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P38073

- EDS1_YEAST

UniProt

P38073 - EDS1_YEAST

Protein

Transcriptional regulatory protein EDS1

Gene

EDS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi56 – 8530Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29010-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulatory protein EDS1
    Alternative name(s):
    Expression dependent on SLT2 protein 1
    Gene namesi
    Name:EDS1
    Ordered Locus Names:YBR033W
    ORF Names:YBR0318
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR033w.
    SGDiS000000237. EDS1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 919919Transcriptional regulatory protein EDS1PRO_0000114991Add
    BLAST

    Proteomic databases

    PaxDbiP38073.

    Expressioni

    Gene expression databases

    GenevestigatoriP38073.

    Interactioni

    Subunit structurei

    Binds DNA in a sequence-specific manner.

    Protein-protein interaction databases

    BioGridi32734. 62 interactions.
    DIPiDIP-4895N.
    MINTiMINT-558290.
    STRINGi4932.YBR033W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38073.
    SMRiP38073. Positions 54-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EDS1/RGT1 family.Curated
    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG73252.
    GeneTreeiENSGT00530000067048.
    OrthoDBiEOG7X6M7G.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF00172. Zn_clus. 1 hit.
    [Graphical view]
    SMARTiSM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38073-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHHVPNLYG TPIRDPHERK RNSASMGEVN QSVSSRNCER GSEKGTKQRK    50
    KASHACDQCR RKRIKCRFDK HTGVCQGCLE VGEKCQFIRV PLKRGPAKKR 100
    GSVVSIEKFS SDNDPLQYRP RTHSYPMNSG NNYLPSLARN SSFPSISSLF 150
    VPSITAQSQQ FVKVPYDDIK RRSSLAILGS DSSISTEFGG NYRLDENLNV 200
    RQEGKDIVAK GMITPVEEMG ACSSNVRRQG SQSLPIQEQR ASPYINPFIS 250
    GRSRLSSLSY TSEATTSEGN TQGKNQCMLT PNSVRSIEKE RLNSLTAGFP 300
    NKKLGTDGRS DKWDKNSTWK PVYRSSNPSH PSTEKNVSLN QEASAKPLML 350
    GTYRQFDATS FYKVLGIYYN FFHINFPVIP INKSKFTDML DPEKPNVIDE 400
    IRQINNEIIQ CFKTALEVLV FCKIKQRRSS KSTKSWSRDS LCDFQKGLYY 450
    IQNFNKCIAD CFQSLITIKP VLKQNSSVIP SRIKFIYFST IIVLNFILIL 500
    AGEESSLLLG PSVGVFNEFQ AHKLFLPFQN TSPMLLLNSN EESGDEILDY 550
    AVLFKRLYIL LNILDTLQSF RLGQPKLINL NFGSAIETYF SDKTGHNQVV 600
    EKAPVALDNI LRNLKLGEFI TYFVLNRKSL QVNVPHHLLF TNQTDYGEFA 650
    VEKGEHDNIA GKFETLLKKK EILIRKLLNI EQKNDHILEN CCNSDAEMKN 700
    IGELVCSMIT LVSGILDSIT NMNAENSVDL DSKPLPNAYF AQDSEEELMS 750
    PTQSITSNLA SEENTRCTTK DLMGTVSIFM LPMVEECYNI ISLIGPIPTT 800
    LISLYIRNGN MAKGINDRIM TLSTALNELV QITALFNTLE PFRKNAHDRA 850
    KRYYVSATSS TGCYESVMKS MYSGKCAASN ASNVAPSEEE NKKILKKFAD 900
    IGWKLMDDSE LGCCCCFFN 919
    Length:919
    Mass (Da):103,397
    Last modified:October 1, 1994 - v1
    Checksum:i18DD2E37A042E246
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76078 Genomic DNA. Translation: CAA53688.1.
    Z35902 Genomic DNA. Translation: CAA84975.1.
    BK006936 Genomic DNA. Translation: DAA07153.1.
    PIRiS45889.
    RefSeqiNP_009589.1. NM_001178381.1.

    Genome annotation databases

    EnsemblFungiiYBR033W; YBR033W; YBR033W.
    GeneIDi852321.
    KEGGisce:YBR033W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76078 Genomic DNA. Translation: CAA53688.1 .
    Z35902 Genomic DNA. Translation: CAA84975.1 .
    BK006936 Genomic DNA. Translation: DAA07153.1 .
    PIRi S45889.
    RefSeqi NP_009589.1. NM_001178381.1.

    3D structure databases

    ProteinModelPortali P38073.
    SMRi P38073. Positions 54-88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32734. 62 interactions.
    DIPi DIP-4895N.
    MINTi MINT-558290.
    STRINGi 4932.YBR033W.

    Proteomic databases

    PaxDbi P38073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR033W ; YBR033W ; YBR033W .
    GeneIDi 852321.
    KEGGi sce:YBR033W.

    Organism-specific databases

    CYGDi YBR033w.
    SGDi S000000237. EDS1.

    Phylogenomic databases

    eggNOGi NOG73252.
    GeneTreei ENSGT00530000067048.
    OrthoDBi EOG7X6M7G.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29010-MONOMER.

    Miscellaneous databases

    NextBioi 971017.

    Gene expression databases

    Genevestigatori P38073.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    SMARTi SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene."
      Smits P.H.M., de Haan M., Maat C., Grivell L.A.
      Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: DNA-BINDING.
    5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEDS1_YEAST
    AccessioniPrimary (citable) accession number: P38073
    Secondary accession number(s): D6VQ33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3