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P38080

- AKL1_YEAST

UniProt

P38080 - AKL1_YEAST

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Protein

Serine/threonine-protein kinase AKL1

Gene

AKL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701ATPPROSITE-ProRule annotation
Active sitei181 – 1811Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 499ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. identical protein binding Source: IntAct
  3. protein kinase activity Source: SGD
  4. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: SGD
  2. regulation of endocytosis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29030-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase AKL1 (EC:2.7.11.1)
Gene namesi
Name:AKL1
Ordered Locus Names:YBR059C
ORF Names:YBR0519
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR059c.
SGDiS000000263. AKL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 11081107Serine/threonine-protein kinase AKL1PRO_0000085603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei10 – 101Phosphoserine1 Publication
Modified residuei407 – 4071Phosphoserine2 Publications
Modified residuei471 – 4711Phosphothreonine1 Publication
Modified residuei504 – 5041Phosphoserine2 Publications
Modified residuei541 – 5411Phosphoserine3 Publications
Modified residuei574 – 5741Phosphoserine1 Publication
Modified residuei801 – 8011Phosphoserine2 Publications
Modified residuei846 – 8461Phosphoserine2 Publications
Modified residuei953 – 9531Phosphoserine1 Publication
Modified residuei960 – 9601Phosphoserine1 Publication
Cross-linki1008 – 1008Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1046 – 1046Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei1048 – 10481Phosphoserine1 Publication
Modified residuei1072 – 10721Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38080.
PaxDbiP38080.
PeptideAtlasiP38080.

Expressioni

Gene expression databases

GenevestigatoriP38080.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-9528,EBI-9528

Protein-protein interaction databases

BioGridi32763. 144 interactions.
DIPiDIP-1717N.
IntActiP38080. 26 interactions.
MINTiMINT-409952.
STRINGi4932.YBR059C.

Structurei

3D structure databases

ProteinModelPortaliP38080.
SMRiP38080. Positions 25-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 319285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00510000046552.
InParanoidiP38080.
KOiK08286.
OMAiQNIYVHT.
OrthoDBiEOG74BK1F.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38080-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSITNGTSRS VSAMGHPAVE RYTPGHIVCV GTHKVEVVNY LAEGGFAQIY
60 70 80 90 100
VVKFLEYLNE FDNTASVPLK IGDVACLKRV LVQDENGLNE MRNEVEVMKK
110 120 130 140 150
LKGAPNIVQY FDSNASRRRD GVQGFEVLLL MELCPNKSLL DYMNQRLSTK
160 170 180 190 200
LTEAEIVKIM YDVALSISQM HYLPVSLIHR DIKIENVLVD AKNNFKLADF
210 220 230 240 250
GSTSTCFPIV TTHQDIALLT QNIYVHTTPQ YRSPEMIDLY RCLPINEKSD
260 270 280 290 300
IWALGVFLYK LLFFTTPFEM TGQFAILHSK YEFPVNKYSS KLINLIIIML
310 320 330 340 350
AENPNLRPNI YQVLYHLCEI LNVEVPIEDK YAEGAYNFSK YTQFQNKLQN
360 370 380 390 400
VQLQMYQLQQ KKIMQNNKLS DSEENLLNDM FLSSFEISSK LPMNASDGHA
410 420 430 440 450
AVSRIPSQNV GQELEEEKES QSDQRKSTLS EDKSSRTTSN ANSSGTANNP
460 470 480 490 500
QEINTIQSPG IEDKSIFENK TPGELYYPSV SELDTYLDKE LVKQSSDPTI
510 520 530 540 550
SEQSPRLNTQ SLPQRQKSTS SYSSGGRSMK STSYGAATIG SDEALANEKT
560 570 580 590 600
AGINKMKQHK SNNPFPKMNV AYHSTNELSN DASNFFLEEQ QQGQRYQQAQ
610 620 630 640 650
NQTGTQGNTF PDESQYQSRV EQQQQQQDQP KGPANYSQRN FYTGRDRSNK
660 670 680 690 700
PMQLGGTIAG DSGNRRVNFQ NISQNYATNS QSGYLPSQNS PAIPMVRPVI
710 720 730 740 750
SMNQQQAQQI QAQQLQAQQM QAKQQMQAKQ QMQVQQQLQV QQQMQIQNAN
760 770 780 790 800
NNGTYVSDRT NHTTEDMRNA QGGEPPILAG NSANEPMHSS SKNEALLIEL
810 820 830 840 850
SPLKEDAGKQ SFQDTNEPQT GGIEDAGGSG TIKGSNNNRN GVLNLSLNEM
860 870 880 890 900
DLSRDDTGAA VSSFSSSSSS ASIQQAKLSG RKGSSKRNNY STDELGDSMV
910 920 930 940 950
SSESIDIDLD DARRGKTAER RPLHNERGHK DQARSSDASK SNQFKSKDFS
960 970 980 990 1000
SVSTRQPRQS LDLNFQEVNL SSPTLTQEHR NKNDSPAPNS HHSYRVSPHA
1010 1020 1030 1040 1050
STAITENKRH STGHELSTRS NGKHETHRTG SKQRHDLERY RHSKDKDSNS
1060 1070 1080 1090 1100
SITISTSTPS EMRKSFARAR QSLDLERVRR EAMASSASSS GGSNGKRRSF

FSVFRSEK
Length:1,108
Mass (Da):123,989
Last modified:October 1, 1994 - v1
Checksum:iAEC6CB0A707164E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35928 Genomic DNA. Translation: CAA85002.1.
BK006936 Genomic DNA. Translation: DAA07179.1.
PIRiS45917.
RefSeqiNP_009615.1. NM_001178407.1.

Genome annotation databases

EnsemblFungiiYBR059C; YBR059C; YBR059C.
GeneIDi852351.
KEGGisce:YBR059C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35928 Genomic DNA. Translation: CAA85002.1 .
BK006936 Genomic DNA. Translation: DAA07179.1 .
PIRi S45917.
RefSeqi NP_009615.1. NM_001178407.1.

3D structure databases

ProteinModelPortali P38080.
SMRi P38080. Positions 25-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32763. 144 interactions.
DIPi DIP-1717N.
IntActi P38080. 26 interactions.
MINTi MINT-409952.
STRINGi 4932.YBR059C.

Proteomic databases

MaxQBi P38080.
PaxDbi P38080.
PeptideAtlasi P38080.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR059C ; YBR059C ; YBR059C .
GeneIDi 852351.
KEGGi sce:YBR059C.

Organism-specific databases

CYGDi YBR059c.
SGDi S000000263. AKL1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00510000046552.
InParanoidi P38080.
KOi K08286.
OMAi QNIYVHT.
OrthoDBi EOG74BK1F.

Enzyme and pathway databases

BioCyci YEAST:G3O-29030-MONOMER.

Miscellaneous databases

NextBioi 971101.

Gene expression databases

Genevestigatori P38080.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  4. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1008 AND LYS-1046.
    Strain: SUB592.
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-541; SER-801 AND SER-1072, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407; THR-471; SER-504; SER-541 AND SER-846, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-407; SER-504; SER-541; SER-574; SER-801; SER-846; SER-953; SER-960 AND SER-1048, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAKL1_YEAST
AccessioniPrimary (citable) accession number: P38080
Secondary accession number(s): D6VQ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3