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Protein

COMPASS component SWD3

Gene

SWD3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.2 Publications

GO - Biological processi

  • chromatin silencing at telomere Source: SGD
  • histone H3-K4 methylation Source: SGD
  • regulation of meiotic DNA double-strand break formation Source: SGD
  • telomere maintenance Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29122-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
COMPASS component SWD3
Alternative name(s):
Complex proteins associated with SET1 protein SWD3
Set1C component SWD3
Gene namesi
Name:SWD3
Synonyms:CPS30, SAF35
Ordered Locus Names:YBR175W
ORF Names:YBR1237
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR175W
SGDiS000000379 SWD3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512551 – 315COMPASS component SWD3Add BLAST315

Proteomic databases

MaxQBiP38123
PaxDbiP38123
PRIDEiP38123

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SWD1P397066EBI-20881,EBI-20737

Protein-protein interaction databases

BioGridi32874, 327 interactors
DIPiDIP-1754N
IntActiP38123, 32 interactors
MINTiP38123
STRINGi4932.YBR175W

Structurei

3D structure databases

ProteinModelPortaliP38123
SMRiP38123
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 93WD 1Add BLAST41
Repeati94 – 133WD 2Add BLAST40
Repeati136 – 178WD 3Add BLAST43
Repeati187 – 228WD 4Add BLAST42
Repeati238 – 278WD 5Add BLAST41
Repeati285 – 314WD 6Add BLAST30

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000091642
InParanoidiP38123
KOiK14963
OMAiDNPICSH
OrthoDBiEOG092C172M

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR037866 Swd3-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR22847:SF603 PTHR22847:SF603, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P38123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQFVTPVGT QNGLKATCAK ISPDGQFLAI TQGLNILIYD INRRTVSQTL
60 70 80 90 100
VTSHARPFSE LCWSPDGQCI ATASDDFSVE IIHLSYGLLH TFIGHTAPVI
110 120 130 140 150
SLTFNRKGNL LFTSSMDESI KIWDTLNGSL MKTISAHSEA VVSVDVPMND
160 170 180 190 200
SSILSSGSYD GLIRIFDAET GHCLKTLTYD KDWKRENGVV PISQVKFSEN
210 220 230 240 250
ARYLLVKSLD GVVKIWDCIG GCVVRTFQVQ PLEKGVLHHS CGMDFLNPED
260 270 280 290 300
GSTPLVISGY ENGDIYCWNS DTKSLLQLLD GSLYHHSSPV MSIHCFGNIM
310
CSLALNGDCC LWRWV
Length:315
Mass (Da):34,754
Last modified:October 1, 1994 - v1
Checksum:iE8E88C483D1CD776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36043 Genomic DNA Translation: CAA85136.1
AY693212 Genomic DNA Translation: AAT93231.1
BK006936 Genomic DNA Translation: DAA07290.1
PIRiS46046
RefSeqiNP_009734.1, NM_001178523.1

Genome annotation databases

EnsemblFungiiYBR175W; YBR175W; YBR175W
GeneIDi852472
KEGGisce:YBR175W

Similar proteinsi

Entry informationi

Entry nameiSWD3_YEAST
AccessioniPrimary (citable) accession number: P38123
Secondary accession number(s): D6VQH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health