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P38090 (AGP2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General amino acid permease AGP2
Gene names
Name:AGP2
Ordered Locus Names:YBR132C
ORF Names:YBR1007
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

General amino acid permease with broad substrate specificity. Can also transport carnitine. Ref.6 Ref.7

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LSB3P436032EBI-2362,EBI-22980
YSC84P327932EBI-2362,EBI-24460

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596General amino acid permease AGP2
PRO_0000054143

Regions

Topological domain1 – 9494Cytoplasmic Potential
Transmembrane95 – 11521Helical; Potential
Topological domain116 – 1172Extracellular Potential
Transmembrane118 – 13821Helical; Potential
Topological domain139 – 16527Cytoplasmic Potential
Transmembrane166 – 18621Helical; Potential
Topological domain187 – 19913Extracellular Potential
Transmembrane200 – 22021Helical; Potential
Topological domain221 – 2277Cytoplasmic Potential
Transmembrane228 – 24821Helical; Potential
Topological domain249 – 28840Extracellular Potential
Transmembrane289 – 30921Helical; Potential
Topological domain310 – 32617Cytoplasmic Potential
Transmembrane327 – 34721Helical; Potential
Topological domain348 – 37932Extracellular Potential
Transmembrane380 – 40021Helical; Potential
Topological domain401 – 42727Cytoplasmic Potential
Transmembrane428 – 44821Helical; Potential
Topological domain449 – 45911Extracellular Potential
Transmembrane460 – 48021Helical; Potential
Topological domain481 – 50525Cytoplasmic Potential
Transmembrane506 – 52621Helical; Potential
Topological domain527 – 5348Extracellular Potential
Transmembrane535 – 55521Helical; Potential
Topological domain556 – 59641Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P38090 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 8658DCDA5A7D6B64

FASTA59667,262
        10         20         30         40         50         60 
MTKERMTIDY ENDGDFEYDK NKYKTITTRI KSIEPSEGWL EPSGSVGHIN TIPEAGDVHV 

        70         80         90        100        110        120 
DEHEDRGSSI DDDSRTYLLY FTETRRKLEN RHVQLIAISG VIGTALFVAI GKALYRGGPA 

       130        140        150        160        170        180 
SLLLAFALWC VPILCITVST AEMVCFFPVS SPFLRLATKC VDDSLAVMAS WNFWFLECVQ 

       190        200        210        220        230        240 
IPFEIVSVNT IIHYWRDDYS AGIPLAVQVV LYLLISICAV KYYGEMEFWL ASFKIILALG 

       250        260        270        280        290        300 
LFTFTFITML GGNPEHDRYG FRNYGESPFK KYFPDGNDVG KSSGYFQGFL ACLIQASFTI 

       310        320        330        340        350        360 
AGGEYISMLA GEVKRPRKVL PKAFKQVFVR LTFLFLGSCL CVGIVCSPND PDLTAAINEA 

       370        380        390        400        410        420 
RPGAGSSPYV IAMNNLKIRI LPDIVNIALI TAAFSAGNAY TYCSSRTFYG MALDGYAPKI 

       430        440        450        460        470        480 
FTRCNRHGVP IYSVAISLVW ALVSLLQLNS NSAVVLNWLI NLITASQLIN FVVLCIVYLF 

       490        500        510        520        530        540 
FRRAYHVQQD SLPKLPFRSW GQPYTAIIGL VSCSAMILIQ GYTVFFPKLW NTQDFLFSYL 

       550        560        570        580        590 
MVFINIGIYV GYKFIWKRGK DHFKNPHEID FSKELTEIEN HEIESSFEKF QYYSKA 

« Hide

References

« Hide 'large scale' references
[1]"The sequence of 29.7 kb from the right arm of chromosome II reveals 13 complete open reading frames, of which ten correspond to new genes."
Becam A.-M., Cullin C., Grzybowska E., Lacroute F., Nasr F., Ozier-Kalogeropoulos O., Palucha A., Slonimski P.P., Zagulski M., Herbert C.J.
Yeast 10:S1-S11(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"An analysis of the sequence of part of the right arm of chromosome II of S. cerevisiae reveals new genes encoding an amino-acid permease and a carboxypeptidase."
Nasr F., Becam A.-M., Grzybowska E., Zagulski M., Slonimski P.P., Herbert C.J.
Curr. Genet. 26:1-7(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.
[5]Garrett J.M., Schreve J.L.
Unpublished observations (JUL-1997)
Cited for: CHARACTERIZATION.
[6]"Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p."
van Roermund C.W., Hettema E.H., van den Berg M., Tabak H.F., Wanders R.J.
EMBO J. 18:5843-5852(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CARNITINE TRANSPORT.
[7]"Carnitine uptake by AGP2 in yeast Saccharomyces cerevisiae is dependent on Hog1 MAP kinase pathway."
Lee J., Lee B., Shin D., Kwak S.S., Bahk J.D., Lim C.O., Yun D.J.
Mol. Cells 13:407-412(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CARNITINE TRANSPORT.
[8]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[9]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75891 Genomic DNA. Translation: CAA53491.1.
Z36001 Genomic DNA. Translation: CAA85089.1.
BK006936 Genomic DNA. Translation: DAA07249.1.
PIRS46001.
RefSeqNP_009690.1. NM_001178480.1.

3D structure databases

ProteinModelPortalP38090.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32833. 21 interactions.
DIPDIP-8141N.
IntActP38090. 8 interactions.
MINTMINT-1552275.
STRING4932.YBR132C.

Protein family/group databases

TCDB2.A.3.10.19. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbP38090.
PRIDEP38090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR132C; YBR132C; YBR132C.
GeneID852429.
KEGGsce:YBR132C.

Organism-specific databases

CYGDYBR132c.
SGDS000000336. AGP2.

Phylogenomic databases

eggNOGCOG0833.
GeneTreeENSGT00510000049744.
HOGENOMHOG000261848.
KOK16261.
OMALAFTIWC.
OrthoDBEOG74J9HZ.

Enzyme and pathway databases

BioCycYEAST:G3O-29087-MONOMER.
SABIO-RKP38090.

Gene expression databases

GenevestigatorP38090.

Family and domain databases

InterProIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
PROSITEPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio971309.

Entry information

Entry nameAGP2_YEAST
AccessionPrimary (citable) accession number: P38090
Secondary accession number(s): D6VQC9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 19, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families