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Protein

Leu/Val/Ile amino-acid permease

Gene

BAP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan.2 Publications

Miscellaneous

Present with 8660 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: SGD
  • L-phenylalanine transmembrane transporter activity Source: CACAO

GO - Biological processi

  • amino acid transport Source: SGD
  • leucine import across plasma membrane Source: CACAO
  • transmembrane transport Source: SGD

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29037-MONOMER

Protein family/group databases

TCDBi2.A.3.10.6 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Leu/Val/Ile amino-acid permease
Alternative name(s):
Branched-chain amino-acid permease 2
Gene namesi
Name:BAP2
Ordered Locus Names:YBR068C
ORF Names:YBR0629
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YBR068C
SGDiS000000272 BAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 99CytoplasmicSequence analysisAdd BLAST99
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 123ExtracellularSequence analysis3
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 173CytoplasmicSequence analysisAdd BLAST29
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 210ExtracellularSequence analysisAdd BLAST16
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 235CytoplasmicSequence analysis4
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 289ExtracellularSequence analysisAdd BLAST33
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 328CytoplasmicSequence analysisAdd BLAST18
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 374ExtracellularSequence analysisAdd BLAST25
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 427CytoplasmicSequence analysisAdd BLAST32
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 451ExtracellularSequence analysis3
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 500CytoplasmicSequence analysisAdd BLAST28
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 536ExtracellularSequence analysisAdd BLAST15
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 609CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541461 – 609Leu/Val/Ile amino-acid permeaseAdd BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineCombined sources1
Modified residuei15PhosphothreonineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38084
PaxDbiP38084
PRIDEiP38084

PTM databases

iPTMnetiP38084
SwissPalmiP38084

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SHR3Q027743EBI-3414,EBI-17099

Protein-protein interaction databases

BioGridi32771, 90 interactors
DIPiDIP-4910N
IntActiP38084, 14 interactors
MINTiP38084
STRINGi4932.YBR068C

Structurei

3D structure databases

ProteinModelPortaliP38084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744
HOGENOMiHOG000261848
InParanoidiP38084
KOiK16261
OMAiFFRITVF
OrthoDBiEOG092C164R

Family and domain databases

InterProiView protein in InterPro
IPR004841 AA-permease/SLC12A_dom
IPR002293 AA/rel_permease1
IPR004762 Amino_acid_permease_fungi
IPR004840 Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324 AA_permease, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00913 2A0310, 1 hit
PROSITEiView protein in PROSITE
PS00218 AMINO_ACID_PERMEASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P38084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSEDFGSS GKKETSPDSI SIRSFSAGNN FQSSSSEKTY SKQKSGSDKL
60 70 80 90 100
IHRFADSFKR AEGSTTRTKQ INENTSDLED GVESITSDSK LKKSMKSRHV
110 120 130 140 150
VMMSLGTGIG TGLLVANAKG LHYGGPAALI IGYILVSFVT YFMIQAAGEM
160 170 180 190 200
AVTYPTLPAN FNAYSSIFIS KSFGFATVWL YCFQWLTVLP LELITASMTI
210 220 230 240 250
QFWNDKINPD IYILIFYVFL VFIHFFGVKA YGETEFIFNC CKILMIAGFI
260 270 280 290 300
ILSIVINCGG AGNDGYIGAT YWHNPGAFAG DTSIGRFKNV CYILVTAYFS
310 320 330 340 350
FGGMELFALS VQEQSNPRKS TPVAAKRSIY RIVVIYLLTM ILIGFNVPYN
360 370 380 390 400
DDQLMGAGGS ATHASPYVLA ASIHGVKIVP HIINAVILIS VVSVANSSLY
410 420 430 440 450
AGPRLICSLA QQGYAPKFLD YVDREGRPLR ALIVCCVFGV IAFVAASSKE
460 470 480 490 500
EIVFTWLAAI AGLSELFTWT SIMLSHLRFR QAMKVQGRSL DELGYKATTG
510 520 530 540 550
IWGSIYGVFF NILVFVAQFW VALAPLGNGG KCDAESFFQN YLAFPIWLAF
560 570 580 590 600
YFGYMVYNRD FTLLNPLDKI DLDFHRRIYD PELMRQEDEE NKEKLRNMSL

MRKAYHFWC
Length:609
Mass (Da):67,769
Last modified:July 27, 2011 - v2
Checksum:iB87FD6A7464E07F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139V → E in CAA85012 (PubMed:7813418).Curated1
Sequence conflicti203W → G in CAA85012 (PubMed:7813418).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35937 Genomic DNA Translation: CAA85012.1
BK006936 Genomic DNA Translation: DAA07187.2
PIRiS45930
RefSeqiNP_009624.4, NM_001178416.4

Genome annotation databases

EnsemblFungiiYBR068C; YBR068C; YBR068C
GeneIDi852360
KEGGisce:YBR068C

Similar proteinsi

Entry informationi

Entry nameiBAP2_YEAST
AccessioniPrimary (citable) accession number: P38084
Secondary accession number(s): D6VQ67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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