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P38073 (EDS1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional regulatory protein EDS1
Alternative name(s):
Expression dependent on SLT2 protein 1
Gene names
Name:EDS1
Ordered Locus Names:YBR033W
ORF Names:YBR0318
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length919 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds DNA in a sequence-specific manner.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the EDS1/RGT1 family.

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 919919Transcriptional regulatory protein EDS1
PRO_0000114991

Regions

DNA binding56 – 8530Zn(2)-C6 fungal-type Ref.4

Sequences

Sequence LengthMass (Da)Tools
P38073 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 18DD2E37A042E246

FASTA919103,397
        10         20         30         40         50         60 
MSHHVPNLYG TPIRDPHERK RNSASMGEVN QSVSSRNCER GSEKGTKQRK KASHACDQCR 

        70         80         90        100        110        120 
RKRIKCRFDK HTGVCQGCLE VGEKCQFIRV PLKRGPAKKR GSVVSIEKFS SDNDPLQYRP 

       130        140        150        160        170        180 
RTHSYPMNSG NNYLPSLARN SSFPSISSLF VPSITAQSQQ FVKVPYDDIK RRSSLAILGS 

       190        200        210        220        230        240 
DSSISTEFGG NYRLDENLNV RQEGKDIVAK GMITPVEEMG ACSSNVRRQG SQSLPIQEQR 

       250        260        270        280        290        300 
ASPYINPFIS GRSRLSSLSY TSEATTSEGN TQGKNQCMLT PNSVRSIEKE RLNSLTAGFP 

       310        320        330        340        350        360 
NKKLGTDGRS DKWDKNSTWK PVYRSSNPSH PSTEKNVSLN QEASAKPLML GTYRQFDATS 

       370        380        390        400        410        420 
FYKVLGIYYN FFHINFPVIP INKSKFTDML DPEKPNVIDE IRQINNEIIQ CFKTALEVLV 

       430        440        450        460        470        480 
FCKIKQRRSS KSTKSWSRDS LCDFQKGLYY IQNFNKCIAD CFQSLITIKP VLKQNSSVIP 

       490        500        510        520        530        540 
SRIKFIYFST IIVLNFILIL AGEESSLLLG PSVGVFNEFQ AHKLFLPFQN TSPMLLLNSN 

       550        560        570        580        590        600 
EESGDEILDY AVLFKRLYIL LNILDTLQSF RLGQPKLINL NFGSAIETYF SDKTGHNQVV 

       610        620        630        640        650        660 
EKAPVALDNI LRNLKLGEFI TYFVLNRKSL QVNVPHHLLF TNQTDYGEFA VEKGEHDNIA 

       670        680        690        700        710        720 
GKFETLLKKK EILIRKLLNI EQKNDHILEN CCNSDAEMKN IGELVCSMIT LVSGILDSIT 

       730        740        750        760        770        780 
NMNAENSVDL DSKPLPNAYF AQDSEEELMS PTQSITSNLA SEENTRCTTK DLMGTVSIFM 

       790        800        810        820        830        840 
LPMVEECYNI ISLIGPIPTT LISLYIRNGN MAKGINDRIM TLSTALNELV QITALFNTLE 

       850        860        870        880        890        900 
PFRKNAHDRA KRYYVSATSS TGCYESVMKS MYSGKCAASN ASNVAPSEEE NKKILKKFAD 

       910 
IGWKLMDDSE LGCCCCFFN 

« Hide

References

« Hide 'large scale' references
[1]"The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene."
Smits P.H.M., de Haan M., Maat C., Grivell L.A.
Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters."
Badis G., Chan E.T., van Bakel H., Pena-Castillo L., Tillo D., Tsui K., Carlson C.D., Gossett A.J., Hasinoff M.J., Warren C.L., Gebbia M., Talukder S., Yang A., Mnaimneh S., Terterov D., Coburn D., Li Yeo A., Yeo Z.X. expand/collapse author list , Clarke N.D., Lieb J.D., Ansari A.Z., Nislow C., Hughes T.R.
Mol. Cell 32:878-887(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING.
[5]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76078 Genomic DNA. Translation: CAA53688.1.
Z35902 Genomic DNA. Translation: CAA84975.1.
BK006936 Genomic DNA. Translation: DAA07153.1.
PIRS45889.
RefSeqNP_009589.1. NM_001178381.1.

3D structure databases

ProteinModelPortalP38073.
SMRP38073. Positions 54-88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32734. 62 interactions.
DIPDIP-4895N.
MINTMINT-558290.
STRING4932.YBR033W.

Proteomic databases

PaxDbP38073.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR033W; YBR033W; YBR033W.
GeneID852321.
KEGGsce:YBR033W.

Organism-specific databases

CYGDYBR033w.
SGDS000000237. EDS1.

Phylogenomic databases

eggNOGNOG73252.
GeneTreeENSGT00530000067048.
OMANDHILEN.
OrthoDBEOG7X6M7G.

Enzyme and pathway databases

BioCycYEAST:G3O-29010-MONOMER.

Gene expression databases

GenevestigatorP38073.

Family and domain databases

Gene3D4.10.240.10. 1 hit.
InterProIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMSSF57701. SSF57701. 1 hit.
PROSITEPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio971017.

Entry information

Entry nameEDS1_YEAST
AccessionPrimary (citable) accession number: P38073
Secondary accession number(s): D6VQ33
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families