Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase YPK3

Gene

YPK3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients (PubMed:11062466). Required for phosphorylation of ribosomal protein S6 (RPS6A/RPS6B) at 'Ser-232' and 'Ser-233' (PubMed:25767889).2 Publications

Miscellaneous

Present with 1470 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157ATPPROSITE-ProRule annotation1
Active sitei277Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi134 – 142ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • peptidyl-serine phosphorylation Source: SGD
  • protein autophosphorylation Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29007-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase YPK31 Publication (EC:2.7.11.11 Publication)
Alternative name(s):
Ribosomal S6 kinase homolog YPK31 Publication
Short name:
S6K homolog YPK3
Gene namesi
Name:YPK31 Publication
Ordered Locus Names:YBR028CImported
ORF Names:YBR0312
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR028C
SGDiS000000232 YPK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860731 – 525Serine/threonine-protein kinase YPK3Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei107PhosphothreonineCombined sources1
Modified residuei321Phosphoserine; by PKH1 or PKH2By similarity1
Modified residuei490Phosphothreonine; by TORC1By similarity1
Modified residuei513Phosphoserine; by TORC1By similarity1

Post-translational modificationi

Phosphorylated by PKA in a TORC1-dependent manner. Phosphorylation at PKA consensus sites RRxS/T decreases upon rapamycin treatment.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38070
PaxDbiP38070
PRIDEiP38070

PTM databases

iPTMnetiP38070

Interactioni

Protein-protein interaction databases

BioGridi32730, 87 interactors
DIPiDIP-4629N
IntActiP38070, 6 interactors
MINTiP38070
STRINGi4932.YBR028C

Structurei

3D structure databases

ProteinModelPortaliP38070
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 424Protein kinasePROSITE-ProRule annotationAdd BLAST297
Domaini445 – 524AGC-kinase C-terminalAdd BLAST80

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00910000145205
InParanoidiP38070
KOiK22008
OMAiIGTPEYC
OrthoDBiEOG092C0HH3

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P38070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFSLDEELH RVSLDDKKND IKVDYSSAIY NDINHEQGSS ITYEESINHL
60 70 80 90 100
SVHSNAIPLN GMSPAHRMRR RSSAYSKFPI LTPPNTRRFS ITGSDAMRTN
110 120 130 140 150
TNRLSITPQD IISSNIGENE LSRNLHDFKP VRVLGQGAYG KVLLVKDVNT
160 170 180 190 200
SKLYAMKQLR KAEILISQTA TDSKREDEDK NDGNNNDNDD GLSKRLERTF
210 220 230 240 250
AERSILSEIE HPNIVKLFYS FHDNSKLYLL LQYIPGGELF YHLKEHGTLD
260 270 280 290 300
ETTVSFYAAE ISCALRFLHT KGVVYRDLKP ENCLLNQRGH LVLTDFGLSK
310 320 330 340 350
KSANDSAVDE EDPENVNALY SIIGTPEYCA PEILLGKAYS QNCDWYSLGC
360 370 380 390 400
LLYDMLVGKP PYTGSNHKVI INKIQQNKQG PKIPFYLSEG MKDILNALLK
410 420 430 440 450
KETAKRWNVD KYWAKTGANN KPTKSKKKKS GAARTSLFTE HFIFRKIDWK
460 470 480 490 500
LLESGQLQKT TLGPIVPVIT DLELAENFDT EFTSMSYEET YTDSKPININ
510 520
SVSKSPDMFK GFSYKASGSY LEKYF
Length:525
Mass (Da):59,591
Last modified:October 1, 1994 - v1
Checksum:iB8FFE61A44067677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76078 Genomic DNA Translation: CAA53684.1
Z35897 Genomic DNA Translation: CAA84970.1
BK006936 Genomic DNA Translation: DAA07149.1
PIRiS45884
RefSeqiNP_009584.1, NM_001178376.1

Genome annotation databases

EnsemblFungiiYBR028C; YBR028C; YBR028C
GeneIDi852316
KEGGisce:YBR028C

Similar proteinsi

Entry informationi

Entry nameiYPK3_YEAST
AccessioniPrimary (citable) accession number: P38070
Secondary accession number(s): D6VQ29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health