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P38067 (UGA2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate-semialdehyde dehydrogenase [NADP(+)]

Short name=SSDH
EC=1.2.1.16
Gene names
Name:UGA2
Synonyms:UGA5
Ordered Locus Names:YBR006W
ORF Names:YBR0112
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.

Pathway

Amino-acid degradation; 4-aminobutanoate degradation.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Succinate-semialdehyde dehydrogenase [NADP(+)]
PRO_0000056568

Sites

Active site2641Proton acceptor By similarity
Active site2981Nucleophile By similarity
Site1641Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P38067 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: F33252EEE24B9B40

FASTA49754,189
        10         20         30         40         50         60 
MTLSKYSKPT LNDPNLFRES GYIDGKWVKG TDEVFEVVDP ASGEIIARVP EQPVSVVEEA 

        70         80         90        100        110        120 
IDVAYETFKT YKNTTPRERA KWLRNMYNLM LENLDDLATI ITLENGKALG EAKGEIKYAA 

       130        140        150        160        170        180 
SYFEWYAEEA PRLYGATIQP LNPHNRVFTI RQPVGVCGII CPWNFPSAMI TRKAAAALAV 

       190        200        210        220        230        240 
GCTVVIKPDS QTPLSALAMA YLAEKAGFPK GSFNVILSHA NTPKLGKTLC ESPKVKKVTF 

       250        260        270        280        290        300 
TGSTNVGKIL MKQSSSTLKK LSFELGGNAP FIVFEDADLD QALEQAMACK FRGLGQTCVC 

       310        320        330        340        350        360 
ANRLYVHSSI IDKFAKLLAE RVKKFVIGHG LDPKTTHGCV INSSAIEKVE RHKQDAIDKG 

       370        380        390        400        410        420 
AKVVLEGGRL TELGPNFYAP VILSHVPSTA IVSKEETFGP LCPIFSFDTM EEVVGYANDT 

       430        440        450        460        470        480 
EFGLAAYVFS KNVNTLYTVS EALETGMVSC NTGVFSDCSI PFGGVKESGF GREGSLYGIE 

       490 
DYTVLKTITI GNLPNSI 

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z35875 Genomic DNA. Translation: CAA84943.1.
Z35876 Genomic DNA. Translation: CAA84945.1.
BK006936 Genomic DNA. Translation: DAA07127.1.
PIRS45858.
RefSeqNP_009560.1. NM_001178354.1.

3D structure databases

ProteinModelPortalP38067.
SMRP38067. Positions 3-496.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32707. 19 interactions.
DIPDIP-1759N.
IntActP38067. 3 interactions.
MINTMINT-411339.

Proteomic databases

PaxDbP38067.
PeptideAtlasP38067.
PRIDEP38067.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR006W; YBR006W; YBR006W.
GeneID852291.
KEGGsce:YBR006W.

Organism-specific databases

CYGDYBR006w.
SGDS000000210. UGA2.

Phylogenomic databases

eggNOGCOG1012.
GeneTreeENSGT00740000115598.
HOGENOMHOG000271509.
KOK00135.
OMAERADILW.
OrthoDBEOG7S226Z.

Enzyme and pathway databases

BioCycMetaCyc:YBR006W-MONOMER.
YEAST:YBR006W-MONOMER.
UniPathwayUPA00733.

Gene expression databases

GenevestigatorP38067.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR01780. SSADH. 1 hit.
PROSITEPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio970937.
PROP38067.

Entry information

Entry nameUGA2_YEAST
AccessionPrimary (citable) accession number: P38067
Secondary accession number(s): D6VQ07, E9PAD1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1999
Last modified: March 19, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways