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Protein

Leu/Val/Ile amino-acid permease

Gene

BAP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan.2 Publications

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: SGD
  • antiporter activity Source: GO_Central
  • L-amino acid transmembrane transporter activity Source: GO_Central
  • L-phenylalanine transmembrane transporter activity Source: CACAO

GO - Biological processi

  • amino acid transport Source: SGD
  • leucine import into cell Source: CACAO
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29037-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.6. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Leu/Val/Ile amino-acid permease
Alternative name(s):
Branched-chain amino-acid permease 2
Gene namesi
Name:BAP2
Ordered Locus Names:YBR068C
ORF Names:YBR0629
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR068C.
SGDiS000000272. BAP2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 99CytoplasmicSequence analysisAdd BLAST99
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 123ExtracellularSequence analysis3
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 173CytoplasmicSequence analysisAdd BLAST29
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 210ExtracellularSequence analysisAdd BLAST16
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 235CytoplasmicSequence analysis4
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 289ExtracellularSequence analysisAdd BLAST33
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 328CytoplasmicSequence analysisAdd BLAST18
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 374ExtracellularSequence analysisAdd BLAST25
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 427CytoplasmicSequence analysisAdd BLAST32
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 451ExtracellularSequence analysis3
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 500CytoplasmicSequence analysisAdd BLAST28
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 536ExtracellularSequence analysisAdd BLAST15
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 609CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
  • vacuole Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541461 – 609Leu/Val/Ile amino-acid permeaseAdd BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1
Modified residuei15PhosphothreonineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38084.
PRIDEiP38084.

PTM databases

iPTMnetiP38084.
SwissPalmiP38084.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SHR3Q027743EBI-3414,EBI-17099

Protein-protein interaction databases

BioGridi32771. 68 interactors.
DIPiDIP-4910N.
IntActiP38084. 12 interactors.
MINTiMINT-516615.

Structurei

3D structure databases

ProteinModelPortaliP38084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP38084.
KOiK16261.
OMAiFTWSSIM.
OrthoDBiEOG092C164R.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSEDFGSS GKKETSPDSI SIRSFSAGNN FQSSSSEKTY SKQKSGSDKL
60 70 80 90 100
IHRFADSFKR AEGSTTRTKQ INENTSDLED GVESITSDSK LKKSMKSRHV
110 120 130 140 150
VMMSLGTGIG TGLLVANAKG LHYGGPAALI IGYILVSFVT YFMIQAAGEM
160 170 180 190 200
AVTYPTLPAN FNAYSSIFIS KSFGFATVWL YCFQWLTVLP LELITASMTI
210 220 230 240 250
QFWNDKINPD IYILIFYVFL VFIHFFGVKA YGETEFIFNC CKILMIAGFI
260 270 280 290 300
ILSIVINCGG AGNDGYIGAT YWHNPGAFAG DTSIGRFKNV CYILVTAYFS
310 320 330 340 350
FGGMELFALS VQEQSNPRKS TPVAAKRSIY RIVVIYLLTM ILIGFNVPYN
360 370 380 390 400
DDQLMGAGGS ATHASPYVLA ASIHGVKIVP HIINAVILIS VVSVANSSLY
410 420 430 440 450
AGPRLICSLA QQGYAPKFLD YVDREGRPLR ALIVCCVFGV IAFVAASSKE
460 470 480 490 500
EIVFTWLAAI AGLSELFTWT SIMLSHLRFR QAMKVQGRSL DELGYKATTG
510 520 530 540 550
IWGSIYGVFF NILVFVAQFW VALAPLGNGG KCDAESFFQN YLAFPIWLAF
560 570 580 590 600
YFGYMVYNRD FTLLNPLDKI DLDFHRRIYD PELMRQEDEE NKEKLRNMSL

MRKAYHFWC
Length:609
Mass (Da):67,769
Last modified:July 27, 2011 - v2
Checksum:iB87FD6A7464E07F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139V → E in CAA85012 (PubMed:7813418).Curated1
Sequence conflicti203W → G in CAA85012 (PubMed:7813418).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35937 Genomic DNA. Translation: CAA85012.1.
BK006936 Genomic DNA. Translation: DAA07187.2.
PIRiS45930.
RefSeqiNP_009624.4. NM_001178416.4.

Genome annotation databases

EnsemblFungiiYBR068C; YBR068C; YBR068C.
GeneIDi852360.
KEGGisce:YBR068C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35937 Genomic DNA. Translation: CAA85012.1.
BK006936 Genomic DNA. Translation: DAA07187.2.
PIRiS45930.
RefSeqiNP_009624.4. NM_001178416.4.

3D structure databases

ProteinModelPortaliP38084.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32771. 68 interactors.
DIPiDIP-4910N.
IntActiP38084. 12 interactors.
MINTiMINT-516615.

Protein family/group databases

TCDBi2.A.3.10.6. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP38084.
SwissPalmiP38084.

Proteomic databases

MaxQBiP38084.
PRIDEiP38084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR068C; YBR068C; YBR068C.
GeneIDi852360.
KEGGisce:YBR068C.

Organism-specific databases

EuPathDBiFungiDB:YBR068C.
SGDiS000000272. BAP2.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiP38084.
KOiK16261.
OMAiFTWSSIM.
OrthoDBiEOG092C164R.

Enzyme and pathway databases

BioCyciYEAST:G3O-29037-MONOMER.

Miscellaneous databases

PROiP38084.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAP2_YEAST
AccessioniPrimary (citable) accession number: P38084
Secondary accession number(s): D6VQ67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8660 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.