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P38113

- ADH5_YEAST

UniProt

P38113 - ADH5_YEAST

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Protein

Alcohol dehydrogenase 5

Gene

ADH5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Binds 2 zinc ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalyticBy similarity
Metal bindingi70 – 701Zinc 1; catalyticBy similarity
Metal bindingi101 – 1011Zinc 2By similarity
Metal bindingi104 – 1041Zinc 2By similarity
Metal bindingi107 – 1071Zinc 2By similarity
Metal bindingi115 – 1151Zinc 2By similarity
Metal bindingi183 – 1831Zinc 1; catalyticBy similarity
Binding sitei205 – 2051NADBy similarity
Binding sitei210 – 2101NADBy similarity
Binding sitei344 – 3441NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi181 – 1877NADBy similarity
Nucleotide bindingi272 – 2743NADBy similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: SGD
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. amino acid catabolic process to alcohol via Ehrlich pathway Source: SGD
  2. ethanol biosynthetic process involved in glucose fermentation to ethanol Source: SGD
  3. NADH oxidation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YBR145W-MONOMER.
YEAST:YBR145W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 5 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase V
Gene namesi
Name:ADH5
Ordered Locus Names:YBR145W
ORF Names:YBR1122
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR145w.
SGDiS000000349. ADH5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Alcohol dehydrogenase 5PRO_0000160733Add
BLAST

Proteomic databases

MaxQBiP38113.
PaxDbiP38113.
PeptideAtlasiP38113.
PRIDEiP38113.

Expressioni

Gene expression databases

GenevestigatoriP38113.

Interactioni

Protein-protein interaction databases

BioGridi32844. 15 interactions.
DIPiDIP-4500N.
IntActiP38113. 1 interaction.
MINTiMINT-570205.
STRINGi4932.YBR145W.

Structurei

3D structure databases

ProteinModelPortaliP38113.
SMRiP38113. Positions 6-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1064.
GeneTreeiENSGT00550000075207.
HOGENOMiHOG000294685.
InParanoidiP38113.
KOiK13953.
OMAiRCEFCAR.
OrthoDBiEOG7JDR73.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38113-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSQVIPEKQ KAIVFYETDG KLEYKDVTVP EPKPNEILVH VKYSGVCHSD
60 70 80 90 100
LHAWHGDWPF QLKFPLIGGH EGAGVVVKLG SNVKGWKVGD FAGIKWLNGT
110 120 130 140 150
CMSCEYCEVG NESQCPYLDG TGFTHDGTFQ EYATADAVQA AHIPPNVNLA
160 170 180 190 200
EVAPILCAGI TVYKALKRAN VIPGQWVTIS GACGGLGSLA IQYALAMGYR
210 220 230 240 250
VIGIDGGNAK RKLFEQLGGE IFIDFTEEKD IVGAIIKATN GGSHGVINVS
260 270 280 290 300
VSEAAIEAST RYCRPNGTVV LVGMPAHAYC NSDVFNQVVK SISIVGSCVG
310 320 330 340 350
NRADTREALD FFARGLIKSP IHLAGLSDVP EIFAKMEKGE IVGRYVVETS

K
Length:351
Mass (Da):37,648
Last modified:October 1, 1994 - v1
Checksum:iF4084DAD1E3C19DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36014 Genomic DNA. Translation: CAA85103.1.
BK006936 Genomic DNA. Translation: DAA07260.1.
PIRiS46016.
RefSeqiNP_009703.3. NM_001178493.3.

Genome annotation databases

EnsemblFungiiYBR145W; YBR145W; YBR145W.
GeneIDi852442.
KEGGisce:YBR145W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36014 Genomic DNA. Translation: CAA85103.1 .
BK006936 Genomic DNA. Translation: DAA07260.1 .
PIRi S46016.
RefSeqi NP_009703.3. NM_001178493.3.

3D structure databases

ProteinModelPortali P38113.
SMRi P38113. Positions 6-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32844. 15 interactions.
DIPi DIP-4500N.
IntActi P38113. 1 interaction.
MINTi MINT-570205.
STRINGi 4932.YBR145W.

Proteomic databases

MaxQBi P38113.
PaxDbi P38113.
PeptideAtlasi P38113.
PRIDEi P38113.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR145W ; YBR145W ; YBR145W .
GeneIDi 852442.
KEGGi sce:YBR145W.

Organism-specific databases

CYGDi YBR145w.
SGDi S000000349. ADH5.

Phylogenomic databases

eggNOGi COG1064.
GeneTreei ENSGT00550000075207.
HOGENOMi HOG000294685.
InParanoidi P38113.
KOi K13953.
OMAi RCEFCAR.
OrthoDBi EOG7JDR73.

Enzyme and pathway databases

BioCyci MetaCyc:YBR145W-MONOMER.
YEAST:YBR145W-MONOMER.

Miscellaneous databases

NextBioi 971342.

Gene expression databases

Genevestigatori P38113.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADH5_YEAST
AccessioniPrimary (citable) accession number: P38113
Secondary accession number(s): D6VQE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3