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P38067

- UGA2_YEAST

UniProt

P38067 - UGA2_YEAST

Protein

Succinate-semialdehyde dehydrogenase [NADP(+)]

Gene

UGA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei164 – 1641Transition state stabilizerBy similarity
    Active sitei264 – 2641Proton acceptorPROSITE-ProRule annotation
    Active sitei298 – 2981NucleophilePROSITE-ProRule annotation

    GO - Molecular functioni

    1. succinate-semialdehyde dehydrogenase [NAD(P)+] activity Source: SGD

    GO - Biological processi

    1. cellular response to oxidative stress Source: SGD
    2. gamma-aminobutyric acid catabolic process Source: SGD
    3. glutamate decarboxylation to succinate Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:YBR006W-MONOMER.
    YEAST:YBR006W-MONOMER.
    ReactomeiREACT_189231. Degradation of GABA.
    UniPathwayiUPA00733.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate-semialdehyde dehydrogenase [NADP(+)] (EC:1.2.1.16)
    Short name:
    SSDH
    Gene namesi
    Name:UGA2
    Synonyms:UGA5
    Ordered Locus Names:YBR006W
    ORF Names:YBR0112
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR006w.
    SGDiS000000210. UGA2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Succinate-semialdehyde dehydrogenase [NADP(+)]PRO_0000056568Add
    BLAST

    Proteomic databases

    MaxQBiP38067.
    PaxDbiP38067.
    PeptideAtlasiP38067.
    PRIDEiP38067.

    Expressioni

    Gene expression databases

    GenevestigatoriP38067.

    Interactioni

    Protein-protein interaction databases

    BioGridi32707. 19 interactions.
    DIPiDIP-1759N.
    IntActiP38067. 3 interactions.
    MINTiMINT-411339.

    Structurei

    3D structure databases

    ProteinModelPortaliP38067.
    SMRiP38067. Positions 11-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00740000115598.
    HOGENOMiHOG000271509.
    KOiK00135.
    OMAiASKFRNM.
    OrthoDBiEOG7S226Z.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR010102. Succ_semiAld_DH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01780. SSADH. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38067-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLSKYSKPT LNDPNLFRES GYIDGKWVKG TDEVFEVVDP ASGEIIARVP    50
    EQPVSVVEEA IDVAYETFKT YKNTTPRERA KWLRNMYNLM LENLDDLATI 100
    ITLENGKALG EAKGEIKYAA SYFEWYAEEA PRLYGATIQP LNPHNRVFTI 150
    RQPVGVCGII CPWNFPSAMI TRKAAAALAV GCTVVIKPDS QTPLSALAMA 200
    YLAEKAGFPK GSFNVILSHA NTPKLGKTLC ESPKVKKVTF TGSTNVGKIL 250
    MKQSSSTLKK LSFELGGNAP FIVFEDADLD QALEQAMACK FRGLGQTCVC 300
    ANRLYVHSSI IDKFAKLLAE RVKKFVIGHG LDPKTTHGCV INSSAIEKVE 350
    RHKQDAIDKG AKVVLEGGRL TELGPNFYAP VILSHVPSTA IVSKEETFGP 400
    LCPIFSFDTM EEVVGYANDT EFGLAAYVFS KNVNTLYTVS EALETGMVSC 450
    NTGVFSDCSI PFGGVKESGF GREGSLYGIE DYTVLKTITI GNLPNSI 497
    Length:497
    Mass (Da):54,189
    Last modified:July 15, 1999 - v2
    Checksum:iF33252EEE24B9B40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35875 Genomic DNA. Translation: CAA84943.1.
    Z35876 Genomic DNA. Translation: CAA84945.1.
    BK006936 Genomic DNA. Translation: DAA07127.1.
    PIRiS45858.
    RefSeqiNP_009560.1. NM_001178354.1.

    Genome annotation databases

    EnsemblFungiiYBR006W; YBR006W; YBR006W.
    GeneIDi852291.
    KEGGisce:YBR006W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35875 Genomic DNA. Translation: CAA84943.1 .
    Z35876 Genomic DNA. Translation: CAA84945.1 .
    BK006936 Genomic DNA. Translation: DAA07127.1 .
    PIRi S45858.
    RefSeqi NP_009560.1. NM_001178354.1.

    3D structure databases

    ProteinModelPortali P38067.
    SMRi P38067. Positions 11-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32707. 19 interactions.
    DIPi DIP-1759N.
    IntActi P38067. 3 interactions.
    MINTi MINT-411339.

    Proteomic databases

    MaxQBi P38067.
    PaxDbi P38067.
    PeptideAtlasi P38067.
    PRIDEi P38067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR006W ; YBR006W ; YBR006W .
    GeneIDi 852291.
    KEGGi sce:YBR006W.

    Organism-specific databases

    CYGDi YBR006w.
    SGDi S000000210. UGA2.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00740000115598.
    HOGENOMi HOG000271509.
    KOi K00135.
    OMAi ASKFRNM.
    OrthoDBi EOG7S226Z.

    Enzyme and pathway databases

    UniPathwayi UPA00733 .
    BioCyci MetaCyc:YBR006W-MONOMER.
    YEAST:YBR006W-MONOMER.
    Reactomei REACT_189231. Degradation of GABA.

    Miscellaneous databases

    NextBioi 970937.
    PROi P38067.

    Gene expression databases

    Genevestigatori P38067.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR010102. Succ_semiAld_DH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01780. SSADH. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUGA2_YEAST
    AccessioniPrimary (citable) accession number: P38067
    Secondary accession number(s): D6VQ07, E9PAD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3