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P38079

- YRO2_YEAST

UniProt

P38079 - YRO2_YEAST

Protein

Protein YRO2

Gene

YRO2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ion channel activity Source: InterPro

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29025-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein YRO2
    Gene namesi
    Name:YRO2
    Ordered Locus Names:YBR054W
    ORF Names:YBR0507
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR054w.
    SGDiS000000258. YRO2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Protein YRO2PRO_0000196286Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki286 – 286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei293 – 2931Phosphoserine1 Publication
    Modified residuei341 – 3411Phosphothreonine3 Publications
    Modified residuei343 – 3431Phosphoserine2 Publications

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP38079.
    PaxDbiP38079.
    PeptideAtlasiP38079.

    Expressioni

    Gene expression databases

    GenevestigatoriP38079.

    Interactioni

    Protein-protein interaction databases

    BioGridi32755. 31 interactions.
    DIPiDIP-4184N.
    IntActiP38079. 11 interactions.
    MINTiMINT-524121.
    STRINGi4932.YBR054W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38079.
    SMRiP38079. Positions 57-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 627CytoplasmicSequence Analysis
    Topological domaini84 – 11936ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 1411CytoplasmicSequence Analysis
    Topological domaini163 – 17210ExtracellularSequence Analysis
    Topological domaini194 – 2029CytoplasmicSequence Analysis
    Topological domaini224 – 23815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 34485CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi304 – 33128Lys-richAdd
    BLAST
    Compositional biasi334 – 34411Glu-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5524.
    GeneTreeiENSGT00390000004481.
    HOGENOMiHOG000248243.
    OrthoDBiEOG754J0K.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38079-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDYVELLKR GGNEAIKINP PTGADFHITS RGSDWLFTVF CVNLLFGVIL    50
    VPLMFRKPVK DRFVYYTAIA PNLFMSIAYF TMASNLGWIP VRAKYNHVQT 100
    STQKEHPGYR QIFYARYVGW FLAFPWPIIQ MSLLGGTPLW QIAFNVGMTE 150
    IFTVCWLIAA CVHSTYKWGY YTIGIGAAIV VCISLMTTTF NLVKARGKDV 200
    SNVFITFMSV IMFLWLIAYP TCFGITDGGN VLQPDSATIF YGIIDLLILS 250
    ILPVLFMPLA NYLGIERLGL IFDEEPAEHV GPVAEKKMPS PASFKSSDSD 300
    SSIKEKLKLK KKHKKDKKKA KKAKKAKKAK KAQEEEEDVA TDSE 344
    Length:344
    Mass (Da):38,720
    Last modified:October 1, 1994 - v1
    Checksum:iBF63AC0398A0B566
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46260 Genomic DNA. Translation: CAA86397.1.
    Z35923 Genomic DNA. Translation: CAA84997.1.
    BK006936 Genomic DNA. Translation: DAA07173.1.
    PIRiS45912.
    RefSeqiNP_009610.1. NM_001178402.1.

    Genome annotation databases

    EnsemblFungiiYBR054W; YBR054W; YBR054W.
    GeneIDi852343.
    KEGGisce:YBR054W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46260 Genomic DNA. Translation: CAA86397.1 .
    Z35923 Genomic DNA. Translation: CAA84997.1 .
    BK006936 Genomic DNA. Translation: DAA07173.1 .
    PIRi S45912.
    RefSeqi NP_009610.1. NM_001178402.1.

    3D structure databases

    ProteinModelPortali P38079.
    SMRi P38079. Positions 57-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32755. 31 interactions.
    DIPi DIP-4184N.
    IntActi P38079. 11 interactions.
    MINTi MINT-524121.
    STRINGi 4932.YBR054W.

    Proteomic databases

    MaxQBi P38079.
    PaxDbi P38079.
    PeptideAtlasi P38079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR054W ; YBR054W ; YBR054W .
    GeneIDi 852343.
    KEGGi sce:YBR054W.

    Organism-specific databases

    CYGDi YBR054w.
    SGDi S000000258. YRO2.

    Phylogenomic databases

    eggNOGi COG5524.
    GeneTreei ENSGT00390000004481.
    HOGENOMi HOG000248243.
    OrthoDBi EOG754J0K.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29025-MONOMER.

    Miscellaneous databases

    NextBioi 971079.

    Gene expression databases

    Genevestigatori P38079.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of 24 kb on chromosome II of Saccharomyces cerevisiae."
      Aljinovic G., Pohl T.M.
      Yeast 11:475-479(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-286.
      Strain: SUB592.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
      Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
      Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-341 AND SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ATCC 76625 / YPH499.
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293; THR-341 AND SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-341, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYRO2_YEAST
    AccessioniPrimary (citable) accession number: P38079
    Secondary accession number(s): D6VQ53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1950 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3