ID   YBQ6_YEAST              Reviewed;         501 AA.
AC   P38081; D6VQ55;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   27-MAR-2024, entry version 163.
DE   RecName: Full=Uncharacterized glycosyl hydrolase YBR056W;
DE            EC=3.2.1.-;
GN   OrderedLocusNames=YBR056W; ORFNames=YBR0510;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7597852; DOI=10.1002/yea.320110511;
RA   Aljinovic G., Pohl T.M.;
RT   "Sequence and analysis of 24 kb on chromosome II of Saccharomyces
RT   cerevisiae.";
RL   Yeast 11:475-479(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP   ANALYSIS].
RX   PubMed=22984289; DOI=10.1074/mcp.m112.021105;
RA   Voegtle F.N., Burkhart J.M., Rao S., Gerbeth C., Hinrichs J.,
RA   Martinou J.C., Chacinska A., Sickmann A., Zahedi R.P., Meisinger C.;
RT   "Intermembrane space proteome of yeast mitochondria.";
RL   Mol. Cell. Proteomics 11:1840-1852(2012).
CC   -!- INTERACTION:
CC       P38081; P39940: RSP5; NbExp=3; IntAct=EBI-21453, EBI-16219;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space
CC       {ECO:0000269|PubMed:22984289}.
CC   -!- MISCELLANEOUS: Present with 1960 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
CC       {ECO:0000305}.
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DR   EMBL; Z35925; CAA84999.1; -; Genomic_DNA.
DR   EMBL; Z46260; CAA86399.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07175.1; -; Genomic_DNA.
DR   PIR; S45914; S45914.
DR   RefSeq; NP_009612.1; NM_001178404.1.
DR   AlphaFoldDB; P38081; -.
DR   SMR; P38081; -.
DR   BioGRID; 32758; 125.
DR   DIP; DIP-5444N; -.
DR   IntAct; P38081; 10.
DR   MINT; P38081; -.
DR   STRING; 4932.YBR056W; -.
DR   CAZy; GH5; Glycoside Hydrolase Family 5.
DR   iPTMnet; P38081; -.
DR   MaxQB; P38081; -.
DR   PaxDb; 4932-YBR056W; -.
DR   PeptideAtlas; P38081; -.
DR   EnsemblFungi; YBR056W_mRNA; YBR056W; YBR056W.
DR   GeneID; 852346; -.
DR   KEGG; sce:YBR056W; -.
DR   AGR; SGD:S000000260; -.
DR   SGD; S000000260; YBR056W.
DR   VEuPathDB; FungiDB:YBR056W; -.
DR   eggNOG; ENOG502QVVM; Eukaryota.
DR   GeneTree; ENSGT00940000176313; -.
DR   HOGENOM; CLU_004624_8_2_1; -.
DR   InParanoid; P38081; -.
DR   OMA; GWFFWTL; -.
DR   OrthoDB; 1692847at2759; -.
DR   BioCyc; YEAST:G3O-29027-MONOMER; -.
DR   BioGRID-ORCS; 852346; 2 hits in 10 CRISPR screens.
DR   PRO; PR:P38081; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P38081; Protein.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005829; C:cytosol; HDA:SGD.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
DR   GO; GO:0046557; F:glucan endo-1,6-beta-glucosidase activity; IBA:GO_Central.
DR   GO; GO:0009251; P:glucan catabolic process; IBA:GO_Central.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR31297:SF34; GLUCAN 1,3-BETA-GLUCOSIDASE 3; 1.
DR   PANTHER; PTHR31297; GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   1: Evidence at protein level;
KW   Glycosidase; Hydrolase; Mitochondrion; Reference proteome.
FT   CHAIN           1..501
FT                   /note="Uncharacterized glycosyl hydrolase YBR056W"
FT                   /id="PRO_0000184055"
FT   ACT_SITE        236
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        333
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   501 AA;  57822 MW;  5133A161736ADDD3 CRC64;
     MIGSLRNKFE HFKVSEKGGQ NLSTTLPKLP PAKDLDRSTI YKYRYNYGVN LGALFVLEPW
     IFSKETICTI DGKEYDSEFD AISQQLKKHS SEDVAKMLSD HYKKYIDRID WEWLSKDAHI
     TALRIPIGYW HVEDGKHLDS LPFAPLRKVY ELAKPWEKLG ELINNAKKMS IGVLIDLHGL
     PGGANCDSHS GSKSGEAAFF HKEKYMTKVY KDILPAIINT MTLGNENIIG IQVVNEACFD
     NNPKGQKFYY SEAINTVEKL QPGLPVIISD GWWPQQWADW VKEKHFSEIV VIDSHVYRCF
     SDSDKSKDAN SIIKDLPNTV NFPHEDADYT VGEFSGVLDG QTWNKTSGDR DAIVQKYVQT
     QADVFSHVAS WGWFFWTLQF EYGDGGEWGL APMMQKGNLP KRPHGDDLQV DKKKIDSIIH
     EHEAYWNGKG KNFEHWRFED GIKTAVDDII AFRKFDNSLI GRWHSWKSQR RAEYVSAKKD
     SEFMWEWDQG YQRGLDEFNK Y
//