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Protein

Putative urea carboxylase

Gene

lamA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the utilization of lactams. Required for the conversion of exogenous 2-pyrrolidinone (gamma-butyrolactam) to endogenous gamma-amino-n-butyrate (GABA).2 Publications

Catalytic activityi

ATP + urea + HCO3- = ADP + phosphate + urea-1-carboxylate.

Cofactori

biotinBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117ATPBy similarity1
Binding sitei201ATPBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Ligase
LigandATP-binding, Biotin, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative urea carboxylase (EC:6.3.4.6)
Alternative name(s):
Lactam utilization protein lamA
Urea amidolyase
Gene namesi
Name:lamA
ORF Names:AN0887
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843541 – 1241Putative urea carboxylaseAdd BLAST1241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1202N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Expressioni

Inductioni

By beta-alanine.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00001770

Structurei

3D structure databases

ProteinModelPortaliP38095
SMRiP38095
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 459Biotin carboxylationAdd BLAST457
Domaini121 – 321ATP-graspPROSITE-ProRule annotationAdd BLAST201
Domaini1159 – 1239Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST81

Phylogenomic databases

HOGENOMiHOG000251581
InParanoidiP38095
KOiK01941
OMAiTLQMWNR
OrthoDBiEOG092C0324

Family and domain databases

Gene3Di2.40.100.10, 2 hits
3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR003778 CT_A_B
IPR003833 CT_C_D
IPR029000 Cyclophilin-like_dom_sf
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
PF02626 CT_A_B, 1 hit
PF02682 CT_C_D, 1 hit
SMARTiView protein in SMART
SM00796 AHS1, 1 hit
SM00797 AHS2, 1 hit
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF50891 SSF50891, 2 hits
SSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALKTLLIA NRGEIAVRVL KTAKKLNIRT IAVYTEPDAA STHVHLADEA
60 70 80 90 100
ILLSGPPSKA YIDGDQIIDI AKRKGADAII PGYGFLSENS NFARDVASAG
110 120 130 140 150
LAFVGPSPES IEAFGLKHTA RELATKAGVP IVPGSQGLVT SEDEAVKIAQ
160 170 180 190 200
SLGFPVMLKA TAGGGGMGLL TCNTEKEVRE SFQTVQSRGE ALFKNAGLFI
210 220 230 240 250
ERYYPSSHHI EVQVFGNGQG KAISIGEREC SIQRRHQKVI EECPSPFVTR
260 270 280 290 300
NPELRKGLCD AAVRLAESID YGSAGTIEYL VDDESGKFFF LEMNTRLQVE
310 320 330 340 350
HGITELCYGV DLVELMLRQA DAQLSGRKGL EAEFLSSIPV GAPQGFAIEA
360 370 380 390 400
RVYAENPVRD FAPCPGILQD VDWKETTGSR IDTWVYRGIK VSANYDPLLA
410 420 430 440 450
KVMYHASSRQ KAIEGLRDIL TGSRICGPPT NLGFLAEILA NKDFNAGNTL
460 470 480 490 500
TKFLNNFEYN LAAIDVISGG AYTLIQDWPG RPTVGRGFCH SGPMDSVAFR
510 520 530 540 550
IANALVGNPV GLEGLEITLS GPELRFLGPA VISLCGAPID AKLDEAPVPM
560 570 580 590 600
WSRVKVSAGQ RLKIGKTTGG GCRAYLAVLG GFPNIAEWFG SKATAPMVGV
610 620 630 640 650
GGYQGRQLTS GDYLTISAQI PESDNELSLP EHLIPQYPDS WELMSMPGPY
660 670 680 690 700
DEGYLAPESI DMLYNAEWTI SHNAARGGIR LLGPKPTWAR PDGGEGGAHP
710 720 730 740 750
SNLIECGYAI GSINWTGDDP VIFPQDAPDL GGFVSSHTIV KADLWKLGQV
760 770 780 790 800
KAGDKLKFRA TSLKDTLLAR NELERFISDI VQCCQKGEDF GSITPLASSL
810 820 830 840 850
PPAMSSSTRV SGIVHQIPEK GNQPLVSYRQ AGDDYLLIDY GVGAFDLNHR
860 870 880 890 900
YRVTALKKVL SEAAGDISVS NGLINLVGCG NYLPKALMIY YDGTKIPQQK
910 920 930 940 950
LIDYLCTIET QLGDLSRAKV PSRRFKLPLT FESKRQTDAI KRYMETQRPY
960 970 980 990 1000
ASYLPDNIDF VARNNAFTRA ELENIYLTAS FMVITVGFFT ALPIALPVDP
1010 1020 1030 1040 1050
RQRMNCPKMN PSRVFTPAGQ VSWGGSCLAI YTVDSPGGYQ MNGMTIPGVD
1060 1070 1080 1090 1100
ILGTKRGYAP EKPWLFEDFD QITFYKVTEE EYERQLALFQ SGRYEYEWEV
1110 1120 1130 1140 1150
VEFDMAEHNR LLKETKEEVK AIRARQRKAQ AEMDLLEKEL LERWAKEKAE
1160 1170 1180 1190 1200
RGVSMDTVEE LLKDPEITVI EAPLNANVWK VEVKEGDKLD KDQVVVILEA
1210 1220 1230 1240
MKLEIAVRAE SAAAGAVVEK ILAQPGKSIE AGKPLMLVRR G
Length:1,241
Mass (Da):135,753
Last modified:May 26, 2009 - v2
Checksum:i0534958F6957FA0F
GO

Sequence cautioni

The sequence AAA33312 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000014 Genomic DNA Translation: EAA65916.1
M77283 Genomic DNA Translation: AAA33312.1 Sequence problems.
BN001308 Genomic DNA Translation: CBF88588.1
PIRiA42064
RefSeqiXP_658491.1, XM_653399.1

Genome annotation databases

EnsemblFungiiCADANIAT00001770; CADANIAP00001770; CADANIAG00001770
EAA65916; EAA65916; AN0887.2
GeneIDi2876661
KEGGiani:AN0887.2

Similar proteinsi

Entry informationi

Entry nameiLAMA_EMENI
AccessioniPrimary (citable) accession number: P38095
Secondary accession number(s): C8VUT6, Q5BEZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 26, 2009
Last modified: April 25, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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