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Reviewed, UniProtKB/Swiss-Prot P38090 (AGP2_YEAST)

Last modified November 24, 2009. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    General amino acid permease AGP2
Gene names
Name: AGP2
Ordered Locus Names: YBR132C
ORF Names: YBR1007
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

General amino acid permease with broad substrate specificity. Can also transport carnitine. Ref.5 Ref.6

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596General amino acid permease AGP2
PRO_0000054143

Regions

Topological domain1 – 9494Cytoplasmic Potential
Transmembrane95 – 11521 Potential
Topological domain116 – 1172Extracellular Potential
Transmembrane118 – 13821 Potential
Topological domain139 – 16527Cytoplasmic Potential
Transmembrane166 – 18621 Potential
Topological domain187 – 19913Extracellular Potential
Transmembrane200 – 22021 Potential
Topological domain221 – 2277Cytoplasmic Potential
Transmembrane228 – 24821 Potential
Topological domain249 – 28840Extracellular Potential
Transmembrane289 – 30921 Potential
Topological domain310 – 32617Cytoplasmic Potential
Transmembrane327 – 34721 Potential
Topological domain348 – 37932Extracellular Potential
Transmembrane380 – 40021 Potential
Topological domain401 – 42727Cytoplasmic Potential
Transmembrane428 – 44821 Potential
Topological domain449 – 45911Extracellular Potential
Transmembrane460 – 48021 Potential
Topological domain481 – 50525Cytoplasmic Potential
Transmembrane506 – 52621 Potential
Topological domain527 – 5348Extracellular Potential
Transmembrane535 – 55521 Potential
Topological domain556 – 59641Cytoplasmic Potential

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Sequences

Sequence LengthMass (Da)Tools
P38090-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 8658DCDA5A7D6B64

FASTA59667,262
        10         20         30         40         50         60 
MTKERMTIDY ENDGDFEYDK NKYKTITTRI KSIEPSEGWL EPSGSVGHIN TIPEAGDVHV 

        70         80         90        100        110        120 
DEHEDRGSSI DDDSRTYLLY FTETRRKLEN RHVQLIAISG VIGTALFVAI GKALYRGGPA 

       130        140        150        160        170        180 
SLLLAFALWC VPILCITVST AEMVCFFPVS SPFLRLATKC VDDSLAVMAS WNFWFLECVQ 

       190        200        210        220        230        240 
IPFEIVSVNT IIHYWRDDYS AGIPLAVQVV LYLLISICAV KYYGEMEFWL ASFKIILALG 

       250        260        270        280        290        300 
LFTFTFITML GGNPEHDRYG FRNYGESPFK KYFPDGNDVG KSSGYFQGFL ACLIQASFTI 

       310        320        330        340        350        360 
AGGEYISMLA GEVKRPRKVL PKAFKQVFVR LTFLFLGSCL CVGIVCSPND PDLTAAINEA 

       370        380        390        400        410        420 
RPGAGSSPYV IAMNNLKIRI LPDIVNIALI TAAFSAGNAY TYCSSRTFYG MALDGYAPKI 

       430        440        450        460        470        480 
FTRCNRHGVP IYSVAISLVW ALVSLLQLNS NSAVVLNWLI NLITASQLIN FVVLCIVYLF 

       490        500        510        520        530        540 
FRRAYHVQQD SLPKLPFRSW GQPYTAIIGL VSCSAMILIQ GYTVFFPKLW NTQDFLFSYL 

       550        560        570        580        590 
MVFINIGIYV GYKFIWKRGK DHFKNPHEID FSKELTEIEN HEIESSFEKF QYYSKA

« Hide

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References

« Hide 'large scale' references
[1]"The sequence of 29.7 kb from the right arm of chromosome II reveals 13 complete open reading frames, of which ten correspond to new genes."
Becam A.-M., Cullin C., Grzybowska E., Lacroute F., Nasr F., Ozier-Kalogeropoulos O., Palucha A., Slonimski P.P., Zagulski M., Herbert C.J.
Yeast 10:S1-S11(1994) [PubMed: 8091856] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"An analysis of the sequence of part of the right arm of chromosome II of S. cerevisiae reveals new genes encoding an amino-acid permease and a carboxypeptidase."
Nasr F., Becam A.-M., Grzybowska E., Zagulski M., Slonimski P.P., Herbert C.J.
Curr. Genet. 26:1-7(1994) [PubMed: 7954890] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.
[4]Garrett J.M., Schreve J.L.
Unpublished observations (JUL-1997)
Cited for: CHARACTERIZATION.
[5]"Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p."
van Roermund C.W., Hettema E.H., van den Berg M., Tabak H.F., Wanders R.J.
EMBO J. 18:5843-5852(1999) [PubMed: 10545096] [Abstract]
Cited for: FUNCTION IN CARNITINE TRANSPORT.
[6]"Carnitine uptake by AGP2 in yeast Saccharomyces cerevisiae is dependent on Hog1 MAP kinase pathway."
Lee J., Lee B., Shin D., Kwak S.S., Bahk J.D., Lim C.O., Yun D.J.
Mol. Cells 13:407-412(2002) [PubMed: 12132580] [Abstract]
Cited for: FUNCTION IN CARNITINE TRANSPORT.
[7]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

X75891 Genomic DNA. Translation: CAA53491.1.
Z36001 Genomic DNA. Translation: CAA85089.1.
PIRS46001.
RefSeqNP_009690.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:8141N.
IntActP38090. 10 interactions.
STRINGP38090.

Protein family/group databases

TCDB2.A.3.10.19. amino acid-polyamine-organocation (APC) family.

Genome annotation databases

EnsemblYBR132C; YBR132C; YBR132C; Saccharomyces cerevisiae. [Genome view]
GeneID852429.
KEGGsce:YBR132C.
NMPDRfig|4932.3.peg.395.

Organism-specific databases

CYGDYBR132c.
SGDS000000336. AGP2.

Phylogenomic databases

HOGENOMP38090.
OMAPYVIAMN
OrthoDBEOG9FXSR3

Gene expression databases

ArrayExpressP38090.
GenevestigatorP38090.
GermOnlineYBR132C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
IPR004841. Permease_region.
[Graphical view]
PANTHERPTHR11785. AA/rel_permease1. 1 hit.
PfamPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
PROSITEPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio971309.

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Entry information

Entry nameAGP2_YEAST
AccessionPrimary (citable) accession number: P38090
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 24, 2009
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents