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Protein

General amino acid permease AGP2

Gene

AGP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

General amino acid permease with broad substrate specificity. Can also transport carnitine.2 Publications

GO - Molecular functioni

GO - Biological processi

  • positive regulation of (R)-carnitine transmembrane transport Source: SGD
  • positive regulation of polyamine transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29087-MONOMER.
SABIO-RKP38090.

Protein family/group databases

TCDBi2.A.3.10.19. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
General amino acid permease AGP2
Gene namesi
Name:AGP2
Ordered Locus Names:YBR132C
ORF Names:YBR1007
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR132C.
SGDiS000000336. AGP2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 94CytoplasmicSequence analysisAdd BLAST94
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 117ExtracellularSequence analysis2
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 165CytoplasmicSequence analysisAdd BLAST27
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 199ExtracellularSequence analysisAdd BLAST13
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 227CytoplasmicSequence analysis7
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 288ExtracellularSequence analysisAdd BLAST40
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 326CytoplasmicSequence analysisAdd BLAST17
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 379ExtracellularSequence analysisAdd BLAST32
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 427CytoplasmicSequence analysisAdd BLAST27
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 459ExtracellularSequence analysisAdd BLAST11
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 505CytoplasmicSequence analysisAdd BLAST25
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 534ExtracellularSequence analysis8
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21
Topological domaini556 – 596CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: SGD
  • fungal-type vacuole membrane Source: SGD
  • integral component of plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541431 – 596General amino acid permease AGP2Add BLAST596

Proteomic databases

MaxQBiP38090.
PRIDEiP38090.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSB3P436032EBI-2362,EBI-22980
YSC84P327932EBI-2362,EBI-24460

Protein-protein interaction databases

BioGridi32833. 20 interactors.
DIPiDIP-8141N.
IntActiP38090. 8 interactors.
MINTiMINT-1552275.

Structurei

3D structure databases

ProteinModelPortaliP38090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP38090.
KOiK16261.
OMAiNFWFLEC.
OrthoDBiEOG092C164R.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKERMTIDY ENDGDFEYDK NKYKTITTRI KSIEPSEGWL EPSGSVGHIN
60 70 80 90 100
TIPEAGDVHV DEHEDRGSSI DDDSRTYLLY FTETRRKLEN RHVQLIAISG
110 120 130 140 150
VIGTALFVAI GKALYRGGPA SLLLAFALWC VPILCITVST AEMVCFFPVS
160 170 180 190 200
SPFLRLATKC VDDSLAVMAS WNFWFLECVQ IPFEIVSVNT IIHYWRDDYS
210 220 230 240 250
AGIPLAVQVV LYLLISICAV KYYGEMEFWL ASFKIILALG LFTFTFITML
260 270 280 290 300
GGNPEHDRYG FRNYGESPFK KYFPDGNDVG KSSGYFQGFL ACLIQASFTI
310 320 330 340 350
AGGEYISMLA GEVKRPRKVL PKAFKQVFVR LTFLFLGSCL CVGIVCSPND
360 370 380 390 400
PDLTAAINEA RPGAGSSPYV IAMNNLKIRI LPDIVNIALI TAAFSAGNAY
410 420 430 440 450
TYCSSRTFYG MALDGYAPKI FTRCNRHGVP IYSVAISLVW ALVSLLQLNS
460 470 480 490 500
NSAVVLNWLI NLITASQLIN FVVLCIVYLF FRRAYHVQQD SLPKLPFRSW
510 520 530 540 550
GQPYTAIIGL VSCSAMILIQ GYTVFFPKLW NTQDFLFSYL MVFINIGIYV
560 570 580 590
GYKFIWKRGK DHFKNPHEID FSKELTEIEN HEIESSFEKF QYYSKA
Length:596
Mass (Da):67,262
Last modified:October 1, 1994 - v1
Checksum:i8658DCDA5A7D6B64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75891 Genomic DNA. Translation: CAA53491.1.
Z36001 Genomic DNA. Translation: CAA85089.1.
BK006936 Genomic DNA. Translation: DAA07249.1.
PIRiS46001.
RefSeqiNP_009690.1. NM_001178480.1.

Genome annotation databases

EnsemblFungiiYBR132C; YBR132C; YBR132C.
GeneIDi852429.
KEGGisce:YBR132C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75891 Genomic DNA. Translation: CAA53491.1.
Z36001 Genomic DNA. Translation: CAA85089.1.
BK006936 Genomic DNA. Translation: DAA07249.1.
PIRiS46001.
RefSeqiNP_009690.1. NM_001178480.1.

3D structure databases

ProteinModelPortaliP38090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32833. 20 interactors.
DIPiDIP-8141N.
IntActiP38090. 8 interactors.
MINTiMINT-1552275.

Protein family/group databases

TCDBi2.A.3.10.19. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

MaxQBiP38090.
PRIDEiP38090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR132C; YBR132C; YBR132C.
GeneIDi852429.
KEGGisce:YBR132C.

Organism-specific databases

EuPathDBiFungiDB:YBR132C.
SGDiS000000336. AGP2.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP38090.
KOiK16261.
OMAiNFWFLEC.
OrthoDBiEOG092C164R.

Enzyme and pathway databases

BioCyciYEAST:G3O-29087-MONOMER.
SABIO-RKP38090.

Miscellaneous databases

PROiP38090.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGP2_YEAST
AccessioniPrimary (citable) accession number: P38090
Secondary accession number(s): D6VQC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.