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Protein

General amino acid permease AGP2

Gene

AGP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General amino acid permease with broad substrate specificity. Can also transport carnitine.2 Publications

GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • positive regulation of (R)-carnitine transmembrane transport Source: SGD
  • positive regulation of polyamine transmembrane transport Source: SGD

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29087-MONOMER
SABIO-RKP38090

Protein family/group databases

TCDBi2.A.3.10.19 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
General amino acid permease AGP2
Gene namesi
Name:AGP2
Ordered Locus Names:YBR132C
ORF Names:YBR1007
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR132C
SGDiS000000336 AGP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 94CytoplasmicSequence analysisAdd BLAST94
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 117ExtracellularSequence analysis2
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 165CytoplasmicSequence analysisAdd BLAST27
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 199ExtracellularSequence analysisAdd BLAST13
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 227CytoplasmicSequence analysis7
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 288ExtracellularSequence analysisAdd BLAST40
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 326CytoplasmicSequence analysisAdd BLAST17
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 379ExtracellularSequence analysisAdd BLAST32
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 427CytoplasmicSequence analysisAdd BLAST27
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 459ExtracellularSequence analysisAdd BLAST11
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 505CytoplasmicSequence analysisAdd BLAST25
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 534ExtracellularSequence analysis8
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21
Topological domaini556 – 596CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541431 – 596General amino acid permease AGP2Add BLAST596

Proteomic databases

MaxQBiP38090
PaxDbiP38090
PRIDEiP38090

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32833, 117 interactors
DIPiDIP-8141N
IntActiP38090, 8 interactors
MINTiP38090
STRINGi4932.YBR132C

Structurei

3D structure databases

ProteinModelPortaliP38090
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744
HOGENOMiHOG000261848
InParanoidiP38090
KOiK16261
OMAiFFFSYTM
OrthoDBiEOG092C164R

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P38090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKERMTIDY ENDGDFEYDK NKYKTITTRI KSIEPSEGWL EPSGSVGHIN
60 70 80 90 100
TIPEAGDVHV DEHEDRGSSI DDDSRTYLLY FTETRRKLEN RHVQLIAISG
110 120 130 140 150
VIGTALFVAI GKALYRGGPA SLLLAFALWC VPILCITVST AEMVCFFPVS
160 170 180 190 200
SPFLRLATKC VDDSLAVMAS WNFWFLECVQ IPFEIVSVNT IIHYWRDDYS
210 220 230 240 250
AGIPLAVQVV LYLLISICAV KYYGEMEFWL ASFKIILALG LFTFTFITML
260 270 280 290 300
GGNPEHDRYG FRNYGESPFK KYFPDGNDVG KSSGYFQGFL ACLIQASFTI
310 320 330 340 350
AGGEYISMLA GEVKRPRKVL PKAFKQVFVR LTFLFLGSCL CVGIVCSPND
360 370 380 390 400
PDLTAAINEA RPGAGSSPYV IAMNNLKIRI LPDIVNIALI TAAFSAGNAY
410 420 430 440 450
TYCSSRTFYG MALDGYAPKI FTRCNRHGVP IYSVAISLVW ALVSLLQLNS
460 470 480 490 500
NSAVVLNWLI NLITASQLIN FVVLCIVYLF FRRAYHVQQD SLPKLPFRSW
510 520 530 540 550
GQPYTAIIGL VSCSAMILIQ GYTVFFPKLW NTQDFLFSYL MVFINIGIYV
560 570 580 590
GYKFIWKRGK DHFKNPHEID FSKELTEIEN HEIESSFEKF QYYSKA
Length:596
Mass (Da):67,262
Last modified:October 1, 1994 - v1
Checksum:i8658DCDA5A7D6B64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75891 Genomic DNA Translation: CAA53491.1
Z36001 Genomic DNA Translation: CAA85089.1
BK006936 Genomic DNA Translation: DAA07249.1
PIRiS46001
RefSeqiNP_009690.1, NM_001178480.1

Genome annotation databases

EnsemblFungiiYBR132C; YBR132C; YBR132C
GeneIDi852429
KEGGisce:YBR132C

Similar proteinsi

Entry informationi

Entry nameiAGP2_YEAST
AccessioniPrimary (citable) accession number: P38090
Secondary accession number(s): D6VQC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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