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Protein

Probable transcriptional regulator NRG2

Gene

NRG2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri153 – 17523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20525C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: SGD

GO - Biological processi

  • cell adhesion involved in single-species biofilm formation Source: SGD
  • negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of invasive growth in response to glucose limitation Source: SGD
  • negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter by glucose Source: SGD
  • pseudohyphal growth Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29035-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transcriptional regulator NRG2
Gene namesi
Name:NRG2
Ordered Locus Names:YBR066C
ORF Names:YBR0616
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR066C.
SGDiS000000270. NRG2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Probable transcriptional regulator NRG2PRO_0000046813Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi32769. 36 interactions.
DIPiDIP-5146N.
MINTiMINT-488921.

Structurei

3D structure databases

ProteinModelPortaliP38082.
SMRiP38082. Positions 60-103, 123-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri153 – 17523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20525C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00650000094227.
HOGENOMiHOG000065960.
InParanoidiP38082.
OMAiHYRTHAN.
OrthoDBiEOG092C5UG7.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIGYKDNLM STILAKDRKC EFPINFECSP SQITLMPEMF SFNNERKYQT
60 70 80 90 100
LIPLMKTSHL IDDDLKDKLN KCAFDFFSGK QANRTSDGTI SRLTASGKTS
110 120 130 140 150
PILPLQNINI VKAENTGNGK SDPYSSIKIS KPTKTVIKLK STKTNTAGQR
160 170 180 190 200
TRHFCKICST GFTTSGHLSR HNRIHTGEKN HICPHEGCGQ RFSRHDNCNQ
210 220
HYRTHANKKK RNWKRREASS
Length:220
Mass (Da):25,009
Last modified:October 1, 1994 - v1
Checksum:i8EA18F326910F1FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35935 Genomic DNA. Translation: CAA85010.1.
AY692862 Genomic DNA. Translation: AAT92881.1.
BK006936 Genomic DNA. Translation: DAA07185.1.
PIRiS45927.
RefSeqiNP_009622.1. NM_001178414.1.

Genome annotation databases

EnsemblFungiiYBR066C; YBR066C; YBR066C.
GeneIDi852358.
KEGGisce:YBR066C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35935 Genomic DNA. Translation: CAA85010.1.
AY692862 Genomic DNA. Translation: AAT92881.1.
BK006936 Genomic DNA. Translation: DAA07185.1.
PIRiS45927.
RefSeqiNP_009622.1. NM_001178414.1.

3D structure databases

ProteinModelPortaliP38082.
SMRiP38082. Positions 60-103, 123-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32769. 36 interactions.
DIPiDIP-5146N.
MINTiMINT-488921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR066C; YBR066C; YBR066C.
GeneIDi852358.
KEGGisce:YBR066C.

Organism-specific databases

EuPathDBiFungiDB:YBR066C.
SGDiS000000270. NRG2.

Phylogenomic databases

GeneTreeiENSGT00650000094227.
HOGENOMiHOG000065960.
InParanoidiP38082.
OMAiHYRTHAN.
OrthoDBiEOG092C5UG7.

Enzyme and pathway databases

BioCyciYEAST:G3O-29035-MONOMER.

Miscellaneous databases

PROiP38082.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRG2_YEAST
AccessioniPrimary (citable) accession number: P38082
Secondary accession number(s): D6VQ65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.