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P38090

- AGP2_YEAST

UniProt

P38090 - AGP2_YEAST

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Protein
General amino acid permease AGP2
Gene
AGP2, YBR132C, YBR1007
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

General amino acid permease with broad substrate specificity. Can also transport carnitine.2 Publications

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: InterPro
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. positive regulation of (R)-carnitine transmembrane transport Source: SGD
  2. positive regulation of polyamine transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29087-MONOMER.
SABIO-RKP38090.

Protein family/group databases

TCDBi2.A.3.10.19. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
General amino acid permease AGP2
Gene namesi
Name:AGP2
Ordered Locus Names:YBR132C
ORF Names:YBR1007
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR132c.
SGDiS000000336. AGP2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9494Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei95 – 11521Helical; Reviewed prediction
Add
BLAST
Topological domaini116 – 1172Extracellular Reviewed prediction
Transmembranei118 – 13821Helical; Reviewed prediction
Add
BLAST
Topological domaini139 – 16527Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei166 – 18621Helical; Reviewed prediction
Add
BLAST
Topological domaini187 – 19913Extracellular Reviewed prediction
Add
BLAST
Transmembranei200 – 22021Helical; Reviewed prediction
Add
BLAST
Topological domaini221 – 2277Cytoplasmic Reviewed prediction
Transmembranei228 – 24821Helical; Reviewed prediction
Add
BLAST
Topological domaini249 – 28840Extracellular Reviewed prediction
Add
BLAST
Transmembranei289 – 30921Helical; Reviewed prediction
Add
BLAST
Topological domaini310 – 32617Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei327 – 34721Helical; Reviewed prediction
Add
BLAST
Topological domaini348 – 37932Extracellular Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Topological domaini401 – 42727Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei428 – 44821Helical; Reviewed prediction
Add
BLAST
Topological domaini449 – 45911Extracellular Reviewed prediction
Add
BLAST
Transmembranei460 – 48021Helical; Reviewed prediction
Add
BLAST
Topological domaini481 – 50525Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei506 – 52621Helical; Reviewed prediction
Add
BLAST
Topological domaini527 – 5348Extracellular Reviewed prediction
Transmembranei535 – 55521Helical; Reviewed prediction
Add
BLAST
Topological domaini556 – 59641Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: SGD
  2. fungal-type vacuole membrane Source: SGD
  3. integral component of plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596General amino acid permease AGP2
PRO_0000054143Add
BLAST

Proteomic databases

MaxQBiP38090.
PaxDbiP38090.
PRIDEiP38090.

Expressioni

Gene expression databases

GenevestigatoriP38090.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSB3P436032EBI-2362,EBI-22980
YSC84P327932EBI-2362,EBI-24460

Protein-protein interaction databases

BioGridi32833. 21 interactions.
DIPiDIP-8141N.
IntActiP38090. 8 interactions.
MINTiMINT-1552275.
STRINGi4932.YBR132C.

Structurei

3D structure databases

ProteinModelPortaliP38090.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0833.
GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
KOiK16261.
OMAiLAFTIWC.
OrthoDBiEOG74J9HZ.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38090-1 [UniParc]FASTAAdd to Basket

« Hide

MTKERMTIDY ENDGDFEYDK NKYKTITTRI KSIEPSEGWL EPSGSVGHIN    50
TIPEAGDVHV DEHEDRGSSI DDDSRTYLLY FTETRRKLEN RHVQLIAISG 100
VIGTALFVAI GKALYRGGPA SLLLAFALWC VPILCITVST AEMVCFFPVS 150
SPFLRLATKC VDDSLAVMAS WNFWFLECVQ IPFEIVSVNT IIHYWRDDYS 200
AGIPLAVQVV LYLLISICAV KYYGEMEFWL ASFKIILALG LFTFTFITML 250
GGNPEHDRYG FRNYGESPFK KYFPDGNDVG KSSGYFQGFL ACLIQASFTI 300
AGGEYISMLA GEVKRPRKVL PKAFKQVFVR LTFLFLGSCL CVGIVCSPND 350
PDLTAAINEA RPGAGSSPYV IAMNNLKIRI LPDIVNIALI TAAFSAGNAY 400
TYCSSRTFYG MALDGYAPKI FTRCNRHGVP IYSVAISLVW ALVSLLQLNS 450
NSAVVLNWLI NLITASQLIN FVVLCIVYLF FRRAYHVQQD SLPKLPFRSW 500
GQPYTAIIGL VSCSAMILIQ GYTVFFPKLW NTQDFLFSYL MVFINIGIYV 550
GYKFIWKRGK DHFKNPHEID FSKELTEIEN HEIESSFEKF QYYSKA 596
Length:596
Mass (Da):67,262
Last modified:October 1, 1994 - v1
Checksum:i8658DCDA5A7D6B64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75891 Genomic DNA. Translation: CAA53491.1.
Z36001 Genomic DNA. Translation: CAA85089.1.
BK006936 Genomic DNA. Translation: DAA07249.1.
PIRiS46001.
RefSeqiNP_009690.1. NM_001178480.1.

Genome annotation databases

EnsemblFungiiYBR132C; YBR132C; YBR132C.
GeneIDi852429.
KEGGisce:YBR132C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75891 Genomic DNA. Translation: CAA53491.1 .
Z36001 Genomic DNA. Translation: CAA85089.1 .
BK006936 Genomic DNA. Translation: DAA07249.1 .
PIRi S46001.
RefSeqi NP_009690.1. NM_001178480.1.

3D structure databases

ProteinModelPortali P38090.
ModBasei Search...

Protein-protein interaction databases

BioGridi 32833. 21 interactions.
DIPi DIP-8141N.
IntActi P38090. 8 interactions.
MINTi MINT-1552275.
STRINGi 4932.YBR132C.

Protein family/group databases

TCDBi 2.A.3.10.19. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

MaxQBi P38090.
PaxDbi P38090.
PRIDEi P38090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR132C ; YBR132C ; YBR132C .
GeneIDi 852429.
KEGGi sce:YBR132C.

Organism-specific databases

CYGDi YBR132c.
SGDi S000000336. AGP2.

Phylogenomic databases

eggNOGi COG0833.
GeneTreei ENSGT00510000049744.
HOGENOMi HOG000261848.
KOi K16261.
OMAi LAFTIWC.
OrthoDBi EOG74J9HZ.

Enzyme and pathway databases

BioCyci YEAST:G3O-29087-MONOMER.
SABIO-RK P38090.

Miscellaneous databases

NextBioi 971309.

Gene expression databases

Genevestigatori P38090.

Family and domain databases

InterProi IPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
Pfami PF00324. AA_permease. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
PROSITEi PS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of 29.7 kb from the right arm of chromosome II reveals 13 complete open reading frames, of which ten correspond to new genes."
    Becam A.-M., Cullin C., Grzybowska E., Lacroute F., Nasr F., Ozier-Kalogeropoulos O., Palucha A., Slonimski P.P., Zagulski M., Herbert C.J.
    Yeast 10:S1-S11(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "An analysis of the sequence of part of the right arm of chromosome II of S. cerevisiae reveals new genes encoding an amino-acid permease and a carboxypeptidase."
    Nasr F., Becam A.-M., Grzybowska E., Zagulski M., Slonimski P.P., Herbert C.J.
    Curr. Genet. 26:1-7(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.
  5. Garrett J.M., Schreve J.L.
    Unpublished observations (JUL-1997)
    Cited for: CHARACTERIZATION.
  6. "Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p."
    van Roermund C.W., Hettema E.H., van den Berg M., Tabak H.F., Wanders R.J.
    EMBO J. 18:5843-5852(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CARNITINE TRANSPORT.
  7. "Carnitine uptake by AGP2 in yeast Saccharomyces cerevisiae is dependent on Hog1 MAP kinase pathway."
    Lee J., Lee B., Shin D., Kwak S.S., Bahk J.D., Lim C.O., Yun D.J.
    Mol. Cells 13:407-412(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CARNITINE TRANSPORT.
  8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAGP2_YEAST
AccessioniPrimary (citable) accession number: P38090
Secondary accession number(s): D6VQC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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