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P38080

- AKL1_YEAST

UniProt

P38080 - AKL1_YEAST

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Protein

Serine/threonine-protein kinase AKL1

Gene
AKL1, YBR059C, YBR0519
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701ATP By similarity
Active sitei181 – 1811Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 499ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. identical protein binding Source: IntAct
  3. protein kinase activity Source: SGD
  4. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: SGD
  2. regulation of endocytosis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29030-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase AKL1 (EC:2.7.11.1)
Gene namesi
Name:AKL1
Ordered Locus Names:YBR059C
ORF Names:YBR0519
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR059c.
SGDiS000000263. AKL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 11081107Serine/threonine-protein kinase AKL1PRO_0000085603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei10 – 101Phosphoserine1 Publication
Modified residuei407 – 4071Phosphoserine2 Publications
Modified residuei471 – 4711Phosphothreonine1 Publication
Modified residuei504 – 5041Phosphoserine2 Publications
Modified residuei541 – 5411Phosphoserine3 Publications
Modified residuei574 – 5741Phosphoserine1 Publication
Modified residuei801 – 8011Phosphoserine2 Publications
Modified residuei846 – 8461Phosphoserine2 Publications
Modified residuei953 – 9531Phosphoserine1 Publication
Modified residuei960 – 9601Phosphoserine1 Publication
Cross-linki1008 – 1008Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1046 – 1046Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei1048 – 10481Phosphoserine1 Publication
Modified residuei1072 – 10721Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38080.
PaxDbiP38080.
PeptideAtlasiP38080.

Expressioni

Gene expression databases

GenevestigatoriP38080.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-9528,EBI-9528

Protein-protein interaction databases

BioGridi32763. 143 interactions.
DIPiDIP-1717N.
IntActiP38080. 26 interactions.
MINTiMINT-409952.
STRINGi4932.YBR059C.

Structurei

3D structure databases

ProteinModelPortaliP38080.
SMRiP38080. Positions 25-365.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 319285Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00510000046552.
KOiK08286.
OMAiQNIYVHT.
OrthoDBiEOG74BK1F.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38080-1 [UniParc]FASTAAdd to Basket

« Hide

MSITNGTSRS VSAMGHPAVE RYTPGHIVCV GTHKVEVVNY LAEGGFAQIY     50
VVKFLEYLNE FDNTASVPLK IGDVACLKRV LVQDENGLNE MRNEVEVMKK 100
LKGAPNIVQY FDSNASRRRD GVQGFEVLLL MELCPNKSLL DYMNQRLSTK 150
LTEAEIVKIM YDVALSISQM HYLPVSLIHR DIKIENVLVD AKNNFKLADF 200
GSTSTCFPIV TTHQDIALLT QNIYVHTTPQ YRSPEMIDLY RCLPINEKSD 250
IWALGVFLYK LLFFTTPFEM TGQFAILHSK YEFPVNKYSS KLINLIIIML 300
AENPNLRPNI YQVLYHLCEI LNVEVPIEDK YAEGAYNFSK YTQFQNKLQN 350
VQLQMYQLQQ KKIMQNNKLS DSEENLLNDM FLSSFEISSK LPMNASDGHA 400
AVSRIPSQNV GQELEEEKES QSDQRKSTLS EDKSSRTTSN ANSSGTANNP 450
QEINTIQSPG IEDKSIFENK TPGELYYPSV SELDTYLDKE LVKQSSDPTI 500
SEQSPRLNTQ SLPQRQKSTS SYSSGGRSMK STSYGAATIG SDEALANEKT 550
AGINKMKQHK SNNPFPKMNV AYHSTNELSN DASNFFLEEQ QQGQRYQQAQ 600
NQTGTQGNTF PDESQYQSRV EQQQQQQDQP KGPANYSQRN FYTGRDRSNK 650
PMQLGGTIAG DSGNRRVNFQ NISQNYATNS QSGYLPSQNS PAIPMVRPVI 700
SMNQQQAQQI QAQQLQAQQM QAKQQMQAKQ QMQVQQQLQV QQQMQIQNAN 750
NNGTYVSDRT NHTTEDMRNA QGGEPPILAG NSANEPMHSS SKNEALLIEL 800
SPLKEDAGKQ SFQDTNEPQT GGIEDAGGSG TIKGSNNNRN GVLNLSLNEM 850
DLSRDDTGAA VSSFSSSSSS ASIQQAKLSG RKGSSKRNNY STDELGDSMV 900
SSESIDIDLD DARRGKTAER RPLHNERGHK DQARSSDASK SNQFKSKDFS 950
SVSTRQPRQS LDLNFQEVNL SSPTLTQEHR NKNDSPAPNS HHSYRVSPHA 1000
STAITENKRH STGHELSTRS NGKHETHRTG SKQRHDLERY RHSKDKDSNS 1050
SITISTSTPS EMRKSFARAR QSLDLERVRR EAMASSASSS GGSNGKRRSF 1100
FSVFRSEK 1108
Length:1,108
Mass (Da):123,989
Last modified:October 1, 1994 - v1
Checksum:iAEC6CB0A707164E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35928 Genomic DNA. Translation: CAA85002.1.
BK006936 Genomic DNA. Translation: DAA07179.1.
PIRiS45917.
RefSeqiNP_009615.1. NM_001178407.1.

Genome annotation databases

EnsemblFungiiYBR059C; YBR059C; YBR059C.
GeneIDi852351.
KEGGisce:YBR059C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35928 Genomic DNA. Translation: CAA85002.1 .
BK006936 Genomic DNA. Translation: DAA07179.1 .
PIRi S45917.
RefSeqi NP_009615.1. NM_001178407.1.

3D structure databases

ProteinModelPortali P38080.
SMRi P38080. Positions 25-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32763. 143 interactions.
DIPi DIP-1717N.
IntActi P38080. 26 interactions.
MINTi MINT-409952.
STRINGi 4932.YBR059C.

Proteomic databases

MaxQBi P38080.
PaxDbi P38080.
PeptideAtlasi P38080.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR059C ; YBR059C ; YBR059C .
GeneIDi 852351.
KEGGi sce:YBR059C.

Organism-specific databases

CYGDi YBR059c.
SGDi S000000263. AKL1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00510000046552.
KOi K08286.
OMAi QNIYVHT.
OrthoDBi EOG74BK1F.

Enzyme and pathway databases

BioCyci YEAST:G3O-29030-MONOMER.

Miscellaneous databases

NextBioi 971101.

Gene expression databases

Genevestigatori P38080.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1008 AND LYS-1046.
    Strain: SUB592.
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-541; SER-801 AND SER-1072, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407; THR-471; SER-504; SER-541 AND SER-846, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-407; SER-504; SER-541; SER-574; SER-801; SER-846; SER-953; SER-960 AND SER-1048, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAKL1_YEAST
AccessioniPrimary (citable) accession number: P38080
Secondary accession number(s): D6VQ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

Similar proteinsi