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P38113

- ADH5_YEAST

UniProt

P38113 - ADH5_YEAST

Protein

Alcohol dehydrogenase 5

Gene

ADH5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An alcohol + NAD+ = an aldehyde or ketone + NADH.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Zinc 1; catalyticBy similarity
    Metal bindingi70 – 701Zinc 1; catalyticBy similarity
    Metal bindingi101 – 1011Zinc 2By similarity
    Metal bindingi104 – 1041Zinc 2By similarity
    Metal bindingi107 – 1071Zinc 2By similarity
    Metal bindingi115 – 1151Zinc 2By similarity
    Metal bindingi183 – 1831Zinc 1; catalyticBy similarity
    Binding sitei205 – 2051NADBy similarity
    Binding sitei210 – 2101NADBy similarity
    Binding sitei344 – 3441NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi181 – 1877NADBy similarity
    Nucleotide bindingi272 – 2743NADBy similarity

    GO - Molecular functioni

    1. alcohol dehydrogenase (NAD) activity Source: SGD
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. amino acid catabolic process to alcohol via Ehrlich pathway Source: SGD
    2. ethanol biosynthetic process involved in glucose fermentation to ethanol Source: SGD
    3. NADH oxidation Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciMetaCyc:YBR145W-MONOMER.
    YEAST:YBR145W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alcohol dehydrogenase 5 (EC:1.1.1.1)
    Alternative name(s):
    Alcohol dehydrogenase V
    Gene namesi
    Name:ADH5
    Ordered Locus Names:YBR145W
    ORF Names:YBR1122
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR145w.
    SGDiS000000349. ADH5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Alcohol dehydrogenase 5PRO_0000160733Add
    BLAST

    Proteomic databases

    MaxQBiP38113.
    PaxDbiP38113.
    PeptideAtlasiP38113.
    PRIDEiP38113.

    Expressioni

    Gene expression databases

    GenevestigatoriP38113.

    Interactioni

    Protein-protein interaction databases

    BioGridi32844. 14 interactions.
    DIPiDIP-4500N.
    IntActiP38113. 1 interaction.
    MINTiMINT-570205.
    STRINGi4932.YBR145W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38113.
    SMRiP38113. Positions 6-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1064.
    GeneTreeiENSGT00550000075207.
    HOGENOMiHOG000294685.
    KOiK13953.
    OMAiRCEFCAR.
    OrthoDBiEOG7JDR73.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38113-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSQVIPEKQ KAIVFYETDG KLEYKDVTVP EPKPNEILVH VKYSGVCHSD    50
    LHAWHGDWPF QLKFPLIGGH EGAGVVVKLG SNVKGWKVGD FAGIKWLNGT 100
    CMSCEYCEVG NESQCPYLDG TGFTHDGTFQ EYATADAVQA AHIPPNVNLA 150
    EVAPILCAGI TVYKALKRAN VIPGQWVTIS GACGGLGSLA IQYALAMGYR 200
    VIGIDGGNAK RKLFEQLGGE IFIDFTEEKD IVGAIIKATN GGSHGVINVS 250
    VSEAAIEAST RYCRPNGTVV LVGMPAHAYC NSDVFNQVVK SISIVGSCVG 300
    NRADTREALD FFARGLIKSP IHLAGLSDVP EIFAKMEKGE IVGRYVVETS 350
    K 351
    Length:351
    Mass (Da):37,648
    Last modified:October 1, 1994 - v1
    Checksum:iF4084DAD1E3C19DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36014 Genomic DNA. Translation: CAA85103.1.
    BK006936 Genomic DNA. Translation: DAA07260.1.
    PIRiS46016.
    RefSeqiNP_009703.3. NM_001178493.3.

    Genome annotation databases

    EnsemblFungiiYBR145W; YBR145W; YBR145W.
    GeneIDi852442.
    KEGGisce:YBR145W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36014 Genomic DNA. Translation: CAA85103.1 .
    BK006936 Genomic DNA. Translation: DAA07260.1 .
    PIRi S46016.
    RefSeqi NP_009703.3. NM_001178493.3.

    3D structure databases

    ProteinModelPortali P38113.
    SMRi P38113. Positions 6-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32844. 14 interactions.
    DIPi DIP-4500N.
    IntActi P38113. 1 interaction.
    MINTi MINT-570205.
    STRINGi 4932.YBR145W.

    Proteomic databases

    MaxQBi P38113.
    PaxDbi P38113.
    PeptideAtlasi P38113.
    PRIDEi P38113.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR145W ; YBR145W ; YBR145W .
    GeneIDi 852442.
    KEGGi sce:YBR145W.

    Organism-specific databases

    CYGDi YBR145w.
    SGDi S000000349. ADH5.

    Phylogenomic databases

    eggNOGi COG1064.
    GeneTreei ENSGT00550000075207.
    HOGENOMi HOG000294685.
    KOi K13953.
    OMAi RCEFCAR.
    OrthoDBi EOG7JDR73.

    Enzyme and pathway databases

    BioCyci MetaCyc:YBR145W-MONOMER.
    YEAST:YBR145W-MONOMER.

    Miscellaneous databases

    NextBioi 971342.

    Gene expression databases

    Genevestigatori P38113.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiADH5_YEAST
    AccessioniPrimary (citable) accession number: P38113
    Secondary accession number(s): D6VQE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1310 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3