SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P38095

- LAMA_EMENI

UniProt

P38095 - LAMA_EMENI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Putative urea carboxylase

Gene
lamA, AN0887
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the utilization of lactams. Required for the conversion of exogenous 2-pyrrolidinone (gamma-butyrolactam) to endogenous gamma-amino-n-butyrate (GABA).2 Publications

Catalytic activityi

ATP + urea + HCO3- = ADP + phosphate + urea-1-carboxylate.

Cofactori

Biotin By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171ATP By similarity
Binding sitei201 – 2011ATP By similarity

GO - Molecular functioni

  1. acetyl-CoA carboxylase activity Source: ASPGD
  2. ATP binding Source: UniProtKB-KW
  3. biotin carboxylase activity Source: InterPro
  4. hydrolase activity Source: UniProtKB-KW
  5. metal ion binding Source: InterPro
  6. methylcrotonoyl-CoA carboxylase activity Source: ASPGD
  7. urea carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbon utilization Source: ASPGD
  2. fatty acid biosynthetic process Source: ASPGD
  3. leucine catabolic process Source: ASPGD
  4. nitrogen compound metabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Ligase

Keywords - Ligandi

ATP-binding, Biotin, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative urea carboxylase (EC:6.3.4.6)
Alternative name(s):
Lactam utilization protein lamA
Urea amidolyase
Gene namesi
Name:lamA
ORF Names:AN0887
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome VIII

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12411241Putative urea carboxylasePRO_0000084354Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1202 – 12021N6-biotinyllysine By similarity

Expressioni

Inductioni

By beta-alanine.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00001770.

Structurei

3D structure databases

ProteinModelPortaliP38095.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 459457Biotin carboxylationAdd
BLAST
Domaini121 – 321201ATP-graspAdd
BLAST
Domaini1159 – 123880Biotinyl-bindingAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG1984.
HOGENOMiHOG000251581.
OMAiPSNVHDC.
OrthoDBiEOG7PGDZZ.

Family and domain databases

Gene3Di2.40.100.10. 2 hits.
3.30.1360.40. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR003833. Allophan_hydro_1.
IPR003778. Allophan_hydro_2.
IPR024946. Arg_repress_C-like.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029000. Cyclophilin-like_dom.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF02682. AHS1. 1 hit.
PF02626. AHS2. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00796. AHS1. 1 hit.
SM00797. AHS2. 1 hit.
SM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 2 hits.
SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38095-1 [UniParc]FASTAAdd to Basket

« Hide

MEALKTLLIA NRGEIAVRVL KTAKKLNIRT IAVYTEPDAA STHVHLADEA     50
ILLSGPPSKA YIDGDQIIDI AKRKGADAII PGYGFLSENS NFARDVASAG 100
LAFVGPSPES IEAFGLKHTA RELATKAGVP IVPGSQGLVT SEDEAVKIAQ 150
SLGFPVMLKA TAGGGGMGLL TCNTEKEVRE SFQTVQSRGE ALFKNAGLFI 200
ERYYPSSHHI EVQVFGNGQG KAISIGEREC SIQRRHQKVI EECPSPFVTR 250
NPELRKGLCD AAVRLAESID YGSAGTIEYL VDDESGKFFF LEMNTRLQVE 300
HGITELCYGV DLVELMLRQA DAQLSGRKGL EAEFLSSIPV GAPQGFAIEA 350
RVYAENPVRD FAPCPGILQD VDWKETTGSR IDTWVYRGIK VSANYDPLLA 400
KVMYHASSRQ KAIEGLRDIL TGSRICGPPT NLGFLAEILA NKDFNAGNTL 450
TKFLNNFEYN LAAIDVISGG AYTLIQDWPG RPTVGRGFCH SGPMDSVAFR 500
IANALVGNPV GLEGLEITLS GPELRFLGPA VISLCGAPID AKLDEAPVPM 550
WSRVKVSAGQ RLKIGKTTGG GCRAYLAVLG GFPNIAEWFG SKATAPMVGV 600
GGYQGRQLTS GDYLTISAQI PESDNELSLP EHLIPQYPDS WELMSMPGPY 650
DEGYLAPESI DMLYNAEWTI SHNAARGGIR LLGPKPTWAR PDGGEGGAHP 700
SNLIECGYAI GSINWTGDDP VIFPQDAPDL GGFVSSHTIV KADLWKLGQV 750
KAGDKLKFRA TSLKDTLLAR NELERFISDI VQCCQKGEDF GSITPLASSL 800
PPAMSSSTRV SGIVHQIPEK GNQPLVSYRQ AGDDYLLIDY GVGAFDLNHR 850
YRVTALKKVL SEAAGDISVS NGLINLVGCG NYLPKALMIY YDGTKIPQQK 900
LIDYLCTIET QLGDLSRAKV PSRRFKLPLT FESKRQTDAI KRYMETQRPY 950
ASYLPDNIDF VARNNAFTRA ELENIYLTAS FMVITVGFFT ALPIALPVDP 1000
RQRMNCPKMN PSRVFTPAGQ VSWGGSCLAI YTVDSPGGYQ MNGMTIPGVD 1050
ILGTKRGYAP EKPWLFEDFD QITFYKVTEE EYERQLALFQ SGRYEYEWEV 1100
VEFDMAEHNR LLKETKEEVK AIRARQRKAQ AEMDLLEKEL LERWAKEKAE 1150
RGVSMDTVEE LLKDPEITVI EAPLNANVWK VEVKEGDKLD KDQVVVILEA 1200
MKLEIAVRAE SAAAGAVVEK ILAQPGKSIE AGKPLMLVRR G 1241
Length:1,241
Mass (Da):135,753
Last modified:May 26, 2009 - v2
Checksum:i0534958F6957FA0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000014 Genomic DNA. Translation: EAA65916.1.
M77283 Genomic DNA. Translation: AAA33312.1. Sequence problems.
BN001308 Genomic DNA. Translation: CBF88588.1.
PIRiA42064.
RefSeqiXP_658491.1. XM_653399.1.

Genome annotation databases

EnsemblFungiiCADANIAT00001770; CADANIAP00001770; CADANIAG00001770.
GeneIDi2876661.
KEGGiani:AN0887.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000014 Genomic DNA. Translation: EAA65916.1 .
M77283 Genomic DNA. Translation: AAA33312.1 . Sequence problems.
BN001308 Genomic DNA. Translation: CBF88588.1 .
PIRi A42064.
RefSeqi XP_658491.1. XM_653399.1.

3D structure databases

ProteinModelPortali P38095.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00001770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00001770 ; CADANIAP00001770 ; CADANIAG00001770 .
GeneIDi 2876661.
KEGGi ani:AN0887.2.

Phylogenomic databases

eggNOGi COG1984.
HOGENOMi HOG000251581.
OMAi PSNVHDC.
OrthoDBi EOG7PGDZZ.

Family and domain databases

Gene3Di 2.40.100.10. 2 hits.
3.30.1360.40. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR003833. Allophan_hydro_1.
IPR003778. Allophan_hydro_2.
IPR024946. Arg_repress_C-like.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR029000. Cyclophilin-like_dom.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF02682. AHS1. 1 hit.
PF02626. AHS2. 1 hit.
PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00796. AHS1. 1 hit.
SM00797. AHS2. 1 hit.
SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50891. SSF50891. 2 hits.
SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "Molecular characterization of the lam locus and sequences involved in regulation by the AmdR protein of Aspergillus nidulans."
    Richardson I.B., Katz M.E., Hynes M.J.
    Mol. Cell. Biol. 12:337-346(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-103.
    Strain: biA1 niiA4.
  4. "Gene function identified by interspecific transformation."
    Katz M.E., Hynes M.J.
    Gene 78:167-171(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Characterization of the amdR-controlled lamA and lamB genes of Aspergillus nidulans."
    Katz M.E., Hynes M.J.
    Genetics 122:331-339(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiLAMA_EMENI
AccessioniPrimary (citable) accession number: P38095
Secondary accession number(s): C8VUT6, Q5BEZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi