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P38089

- PP2C4_YEAST

UniProt

P38089 - PP2C4_YEAST

Protein

Protein phosphatase 2C homolog 4

Gene

PTC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831Manganese 1By similarity
    Metal bindingi83 – 831Manganese 2By similarity
    Metal bindingi84 – 841Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi310 – 3101Manganese 2By similarity
    Metal bindingi359 – 3591Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine phosphatase activity Source: SGD

    GO - Biological processi

    1. protein dephosphorylation Source: SGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29081-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C homolog 4 (EC:3.1.3.16)
    Short name:
    PP2C-4
    Gene namesi
    Name:PTC4
    Synonyms:GCT1
    Ordered Locus Names:YBR125C
    ORF Names:YBR0921
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR125c.
    SGDiS000000329. PTC4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Protein phosphatase 2C homolog 4PRO_0000057777Add
    BLAST

    Proteomic databases

    MaxQBiP38089.
    PaxDbiP38089.
    PeptideAtlasiP38089.

    Expressioni

    Gene expression databases

    GenevestigatoriP38089.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PAA1Q124475EBI-12814,EBI-33397

    Protein-protein interaction databases

    BioGridi32826. 82 interactions.
    DIPiDIP-6437N.
    IntActiP38089. 8 interactions.
    MINTiMINT-397378.
    STRINGi4932.YBR125C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38089.
    SMRiP38089. Positions 1-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00730000110861.
    HOGENOMiHOG000233896.
    KOiK01090.
    OMAiCIGSMQG.
    OrthoDBiEOG79930T.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38089-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQLLSHPLT EKTIEYNEYK NNQASTGIVP RFYNCVGSMQ GYRLTQEDAH    50
    LIRNENSVVY VRFFNPFIDK YETLSLNVFA VFDGHGGDDC SKFLSGGRHH 100
    RDGNGSSNGN GEPNAGLIKW IAYSFENHHY TSTTNNDSSK FKRSFNTLEG 150
    LVSQIFKDAF ILQDEELYRH FANSSCGSTA VVACIINEES LYVANCGDSR 200
    CILSSKSNGI KTMSFDHKPQ HIGELIRIND NGGTVSLGRV GGVLALSRAF 250
    SDFQFKRGVT YPHRRTKLTN ITQNLTYGTP PQEAQVTVEP DVLMHKIDYS 300
    KDEFLVLACD GIWDIYNNKQ LIHFIKYHLV SGTKLDTIIT KLLDHGIAQA 350
    NSNTGVGFDN MTAIIVVLNR KGETLQDWFN KMKTRLERER GLV 393
    Length:393
    Mass (Da):44,176
    Last modified:October 1, 1994 - v1
    Checksum:i27F2903048541B6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78993 Genomic DNA. Translation: CAA55626.1.
    Z35994 Genomic DNA. Translation: CAA85082.1.
    BK006936 Genomic DNA. Translation: DAA07242.1.
    PIRiS48288.
    RefSeqiNP_009683.1. NM_001178473.1.

    Genome annotation databases

    EnsemblFungiiYBR125C; YBR125C; YBR125C.
    GeneIDi852422.
    KEGGisce:YBR125C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78993 Genomic DNA. Translation: CAA55626.1 .
    Z35994 Genomic DNA. Translation: CAA85082.1 .
    BK006936 Genomic DNA. Translation: DAA07242.1 .
    PIRi S48288.
    RefSeqi NP_009683.1. NM_001178473.1.

    3D structure databases

    ProteinModelPortali P38089.
    SMRi P38089. Positions 1-369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32826. 82 interactions.
    DIPi DIP-6437N.
    IntActi P38089. 8 interactions.
    MINTi MINT-397378.
    STRINGi 4932.YBR125C.

    Proteomic databases

    MaxQBi P38089.
    PaxDbi P38089.
    PeptideAtlasi P38089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR125C ; YBR125C ; YBR125C .
    GeneIDi 852422.
    KEGGi sce:YBR125C.

    Organism-specific databases

    CYGDi YBR125c.
    SGDi S000000329. PTC4.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00730000110861.
    HOGENOMi HOG000233896.
    KOi K01090.
    OMAi CIGSMQG.
    OrthoDBi EOG79930T.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29081-MONOMER.

    Miscellaneous databases

    NextBioi 971288.

    Gene expression databases

    Genevestigatori P38089.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a 70 kb region on the right arm of yeast chromosome II."
      Mannhaupt G., Stucka R., Ehnle S., Vetter I., Feldmann H.
      Yeast 10:1363-1381(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPP2C4_YEAST
    AccessioniPrimary (citable) accession number: P38089
    Secondary accession number(s): D6VQC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 149 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3