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Protein

Transcriptional regulatory protein EDS1

Gene

EDS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi56 – 8530Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29010-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein EDS1
Alternative name(s):
Expression dependent on SLT2 protein 1
Gene namesi
Name:EDS1
Ordered Locus Names:YBR033W
ORF Names:YBR0318
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR033w.
SGDiS000000237. EDS1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Transcriptional regulatory protein EDS1PRO_0000114991Add
BLAST

Proteomic databases

PaxDbiP38073.

Expressioni

Gene expression databases

GenevestigatoriP38073.

Interactioni

Subunit structurei

Binds DNA in a sequence-specific manner.

Protein-protein interaction databases

BioGridi32734. 62 interactions.
DIPiDIP-4895N.
MINTiMINT-558290.
STRINGi4932.YBR033W.

Structurei

3D structure databases

ProteinModelPortaliP38073.
SMRiP38073. Positions 54-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EDS1/RGT1 family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG73252.
GeneTreeiENSGT00530000067048.
InParanoidiP38073.
OMAiNDHILEN.
OrthoDBiEOG7X6M7G.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38073-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHHVPNLYG TPIRDPHERK RNSASMGEVN QSVSSRNCER GSEKGTKQRK
60 70 80 90 100
KASHACDQCR RKRIKCRFDK HTGVCQGCLE VGEKCQFIRV PLKRGPAKKR
110 120 130 140 150
GSVVSIEKFS SDNDPLQYRP RTHSYPMNSG NNYLPSLARN SSFPSISSLF
160 170 180 190 200
VPSITAQSQQ FVKVPYDDIK RRSSLAILGS DSSISTEFGG NYRLDENLNV
210 220 230 240 250
RQEGKDIVAK GMITPVEEMG ACSSNVRRQG SQSLPIQEQR ASPYINPFIS
260 270 280 290 300
GRSRLSSLSY TSEATTSEGN TQGKNQCMLT PNSVRSIEKE RLNSLTAGFP
310 320 330 340 350
NKKLGTDGRS DKWDKNSTWK PVYRSSNPSH PSTEKNVSLN QEASAKPLML
360 370 380 390 400
GTYRQFDATS FYKVLGIYYN FFHINFPVIP INKSKFTDML DPEKPNVIDE
410 420 430 440 450
IRQINNEIIQ CFKTALEVLV FCKIKQRRSS KSTKSWSRDS LCDFQKGLYY
460 470 480 490 500
IQNFNKCIAD CFQSLITIKP VLKQNSSVIP SRIKFIYFST IIVLNFILIL
510 520 530 540 550
AGEESSLLLG PSVGVFNEFQ AHKLFLPFQN TSPMLLLNSN EESGDEILDY
560 570 580 590 600
AVLFKRLYIL LNILDTLQSF RLGQPKLINL NFGSAIETYF SDKTGHNQVV
610 620 630 640 650
EKAPVALDNI LRNLKLGEFI TYFVLNRKSL QVNVPHHLLF TNQTDYGEFA
660 670 680 690 700
VEKGEHDNIA GKFETLLKKK EILIRKLLNI EQKNDHILEN CCNSDAEMKN
710 720 730 740 750
IGELVCSMIT LVSGILDSIT NMNAENSVDL DSKPLPNAYF AQDSEEELMS
760 770 780 790 800
PTQSITSNLA SEENTRCTTK DLMGTVSIFM LPMVEECYNI ISLIGPIPTT
810 820 830 840 850
LISLYIRNGN MAKGINDRIM TLSTALNELV QITALFNTLE PFRKNAHDRA
860 870 880 890 900
KRYYVSATSS TGCYESVMKS MYSGKCAASN ASNVAPSEEE NKKILKKFAD
910
IGWKLMDDSE LGCCCCFFN
Length:919
Mass (Da):103,397
Last modified:October 1, 1994 - v1
Checksum:i18DD2E37A042E246
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76078 Genomic DNA. Translation: CAA53688.1.
Z35902 Genomic DNA. Translation: CAA84975.1.
BK006936 Genomic DNA. Translation: DAA07153.1.
PIRiS45889.
RefSeqiNP_009589.1. NM_001178381.1.

Genome annotation databases

EnsemblFungiiYBR033W; YBR033W; YBR033W.
GeneIDi852321.
KEGGisce:YBR033W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76078 Genomic DNA. Translation: CAA53688.1.
Z35902 Genomic DNA. Translation: CAA84975.1.
BK006936 Genomic DNA. Translation: DAA07153.1.
PIRiS45889.
RefSeqiNP_009589.1. NM_001178381.1.

3D structure databases

ProteinModelPortaliP38073.
SMRiP38073. Positions 54-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32734. 62 interactions.
DIPiDIP-4895N.
MINTiMINT-558290.
STRINGi4932.YBR033W.

Proteomic databases

PaxDbiP38073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR033W; YBR033W; YBR033W.
GeneIDi852321.
KEGGisce:YBR033W.

Organism-specific databases

CYGDiYBR033w.
SGDiS000000237. EDS1.

Phylogenomic databases

eggNOGiNOG73252.
GeneTreeiENSGT00530000067048.
InParanoidiP38073.
OMAiNDHILEN.
OrthoDBiEOG7X6M7G.

Enzyme and pathway databases

BioCyciYEAST:G3O-29010-MONOMER.

Miscellaneous databases

NextBioi971017.

Gene expression databases

GenevestigatoriP38073.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene."
    Smits P.H.M., de Haan M., Maat C., Grivell L.A.
    Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: DNA-BINDING.
  5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEDS1_YEAST
AccessioniPrimary (citable) accession number: P38073
Secondary accession number(s): D6VQ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 7, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.