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Protein

Protein YRO2

Gene

YRO2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-29025-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YRO2
Gene namesi
Name:YRO2
Ordered Locus Names:YBR054W
ORF Names:YBR0507
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome II

Organism-specific databases

CYGDiYBR054w.
SGDiS000000258. YRO2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Topological domaini56 – 627CytoplasmicSequence Analysis
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Topological domaini84 – 11936ExtracellularSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Topological domaini141 – 1411CytoplasmicSequence Analysis
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 17210ExtracellularSequence Analysis
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Topological domaini194 – 2029CytoplasmicSequence Analysis
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Topological domaini224 – 23815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 34485CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Protein YRO2PRO_0000196286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki286 – 286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei293 – 2931Phosphoserine1 Publication
Modified residuei341 – 3411Phosphothreonine3 Publications
Modified residuei343 – 3431Phosphoserine2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38079.
PaxDbiP38079.
PeptideAtlasiP38079.

Expressioni

Gene expression databases

GenevestigatoriP38079.

Interactioni

Protein-protein interaction databases

BioGridi32755. 32 interactions.
DIPiDIP-4184N.
IntActiP38079. 11 interactions.
MINTiMINT-524121.
STRINGi4932.YBR054W.

Structurei

3D structure databases

ProteinModelPortaliP38079.
SMRiP38079. Positions 57-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi304 – 33128Lys-richAdd
BLAST
Compositional biasi334 – 34411Glu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5524.
GeneTreeiENSGT00390000004481.
HOGENOMiHOG000248243.
InParanoidiP38079.
OMAiDSATIFY.
OrthoDBiEOG754J0K.

Family and domain databases

InterProiIPR029730. Arc/bac/fun_rhod-like.
[Graphical view]
PfamiPF01036. Bac_rhodopsin. 1 hit.
[Graphical view]
SMARTiSM01021. Bac_rhodopsin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDYVELLKR GGNEAIKINP PTGADFHITS RGSDWLFTVF CVNLLFGVIL
60 70 80 90 100
VPLMFRKPVK DRFVYYTAIA PNLFMSIAYF TMASNLGWIP VRAKYNHVQT
110 120 130 140 150
STQKEHPGYR QIFYARYVGW FLAFPWPIIQ MSLLGGTPLW QIAFNVGMTE
160 170 180 190 200
IFTVCWLIAA CVHSTYKWGY YTIGIGAAIV VCISLMTTTF NLVKARGKDV
210 220 230 240 250
SNVFITFMSV IMFLWLIAYP TCFGITDGGN VLQPDSATIF YGIIDLLILS
260 270 280 290 300
ILPVLFMPLA NYLGIERLGL IFDEEPAEHV GPVAEKKMPS PASFKSSDSD
310 320 330 340
SSIKEKLKLK KKHKKDKKKA KKAKKAKKAK KAQEEEEDVA TDSE
Length:344
Mass (Da):38,720
Last modified:September 30, 1994 - v1
Checksum:iBF63AC0398A0B566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46260 Genomic DNA. Translation: CAA86397.1.
Z35923 Genomic DNA. Translation: CAA84997.1.
BK006936 Genomic DNA. Translation: DAA07173.1.
PIRiS45912.
RefSeqiNP_009610.1. NM_001178402.1.

Genome annotation databases

EnsemblFungiiYBR054W; YBR054W; YBR054W.
GeneIDi852343.
KEGGisce:YBR054W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46260 Genomic DNA. Translation: CAA86397.1.
Z35923 Genomic DNA. Translation: CAA84997.1.
BK006936 Genomic DNA. Translation: DAA07173.1.
PIRiS45912.
RefSeqiNP_009610.1. NM_001178402.1.

3D structure databases

ProteinModelPortaliP38079.
SMRiP38079. Positions 57-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32755. 32 interactions.
DIPiDIP-4184N.
IntActiP38079. 11 interactions.
MINTiMINT-524121.
STRINGi4932.YBR054W.

Proteomic databases

MaxQBiP38079.
PaxDbiP38079.
PeptideAtlasiP38079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR054W; YBR054W; YBR054W.
GeneIDi852343.
KEGGisce:YBR054W.

Organism-specific databases

CYGDiYBR054w.
SGDiS000000258. YRO2.

Phylogenomic databases

eggNOGiCOG5524.
GeneTreeiENSGT00390000004481.
HOGENOMiHOG000248243.
InParanoidiP38079.
OMAiDSATIFY.
OrthoDBiEOG754J0K.

Enzyme and pathway databases

BioCyciYEAST:G3O-29025-MONOMER.

Miscellaneous databases

NextBioi971079.

Gene expression databases

GenevestigatoriP38079.

Family and domain databases

InterProiIPR029730. Arc/bac/fun_rhod-like.
[Graphical view]
PfamiPF01036. Bac_rhodopsin. 1 hit.
[Graphical view]
SMARTiSM01021. Bac_rhodopsin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of 24 kb on chromosome II of Saccharomyces cerevisiae."
    Aljinovic G., Pohl T.M.
    Yeast 11:475-479(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-286.
    Strain: SUB592.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
    Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
    Mol. Cell. Proteomics 6:1896-1906(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-341 AND SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293; THR-341 AND SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-341, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYRO2_YEAST
AccessioniPrimary (citable) accession number: P38079
Secondary accession number(s): D6VQ53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1994
Last sequence update: September 30, 1994
Last modified: March 31, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1950 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.