Reviewed, UniProtKB/Swiss-Prot P38111 (ATR_YEAST)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase MEC1
    EC=2.7.11.1
Alternative name(s):
    DNA-damage checkpoint kinase MEC1
    Mitosis entry checkpoint protein 1
    ATR homolog

Gene names

Name:	MEC1
Synonyms:	ESR1, SAD3
Ordered Locus Names:	YBR136W
ORF Names:	YBR1012

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	2368 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited in complex with protein LCD1 by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Phosphorylates LCD1 and RPA2, a subunit of RPA, involved in DNA replication, repair and recombination. Phosphorylates RAD9, CHK1 and RAD53, which leads to the activation of the CHK1 and RAD53 kinases involved in DNA damage repair cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are proteins involved in genome stability. Required for cell growth and meiotic recombination. Ref.1 Ref.5 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.17 Ref.18 Ref.19
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts with LCD1, which is required for localization MEC1 to the RPA complex. Interacts directly with the RPA subunits RFA1 and RFA2. Ref.11 Ref.19 Ref.7 Ref.8
Subcellular location	Nucleus. Note: Localizes to nuclear DNA repair foci in response to DNA double strand breaks. The recruitment to DNA lesion sites requires its interaction with LCD1 and the presence of the RPA complex on DNA.
Developmental stage	Induced during meiosis.
Sequence similarities	Belongs to the PI3/PI4-kinase family. ATM subfamily. Contains 1 FAT domain. Contains 1 FATC domain. Contains 5 HEAT repeats. Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
Biological process	DNA damage DNA repair Meiosis
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chromatin regulator Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA damage checkpoint Traceable author statement. Source: SGD DNA damage induced protein phosphorylation Inferred from mutant phenotype. Source: SGD DNA repair Inferred from electronic annotation. Source: UniProtKB-KW DNA replication checkpoint Inferred from mutant phenotype. Source: SGD histone phosphorylation Ref.9 Inferred from genetic interaction. Source: SGD reciprocal meiotic recombination Inferred from mutant phenotype. Source: SGD telomere maintenance via recombination Inferred from genetic interaction. Source: SGD
Cellular component	mitochondrion Inferred from direct assay. Source: SGD nucleus Inferred by curator. Source: SGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Ref.8 Inferred from physical interaction. Source: IntAct protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LCD1	Q04377	4	EBI-6668,EBI-35652
PIN4	P34217	1	EBI-6668,EBI-21256

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2368	2368	Serine/threonine-protein kinase MEC1		PRO_0000088836
Regions
	Domain	1399 – 1944	546	FAT
	Domain	2082 – 2368	287	PI3K/PI4K
	Domain	2336 – 2368	33	FATC
	Region	2140 – 2368	229	Binding to the RPA complex
Amino acid modifications
	Modified residue	37	1	Phosphoserine Ref.21
	Modified residue	38	1	Phosphoserine; by ATM or ATR Ref.21 Ref.20
Experimental info
	Mutagenesis	225	1	V → G in MEC1-101; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with P-552 and S-781. Ref.11
	Mutagenesis	552	1	S → P in MEC1-101; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with S-225 and S-781. Ref.11
	Mutagenesis	781	1	L → S in MEC1-101; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with S-225 and P-552. Ref.11
	Mutagenesis	1179	1	F → S in MEC1-100; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with S-1700. Ref.11
	Mutagenesis	1700	1	N → S in MEC1-100; impairs both the G1/S and intra-S damage checkpoints but not the G2/M damage checkpoint; when associated with S-1179. Ref.11
	Mutagenesis	2224	1	D → A: Impairs kinase activity; when associated with K-2229. Ref.10 Ref.11
	Mutagenesis	2229	1	N → K: Impairs kinase activity; when associated with A-2224. Ref.10
	Mutagenesis	2243	1	D → E: Impairs kinase activity. Ref.11
	Mutagenesis	2360 – 2362	3	MYI → AAA in MEC1-85; disrupts interaction with RFA1 and severely impairs kinase activity. Ref.19
	Mutagenesis	2367 – 2368	2	FW → AA in MEC1-87; decreases the level of MEC1 and impairs viability.
	Sequence conflict	197	1	N → D in BAA01860. Ref.1
	Sequence conflict	716	1	S → P in AAA74482. Ref.2
	Sequence conflict	1255	1	K → Q in AAA74482. Ref.2
	Sequence conflict	1276	1	L → G in AAA74482. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P38111-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: C06AEF9F0484A615	FASTA	2,368	273,342
	10 20 30 40 50 60 MESHVKYLDE LILAIKDLNS GVDSKVQIKK VPTDPSSSQE YAKSLKILNT LIRNLKDQRR 70 80 90 100 110 120 NNIMKNDTIF SKTVSALALL LEYNPFLLVM KDSNGNFEIQ RLIDDFLNIS VLNYDNYHRI 130 140 150 160 170 180 WFMRRKLGSW CKACVEFYGK PAKFQLTAHF ENTMNLYEQA LTEVLLGKTE LLKFYDTLKG 190 200 210 220 230 240 LYILLYWFTS EYSTFGNSIA FLDSSLGFTK FDFNFQRLIR IVLYVFDSCE LAALEYAEIQ 250 260 270 280 290 300 LKYISLVVDY VCNRTISTAL DAPALVCCEQ LKFVLTTMHH FLDNKYGLLD NDPTMAKGIL 310 320 330 340 350 360 RLYSLCISND FSKCFVDHFP IDQWADFSQS EHFPFTQLTN KALSIVYFDL KRRSLPVEAL 370 380 390 400 410 420 KYDNKFNIWV YQSEPDSSLK NVTSPFDDRY KQLEKLRLLV LKKFNKTERG TLLKYRVNQL 430 440 450 460 470 480 SPGFFQRAGN DFKLILNEAS VSIQTCFKTN NITRLTSWTV ILGRLACLES EKFSGTLPNS 490 500 510 520 530 540 TKDMDNWYVC HLCDIEKTGN PFVRINPNRP EAAGKSEIFR ILHSNFLSHP NIDEFSESLL 550 560 570 580 590 600 SGILFSLHRI FSHFQPPKLT DGNGQINKSF KLVQKCFMNS NRYLRLLSTR IIPLFNISDS 610 620 630 640 650 660 HNSEDEHTAT LIKFLQSQKL PVVKENLVIA WTQLTLTTSN DVFDTLLLKL IDIFNSDDYS 670 680 690 700 710 720 LRIMMTLQIK NMAKILKKTP YQLLSPILPV LLRQLGKNLV ERKVGFQNLI ELLGYSSKTI 730 740 750 760 770 780 LDIFQRYIIP YAIIQYKSDV LSEIAKIMCD GDTSLINQMK VNLLKKNSRQ IFAVALVKHG 790 800 810 820 830 840 LFSLDILETL FLNRAPTFDK GYITAYLPDY KTLAEITKLY KNSVTKDASD SENANMILCS 850 860 870 880 890 900 LRFLITNFEK DKRHGSKYKN INNWTDDQEQ AFQKKLQDNI LGIFQVFSSD IHDVEGRTTY 910 920 930 940 950 960 YEKLRVINGI SFLIIYAPKK SIISALAQIS ICLQTGLGLK EVRYEAFRCW HLLVRHLNDE 970 980 990 1000 1010 1020 ELSTVIDSLI AFILQKWSEF NGKLRNIVYS ILDTLIKEKS DLILKLKPYT TLALVGKPEL 1030 1040 1050 1060 1070 1080 GILARDGQFA RMVNKIRSTT DLIPIFANNL KSSNKYVINQ NLDDIEVYLR RKQTERSIDF 1090 1100 1110 1120 1130 1140 TPKKVGQTSD ITLVLGALLD TSHKFRNLDK DLCEKCAKCI SMIGVLDVTK HEFKRTTYSE 1150 1160 1170 1180 1190 1200 NEVYDLNDSV QTIKFLIWVI NDILVPAFWQ SENPSKQLFV ALVIQESLKY CGLSSESWDM 1210 1220 1230 1240 1250 1260 NHKELYPNEA KLWEKFNSVS KTTIYPLLSS LYLAQSWKEY VPLKYPSNNF KEGYKIWVKR 1270 1280 1290 1300 1310 1320 FTLDLLKTGT TENHPLHVFS SLIREDDGSL SNFLLPYISL DIIIKAEKGT PYADILNGII 1330 1340 1350 1360 1370 1380 IEFDSIFTCN LEGMNNLQVD SLRMCYESIF RVFEYCKKWA TEFKQNYSKL HGTFIIKDTK 1390 1400 1410 1420 1430 1440 TTNMLLRIDE FLRTTPSDLL AQRSLETDSF ERSALYLEQC YRQNPHDKNQ NGQLLKNLQI 1450 1460 1470 1480 1490 1500 TYEEIGDIDS LDGVLRTFAT GNLVSKIEEL QYSENWKLAQ DCFNVLGKFS DDPKTTTRML 1510 1520 1530 1540 1550 1560 KSMYDHQLYS QIISNSSFHS SDGKISLSPD VKEWYSIGLE AANLEGNVQT LKNWVEQIES 1570 1580 1590 1600 1610 1620 LRNIDDREVL LQYNIAKALI AISNEDPLRT QKYIHNSFRL IGTNFITSSK ETTLLKKQNL 1630 1640 1650 1660 1670 1680 LMKLHSLYDL SFLSSAKDKF EYKSNTTILD YRMERIGADF VPNHYILSMR KSFDQLKMNE 1690 1700 1710 1720 1730 1740 QADADLGKTF FTLAQLARNN ARLDIASESL MHCLERRLPQ AELEFAEILW KQGENDRALK 1750 1760 1770 1780 1790 1800 IVQEIHEKYQ ENSSVNARDR AAVLLKFTEW LDLSNNSASE QIIKQYQDIF QIDSKWDKPY 1810 1820 1830 1840 1850 1860 YSIGLYYSRL LERKKAEGYI TNGRFEYRAI SYFLLAFEKN TAKVRENLPK VITFWLDIAA 1870 1880 1890 1900 1910 1920 ASISEAPGNR KEMLSKATED ICSHVEEALQ HCPTYIWYFV LTQLLSRLLH SHQSSAQIIM 1930 1940 1950 1960 1970 1980 HILLSLAVEY PSHILWYITA LVNSNSSKRV LRGKHILEKY RQHSQNPHDL VSSALDLTKA 1990 2000 2010 2020 2030 2040 LTRVCLQDVK SITSRSGKSL EKDFKFDMNV APSAMVVPVR KNLDIISPLE SNSMRGYQPF 2050 2060 2070 2080 2090 2100 RPVVSIIRFG SSYKVFSSLK KPKQLNIIGS DGNIYGIMCK KEDVRQDNQY MQFATTMDFL 2110 2120 2130 2140 2150 2160 LSKDIASRKR SLGINIYSVL SLREDCGILE MVPNVVTLRS ILSTKYESLK IKYSLKSLHD 2170 2180 2190 2200 2210 2220 RWQHTAVDGK LEFYMEQVDK FPPILYQWFL ENFPDPINWF NARNTYARSY AVMAMVGHIL 2230 2240 2250 2260 2270 2280 GLGDRHCENI LLDIQTGKVL HVDFDCLFEK GKRLPVPEIV PFRLTPNLLD ALGIIGTEGT 2290 2300 2310 2320 2330 2340 FKKSSEVTLA LMRKNEVALM NVIETIMYDR NMDHSIQKAL KVLRNKIRGI DPQDGLVLSV 2350 2360 AGQTETLIQE ATSEDNLSKM YIGWLPFW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae." Kato R., Ogawa H. Nucleic Acids Res. 22:3104-3112(1994) [PubMed: 8065923] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
[2]	"Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair." Weinert T.A., Kiser G.L., Hartwell L.H. Genes Dev. 8:652-665(1994) [PubMed: 7926756] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The sequence of 29.7 kb from the right arm of chromosome II reveals 13 complete open reading frames, of which ten correspond to new genes." Becam A.-M., Cullin C., Grzybowska E., Lacroute F., Nasr F., Ozier-Kalogeropoulos O., Palucha A., Slonimski P.P., Zagulski M., Herbert C.J. Yeast 10:S1-S11(1994) [PubMed: 8091856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways." Sanchez Y., Desany B.A., Jones W.J., Liu Q., Wang B., Elledge S.J. Science 271:357-360(1996) [PubMed: 8553072] [Abstract] Cited for: FUNCTION.
[6]	"The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast." Brush G.S., Morrow D.M., Hieter P., Kelly T.J. Proc. Natl. Acad. Sci. U.S.A. 93:15075-15080(1996) [PubMed: 8986766] [Abstract] Cited for: PHOSPHORYLATION OF RPA2.
[7]	"LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae." Rouse J., Jackson S.P. EMBO J. 19:5801-5812(2000) [PubMed: 11060031] [Abstract] Cited for: INTERACTION WITH LCD1.
[8]	"The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast." Paciotti V., Clerici M., Lucchini G., Longhese M.P. Genes Dev. 14:2046-2059(2000) [PubMed: 10950868] [Abstract] Cited for: PHOSPHORYLATION OF LCD1, INTERACTION WITH LCD1.
[9]	"A role for Saccharomyces cerevisiae histone H2A in DNA repair." Downs J.A., Lowndes N.F., Jackson S.P. Nature 408:1001-1004(2000) [PubMed: 11140636] [Abstract] Cited for: FUNCTION.
[10]	"Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase." Mallory J.C., Petes T.D. Proc. Natl. Acad. Sci. U.S.A. 97:13749-13754(2000) [PubMed: 11095737] [Abstract] Cited for: IDENTIFICATION AS A KINASE, FUNCTION, MUTAGENESIS OF ASP-2224 AND ASN-2229.
[11]	"Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway." Paciotti V., Clerici M., Scotti M., Lucchini G., Longhese M.P. Mol. Cell. Biol. 21:3913-3925(2001) [PubMed: 11359899] [Abstract] Cited for: FUNCTION, INTERACTION WITH LCD1, PHOSPHORYLATION OF LCD1, MUTAGENESIS OF VAL-225; SER-552; LEU-781; PHE-1179; ASN-1700; ASP-2224 AND ASP-2243.
[12]	"MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae." Enomoto S., Glowczewski L., Berman J. Mol. Biol. Cell 13:2626-2638(2002) [PubMed: 12181334] [Abstract] Cited for: FUNCTION.
[13]	"Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage." Redon C., Pilch D.R., Rogakou E.P., Orr A.H., Lowndes N.F., Bonner W.M. EMBO Rep. 4:678-684(2003) [PubMed: 12792653] [Abstract] Cited for: FUNCTION.
[14]	"Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins." Lisby M., Barlow J.H., Burgess R.C., Rothstein R. Cell 118:699-713(2004) [PubMed: 15369670] [Abstract] Cited for: FUNCTION.
[15]	"Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break." Shroff R., Arbel-Eden A., Pilch D.R., Ira G., Bonner W.M., Petrini J.H.J., Haber J.E., Lichten M. Curr. Biol. 14:1703-1711(2004) [PubMed: 15458641] [Abstract] Cited for: FUNCTION.
[16]	"Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage." Rouse J. EMBO J. 23:1188-1197(2004) [PubMed: 14988729] [Abstract] Cited for: PHOSPHORYLATION OF RTT107.
[17]	"Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage." Flott S., Rouse J. Biochem. J. 391:325-333(2005) [PubMed: 15975089] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION OF SLX4.
[18]	"Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1." Ma J.-L., Lee S.-J., Duong J.K., Stern D.F. J. Biol. Chem. 281:3954-3963(2006) [PubMed: 16365046] [Abstract] Cited for: FUNCTION OF THE MEC1-LCD1 COMPLEX, PHOSPHORYLATION OF LCD1 AND RAD53.
[19]	"Role of the C-terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage." Nakada D., Hirano Y., Tanaka Y., Sugimoto K. Mol. Biol. Cell 16:5227-5235(2005) [PubMed: 16148046] [Abstract] Cited for: FUNCTION, INTERACTION WITH LCD1; RFA1 AND RFA2, MUTAGENESIS OF 2360-MET--ILE-2362 AND 2367-PHE-TRP-2368.
[20]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, MASS SPECTROMETRY.
[21]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-38, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X75891 Genomic DNA. Translation: CAA53494.1. U31109 Genomic DNA. Translation: AAA74482.1. D11088 Genomic DNA. Translation: BAA01860.1. Z36005 Genomic DNA. Translation: CAA85094.1.
PIR	S46005.
RefSeq	NP_009694.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:799N.
IntAct	P38111. 42 interactions.
STRING	P38111.
Proteomic databases
PeptideAtlas	P38111.
PRIDE	P38111.
Genome annotation databases
Ensembl	YBR136W; YBR136W; YBR136W; Saccharomyces cerevisiae. [Genome view]
GeneID	852433.
KEGG	sce:YBR136W.
NMPDR	fig|4932.3.peg.399.
Organism-specific databases
CYGD	YBR136w.
SGD	S000000340. MEC1.
Phylogenomic databases
HOGENOM	P38111.
OMA	HCENILL
OrthoDB	EOG9SFBPC
Enzyme and pathway databases
BRENDA	2.7.11.1. 250.
Gene expression databases
ArrayExpress	P38111.
Genevestigator	P38111.
GermOnline	YBR136W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR003152. FATC. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR003151. PIK-rel_kinase_FAT. IPR014009. PIK_FAT. IPR012993. UME. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
Pfam	PF02259. FAT. 1 hit. PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. PF08064. UME. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. SM00802. UME. 1 hit. [Graphical view]
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	971318.

Entry information

Entry name

ATR_YEAST

Accession

Primary (citable) accession number: P38111
Secondary accession number(s): Q02580

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 24, 2009
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)