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P38089

- PP2C4_YEAST

UniProt

P38089 - PP2C4_YEAST

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Protein

Protein phosphatase 2C homolog 4

Gene
PTC4, GCT1, YBR125C, YBR0921
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Manganese 1 By similarity
Metal bindingi83 – 831Manganese 2 By similarity
Metal bindingi84 – 841Manganese 1; via carbonyl oxygen By similarity
Metal bindingi310 – 3101Manganese 2 By similarity
Metal bindingi359 – 3591Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  1. protein dephosphorylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29081-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 4 (EC:3.1.3.16)
Short name:
PP2C-4
Gene namesi
Name:PTC4
Synonyms:GCT1
Ordered Locus Names:YBR125C
ORF Names:YBR0921
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR125c.
SGDiS000000329. PTC4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Protein phosphatase 2C homolog 4PRO_0000057777Add
BLAST

Proteomic databases

MaxQBiP38089.
PaxDbiP38089.
PeptideAtlasiP38089.

Expressioni

Gene expression databases

GenevestigatoriP38089.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PAA1Q124475EBI-12814,EBI-33397

Protein-protein interaction databases

BioGridi32826. 82 interactions.
DIPiDIP-6437N.
IntActiP38089. 8 interactions.
MINTiMINT-397378.
STRINGi4932.YBR125C.

Structurei

3D structure databases

ProteinModelPortaliP38089.
SMRiP38089. Positions 1-369.

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00730000110861.
HOGENOMiHOG000233896.
KOiK01090.
OMAiCIGSMQG.
OrthoDBiEOG79930T.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38089-1 [UniParc]FASTAAdd to Basket

« Hide

MGQLLSHPLT EKTIEYNEYK NNQASTGIVP RFYNCVGSMQ GYRLTQEDAH    50
LIRNENSVVY VRFFNPFIDK YETLSLNVFA VFDGHGGDDC SKFLSGGRHH 100
RDGNGSSNGN GEPNAGLIKW IAYSFENHHY TSTTNNDSSK FKRSFNTLEG 150
LVSQIFKDAF ILQDEELYRH FANSSCGSTA VVACIINEES LYVANCGDSR 200
CILSSKSNGI KTMSFDHKPQ HIGELIRIND NGGTVSLGRV GGVLALSRAF 250
SDFQFKRGVT YPHRRTKLTN ITQNLTYGTP PQEAQVTVEP DVLMHKIDYS 300
KDEFLVLACD GIWDIYNNKQ LIHFIKYHLV SGTKLDTIIT KLLDHGIAQA 350
NSNTGVGFDN MTAIIVVLNR KGETLQDWFN KMKTRLERER GLV 393
Length:393
Mass (Da):44,176
Last modified:October 1, 1994 - v1
Checksum:i27F2903048541B6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78993 Genomic DNA. Translation: CAA55626.1.
Z35994 Genomic DNA. Translation: CAA85082.1.
BK006936 Genomic DNA. Translation: DAA07242.1.
PIRiS48288.
RefSeqiNP_009683.1. NM_001178473.1.

Genome annotation databases

EnsemblFungiiYBR125C; YBR125C; YBR125C.
GeneIDi852422.
KEGGisce:YBR125C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78993 Genomic DNA. Translation: CAA55626.1 .
Z35994 Genomic DNA. Translation: CAA85082.1 .
BK006936 Genomic DNA. Translation: DAA07242.1 .
PIRi S48288.
RefSeqi NP_009683.1. NM_001178473.1.

3D structure databases

ProteinModelPortali P38089.
SMRi P38089. Positions 1-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32826. 82 interactions.
DIPi DIP-6437N.
IntActi P38089. 8 interactions.
MINTi MINT-397378.
STRINGi 4932.YBR125C.

Proteomic databases

MaxQBi P38089.
PaxDbi P38089.
PeptideAtlasi P38089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR125C ; YBR125C ; YBR125C .
GeneIDi 852422.
KEGGi sce:YBR125C.

Organism-specific databases

CYGDi YBR125c.
SGDi S000000329. PTC4.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00730000110861.
HOGENOMi HOG000233896.
KOi K01090.
OMAi CIGSMQG.
OrthoDBi EOG79930T.

Enzyme and pathway databases

BioCyci YEAST:G3O-29081-MONOMER.

Miscellaneous databases

NextBioi 971288.

Gene expression databases

Genevestigatori P38089.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 70 kb region on the right arm of yeast chromosome II."
    Mannhaupt G., Stucka R., Ehnle S., Vetter I., Feldmann H.
    Yeast 10:1363-1381(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPP2C4_YEAST
AccessioniPrimary (citable) accession number: P38089
Secondary accession number(s): D6VQC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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