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Protein

Fluconazole resistance protein 1

Gene

FLR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable efflux transporter. Confers resistance to the azole derivative fluconazole (FCZ).

GO - Molecular functioni

  • drug transmembrane transporter activity Source: InterPro
  • fluconazole transporter activity Source: SGD

GO - Biological processi

  • drug transmembrane transport Source: SGD
  • fluconazole transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28995-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.17. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Fluconazole resistance protein 1
Gene namesi
Name:FLR1
Ordered Locus Names:YBR008C
ORF Names:YBR0120
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR008C.
SGDiS000000212. FLR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei104 – 12421HelicalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence analysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence analysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence analysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence analysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence analysisAdd
BLAST
Transmembranei440 – 46021HelicalSequence analysisAdd
BLAST
Transmembranei476 – 49621HelicalSequence analysisAdd
BLAST
Transmembranei511 – 53121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Fluconazole resistance protein 1PRO_0000173435Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi32709. 6 interactions.
DIPiDIP-4503N.
MINTiMINT-556771.

Structurei

3D structure databases

ProteinModelPortaliP38124.
SMRiP38124. Positions 109-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000160689.
InParanoidiP38124.
KOiK08158.
OMAiEILLVEW.
OrthoDBiEOG77M8XK.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYTSTYRHT IVVDLLEYLG IVSNLETLQS AREDETRKPE NTDKKECKPD
60 70 80 90 100
YDIECGPNRS CSESSTDSDS SGSQIEKNDP FRVDWNGPSD PENPQNWPLL
110 120 130 140 150
KKSLVVFQIM LLTCVTYMGS SIYTPGQEYI QEEFHVGHVV ATLNLSLYVL
160 170 180 190 200
GYGLGPIIFS PLSETARYGR LNLYMVTLFF FMIFQVGCAT VHNIGGLIVM
210 220 230 240 250
RFISGILCSP SLATGGGTVA DIISPEMVPL VLGMWSAGAV AAPVLAPLLG
260 270 280 290 300
AAMVDAKNWR FIFWLLMWLS AATFILLAFF FPETQHHNIL YRRALKLRKE
310 320 330 340 350
TGDDRYYTEQ DKLDREVDAR TFLINTLYRP LKMIIKEPAI LAFDLYIAVA
360 370 380 390 400
YGCFYLFFEA FPIVFVGIYH FSLVEVGLAY MGFCVGCVLA YGLFGILNMR
410 420 430 440 450
IIVPRFRNGT FTPEAFLIVA MCVCWCLPLS LFLFGWTARV HWILPVISEV
460 470 480 490 500
FFVLAVFNIF QATFAYLATC YPKYVASVFA GNGFCRASFA CAFPLFGRAM
510 520 530 540
YDNLATKNYP VAWGSSLVGF LTLGLAIIPF ILYKYGPSLR TRSSYTEE
Length:548
Mass (Da):61,629
Last modified:October 1, 1994 - v1
Checksum:iF734B59FCB4ACF75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35877 Genomic DNA. Translation: CAA84946.1.
BK006936 Genomic DNA. Translation: DAA07129.1.
PIRiS45860.
RefSeqiNP_009562.1. NM_001178356.1.

Genome annotation databases

EnsemblFungiiYBR008C; YBR008C; YBR008C.
GeneIDi852293.
KEGGisce:YBR008C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35877 Genomic DNA. Translation: CAA84946.1.
BK006936 Genomic DNA. Translation: DAA07129.1.
PIRiS45860.
RefSeqiNP_009562.1. NM_001178356.1.

3D structure databases

ProteinModelPortaliP38124.
SMRiP38124. Positions 109-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32709. 6 interactions.
DIPiDIP-4503N.
MINTiMINT-556771.

Protein family/group databases

TCDBi2.A.1.2.17. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR008C; YBR008C; YBR008C.
GeneIDi852293.
KEGGisce:YBR008C.

Organism-specific databases

EuPathDBiFungiDB:YBR008C.
SGDiS000000212. FLR1.

Phylogenomic databases

GeneTreeiENSGT00620000088227.
HOGENOMiHOG000160689.
InParanoidiP38124.
KOiK08158.
OMAiEILLVEW.
OrthoDBiEOG77M8XK.

Enzyme and pathway databases

BioCyciYEAST:G3O-28995-MONOMER.

Miscellaneous databases

PROiP38124.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004734. Multidrug-R.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00880. 2_A_01_02. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily."
    Alarco A.-M., Balan I., Talibi D., Mainville N., Raymond M.
    J. Biol. Chem. 272:19304-19313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiFLR1_YEAST
AccessioniPrimary (citable) accession number: P38124
Secondary accession number(s): D6VQ09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.