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Protein

Serine/threonine-protein kinase AKL1

Gene

AKL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei70ATPPROSITE-ProRule annotation1
Active sitei181Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 49ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • actin cortical patch assembly Source: GO_Central
  • actin cytoskeleton organization Source: SGD
  • actin filament organization Source: GO_Central
  • regulation of endocytosis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29030-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase AKL1 (EC:2.7.11.1)
Gene namesi
Name:AKL1
Ordered Locus Names:YBR059C
ORF Names:YBR0519
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR059C.
SGDiS000000263. AKL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000856032 – 1108Serine/threonine-protein kinase AKL1Add BLAST1107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei471PhosphothreonineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei541PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1
Modified residuei801PhosphoserineCombined sources1
Modified residuei846PhosphoserineCombined sources1
Modified residuei953PhosphoserineCombined sources1
Modified residuei960PhosphoserineCombined sources1
Cross-linki1008Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1046Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei1048PhosphoserineCombined sources1
Modified residuei1072PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38080.
PRIDEiP38080.

PTM databases

iPTMnetiP38080.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-9528,EBI-9528

Protein-protein interaction databases

BioGridi32763. 147 interactors.
DIPiDIP-1717N.
IntActiP38080. 27 interactors.
MINTiMINT-409952.

Structurei

3D structure databases

ProteinModelPortaliP38080.
SMRiP38080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 319Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00810000125451.
InParanoidiP38080.
KOiK08286.
OMAiMQAKQQM.
OrthoDBiEOG092C0MJY.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITNGTSRS VSAMGHPAVE RYTPGHIVCV GTHKVEVVNY LAEGGFAQIY
60 70 80 90 100
VVKFLEYLNE FDNTASVPLK IGDVACLKRV LVQDENGLNE MRNEVEVMKK
110 120 130 140 150
LKGAPNIVQY FDSNASRRRD GVQGFEVLLL MELCPNKSLL DYMNQRLSTK
160 170 180 190 200
LTEAEIVKIM YDVALSISQM HYLPVSLIHR DIKIENVLVD AKNNFKLADF
210 220 230 240 250
GSTSTCFPIV TTHQDIALLT QNIYVHTTPQ YRSPEMIDLY RCLPINEKSD
260 270 280 290 300
IWALGVFLYK LLFFTTPFEM TGQFAILHSK YEFPVNKYSS KLINLIIIML
310 320 330 340 350
AENPNLRPNI YQVLYHLCEI LNVEVPIEDK YAEGAYNFSK YTQFQNKLQN
360 370 380 390 400
VQLQMYQLQQ KKIMQNNKLS DSEENLLNDM FLSSFEISSK LPMNASDGHA
410 420 430 440 450
AVSRIPSQNV GQELEEEKES QSDQRKSTLS EDKSSRTTSN ANSSGTANNP
460 470 480 490 500
QEINTIQSPG IEDKSIFENK TPGELYYPSV SELDTYLDKE LVKQSSDPTI
510 520 530 540 550
SEQSPRLNTQ SLPQRQKSTS SYSSGGRSMK STSYGAATIG SDEALANEKT
560 570 580 590 600
AGINKMKQHK SNNPFPKMNV AYHSTNELSN DASNFFLEEQ QQGQRYQQAQ
610 620 630 640 650
NQTGTQGNTF PDESQYQSRV EQQQQQQDQP KGPANYSQRN FYTGRDRSNK
660 670 680 690 700
PMQLGGTIAG DSGNRRVNFQ NISQNYATNS QSGYLPSQNS PAIPMVRPVI
710 720 730 740 750
SMNQQQAQQI QAQQLQAQQM QAKQQMQAKQ QMQVQQQLQV QQQMQIQNAN
760 770 780 790 800
NNGTYVSDRT NHTTEDMRNA QGGEPPILAG NSANEPMHSS SKNEALLIEL
810 820 830 840 850
SPLKEDAGKQ SFQDTNEPQT GGIEDAGGSG TIKGSNNNRN GVLNLSLNEM
860 870 880 890 900
DLSRDDTGAA VSSFSSSSSS ASIQQAKLSG RKGSSKRNNY STDELGDSMV
910 920 930 940 950
SSESIDIDLD DARRGKTAER RPLHNERGHK DQARSSDASK SNQFKSKDFS
960 970 980 990 1000
SVSTRQPRQS LDLNFQEVNL SSPTLTQEHR NKNDSPAPNS HHSYRVSPHA
1010 1020 1030 1040 1050
STAITENKRH STGHELSTRS NGKHETHRTG SKQRHDLERY RHSKDKDSNS
1060 1070 1080 1090 1100
SITISTSTPS EMRKSFARAR QSLDLERVRR EAMASSASSS GGSNGKRRSF

FSVFRSEK
Length:1,108
Mass (Da):123,989
Last modified:October 1, 1994 - v1
Checksum:iAEC6CB0A707164E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35928 Genomic DNA. Translation: CAA85002.1.
BK006936 Genomic DNA. Translation: DAA07179.1.
PIRiS45917.
RefSeqiNP_009615.1. NM_001178407.1.

Genome annotation databases

EnsemblFungiiYBR059C; YBR059C; YBR059C.
GeneIDi852351.
KEGGisce:YBR059C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35928 Genomic DNA. Translation: CAA85002.1.
BK006936 Genomic DNA. Translation: DAA07179.1.
PIRiS45917.
RefSeqiNP_009615.1. NM_001178407.1.

3D structure databases

ProteinModelPortaliP38080.
SMRiP38080.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32763. 147 interactors.
DIPiDIP-1717N.
IntActiP38080. 27 interactors.
MINTiMINT-409952.

PTM databases

iPTMnetiP38080.

Proteomic databases

MaxQBiP38080.
PRIDEiP38080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR059C; YBR059C; YBR059C.
GeneIDi852351.
KEGGisce:YBR059C.

Organism-specific databases

EuPathDBiFungiDB:YBR059C.
SGDiS000000263. AKL1.

Phylogenomic databases

GeneTreeiENSGT00810000125451.
InParanoidiP38080.
KOiK08286.
OMAiMQAKQQM.
OrthoDBiEOG092C0MJY.

Enzyme and pathway databases

BioCyciYEAST:G3O-29030-MONOMER.

Miscellaneous databases

PROiP38080.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKL1_YEAST
AccessioniPrimary (citable) accession number: P38080
Secondary accession number(s): D6VQ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.