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Protein

COMPASS component SWD3

Gene

SWD3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.2 Publications

GO - Biological processi

  • chromatin silencing at telomere Source: SGD
  • histone H3-K4 methylation Source: SGD
  • regulation of meiotic DNA double-strand break formation Source: SGD
  • telomere maintenance Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29122-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
COMPASS component SWD3
Alternative name(s):
Complex proteins associated with SET1 protein SWD3
Set1C component SWD3
Gene namesi
Name:SWD3
Synonyms:CPS30, SAF35
Ordered Locus Names:YBR175W
ORF Names:YBR1237
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR175W.
SGDiS000000379. SWD3.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: UniProtKB-SubCell
  • Set1C/COMPASS complex Source: SGD

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512551 – 315COMPASS component SWD3Add BLAST315

Proteomic databases

MaxQBiP38123.
PRIDEiP38123.

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SWD1P397067EBI-20881,EBI-20737

Protein-protein interaction databases

BioGridi32874. 322 interactors.
DIPiDIP-1754N.
IntActiP38123. 19 interactors.
MINTiMINT-393581.
STRINGi4932.YBR175W.

Structurei

3D structure databases

ProteinModelPortaliP38123.
SMRiP38123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 93WD 1Add BLAST41
Repeati94 – 133WD 2Add BLAST40
Repeati136 – 178WD 3Add BLAST43
Repeati187 – 228WD 4Add BLAST42
Repeati238 – 278WD 5Add BLAST41
Repeati285 – 314WD 6Add BLAST30

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000091642.
InParanoidiP38123.
KOiK14963.
OMAiDNPICSH.
OrthoDBiEOG092C172M.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 4 hits.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

P38123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQFVTPVGT QNGLKATCAK ISPDGQFLAI TQGLNILIYD INRRTVSQTL
60 70 80 90 100
VTSHARPFSE LCWSPDGQCI ATASDDFSVE IIHLSYGLLH TFIGHTAPVI
110 120 130 140 150
SLTFNRKGNL LFTSSMDESI KIWDTLNGSL MKTISAHSEA VVSVDVPMND
160 170 180 190 200
SSILSSGSYD GLIRIFDAET GHCLKTLTYD KDWKRENGVV PISQVKFSEN
210 220 230 240 250
ARYLLVKSLD GVVKIWDCIG GCVVRTFQVQ PLEKGVLHHS CGMDFLNPED
260 270 280 290 300
GSTPLVISGY ENGDIYCWNS DTKSLLQLLD GSLYHHSSPV MSIHCFGNIM
310
CSLALNGDCC LWRWV
Length:315
Mass (Da):34,754
Last modified:October 1, 1994 - v1
Checksum:iE8E88C483D1CD776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36043 Genomic DNA. Translation: CAA85136.1.
AY693212 Genomic DNA. Translation: AAT93231.1.
BK006936 Genomic DNA. Translation: DAA07290.1.
PIRiS46046.
RefSeqiNP_009734.1. NM_001178523.1.

Genome annotation databases

EnsemblFungiiYBR175W; YBR175W; YBR175W.
GeneIDi852472.
KEGGisce:YBR175W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSWD3_YEAST
AccessioniPrimary (citable) accession number: P38123
Secondary accession number(s): D6VQH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 5, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names