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Protein

Uncharacterized transcriptional regulatory protein TBS1

Gene

TBS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in tolerance to thiabendazole.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi107 – 137Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29101-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized transcriptional regulatory protein TBS1
Alternative name(s):
Thiabendazole sensitive protein 1
Gene namesi
Name:TBS1
Ordered Locus Names:YBR150C
ORF Names:YBR1133
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR150C.
SGDiS000000354. TBS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei755 – 775HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149921 – 1094Uncharacterized transcriptional regulatory protein TBS1Add BLAST1094

Proteomic databases

MaxQBiP38114.
PRIDEiP38114.

PTM databases

iPTMnetiP38114.

Interactioni

Protein-protein interaction databases

BioGridi32849. 36 interactors.
DIPiDIP-6485N.
IntActiP38114. 4 interactors.
MINTiMINT-2786365.

Structurei

3D structure databases

ProteinModelPortaliP38114.
SMRiP38114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi935 – 991Asn-richAdd BLAST57
Compositional biasi985 – 1032Asp-richAdd BLAST48

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00700000105830.
InParanoidiP38114.
OMAiPERTAND.
OrthoDBiEOG092C2P2C.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
4.10.240.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMDSGITSS HGSMDKTQKQ SSEWAANQKH NQRVENTRVL MGPAVPAMPP
60 70 80 90 100
VPSNFPPVPT GTIMSPQLSP FPDHRLRHHP LAHMMPADKN FLAYNMESFK
110 120 130 140 150
SRVTKACDYC RKRKIRCTEI EPISGKCRNC IKYNKDCTFH FHEELKRRRE
160 170 180 190 200
EALNNKGNGK SVKKPRLDKE NKFKDENFDI AVRSRNTSST DSSPKLHTNL
210 220 230 240 250
SQEYIGVSAG KSASDKEDTW PDFVPIDRTV LEKIELNHTK VAGKVFVLEE
260 270 280 290 300
ICKNMKGTIE KLAEKSKIDV IDKEYMKRPK RKQYSKALLT KQKMFHFRQN
310 320 330 340 350
VLSHLTDEEF LSPINEMFTT TFKYSILQTK LVLDFSFRSA SSPSSDNILY
360 370 380 390 400
PLPRLAIAKR LLKNIKCPSL ASLLHIVDVD QCLQFADVHF DPAKGRLTSS
410 420 430 440 450
QAFLLNICLC LGATVTNFEE KQELVDEDNH ETYYFEKFEL WRLRSFTFLN
460 470 480 490 500
SVYYYHKLSV ARADMTALKA LLLLAKFAQQ KISASSAVKV LSVAIKVALD
510 520 530 540 550
LRLNLHSTYE DLELDEIIKR RRLWCYCFST DKFFSVVLSR PPFLKEENTD
560 570 580 590 600
VLTDESYVEL FRDKILPNLS IKYDDSKLEG VKDIVSVVNL LANHLEYVPY
610 620 630 640 650
IQSYFLSRLS LIESQIYYSC FSIRTTLDDT LDEIIENVLE NQKALDRMRD
660 670 680 690 700
DLPTILSLEN YKENMRILSL DSSKLDFEVS CCTTILLHLR WYHQKITLSL
710 720 730 740 750
FVISIIGDNL DQRESSRHDI AEIIRRSRLD FKRNCIEVLN ILKDFEYYPT
760 770 780 790 800
VQNEFLYFSL TTVFSMFLYL SEIMVNDEHA METGYIIGLL RDTHTRMLGS
810 820 830 840 850
EERCLSVHNL KWQTSLFFYT FFLRSTMEKF NLTSKYAKFY AFDSNYYEGV
860 870 880 890 900
LNRLVKHTRE SKDDMVELLK TSFINKEKMA AFGSFVTEDQ EKMEVSFNIF
910 920 930 940 950
NEITIQDLNF LQFSSIPKLW ENKTLEPGEE YHHSNGTNTD NNETTGADDT
960 970 980 990 1000
DDNNNNNNNN NKNGNNSSST INNNNNNYSN SNNNDNDNNI NDDDDDDDDD
1010 1020 1030 1040 1050
DDDDDDDDDD DDNDDDYSNN GADDDEEDDD YDRSLFPTGL ASLLDASYPE
1060 1070 1080 1090
RTANDYRDEN EQSNKLFEKI EGHLEHGVFF YDRDFFFKNV CVKM
Length:1,094
Mass (Da):126,904
Last modified:October 1, 1994 - v1
Checksum:i3C08F83F5879D14F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36019 Genomic DNA. Translation: CAA85108.1.
Z36020 Genomic DNA. Translation: CAA85110.1.
BK006936 Genomic DNA. Translation: DAA07265.1.
PIRiS46021.
RefSeqiNP_009708.1. NM_001178498.1.

Genome annotation databases

EnsemblFungiiYBR150C; YBR150C; YBR150C.
GeneIDi852447.
KEGGisce:YBR150C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36019 Genomic DNA. Translation: CAA85108.1.
Z36020 Genomic DNA. Translation: CAA85110.1.
BK006936 Genomic DNA. Translation: DAA07265.1.
PIRiS46021.
RefSeqiNP_009708.1. NM_001178498.1.

3D structure databases

ProteinModelPortaliP38114.
SMRiP38114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32849. 36 interactors.
DIPiDIP-6485N.
IntActiP38114. 4 interactors.
MINTiMINT-2786365.

PTM databases

iPTMnetiP38114.

Proteomic databases

MaxQBiP38114.
PRIDEiP38114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR150C; YBR150C; YBR150C.
GeneIDi852447.
KEGGisce:YBR150C.

Organism-specific databases

EuPathDBiFungiDB:YBR150C.
SGDiS000000354. TBS1.

Phylogenomic databases

GeneTreeiENSGT00700000105830.
InParanoidiP38114.
OMAiPERTAND.
OrthoDBiEOG092C2P2C.

Enzyme and pathway databases

BioCyciYEAST:G3O-29101-MONOMER.

Miscellaneous databases

PROiP38114.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
4.10.240.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBS1_YEAST
AccessioniPrimary (citable) accession number: P38114
Secondary accession number(s): D6VQE5, E9PAD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 573 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.