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P38079 (YRO2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein YRO2
Gene names
Name:YRO2
Ordered Locus Names:YBR054W
ORF Names:YBR0507
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Present with 1950 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the archaeal/bacterial/fungal opsin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Protein YRO2
PRO_0000196286

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 627Cytoplasmic Potential
Transmembrane63 – 8321Helical; Potential
Topological domain84 – 11936Extracellular Potential
Transmembrane120 – 14021Helical; Potential
Topological domain1411Cytoplasmic Potential
Transmembrane142 – 16221Helical; Potential
Topological domain163 – 17210Extracellular Potential
Transmembrane173 – 19321Helical; Potential
Topological domain194 – 2029Cytoplasmic Potential
Transmembrane203 – 22321Helical; Potential
Topological domain224 – 23815Extracellular Potential
Transmembrane239 – 25921Helical; Potential
Topological domain260 – 34485Cytoplasmic Potential
Compositional bias304 – 33128Lys-rich
Compositional bias334 – 34411Glu-rich

Amino acid modifications

Modified residue2931Phosphoserine Ref.10
Modified residue2991Phosphoserine Ref.10
Modified residue3011Phosphoserine Ref.9 Ref.10
Modified residue3021Phosphoserine Ref.10
Modified residue3411Phosphothreonine Ref.4 Ref.8 Ref.10
Modified residue3431Phosphoserine Ref.4 Ref.8 Ref.10
Cross-link286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Sequences

Sequence LengthMass (Da)Tools
P38079 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: BF63AC0398A0B566

FASTA34438,720
        10         20         30         40         50         60 
MSDYVELLKR GGNEAIKINP PTGADFHITS RGSDWLFTVF CVNLLFGVIL VPLMFRKPVK 

        70         80         90        100        110        120 
DRFVYYTAIA PNLFMSIAYF TMASNLGWIP VRAKYNHVQT STQKEHPGYR QIFYARYVGW 

       130        140        150        160        170        180 
FLAFPWPIIQ MSLLGGTPLW QIAFNVGMTE IFTVCWLIAA CVHSTYKWGY YTIGIGAAIV 

       190        200        210        220        230        240 
VCISLMTTTF NLVKARGKDV SNVFITFMSV IMFLWLIAYP TCFGITDGGN VLQPDSATIF 

       250        260        270        280        290        300 
YGIIDLLILS ILPVLFMPLA NYLGIERLGL IFDEEPAEHV GPVAEKKMPS PASFKSSDSD 

       310        320        330        340 
SSIKEKLKLK KKHKKDKKKA KKAKKAKKAK KAQEEEEDVA TDSE

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of 24 kb on chromosome II of Saccharomyces cerevisiae."
Aljinovic G., Pohl T.M.
Yeast 11:475-479(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae."
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M., Shabanowitz J., Hunt D.F., White F.M.
Nat. Biotechnol. 20:301-305(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-341 AND SER-343, MASS SPECTROMETRY.
Strain: 2124.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"A proteomics approach to understanding protein ubiquitination."
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D., Marsischky G., Roelofs J., Finley D., Gygi S.P.
Nat. Biotechnol. 21:921-926(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-286, MASS SPECTROMETRY.
Strain: SUB592.
[7]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[8]"Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-341 AND SER-343, MASS SPECTROMETRY.
Strain: ATCC 76625 / YPH499.
[9]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, MASS SPECTROMETRY.
[10]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293; SER-299; SER-301; SER-302; THR-341 AND SER-343, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46260 Genomic DNA. Translation: CAA86397.1.
Z35923 Genomic DNA. Translation: CAA84997.1.
BK006936 Genomic DNA. Translation: DAA07173.1.
PIRS45912.
RefSeqNP_009610.1. NM_001178402.1.

3D structure databases

ProteinModelPortalP38079.
SMRP38079. Positions 57-247.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4184N.
MINTMINT-524121.
STRING4932.YBR054W.

Proteomic databases

PaxDbP38079.
PeptideAtlasP38079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR054W; YBR054W; YBR054W.
GeneID852343.
KEGGsce:YBR054W.

Organism-specific databases

CYGDYBR054w.
SGDS000000258. YRO2.

Phylogenomic databases

eggNOGCOG5524.
GeneTreeENSGT00390000004481.
HOGENOMHOG000248243.
OMADSATIFY.
OrthoDBEOG4HX897.

Gene expression databases

GenevestigatorP38079.
GermOnlineYBR054W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001425. Rhodopsin_arc/bac/fun.
[Graphical view]
PfamPF01036. Bac_rhodopsin. 1 hit.
[Graphical view]
SMARTSM01021. Bac_rhodopsin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio971079.

Entry information

Entry nameYRO2_YEAST
AccessionPrimary (citable) accession number: P38079
Secondary accession number(s): D6VQ53
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents