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Protein

Protein phosphatase 2C homolog 4

Gene

PTC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Manganese 1By similarity
Metal bindingi83 – 831Manganese 2By similarity
Metal bindingi84 – 841Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi310 – 3101Manganese 2By similarity
Metal bindingi359 – 3591Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  1. protein dephosphorylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29081-MONOMER.
ReactomeiREACT_209479. Regulation of AMPK activity via LKB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 4 (EC:3.1.3.16)
Short name:
PP2C-4
Gene namesi
Name:PTC4
Synonyms:GCT1
Ordered Locus Names:YBR125C
ORF Names:YBR0921
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR125c.
SGDiS000000329. PTC4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Protein phosphatase 2C homolog 4PRO_0000057777Add
BLAST

Proteomic databases

MaxQBiP38089.
PaxDbiP38089.
PeptideAtlasiP38089.

Expressioni

Gene expression databases

GenevestigatoriP38089.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PAA1Q124475EBI-12814,EBI-33397

Protein-protein interaction databases

BioGridi32826. 85 interactions.
DIPiDIP-6437N.
IntActiP38089. 8 interactions.
MINTiMINT-397378.
STRINGi4932.YBR125C.

Structurei

3D structure databases

ProteinModelPortaliP38089.
SMRiP38089. Positions 1-369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00770000120571.
HOGENOMiHOG000233896.
InParanoidiP38089.
KOiK01090.
OMAiCIGSMQG.
OrthoDBiEOG79930T.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38089-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQLLSHPLT EKTIEYNEYK NNQASTGIVP RFYNCVGSMQ GYRLTQEDAH
60 70 80 90 100
LIRNENSVVY VRFFNPFIDK YETLSLNVFA VFDGHGGDDC SKFLSGGRHH
110 120 130 140 150
RDGNGSSNGN GEPNAGLIKW IAYSFENHHY TSTTNNDSSK FKRSFNTLEG
160 170 180 190 200
LVSQIFKDAF ILQDEELYRH FANSSCGSTA VVACIINEES LYVANCGDSR
210 220 230 240 250
CILSSKSNGI KTMSFDHKPQ HIGELIRIND NGGTVSLGRV GGVLALSRAF
260 270 280 290 300
SDFQFKRGVT YPHRRTKLTN ITQNLTYGTP PQEAQVTVEP DVLMHKIDYS
310 320 330 340 350
KDEFLVLACD GIWDIYNNKQ LIHFIKYHLV SGTKLDTIIT KLLDHGIAQA
360 370 380 390
NSNTGVGFDN MTAIIVVLNR KGETLQDWFN KMKTRLERER GLV
Length:393
Mass (Da):44,176
Last modified:October 1, 1994 - v1
Checksum:i27F2903048541B6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78993 Genomic DNA. Translation: CAA55626.1.
Z35994 Genomic DNA. Translation: CAA85082.1.
BK006936 Genomic DNA. Translation: DAA07242.1.
PIRiS48288.
RefSeqiNP_009683.1. NM_001178473.1.

Genome annotation databases

EnsemblFungiiYBR125C; YBR125C; YBR125C.
GeneIDi852422.
KEGGisce:YBR125C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78993 Genomic DNA. Translation: CAA55626.1.
Z35994 Genomic DNA. Translation: CAA85082.1.
BK006936 Genomic DNA. Translation: DAA07242.1.
PIRiS48288.
RefSeqiNP_009683.1. NM_001178473.1.

3D structure databases

ProteinModelPortaliP38089.
SMRiP38089. Positions 1-369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32826. 85 interactions.
DIPiDIP-6437N.
IntActiP38089. 8 interactions.
MINTiMINT-397378.
STRINGi4932.YBR125C.

Proteomic databases

MaxQBiP38089.
PaxDbiP38089.
PeptideAtlasiP38089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR125C; YBR125C; YBR125C.
GeneIDi852422.
KEGGisce:YBR125C.

Organism-specific databases

CYGDiYBR125c.
SGDiS000000329. PTC4.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00770000120571.
HOGENOMiHOG000233896.
InParanoidiP38089.
KOiK01090.
OMAiCIGSMQG.
OrthoDBiEOG79930T.

Enzyme and pathway databases

BioCyciYEAST:G3O-29081-MONOMER.
ReactomeiREACT_209479. Regulation of AMPK activity via LKB1.

Miscellaneous databases

NextBioi971288.

Gene expression databases

GenevestigatoriP38089.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 70 kb region on the right arm of yeast chromosome II."
    Mannhaupt G., Stucka R., Ehnle S., Vetter I., Feldmann H.
    Yeast 10:1363-1381(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPP2C4_YEAST
AccessioniPrimary (citable) accession number: P38089
Secondary accession number(s): D6VQC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 7, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.