P38073 (EDS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional regulatory protein EDS1

Alternative name(s):
Expression dependent on SLT2 protein 1

Gene names

Name:	EDS1
Ordered Locus Names:	YBR033W
ORF Names:	YBR0318

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	919 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Binds DNA in a sequence-specific manner.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the EDS1/RGT1 family. Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: GOC transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: GOC
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from direct assay Ref.4. Source: SGD sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 919	919	Transcriptional regulatory protein EDS1		PRO_0000114991
Regions
	DNA binding	56 – 85	30	Zn(2)-C6 fungal-type Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P38073 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 18DD2E37A042E246	FASTA	919	103,397
	10 20 30 40 50 60 MSHHVPNLYG TPIRDPHERK RNSASMGEVN QSVSSRNCER GSEKGTKQRK KASHACDQCR 70 80 90 100 110 120 RKRIKCRFDK HTGVCQGCLE VGEKCQFIRV PLKRGPAKKR GSVVSIEKFS SDNDPLQYRP 130 140 150 160 170 180 RTHSYPMNSG NNYLPSLARN SSFPSISSLF VPSITAQSQQ FVKVPYDDIK RRSSLAILGS 190 200 210 220 230 240 DSSISTEFGG NYRLDENLNV RQEGKDIVAK GMITPVEEMG ACSSNVRRQG SQSLPIQEQR 250 260 270 280 290 300 ASPYINPFIS GRSRLSSLSY TSEATTSEGN TQGKNQCMLT PNSVRSIEKE RLNSLTAGFP 310 320 330 340 350 360 NKKLGTDGRS DKWDKNSTWK PVYRSSNPSH PSTEKNVSLN QEASAKPLML GTYRQFDATS 370 380 390 400 410 420 FYKVLGIYYN FFHINFPVIP INKSKFTDML DPEKPNVIDE IRQINNEIIQ CFKTALEVLV 430 440 450 460 470 480 FCKIKQRRSS KSTKSWSRDS LCDFQKGLYY IQNFNKCIAD CFQSLITIKP VLKQNSSVIP 490 500 510 520 530 540 SRIKFIYFST IIVLNFILIL AGEESSLLLG PSVGVFNEFQ AHKLFLPFQN TSPMLLLNSN 550 560 570 580 590 600 EESGDEILDY AVLFKRLYIL LNILDTLQSF RLGQPKLINL NFGSAIETYF SDKTGHNQVV 610 620 630 640 650 660 EKAPVALDNI LRNLKLGEFI TYFVLNRKSL QVNVPHHLLF TNQTDYGEFA VEKGEHDNIA 670 680 690 700 710 720 GKFETLLKKK EILIRKLLNI EQKNDHILEN CCNSDAEMKN IGELVCSMIT LVSGILDSIT 730 740 750 760 770 780 NMNAENSVDL DSKPLPNAYF AQDSEEELMS PTQSITSNLA SEENTRCTTK DLMGTVSIFM 790 800 810 820 830 840 LPMVEECYNI ISLIGPIPTT LISLYIRNGN MAKGINDRIM TLSTALNELV QITALFNTLE 850 860 870 880 890 900 PFRKNAHDRA KRYYVSATSS TGCYESVMKS MYSGKCAASN ASNVAPSEEE NKKILKKFAD 910 IGWKLMDDSE LGCCCCFFN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene." Smits P.H.M., de Haan M., Maat C., Grivell L.A. Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters." Badis G., Chan E.T., van Bakel H., Pena-Castillo L., Tillo D., Tsui K., Carlson C.D., Gossett A.J., Hasinoff M.J., Warren C.L., Gebbia M., Talukder S., Yang A., Mnaimneh S., Terterov D., Coburn D., Li Yeo A., Yeo Z.X. , Clarke N.D., Lieb J.D., Ansari A.Z., Nislow C., Hughes T.R. Mol. Cell 32:878-887(2008) [PubMed] [Europe PMC] [Abstract] Cited for: DNA-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X76078 Genomic DNA. Translation: CAA53688.1. Z35902 Genomic DNA. Translation: CAA84975.1. BK006936 Genomic DNA. Translation: DAA07153.1.
PIR	S45889.
RefSeq	NP_009589.1. NM_001178381.1.
3D structure databases
ProteinModelPortal	P38073.
SMR	P38073. Positions 54-88.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4895N.
MINT	MINT-558290.
STRING	4932.YBR033W.
Proteomic databases
PaxDb	P38073.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR033W; YBR033W; YBR033W.
GeneID	852321.
KEGG	sce:YBR033W.
Organism-specific databases
CYGD	YBR033w.
SGD	S000000237. EDS1.
Phylogenomic databases
eggNOG	NOG73252.
GeneTree	ENSGT00530000067048.
OMA	NDHILEN.
OrthoDB	EOG4PCF28.
Enzyme and pathway databases
BioCyc	YEAST:G3O-29010-MONOMER.
Gene expression databases
Genevestigator	P38073.
GermOnline	YBR033W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	4.10.240.10. 1 hit.
InterPro	IPR001138. Zn2-C6_fun-type_DNA-bd. [Graphical view]
Pfam	PF00172. Zn_clus. 1 hit. [Graphical view]
SMART	SM00066. GAL4. 1 hit. [Graphical view]
SUPFAM	SSF57701. Fungi_TrN. 1 hit.
PROSITE	PS00463. ZN2_CY6_FUNGAL_1. 1 hit. PS50048. ZN2_CY6_FUNGAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	971017.

Entry information

Entry name

EDS1_YEAST

Accession

Primary (citable) accession number: P38073
Secondary accession number(s): D6VQ33

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 29, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program