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Protein

Fluconazole resistance protein 1

Gene

FLR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable efflux transporter. Confers resistance to the azole derivative fluconazole (FCZ).

GO - Molecular functioni

  • fluconazole transmembrane transporter activity Source: SGD

GO - Biological processi

  • drug transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-28995-MONOMER

Protein family/group databases

TCDBi2.A.1.2.17 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Fluconazole resistance protein 1
Gene namesi
Name:FLR1
Ordered Locus Names:YBR008C
ORF Names:YBR0120
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR008C
SGDiS000000212 FLR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Transmembranei476 – 496HelicalSequence analysisAdd BLAST21
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734351 – 548Fluconazole resistance protein 1Add BLAST548

Proteomic databases

PaxDbiP38124
PRIDEiP38124

Interactioni

Protein-protein interaction databases

BioGridi32709, 26 interactors
DIPiDIP-4503N
STRINGi4932.YBR008C

Structurei

3D structure databases

ProteinModelPortaliP38124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227
HOGENOMiHOG000160689
InParanoidiP38124
KOiK08158
OMAiSSANILY
OrthoDBiEOG092C2079

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004734 Multidrug-R
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00880 2_A_01_02, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P38124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYTSTYRHT IVVDLLEYLG IVSNLETLQS AREDETRKPE NTDKKECKPD
60 70 80 90 100
YDIECGPNRS CSESSTDSDS SGSQIEKNDP FRVDWNGPSD PENPQNWPLL
110 120 130 140 150
KKSLVVFQIM LLTCVTYMGS SIYTPGQEYI QEEFHVGHVV ATLNLSLYVL
160 170 180 190 200
GYGLGPIIFS PLSETARYGR LNLYMVTLFF FMIFQVGCAT VHNIGGLIVM
210 220 230 240 250
RFISGILCSP SLATGGGTVA DIISPEMVPL VLGMWSAGAV AAPVLAPLLG
260 270 280 290 300
AAMVDAKNWR FIFWLLMWLS AATFILLAFF FPETQHHNIL YRRALKLRKE
310 320 330 340 350
TGDDRYYTEQ DKLDREVDAR TFLINTLYRP LKMIIKEPAI LAFDLYIAVA
360 370 380 390 400
YGCFYLFFEA FPIVFVGIYH FSLVEVGLAY MGFCVGCVLA YGLFGILNMR
410 420 430 440 450
IIVPRFRNGT FTPEAFLIVA MCVCWCLPLS LFLFGWTARV HWILPVISEV
460 470 480 490 500
FFVLAVFNIF QATFAYLATC YPKYVASVFA GNGFCRASFA CAFPLFGRAM
510 520 530 540
YDNLATKNYP VAWGSSLVGF LTLGLAIIPF ILYKYGPSLR TRSSYTEE
Length:548
Mass (Da):61,629
Last modified:October 1, 1994 - v1
Checksum:iF734B59FCB4ACF75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35877 Genomic DNA Translation: CAA84946.1
BK006936 Genomic DNA Translation: DAA07129.1
PIRiS45860
RefSeqiNP_009562.1, NM_001178356.1

Genome annotation databases

EnsemblFungiiYBR008C; YBR008C; YBR008C
GeneIDi852293
KEGGisce:YBR008C

Similar proteinsi

Entry informationi

Entry nameiFLR1_YEAST
AccessioniPrimary (citable) accession number: P38124
Secondary accession number(s): D6VQ09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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