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P38090

- AGP2_YEAST

UniProt

P38090 - AGP2_YEAST

Protein

General amino acid permease AGP2

Gene

AGP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    General amino acid permease with broad substrate specificity. Can also transport carnitine.2 Publications

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. positive regulation of (R)-carnitine transmembrane transport Source: SGD
    2. positive regulation of polyamine transmembrane transport Source: SGD

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29087-MONOMER.
    SABIO-RKP38090.

    Protein family/group databases

    TCDBi2.A.3.10.19. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General amino acid permease AGP2
    Gene namesi
    Name:AGP2
    Ordered Locus Names:YBR132C
    ORF Names:YBR1007
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR132c.
    SGDiS000000336. AGP2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: SGD
    2. fungal-type vacuole membrane Source: SGD
    3. integral component of plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 596596General amino acid permease AGP2PRO_0000054143Add
    BLAST

    Proteomic databases

    MaxQBiP38090.
    PaxDbiP38090.
    PRIDEiP38090.

    Expressioni

    Gene expression databases

    GenevestigatoriP38090.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LSB3P436032EBI-2362,EBI-22980
    YSC84P327932EBI-2362,EBI-24460

    Protein-protein interaction databases

    BioGridi32833. 21 interactions.
    DIPiDIP-8141N.
    IntActiP38090. 8 interactions.
    MINTiMINT-1552275.
    STRINGi4932.YBR132C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38090.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9494CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini116 – 1172ExtracellularSequence Analysis
    Topological domaini139 – 16527CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini187 – 19913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 2277CytoplasmicSequence Analysis
    Topological domaini249 – 28840ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 32617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini348 – 37932ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini401 – 42727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini449 – 45911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini481 – 50525CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini527 – 5348ExtracellularSequence Analysis
    Topological domaini556 – 59641CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei327 – 34721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei460 – 48021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei506 – 52621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei535 – 55521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0833.
    GeneTreeiENSGT00510000049744.
    HOGENOMiHOG000261848.
    KOiK16261.
    OMAiLAFTIWC.
    OrthoDBiEOG74J9HZ.

    Family and domain databases

    InterProiIPR004841. AA-permease/SLC12A_dom.
    IPR002293. AA/rel_permease1.
    IPR004840. Amoino_acid_permease_CS.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF00324. AA_permease. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38090-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKERMTIDY ENDGDFEYDK NKYKTITTRI KSIEPSEGWL EPSGSVGHIN    50
    TIPEAGDVHV DEHEDRGSSI DDDSRTYLLY FTETRRKLEN RHVQLIAISG 100
    VIGTALFVAI GKALYRGGPA SLLLAFALWC VPILCITVST AEMVCFFPVS 150
    SPFLRLATKC VDDSLAVMAS WNFWFLECVQ IPFEIVSVNT IIHYWRDDYS 200
    AGIPLAVQVV LYLLISICAV KYYGEMEFWL ASFKIILALG LFTFTFITML 250
    GGNPEHDRYG FRNYGESPFK KYFPDGNDVG KSSGYFQGFL ACLIQASFTI 300
    AGGEYISMLA GEVKRPRKVL PKAFKQVFVR LTFLFLGSCL CVGIVCSPND 350
    PDLTAAINEA RPGAGSSPYV IAMNNLKIRI LPDIVNIALI TAAFSAGNAY 400
    TYCSSRTFYG MALDGYAPKI FTRCNRHGVP IYSVAISLVW ALVSLLQLNS 450
    NSAVVLNWLI NLITASQLIN FVVLCIVYLF FRRAYHVQQD SLPKLPFRSW 500
    GQPYTAIIGL VSCSAMILIQ GYTVFFPKLW NTQDFLFSYL MVFINIGIYV 550
    GYKFIWKRGK DHFKNPHEID FSKELTEIEN HEIESSFEKF QYYSKA 596
    Length:596
    Mass (Da):67,262
    Last modified:October 1, 1994 - v1
    Checksum:i8658DCDA5A7D6B64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75891 Genomic DNA. Translation: CAA53491.1.
    Z36001 Genomic DNA. Translation: CAA85089.1.
    BK006936 Genomic DNA. Translation: DAA07249.1.
    PIRiS46001.
    RefSeqiNP_009690.1. NM_001178480.1.

    Genome annotation databases

    EnsemblFungiiYBR132C; YBR132C; YBR132C.
    GeneIDi852429.
    KEGGisce:YBR132C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75891 Genomic DNA. Translation: CAA53491.1 .
    Z36001 Genomic DNA. Translation: CAA85089.1 .
    BK006936 Genomic DNA. Translation: DAA07249.1 .
    PIRi S46001.
    RefSeqi NP_009690.1. NM_001178480.1.

    3D structure databases

    ProteinModelPortali P38090.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32833. 21 interactions.
    DIPi DIP-8141N.
    IntActi P38090. 8 interactions.
    MINTi MINT-1552275.
    STRINGi 4932.YBR132C.

    Protein family/group databases

    TCDBi 2.A.3.10.19. the amino acid-polyamine-organocation (apc) family.

    Proteomic databases

    MaxQBi P38090.
    PaxDbi P38090.
    PRIDEi P38090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR132C ; YBR132C ; YBR132C .
    GeneIDi 852429.
    KEGGi sce:YBR132C.

    Organism-specific databases

    CYGDi YBR132c.
    SGDi S000000336. AGP2.

    Phylogenomic databases

    eggNOGi COG0833.
    GeneTreei ENSGT00510000049744.
    HOGENOMi HOG000261848.
    KOi K16261.
    OMAi LAFTIWC.
    OrthoDBi EOG74J9HZ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29087-MONOMER.
    SABIO-RK P38090.

    Miscellaneous databases

    NextBioi 971309.

    Gene expression databases

    Genevestigatori P38090.

    Family and domain databases

    InterProi IPR004841. AA-permease/SLC12A_dom.
    IPR002293. AA/rel_permease1.
    IPR004840. Amoino_acid_permease_CS.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF00324. AA_permease. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    PROSITEi PS00218. AMINO_ACID_PERMEASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of 29.7 kb from the right arm of chromosome II reveals 13 complete open reading frames, of which ten correspond to new genes."
      Becam A.-M., Cullin C., Grzybowska E., Lacroute F., Nasr F., Ozier-Kalogeropoulos O., Palucha A., Slonimski P.P., Zagulski M., Herbert C.J.
      Yeast 10:S1-S11(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "An analysis of the sequence of part of the right arm of chromosome II of S. cerevisiae reveals new genes encoding an amino-acid permease and a carboxypeptidase."
      Nasr F., Becam A.-M., Grzybowska E., Zagulski M., Slonimski P.P., Herbert C.J.
      Curr. Genet. 26:1-7(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.
    5. Garrett J.M., Schreve J.L.
      Unpublished observations (JUL-1997)
      Cited for: CHARACTERIZATION.
    6. "Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p."
      van Roermund C.W., Hettema E.H., van den Berg M., Tabak H.F., Wanders R.J.
      EMBO J. 18:5843-5852(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CARNITINE TRANSPORT.
    7. "Carnitine uptake by AGP2 in yeast Saccharomyces cerevisiae is dependent on Hog1 MAP kinase pathway."
      Lee J., Lee B., Shin D., Kwak S.S., Bahk J.D., Lim C.O., Yun D.J.
      Mol. Cells 13:407-412(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CARNITINE TRANSPORT.
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAGP2_YEAST
    AccessioniPrimary (citable) accession number: P38090
    Secondary accession number(s): D6VQC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3