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P38041

- BOB1_YEAST

UniProt

P38041 - BOB1_YEAST

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Protein

Protein BOB1

Gene

BOI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the BEM1 protein.

GO - Molecular functioni

  1. phospholipid binding Source: SGD

GO - Biological processi

  1. budding cell apical bud growth Source: SGD
  2. cytokinesis, completion of separation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-28974-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BOB1
Alternative name(s):
BEM1-binding protein
Growth inhibitory protein 7
Gene namesi
Name:BOI1
Synonyms:BOB1, GIN7
Ordered Locus Names:YBL085W
ORF Names:YBL0717
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBL085w.
SGDiS000000181. BOI1.

Subcellular locationi

GO - Cellular componenti

  1. cellular bud Source: SGD
  2. cellular bud neck Source: SGD
  3. site of polarized growth Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 980980Protein BOB1PRO_0000064968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041Phosphoserine2 Publications
Modified residuei106 – 1061Phosphoserine1 Publication
Modified residuei128 – 1281Phosphoserine1 Publication
Modified residuei151 – 1511Phosphothreonine1 Publication
Modified residuei158 – 1581Phosphothreonine1 Publication
Modified residuei209 – 2091Phosphoserine3 Publications
Modified residuei393 – 3931Phosphoserine1 Publication
Modified residuei412 – 4121Phosphoserine1 Publication
Modified residuei525 – 5251Phosphoserine1 Publication
Modified residuei528 – 5281Phosphoserine2 Publications
Modified residuei589 – 5891Phosphoserine1 Publication
Modified residuei590 – 5901Phosphoserine1 Publication
Modified residuei593 – 5931Phosphoserine1 Publication
Modified residuei644 – 6441Phosphoserine2 Publications
Modified residuei655 – 6551Phosphoserine1 Publication
Modified residuei735 – 7351Phosphoserine1 Publication
Modified residuei919 – 9191Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38041.
PaxDbiP38041.
PRIDEiP38041.

Expressioni

Gene expression databases

GenevestigatoriP38041.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BEM1P293665EBI-3719,EBI-3508
CDC14Q006842EBI-3719,EBI-4192
FIR1P400202EBI-3719,EBI-13431
NBA1Q082293EBI-3719,EBI-36841
YDR239CQ037802EBI-3719,EBI-30094
YER158CP400954EBI-3719,EBI-22734
YJR056CP471153EBI-3719,EBI-25514
ZDS2P547863EBI-3719,EBI-29637

Protein-protein interaction databases

BioGridi32619. 92 interactions.
DIPiDIP-2226N.
IntActiP38041. 72 interactions.
MINTiMINT-584486.
STRINGi4932.YBL085W.

Structurei

3D structure databases

ProteinModelPortaliP38041.
SMRiP38041. Positions 14-75, 781-902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 7765SH3PROSITE-ProRule annotationAdd
BLAST
Domaini228 – 29265SAMPROSITE-ProRule annotationAdd
BLAST
Domaini776 – 895120PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG73665.
GeneTreeiENSGT00530000066577.
HOGENOMiHOG000066063.
InParanoidiP38041.
OMAiYVQRPST.
OrthoDBiEOG7N63W3.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF07647. SAM_2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38041-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLEGNTLGK GAKSFPLYIA VNQYSKRMED ELNMKPGDKI KVITDDGEYN
60 70 80 90 100
DGWYYGRNLR TKEEGLYPAV FTKRIAIEKP ENLHKSPTQE SGNSGVKYGN
110 120 130 140 150
LNDSASNIGK VSSHQQENRY TSLKSTMSDI DKALEELRSG SVEQEVSKSP
160 170 180 190 200
TRVPEVSTPQ LQDEQTLIQE KTRNEENTTH DSLFSSTADL NLSSESLKNI
210 220 230 240 250
SKSNISTKSL EPSSESVRQL DLKMAKSWSP EEVTDYFSLV GFDQSTCNKF
260 270 280 290 300
KEHQVSGKIL LELELEHLKE LEINSFGIRF QIFKEIRNIK SAIDSSSNKL
310 320 330 340 350
DADYSTFAFE NQAAQLMPAA TVNRDEIQQQ ISSKCNKLSS ESSDRKSSSV
360 370 380 390 400
TTELQRPSSV VVNPNFKLHD PAEQILDMTE VPNLFADKDI FESPGRAPKP
410 420 430 440 450
PSYPSPVQPP QSPSFNNRYT NNNARFPPQT TYPPKNKNPT VYSNGLIPNS
460 470 480 490 500
STSSDNSTGK FKFPAMNGHD SNSRKTTLTS ATIPSINTVN TDESLPAISN
510 520 530 540 550
ISSNATSHHP NRNSVVYNNH KRTESGSSFV DLFNRISMLS PVKSSFDEEE
560 570 580 590 600
TKQPSKASRA VFDSARRKSS YGHSRDASLS EMKKHRRNSS ILSFFSSKSQ
610 620 630 640 650
SNPTSPTKQT FTIDPAKMTS HSRSQSNSYS HARSQSYSHS RKHSLVTSPL
660 670 680 690 700
KTSLSPINSK SNIALAHSET PTSSNNKEAV SQPSEGKHKH KHKHKSKHKH
710 720 730 740 750
KNSSSKDGSS EEKSKKKLFS STKESFVGSK EFKRSPSELT QKSTKSILPR
760 770 780 790 800
SNAKKQQTSA FTEGIRSITA KESMQTADCS GWMSKKGTGA MGTWKQRFFT
810 820 830 840 850
LHGTRLSYFT NTNDEKERGL IDITAHRVLP ASDDDRLISL YAASLGKGKY
860 870 880 890 900
CFKLVPPQPG SKKGLTFTEP RVHYFAVENK SEMKAWLSAI IKATIDIDTS
910 920 930 940 950
VPVISSYATP TIPLSKAQTL LEEARLQTQL RDAEEEEGRD QFGWDDTQNK
960 970 980
RNSNYPIEQD QFETSDYLES SAFEYPGGRL
Length:980
Mass (Da):109,295
Last modified:October 1, 1994 - v1
Checksum:i09F1DD1F9EF30F36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L31406 Genomic DNA. Translation: AAB08439.1.
X79489 Genomic DNA. Translation: CAA56021.1.
Z35846 Genomic DNA. Translation: CAA84906.1.
BK006936 Genomic DNA. Translation: DAA07039.1.
PIRiS45444.
RefSeqiNP_009468.1. NM_001178325.1.

Genome annotation databases

EnsemblFungiiYBL085W; YBL085W; YBL085W.
GeneIDi852193.
KEGGisce:YBL085W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L31406 Genomic DNA. Translation: AAB08439.1 .
X79489 Genomic DNA. Translation: CAA56021.1 .
Z35846 Genomic DNA. Translation: CAA84906.1 .
BK006936 Genomic DNA. Translation: DAA07039.1 .
PIRi S45444.
RefSeqi NP_009468.1. NM_001178325.1.

3D structure databases

ProteinModelPortali P38041.
SMRi P38041. Positions 14-75, 781-902.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32619. 92 interactions.
DIPi DIP-2226N.
IntActi P38041. 72 interactions.
MINTi MINT-584486.
STRINGi 4932.YBL085W.

Proteomic databases

MaxQBi P38041.
PaxDbi P38041.
PRIDEi P38041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBL085W ; YBL085W ; YBL085W .
GeneIDi 852193.
KEGGi sce:YBL085W.

Organism-specific databases

CYGDi YBL085w.
SGDi S000000181. BOI1.

Phylogenomic databases

eggNOGi NOG73665.
GeneTreei ENSGT00530000066577.
HOGENOMi HOG000066063.
InParanoidi P38041.
OMAi YVQRPST.
OrthoDBi EOG7N63W3.

Enzyme and pathway databases

BioCyci YEAST:G3O-28974-MONOMER.

Miscellaneous databases

NextBioi 970676.

Gene expression databases

Genevestigatori P38041.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
PF07647. SAM_2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Associations among PH and SH3 domain-containing proteins and Rho-type GTPases in Yeast."
    Bender L., Lo H.S., Lee H., Kokojan V., Peterson V., Bender A.
    J. Cell Biol. 133:879-894(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of a 78.6 kb segment of the left end of Saccharomyces cerevisiae chromosome II."
    Obermaier B., Gassenhuber J., Piravandi E., Domdey H.
    Yeast 11:1103-1112(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104; SER-209; SER-528; SER-644 AND THR-919, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-735, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-655, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104; SER-106; SER-128; THR-151; THR-158; SER-209; SER-393; SER-412; SER-525; SER-528; SER-589; SER-590; SER-593 AND SER-644, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBOB1_YEAST
AccessioniPrimary (citable) accession number: P38041
Secondary accession number(s): D6VPR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1040 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3