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Protein

Cysteine/O-acetylserine efflux protein

Gene

eamB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Exporter of O-acetylserine (OAS) and cysteine.1 Publication

GO - Molecular functioni

  • cysteine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • cysteine export Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG12445-MONOMER.
ECOL316407:JW2562-MONOMER.
MetaCyc:EG12445-MONOMER.

Protein family/group databases

TCDBi2.A.76.1.4. the resistance to homoserine/threonine (rhtb) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/O-acetylserine efflux protein
Gene namesi
Name:eamB
Synonyms:yfiK
Ordered Locus Names:b2578, JW2562
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12445. eamB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7PeriplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 46CytoplasmicSequence analysisAdd BLAST18
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 69PeriplasmicSequence analysis2
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 104CytoplasmicSequence analysisAdd BLAST14
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 141PeriplasmicSequence analysisAdd BLAST16
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 176CytoplasmicSequence analysisAdd BLAST14
Transmembranei177 – 194HelicalSequence analysisAdd BLAST18
Topological domaini195PeriplasmicSequence analysis1

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947431 – 195Cysteine/O-acetylserine efflux proteinAdd BLAST195

Proteomic databases

PaxDbiP38101.
PRIDEiP38101.

Interactioni

Protein-protein interaction databases

BioGridi4261635. 13 interactors.
STRINGi511145.b2578.

Structurei

3D structure databases

ProteinModelPortaliP38101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rht family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108VP3. Bacteria.
COG1280. LUCA.
HOGENOMiHOG000122950.
InParanoidiP38101.
KOiK11249.
OMAiWIAWKIA.
PhylomeDBiP38101.

Family and domain databases

InterProiIPR001123. LysE-type.
[Graphical view]
PANTHERiPTHR30086. PTHR30086. 1 hit.
PfamiPF01810. LysE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPTLLSAFW TYTLITAMTP GPNNILALSS ATSHGFRQST RVLAGMSLGF
60 70 80 90 100
LIVMLLCAGI SFSLAVIDPA AVHLLSWAGA AYIVWLAWKI ATSPTKEDGL
110 120 130 140 150
QAKPISFWAS FALQFVNVKI ILYGVTALST FVLPQTQALS WVVGVSVLLA
160 170 180 190
MIGTFGNVCW ALAGHLFQRL FRQYGRQLNI VLALLLVYCA VRIFY
Length:195
Mass (Da):21,248
Last modified:October 1, 1994 - v1
Checksum:i5F86B828DDDEC090
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13169 Genomic DNA. No translation available.
D64044 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAC75631.1.
AP009048 Genomic DNA. Translation: BAA16464.1.
PIRiA65036.
RefSeqiNP_417073.1. NC_000913.3.
WP_000189207.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75631; AAC75631; b2578.
BAA16464; BAA16464; BAA16464.
GeneIDi947065.
KEGGiecj:JW2562.
eco:b2578.
PATRICi32120557. VBIEscCol129921_2681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13169 Genomic DNA. No translation available.
D64044 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: AAC75631.1.
AP009048 Genomic DNA. Translation: BAA16464.1.
PIRiA65036.
RefSeqiNP_417073.1. NC_000913.3.
WP_000189207.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP38101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261635. 13 interactors.
STRINGi511145.b2578.

Protein family/group databases

TCDBi2.A.76.1.4. the resistance to homoserine/threonine (rhtb) family.

Proteomic databases

PaxDbiP38101.
PRIDEiP38101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75631; AAC75631; b2578.
BAA16464; BAA16464; BAA16464.
GeneIDi947065.
KEGGiecj:JW2562.
eco:b2578.
PATRICi32120557. VBIEscCol129921_2681.

Organism-specific databases

EchoBASEiEB2339.
EcoGeneiEG12445. eamB.

Phylogenomic databases

eggNOGiENOG4108VP3. Bacteria.
COG1280. LUCA.
HOGENOMiHOG000122950.
InParanoidiP38101.
KOiK11249.
OMAiWIAWKIA.
PhylomeDBiP38101.

Enzyme and pathway databases

BioCyciEcoCyc:EG12445-MONOMER.
ECOL316407:JW2562-MONOMER.
MetaCyc:EG12445-MONOMER.

Miscellaneous databases

PROiP38101.

Family and domain databases

InterProiIPR001123. LysE-type.
[Graphical view]
PANTHERiPTHR30086. PTHR30086. 1 hit.
PfamiPF01810. LysE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAMB_ECOLI
AccessioniPrimary (citable) accession number: P38101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.