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Protein

Uncharacterized fimbrial-like protein SfmF

Gene

sfmF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG12388-MONOMER.
ECOL316407:JW5072-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein SfmF
Gene namesi
Name:sfmF
Synonyms:ybcG
Ordered Locus Names:b0534, JW5072
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12388. sfmF.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000920821 – 171Uncharacterized fimbrial-like protein SfmFAdd BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 80Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP38052.
PRIDEiP38052.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263147. 12 interactors.
STRINGi511145.b0534.

Structurei

3D structure databases

ProteinModelPortaliP38052.
SMRiP38052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108ZI2. Bacteria.
ENOG4111SMY. LUCA.
HOGENOMiHOG000260127.
InParanoidiP38052.
KOiK07355.
OMAiPHYLIRI.
PhylomeDBiP38052.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38052-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRVLFSCFC GLLWSSSGWA VDPLGTININ LHGNVVDFSC TVNTADIDKT
60 70 80 90 100
VDLGRWPTTQ LLNAGDTTAL VPFSLRLEGC PPGSVAILFT GTPASDTNLL
110 120 130 140 150
ALDDPAMAQT VAIELRNSDR SRLALGEASP TEEVDANGNV TLNFFANYRA
160 170
LASGVRPGVA KADAIFMINY N
Length:171
Mass (Da):18,223
Last modified:November 1, 1997 - v2
Checksum:i59230981242A1DCA
GO

Sequence cautioni

The sequence AAB40732 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40732.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73636.1.
AP009048 Genomic DNA. Translation: BAE76311.1.
X51662 Genomic DNA. No translation available.
PIRiE64785.
RefSeqiNP_415067.1. NC_000913.3.
WP_001255230.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73636; AAC73636; b0534.
BAE76311; BAE76311; BAE76311.
GeneIDi944977.
KEGGiecj:JW5072.
eco:b0534.
PATRICi32116228. VBIEscCol129921_0555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82598 Genomic DNA. Translation: AAB40732.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73636.1.
AP009048 Genomic DNA. Translation: BAE76311.1.
X51662 Genomic DNA. No translation available.
PIRiE64785.
RefSeqiNP_415067.1. NC_000913.3.
WP_001255230.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP38052.
SMRiP38052.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263147. 12 interactors.
STRINGi511145.b0534.

Proteomic databases

PaxDbiP38052.
PRIDEiP38052.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73636; AAC73636; b0534.
BAE76311; BAE76311; BAE76311.
GeneIDi944977.
KEGGiecj:JW5072.
eco:b0534.
PATRICi32116228. VBIEscCol129921_0555.

Organism-specific databases

EchoBASEiEB2289.
EcoGeneiEG12388. sfmF.

Phylogenomic databases

eggNOGiENOG4108ZI2. Bacteria.
ENOG4111SMY. LUCA.
HOGENOMiHOG000260127.
InParanoidiP38052.
KOiK07355.
OMAiPHYLIRI.
PhylomeDBiP38052.

Enzyme and pathway databases

BioCyciEcoCyc:EG12388-MONOMER.
ECOL316407:JW5072-MONOMER.

Miscellaneous databases

PROiP38052.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSFMF_ECOLI
AccessioniPrimary (citable) accession number: P38052
Secondary accession number(s): P75716, P77079, Q2MBP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.