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P38079

- YRO2_YEAST

UniProt

P38079 - YRO2_YEAST

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Protein
Protein YRO2
Gene
YRO2, YBR054W, YBR0507
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ion channel activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29025-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YRO2
Gene namesi
Name:YRO2
Ordered Locus Names:YBR054W
ORF Names:YBR0507
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR054w.
SGDiS000000258. YRO2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Extracellular Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Topological domaini56 – 627Cytoplasmic Reviewed prediction
Transmembranei63 – 8321Helical; Reviewed prediction
Add
BLAST
Topological domaini84 – 11936Extracellular Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Reviewed prediction
Add
BLAST
Topological domaini141 – 1411Cytoplasmic Reviewed prediction
Transmembranei142 – 16221Helical; Reviewed prediction
Add
BLAST
Topological domaini163 – 17210Extracellular Reviewed prediction
Transmembranei173 – 19321Helical; Reviewed prediction
Add
BLAST
Topological domaini194 – 2029Cytoplasmic Reviewed prediction
Transmembranei203 – 22321Helical; Reviewed prediction
Add
BLAST
Topological domaini224 – 23815Extracellular Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST
Topological domaini260 – 34485Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Protein YRO2
PRO_0000196286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki286 – 286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei293 – 2931Phosphoserine1 Publication
Modified residuei341 – 3411Phosphothreonine3 Publications
Modified residuei343 – 3431Phosphoserine2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38079.
PaxDbiP38079.
PeptideAtlasiP38079.

Expressioni

Gene expression databases

GenevestigatoriP38079.

Interactioni

Protein-protein interaction databases

BioGridi32755. 31 interactions.
DIPiDIP-4184N.
IntActiP38079. 11 interactions.
MINTiMINT-524121.
STRINGi4932.YBR054W.

Structurei

3D structure databases

ProteinModelPortaliP38079.
SMRiP38079. Positions 57-247.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi304 – 33128Lys-rich
Add
BLAST
Compositional biasi334 – 34411Glu-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5524.
GeneTreeiENSGT00390000004481.
HOGENOMiHOG000248243.
OrthoDBiEOG754J0K.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38079-1 [UniParc]FASTAAdd to Basket

« Hide

MSDYVELLKR GGNEAIKINP PTGADFHITS RGSDWLFTVF CVNLLFGVIL    50
VPLMFRKPVK DRFVYYTAIA PNLFMSIAYF TMASNLGWIP VRAKYNHVQT 100
STQKEHPGYR QIFYARYVGW FLAFPWPIIQ MSLLGGTPLW QIAFNVGMTE 150
IFTVCWLIAA CVHSTYKWGY YTIGIGAAIV VCISLMTTTF NLVKARGKDV 200
SNVFITFMSV IMFLWLIAYP TCFGITDGGN VLQPDSATIF YGIIDLLILS 250
ILPVLFMPLA NYLGIERLGL IFDEEPAEHV GPVAEKKMPS PASFKSSDSD 300
SSIKEKLKLK KKHKKDKKKA KKAKKAKKAK KAQEEEEDVA TDSE 344
Length:344
Mass (Da):38,720
Last modified:October 1, 1994 - v1
Checksum:iBF63AC0398A0B566
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46260 Genomic DNA. Translation: CAA86397.1.
Z35923 Genomic DNA. Translation: CAA84997.1.
BK006936 Genomic DNA. Translation: DAA07173.1.
PIRiS45912.
RefSeqiNP_009610.1. NM_001178402.1.

Genome annotation databases

EnsemblFungiiYBR054W; YBR054W; YBR054W.
GeneIDi852343.
KEGGisce:YBR054W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46260 Genomic DNA. Translation: CAA86397.1 .
Z35923 Genomic DNA. Translation: CAA84997.1 .
BK006936 Genomic DNA. Translation: DAA07173.1 .
PIRi S45912.
RefSeqi NP_009610.1. NM_001178402.1.

3D structure databases

ProteinModelPortali P38079.
SMRi P38079. Positions 57-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32755. 31 interactions.
DIPi DIP-4184N.
IntActi P38079. 11 interactions.
MINTi MINT-524121.
STRINGi 4932.YBR054W.

Proteomic databases

MaxQBi P38079.
PaxDbi P38079.
PeptideAtlasi P38079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR054W ; YBR054W ; YBR054W .
GeneIDi 852343.
KEGGi sce:YBR054W.

Organism-specific databases

CYGDi YBR054w.
SGDi S000000258. YRO2.

Phylogenomic databases

eggNOGi COG5524.
GeneTreei ENSGT00390000004481.
HOGENOMi HOG000248243.
OrthoDBi EOG754J0K.

Enzyme and pathway databases

BioCyci YEAST:G3O-29025-MONOMER.

Miscellaneous databases

NextBioi 971079.

Gene expression databases

Genevestigatori P38079.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of 24 kb on chromosome II of Saccharomyces cerevisiae."
    Aljinovic G., Pohl T.M.
    Yeast 11:475-479(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-286.
    Strain: SUB592.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
    Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
    Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-341 AND SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293; THR-341 AND SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-341, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYRO2_YEAST
AccessioniPrimary (citable) accession number: P38079
Secondary accession number(s): D6VQ53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1950 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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