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Protein

Succinate-semialdehyde dehydrogenase [NADP(+)]

Gene

UGA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.

Pathway: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei164 – 1641Transition state stabilizerBy similarity
Active sitei264 – 2641Proton acceptorPROSITE-ProRule annotation
Active sitei298 – 2981NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity Source: SGD

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
  • gamma-aminobutyric acid catabolic process Source: SGD
  • glutamate decarboxylation to succinate Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:YBR006W-MONOMER.
YEAST:YBR006W-MONOMER.
ReactomeiREACT_313750. Degradation of GABA.
UniPathwayiUPA00733.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate-semialdehyde dehydrogenase [NADP(+)] (EC:1.2.1.16)
Short name:
SSDH
Gene namesi
Name:UGA2
Synonyms:UGA5
Ordered Locus Names:YBR006W
ORF Names:YBR0112
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome II

Organism-specific databases

CYGDiYBR006w.
EuPathDBiFungiDB:YBR006W.
SGDiS000000210. UGA2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Succinate-semialdehyde dehydrogenase [NADP(+)]PRO_0000056568Add
BLAST

Proteomic databases

MaxQBiP38067.
PaxDbiP38067.
PeptideAtlasiP38067.
PRIDEiP38067.

Interactioni

Protein-protein interaction databases

BioGridi32707. 20 interactions.
DIPiDIP-1759N.
IntActiP38067. 3 interactions.
MINTiMINT-411339.
STRINGi4932.YBR006W.

Structurei

3D structure databases

ProteinModelPortaliP38067.
SMRiP38067. Positions 11-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00780000121975.
HOGENOMiHOG000271509.
InParanoidiP38067.
KOiK00135.
OMAiGCLINTK.
OrthoDBiEOG7S226Z.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSKYSKPT LNDPNLFRES GYIDGKWVKG TDEVFEVVDP ASGEIIARVP
60 70 80 90 100
EQPVSVVEEA IDVAYETFKT YKNTTPRERA KWLRNMYNLM LENLDDLATI
110 120 130 140 150
ITLENGKALG EAKGEIKYAA SYFEWYAEEA PRLYGATIQP LNPHNRVFTI
160 170 180 190 200
RQPVGVCGII CPWNFPSAMI TRKAAAALAV GCTVVIKPDS QTPLSALAMA
210 220 230 240 250
YLAEKAGFPK GSFNVILSHA NTPKLGKTLC ESPKVKKVTF TGSTNVGKIL
260 270 280 290 300
MKQSSSTLKK LSFELGGNAP FIVFEDADLD QALEQAMACK FRGLGQTCVC
310 320 330 340 350
ANRLYVHSSI IDKFAKLLAE RVKKFVIGHG LDPKTTHGCV INSSAIEKVE
360 370 380 390 400
RHKQDAIDKG AKVVLEGGRL TELGPNFYAP VILSHVPSTA IVSKEETFGP
410 420 430 440 450
LCPIFSFDTM EEVVGYANDT EFGLAAYVFS KNVNTLYTVS EALETGMVSC
460 470 480 490
NTGVFSDCSI PFGGVKESGF GREGSLYGIE DYTVLKTITI GNLPNSI
Length:497
Mass (Da):54,189
Last modified:July 15, 1999 - v2
Checksum:iF33252EEE24B9B40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35875 Genomic DNA. Translation: CAA84943.1.
Z35876 Genomic DNA. Translation: CAA84945.1.
BK006936 Genomic DNA. Translation: DAA07127.1.
PIRiS45858.
RefSeqiNP_009560.1. NM_001178354.1.

Genome annotation databases

EnsemblFungiiYBR006W; YBR006W; YBR006W.
GeneIDi852291.
KEGGisce:YBR006W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35875 Genomic DNA. Translation: CAA84943.1.
Z35876 Genomic DNA. Translation: CAA84945.1.
BK006936 Genomic DNA. Translation: DAA07127.1.
PIRiS45858.
RefSeqiNP_009560.1. NM_001178354.1.

3D structure databases

ProteinModelPortaliP38067.
SMRiP38067. Positions 11-491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32707. 20 interactions.
DIPiDIP-1759N.
IntActiP38067. 3 interactions.
MINTiMINT-411339.
STRINGi4932.YBR006W.

Proteomic databases

MaxQBiP38067.
PaxDbiP38067.
PeptideAtlasiP38067.
PRIDEiP38067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR006W; YBR006W; YBR006W.
GeneIDi852291.
KEGGisce:YBR006W.

Organism-specific databases

CYGDiYBR006w.
EuPathDBiFungiDB:YBR006W.
SGDiS000000210. UGA2.

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00780000121975.
HOGENOMiHOG000271509.
InParanoidiP38067.
KOiK00135.
OMAiGCLINTK.
OrthoDBiEOG7S226Z.

Enzyme and pathway databases

UniPathwayiUPA00733.
BioCyciMetaCyc:YBR006W-MONOMER.
YEAST:YBR006W-MONOMER.
ReactomeiREACT_313750. Degradation of GABA.

Miscellaneous databases

NextBioi970937.
PROiP38067.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUGA2_YEAST
AccessioniPrimary (citable) accession number: P38067
Secondary accession number(s): D6VQ07, E9PAD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1999
Last modified: June 24, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.