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Protein

Succinate-semialdehyde dehydrogenase [NADP(+)]

Gene

UGA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei164Transition state stabilizerBy similarity1
Active sitei264Proton acceptorPROSITE-ProRule annotation1
Active sitei298NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
  • gamma-aminobutyric acid catabolic process Source: SGD
  • glutamate decarboxylation to succinate Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciMetaCyc:YBR006W-MONOMER
YEAST:YBR006W-MONOMER
ReactomeiR-SCE-916853 Degradation of GABA
UniPathwayiUPA00733

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate-semialdehyde dehydrogenase [NADP(+)] (EC:1.2.1.16)
Short name:
SSDH
Gene namesi
Name:UGA2
Synonyms:UGA5
Ordered Locus Names:YBR006W
ORF Names:YBR0112
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR006W
SGDiS000000210 UGA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000565681 – 497Succinate-semialdehyde dehydrogenase [NADP(+)]Add BLAST497

Proteomic databases

MaxQBiP38067
PaxDbiP38067
PRIDEiP38067

Interactioni

Protein-protein interaction databases

BioGridi3270760 interactors.
DIPiDIP-1759N
IntActiP38067 6 interactors.
MINTiP38067
STRINGi4932.YBR006W

Structurei

3D structure databases

ProteinModelPortaliP38067
SMRiP38067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000144187
HOGENOMiHOG000271509
InParanoidiP38067
KOiK00135
OMAiVGTNTQG
OrthoDBiEOG092C1LLH

Family and domain databases

Gene3Di3.40.309.101 hit
3.40.605.102 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR010102 Succ_semiAld_DH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01780 SSADH, 1 hit
PROSITEiView protein in PROSITE
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

P38067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSKYSKPT LNDPNLFRES GYIDGKWVKG TDEVFEVVDP ASGEIIARVP
60 70 80 90 100
EQPVSVVEEA IDVAYETFKT YKNTTPRERA KWLRNMYNLM LENLDDLATI
110 120 130 140 150
ITLENGKALG EAKGEIKYAA SYFEWYAEEA PRLYGATIQP LNPHNRVFTI
160 170 180 190 200
RQPVGVCGII CPWNFPSAMI TRKAAAALAV GCTVVIKPDS QTPLSALAMA
210 220 230 240 250
YLAEKAGFPK GSFNVILSHA NTPKLGKTLC ESPKVKKVTF TGSTNVGKIL
260 270 280 290 300
MKQSSSTLKK LSFELGGNAP FIVFEDADLD QALEQAMACK FRGLGQTCVC
310 320 330 340 350
ANRLYVHSSI IDKFAKLLAE RVKKFVIGHG LDPKTTHGCV INSSAIEKVE
360 370 380 390 400
RHKQDAIDKG AKVVLEGGRL TELGPNFYAP VILSHVPSTA IVSKEETFGP
410 420 430 440 450
LCPIFSFDTM EEVVGYANDT EFGLAAYVFS KNVNTLYTVS EALETGMVSC
460 470 480 490
NTGVFSDCSI PFGGVKESGF GREGSLYGIE DYTVLKTITI GNLPNSI
Length:497
Mass (Da):54,189
Last modified:July 15, 1999 - v2
Checksum:iF33252EEE24B9B40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35875 Genomic DNA Translation: CAA84943.1
Z35876 Genomic DNA Translation: CAA84945.1
BK006936 Genomic DNA Translation: DAA07127.1
PIRiS45858
RefSeqiNP_009560.1, NM_001178354.1

Genome annotation databases

EnsemblFungiiYBR006W; YBR006W; YBR006W
GeneIDi852291
KEGGisce:YBR006W

Similar proteinsi

Entry informationi

Entry nameiUGA2_YEAST
AccessioniPrimary (citable) accession number: P38067
Secondary accession number(s): D6VQ07, E9PAD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1999
Last modified: March 28, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome