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Protein

Protein phosphatase 2C homolog 4

Gene

PTC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Manganese 1By similarity1
Metal bindingi83Manganese 2By similarity1
Metal bindingi84Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi310Manganese 2By similarity1
Metal bindingi359Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  • protein dephosphorylation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29081-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 4 (EC:3.1.3.16)
Short name:
PP2C-4
Gene namesi
Name:PTC4
Synonyms:GCT1
Ordered Locus Names:YBR125C
ORF Names:YBR0921
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR125C
SGDiS000000329 PTC4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577771 – 393Protein phosphatase 2C homolog 4Add BLAST393

Proteomic databases

MaxQBiP38089
PaxDbiP38089
PRIDEiP38089

PTM databases

iPTMnetiP38089

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PAA1Q124475EBI-12814,EBI-33397

Protein-protein interaction databases

BioGridi32826, 202 interactors
DIPiDIP-6437N
IntActiP38089, 11 interactors
MINTiP38089
STRINGi4932.YBR125C

Structurei

3D structure databases

ProteinModelPortaliP38089
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 368PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST336

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000144272
HOGENOMiHOG000233896
InParanoidiP38089
KOiK19705
OMAiGSMQGYR
OrthoDBiEOG092C1UK5

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 2 hits
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

P38089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQLLSHPLT EKTIEYNEYK NNQASTGIVP RFYNCVGSMQ GYRLTQEDAH
60 70 80 90 100
LIRNENSVVY VRFFNPFIDK YETLSLNVFA VFDGHGGDDC SKFLSGGRHH
110 120 130 140 150
RDGNGSSNGN GEPNAGLIKW IAYSFENHHY TSTTNNDSSK FKRSFNTLEG
160 170 180 190 200
LVSQIFKDAF ILQDEELYRH FANSSCGSTA VVACIINEES LYVANCGDSR
210 220 230 240 250
CILSSKSNGI KTMSFDHKPQ HIGELIRIND NGGTVSLGRV GGVLALSRAF
260 270 280 290 300
SDFQFKRGVT YPHRRTKLTN ITQNLTYGTP PQEAQVTVEP DVLMHKIDYS
310 320 330 340 350
KDEFLVLACD GIWDIYNNKQ LIHFIKYHLV SGTKLDTIIT KLLDHGIAQA
360 370 380 390
NSNTGVGFDN MTAIIVVLNR KGETLQDWFN KMKTRLERER GLV
Length:393
Mass (Da):44,176
Last modified:October 1, 1994 - v1
Checksum:i27F2903048541B6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78993 Genomic DNA Translation: CAA55626.1
Z35994 Genomic DNA Translation: CAA85082.1
BK006936 Genomic DNA Translation: DAA07242.1
PIRiS48288
RefSeqiNP_009683.1, NM_001178473.1

Genome annotation databases

EnsemblFungiiYBR125C; YBR125C; YBR125C
GeneIDi852422
KEGGisce:YBR125C

Similar proteinsi

Entry informationi

Entry nameiPP2C4_YEAST
AccessioniPrimary (citable) accession number: P38089
Secondary accession number(s): D6VQC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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