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Protein

Starvation-sensing protein RspA

Gene

rspA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6839-MONOMER.
ECOL316407:JW1573-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Starvation-sensing protein RspA
Gene namesi
Name:rspA1 Publication
Ordered Locus Names:b1581, JW1573
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12451. rspA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Starvation-sensing protein RspAPRO_0000171260Add
BLAST

Proteomic databases

PaxDbiP38104.
PRIDEiP38104.

Expressioni

Inductioni

Repressed by RspR.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
groLP0A6F51EBI-1115648,EBI-543750
intRP760561EBI-1115648,EBI-1119761
purAP0A7D41EBI-1115648,EBI-561301

Protein-protein interaction databases

BioGridi4260233. 6 interactions.
DIPiDIP-10805N.
IntActiP38104. 11 interactions.
STRINGi511145.b1581.

Structurei

3D structure databases

ProteinModelPortaliP38104.
SMRiP38104. Positions 1-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXK. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000113758.
InParanoidiP38104.
KOiK08323.
OMAiSIEEFRM.
OrthoDBiEOG6SBSZM.
PhylomeDBiP38104.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 2 hits.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVKAEVFV TCPGRNFVTL KITTEDGITG LGDATLNGRE LSVASYLQDH
60 70 80 90 100
LCPQLIGRDA HRIEDIWQFF YKGAYWRRGP VTMSAISAVD MALWDIKAKA
110 120 130 140 150
ANMPLYQLLG GASREGVMVY CHTTGHSIDE ALDDYARHQE LGFKAIRVQC
160 170 180 190 200
GIPGMKTTYG MSKGKGLAYE PATKGQWPEE QLWSTEKYLD FMPKLFDAVR
210 220 230 240 250
NKFGFNEHLL HDMHHRLTPI EAARFGKSIE DYRMFWMEDP TPAENQECFR
260 270 280 290 300
LIRQHTVTPI AVGEVFNSIW DCKQLIEEQL IDYIRTTLTH AGGITGMRRI
310 320 330 340 350
ADFASLYQVR TGSHGPSDLS PVCMAAALHF DLWVPNFGVQ EYMGYSEQML
360 370 380 390 400
EVFPHNWTFD NGYMHPGDKP GLGIEFDEKL AAKYPYEPAY LPVARLEDGT

LWNW
Length:404
Mass (Da):45,968
Last modified:October 1, 1994 - v1
Checksum:iA2C945E0716808AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31628 Genomic DNA. Translation: AAA21685.1.
U00096 Genomic DNA. Translation: AAC74653.1.
AP009048 Genomic DNA. Translation: BAA15285.1.
PIRiI59589.
RefSeqiNP_416098.1. NC_000913.3.
WP_001295394.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74653; AAC74653; b1581.
BAA15285; BAA15285; BAA15285.
GeneIDi946126.
KEGGiecj:JW1573.
eco:b1581.
PATRICi32118464. VBIEscCol129921_1652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31628 Genomic DNA. Translation: AAA21685.1.
U00096 Genomic DNA. Translation: AAC74653.1.
AP009048 Genomic DNA. Translation: BAA15285.1.
PIRiI59589.
RefSeqiNP_416098.1. NC_000913.3.
WP_001295394.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP38104.
SMRiP38104. Positions 1-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260233. 6 interactions.
DIPiDIP-10805N.
IntActiP38104. 11 interactions.
STRINGi511145.b1581.

Proteomic databases

PaxDbiP38104.
PRIDEiP38104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74653; AAC74653; b1581.
BAA15285; BAA15285; BAA15285.
GeneIDi946126.
KEGGiecj:JW1573.
eco:b1581.
PATRICi32118464. VBIEscCol129921_1652.

Organism-specific databases

EchoBASEiEB2345.
EcoGeneiEG12451. rspA.

Phylogenomic databases

eggNOGiENOG4105CXK. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000113758.
InParanoidiP38104.
KOiK08323.
OMAiSIEEFRM.
OrthoDBiEOG6SBSZM.
PhylomeDBiP38104.

Enzyme and pathway databases

BioCyciEcoCyc:G6839-MONOMER.
ECOL316407:JW1573-MONOMER.

Miscellaneous databases

PROiP38104.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 2 hits.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sensing starvation: a homoserine lactone-dependent signaling pathway in Escherichia coli."
    Huisman G.W., Kolter R.
    Science 265:537-539(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], OVEREXPRESSION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "YdfH identified as a repressor of rspA by the use of reduced genome Escherichia coli MGF-01."
    Sakihama Y., Mizoguchi H., Oshima T., Ogasawara N.
    Biosci. Biotechnol. Biochem. 76:1688-1693(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSCRIPTIONAL REGULATION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiRSPA_ECOLI
AccessioniPrimary (citable) accession number: P38104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 20, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression prevents homoserine lactone-dependent synthesis of the sigma S factor (rpoS).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.