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Protein

ADP-ribosylation factor-like protein 1

Gene

ARL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recruits golgins such as IMH1 to the Golgi. Can bind and hydrolyze GTP. May be involved in trafficking events within the endosomal system.3 Publications

Miscellaneous

Present with 5190 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 32GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cellular protein-containing complex localization Source: SGD
  • endocytosis Source: SGD
  • Golgi to plasma membrane protein transport Source: SGD
  • macroautophagy Source: SGD
  • protein localization by the Cvt pathway Source: SGD
  • protein localization to Golgi apparatus Source: SGD
  • protein localization to phagophore assembly site Source: SGD
  • protein targeting to vacuole Source: SGD
  • response to endoplasmic reticulum stress Source: SGD
  • vesicle-mediated transport Source: SGD

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29114-MONOMER
ReactomeiR-SCE-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 1
Alternative name(s):
Arf-like GTPase 1
Gene namesi
Name:ARL1
Synonyms:ARF3
Ordered Locus Names:YBR164C
ORF Names:YBR1216
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR164C
SGDiS000000368 ARL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002074212 – 183ADP-ribosylation factor-like protein 1Add BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP38116
PaxDbiP38116
PRIDEiP38116

PTM databases

iPTMnetiP38116

Interactioni

Subunit structurei

Homodimer. Binds in a GTP-dependent manner to the GRIP domain of IMH1. Interacts with MON2.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32864, 399 interactors
IntActiP38116, 8 interactors
MINTiP38116
STRINGi4932.YBR164C

Structurei

Secondary structure

1183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 9Combined sources7
Helixi10 – 12Combined sources3
Beta strandi19 – 26Combined sources8
Helixi31 – 37Combined sources7
Beta strandi41 – 46Combined sources6
Beta strandi54 – 59Combined sources6
Beta strandi62 – 69Combined sources8
Helixi79 – 81Combined sources3
Turni82 – 85Combined sources4
Beta strandi86 – 94Combined sources9
Turni98 – 100Combined sources3
Helixi101 – 111Combined sources11
Beta strandi121 – 127Combined sources7
Helixi137 – 143Combined sources7
Turni144 – 148Combined sources5
Beta strandi154 – 160Combined sources7
Helixi161 – 163Combined sources3
Helixi167 – 182Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MOZX-ray3.17A/B1-183[»]
ProteinModelPortaliP38116
SMRiP38116
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38116

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000144027
HOGENOMiHOG000163691
InParanoidiP38116
KOiK07942
OMAiWSKDQDV
OrthoDBiEOG092C508L

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNIFSSMFD KLWGSNKELR ILILGLDGAG KTTILYRLQI GEVVTTKPTI
60 70 80 90 100
GFNVETLSYK NLKLNVWDLG GQTSIRPYWR CYYADTAAVI FVVDSTDKDR
110 120 130 140 150
MSTASKELHL MLQEEELQDA ALLVFANKQD QPGALSASEV SKELNLVELK
160 170 180
DRSWSIVASS AIKGEGITEG LDWLIDVIKE EQL
Length:183
Mass (Da):20,434
Last modified:January 23, 2007 - v4
Checksum:i84D0E1F79EC21E38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89332 mRNA Translation: AAC49875.1
Z36033 Genomic DNA Translation: CAA85125.1
BK006936 Genomic DNA Translation: DAA07280.1
PIRiS46035
RefSeqiNP_009723.3, NM_001178512.3

Genome annotation databases

EnsemblFungiiYBR164C; YBR164C; YBR164C
GeneIDi852462
KEGGisce:YBR164C

Similar proteinsi

Entry informationi

Entry nameiARL1_YEAST
AccessioniPrimary (citable) accession number: P38116
Secondary accession number(s): D6VQG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 168 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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