Reviewed, UniProtKB/Swiss-Prot P38058 (CBPA_CLOCL)

Names and origin

Protein names

Recommended name:
    Cellulose-binding protein A

Gene names

Name:

cbpA

Organism

Clostridium cellulovorans

Taxonomic identifier

1493 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	1848 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted.

General annotation (Comments)

Function	Binds to cellulose fibers and coordinates cellulase enzymes.
Subcellular location	Secreted. Note: Remains at the cell surface.
Post-translational modification	The N-terminus is blocked. Glycosylated Probable.
Sequence similarities	Contains 1 CBM3 (carbohydrate binding type-3) domain. Contains 9 cohesin domains.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Cell wall biogenesis/degradation Cellulose degradation Polysaccharide degradation
Cellular component	Secreted
Domain	Repeat Signal
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW cellulose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell peptidoglycan-based cell wall Inferred from electronic annotation. Source: InterPro
Molecular function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 1848	1820	Cellulose-binding protein A		PRO_0000020846
Regions
	Domain	29 – 190	162	CBM3
	Domain	291 – 428	138	Cohesin 1
	Domain	435 – 570	136	Cohesin 2
	Domain	668 – 801	134	Cohesin 3
	Domain	810 – 943	134	Cohesin 4
	Domain	952 – 1085	134	Cohesin 5
	Domain	1094 – 1227	134	Cohesin 6
	Domain	1236 – 1369	134	Cohesin 7
	Domain	1377 – 1511	135	Cohesin 8
	Domain	1709 – 1847	139	Cohesin 9

Sequences

	Sequence		Length	Mass (Da)
	P38058-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 85FA6CE6F771AF1A	FASTA	1,848	189,152
	10 20 30 40 50 60 MQKKKSLNLL LALMMVFALV LPSIPALAAT SSMSVEFYNS NKSAQTNSIT PIIKITNTSD 70 80 90 100 110 120 SDLNLNDVKV RYYYTSDGTQ GQTFWCDHAG ALLGNSYVDN TSKVTANFVK ETASPTSTYD 130 140 150 160 170 180 TYVEFGFASG RATLKKGQFI TIQGRITKSD WSNYTQTNDY SFDASSSTPV VNPKVTGYIG 190 200 210 220 230 240 GAKVLGTAPG PDVPSSIINP TSATFDKNVT KQADVKTTMT LNGNTFKTIT DANGTALNAS 250 260 270 280 290 300 TDYSVSGNDV TISKAYLAKQ SVGTTTLNFN FSAGNPQKLV ITVVDTPVEA VTATIGKVQV 310 320 330 340 350 360 NAGETVAVPV NLTKVPAAGL ATIELPLTFD SASLEVVSIT AGDIVLNPSV NFSSTVSGST 370 380 390 400 410 420 IKLLFLDDTL GSQLITKDGV FATITFKAKA ITGTTAKVTS VKLAGTPVVG DAQLQEKPCA 430 440 450 460 470 480 VNPGTVTINP IDNRMQISVG TATVKAGEIA AVPVTLTSVP STGIATAEAQ VSFDATLLEV 490 500 510 520 530 540 ASVTAGDIVL NPTVNFSYTV NGNVIKLLFL DDTLGSQLIS KDGVFVTINF KAKAVTSTVT 550 560 570 580 590 600 TPVTVSGTPV FADGTLAEVQ SKTAAGSVTI NIGDPILEPT ISPVTATFDK KAPADVATTM 610 620 630 640 650 660 TLNGYTFNGI TGLTTSDYSI SGNVVKISQA YLAKQPVGDL TLTFNFSNGN KTATAKLVVS 670 680 690 700 710 720 IKDAPKTVTA TVGTATVNAG ETVAVPVTLS NVSGISTAEL QLSFDATLLE VVSITAGDIV 730 740 750 760 770 780 LNPSVNFSSV VNGSTIKLLF LDDTLGSQLI SKDGVFATIN FKAKSVTSTV TTPVKVSGTP 790 800 810 820 830 840 VFADGTLAEL SYETVAGSVT INAIGPVKTV TATVGTATVK SGETVAVPVT LSNVPGIATA 850 860 870 880 890 900 ELQLSFDATL LEVASITVGD IVLNPSVNFS SVVNGSTIKL LFLDDTLGSQ LISKDGVLAT 910 920 930 940 950 960 INFKAKTVTS TVTTPVAVSG TPVFADGTLA ELQSKTVAGS VTIEPSQPVK TVTATVGTAT 970 980 990 1000 1010 1020 VKSGETVAVP VTLSNVPGIA TAELQVGFDA TLLEVASITV GDIVLNPSVN FSSVVNGSTI 1030 1040 1050 1060 1070 1080 KLLFLDDTLG SQLISKDGVL ATINFKAKTV TSKVTTPVAV SGTPVFADGT LAELNMKTVA 1090 1100 1110 1120 1130 1140 GSVTIEPSQP VKTVTATVGT ATVKSGETVA VPVTLSNVPG IATAELQVGF DATLLEVASI 1150 1160 1170 1180 1190 1200 TVGDIVLNPS VNFSSVVNGS TIKLLFLDDT LGSQLISKDG VLATINFKAK TVTSKVTTPV 1210 1220 1230 1240 1250 1260 AVSGTPVFAD GTLAELKYET VAGSVTIEPS QPVKTVTATV GTATGKVGET VAVPVTLSNV 1270 1280 1290 1300 1310 1320 PGIATAEVQV GFDATLLEVA SITAGDIVLN PSVNFSSVVN GSTIKILFLD DTLGSQLISK 1330 1340 1350 1360 1370 1380 DGVFATINFK IKAVPSTGTT PVAISGTPVF ADGTLAEVQY KTVAGSVTIA AADIKAVKAT 1390 1400 1410 1420 1430 1440 VGTATGKAGD TVAVPVTLSN VSGIATVELQ LSFDATLLEV ASITAGDIVL NPSVNFSSVV 1450 1460 1470 1480 1490 1500 NGSTIKILFL DDTLGSQLIS KDGVFATVNF KVKSTATNSA VTPVTVSGTP VFADGTLAEL 1510 1520 1530 1540 1550 1560 KSESAAGRLT ILPTVIIVDS TVAPTAVTFD KANQADAAIT MTLNGNTFSA IKNGTATLVK 1570 1580 1590 1600 1610 1620 GTDYTVSENV VTISKAYLAK QTGTVTLEFV FDKGNSAKVV VAVKEIQIVN STITPVVATF 1630 1640 1650 1660 1670 1680 EKTAAKQADV VVTMSLNGNT FSAIKNGTTT LVKGTDYTIS GSTVTISKAY LATLADGSAT 1690 1700 1710 1720 1730 1740 LEFVFNQGAS AKLRLTIVPA VVDPVVTDFA VKIDKVSAAA GSTVKVPVSL INVSKVGNVC 1750 1760 1770 1780 1790 1800 VAEYKISFDS SVLTYVGTTA GTSIKNPAVN FSSQLNGNTI TLLFFDNTIG NELITADGQF 1810 1820 1830 1840 ATIEFKVNAA ATSGTTAEVK VATISSFADA SLTEITKVAT VNGSVKVS

References

[1]	"Primary sequence analysis of Clostridium cellulovorans cellulose binding protein A." Shoseyov O., Takagi M., Goldstein M.A., Doi R.H. Proc. Natl. Acad. Sci. U.S.A. 89:3483-3487(1992) [PubMed: 1565642] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M73817 Genomic DNA. Translation: AAA23218.1.
PIR	A44140.
3D structure databases
HSSP	HSSP built from PDB template 1NBC based on UniProtKB Q06851.
ModBase	Search...
Protein family/group databases
CAZy	CBM3. Carbohydrate-Binding Module Family 3.
Family and domain databases
InterPro	IPR001956. CBD_3. IPR002102. Cohesin. IPR018452. Cohesin_region_subgroup. IPR005102. DUF291. IPR013783. Ig-like_fold. [Graphical view]
Gene3D	G3DSA:2.60.40.710. CBD_3. 1 hit. G3DSA:2.60.40.680. Cohesin. 9 hits. G3DSA:2.60.40.10. Ig-like_fold. 2 hits.
Pfam	PF00942. CBM_3. 1 hit. PF00963. Cohesin. 9 hits. PF03442. DUF291. 4 hits. [Graphical view]
ProDom	PD001947. CBD_3. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS51172. CBM3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CBPA_CLOCL

Accession

Primary (citable) accession number: P38058

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)