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Protein

Valine/tyrosine/tryptophan amino-acid permease 1

Gene

TAT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity transport of valine and tyrosine. Low-affinity transport of tryptophan. Can also transport L-cysteine.1 Publication

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: SGD
  • low-affinity tryptophan transmembrane transporter activity Source: SGD

GO - Biological processi

  • amino acid transport Source: SGD
  • transmembrane transport Source: SGD
  • tryptophan transport Source: SGD
  • tyrosine transport Source: SGD

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29038-MONOMER

Protein family/group databases

TCDBi2.A.3.10.9 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Valine/tyrosine/tryptophan amino-acid permease 1
Alternative name(s):
Tyrosine and tryptophan amino acid transporter 1
Gene namesi
Name:TAT1
Synonyms:TAP1, VAP1
Ordered Locus Names:YBR069C
ORF Names:YBR0710
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR069C
SGDiS000000273 TAT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 99CytoplasmicSequence analysisAdd BLAST99
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 122ExtracellularSequence analysis2
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 172CytoplasmicSequence analysisAdd BLAST29
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 204ExtracellularSequence analysisAdd BLAST11
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 233CytoplasmicSequence analysis8
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 281ExtracellularSequence analysisAdd BLAST27
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Topological domaini303 – 320CytoplasmicSequence analysisAdd BLAST18
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 368ExtracellularSequence analysisAdd BLAST27
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 422CytoplasmicSequence analysisAdd BLAST33
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 446ExtracellularSequence analysis3
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 499CytoplasmicSequence analysisAdd BLAST32
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 529ExtracellularSequence analysis9
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Topological domaini551 – 619CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541621 – 619Valine/tyrosine/tryptophan amino-acid permease 1Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Cross-linki39Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei80PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38085
PaxDbiP38085
PRIDEiP38085

PTM databases

iPTMnetiP38085
SwissPalmiP38085

Interactioni

Protein-protein interaction databases

BioGridi32772, 85 interactors
DIPiDIP-4912N
IntActiP38085, 33 interactors
MINTiP38085
STRINGi4932.YBR069C

Structurei

3D structure databases

ProteinModelPortaliP38085
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744
InParanoidiP38085
KOiK16261
OMAiVFCYAAF
OrthoDBiEOG092C164R

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P38085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDSVSFIAK EASPAQYSHS LHERTHSEKQ KRDFTITEKQ DEVSGQTAEP
60 70 80 90 100
RRTDSKSILQ RKCKEFFDSF KRQLPPDRNS ELESQEKNNL TKSIKSRHLV
110 120 130 140 150
MISLGTGIGT GLLVGNGQVL GTAGPAGLVL GYGIASIMLY CIIQAAGELG
160 170 180 190 200
LCYAGLTGNY TRYPSILVDP SLGFAVSVVY TIQWLTVLPL QLVTAAMTVK
210 220 230 240 250
YWTSVNADIF VAVVFVFVII INLFGSRGYA EAEFIFNSCK ILMVIGFVIL
260 270 280 290 300
AIIINCGGAG DRRYIGAEYW HNPGPFAHGF KGVCTVFCYA AFSYGGIEVL
310 320 330 340 350
LLSAAEQENP TKSIPNACKK VVYRILLIYM LTTILVCFLV PYNSDELLGS
360 370 380 390 400
SDSSGSHASP FVIAVASHGV KVVPHFINAV ILISVISVAN SSLYSGPRLL
410 420 430 440 450
LSLAEQGVLP KCLAYVDRNG RPLLCFFVSL VFGCIGFVAT SDAEEQVFTW
460 470 480 490 500
LLAISSLSQL FIWMSMSLSH IRFRDAMAKQ GRSMNEVGYK AQTGYWGSWL
510 520 530 540 550
AVLIAIFFLV CQFWVAIAPV NEHGKLNVKV FFQNYLAMPI VLFAYFGHKI
560 570 580 590 600
YFKSWSFWIP AEKIDLDSHR NIFVSPSLTE IDKVDDNDDL KEYENSESSE
610
NPNSSRSRKF FKRMTNFWC
Length:619
Mass (Da):68,758
Last modified:October 1, 1994 - v1
Checksum:i7A575A9BF2A084F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10503 Genomic DNA Translation: AAA50552.1
X79151 Genomic DNA Translation: CAA55778.1
X76294 Genomic DNA Translation: CAA53926.1
Z35938 Genomic DNA Translation: CAA85013.1
BK006936 Genomic DNA Translation: DAA07188.1
PIRiS45932
RefSeqiNP_009625.1, NM_001178417.1

Genome annotation databases

EnsemblFungiiYBR069C; YBR069C; YBR069C
GeneIDi852361
KEGGisce:YBR069C

Similar proteinsi

Entry informationi

Entry nameiTAT1_YEAST
AccessioniPrimary (citable) accession number: P38085
Secondary accession number(s): D6VQ68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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