeqNP_009739.1. NM_001178528.1.

3D structure databases

ProteinModelPortalP38125.
SMRP38125. Positions 133-298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32878. 17 interactions.
DIPDIP-5179N.
IntActP38125. 3 interactions.
MINTMINT-540134.
STRING4932.YBR180W.

Protein family/group databases

TCDB2.A.1.2.40. the major facilitator superfamily (mfs).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR180W; YBR180W; YBR180W.
GeneID852478.
KEGGsce:YBR180W.

Organism-specific databases

CYGDYBR180w.
SGDS000000384. DTR1.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00620000088227.
OMAFGMTWVF.
OrthoDBEOG7HXD0V.

Enzyme and pathway databases

BioCycYEAST:G3O-29124-MONOMER.

Gene expression databases

GenevestigatorP38125.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio971444.

Entry information

Entry nameDTR1_YEAST
AccessionPrimary (citable) accession number: P38125
Secondary accession number(s): D6VQH4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families