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Protein

Guanine nucleotide-binding protein subunit gamma-1

Gene

Ggamma1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.1 Publication

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: FlyBase
  • apical protein localization Source: FlyBase
  • asymmetric neuroblast division Source: FlyBase
  • cell adhesion Source: FlyBase
  • cell adhesion involved in heart morphogenesis Source: FlyBase
  • convergent extension involved in gastrulation Source: FlyBase
  • dorsal closure Source: FlyBase
  • embryonic heart tube development Source: FlyBase
  • establishment or maintenance of cytoskeleton polarity involved in gastrulation Source: FlyBase
  • G-protein coupled receptor signaling pathway Source: FlyBase
  • heart process Source: FlyBase
  • mesectoderm development Source: FlyBase
  • neurogenesis Source: FlyBase
  • proboscis extension reflex Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • regulation of gastrulation Source: FlyBase
  • regulation of myosin II filament organization Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gamma-1
Gene namesi
Name:Ggamma1
Synonyms:G1
ORF Names:CG8261
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0004921. Ggamma1.

Subcellular locationi

GO - Cellular componenti

  • heterotrimeric G-protein complex Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6767Guanine nucleotide-binding protein subunit gamma-1PRO_0000012677Add
BLAST
Propeptidei68 – 703Removed in mature formBy similarityPRO_0000012678

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671Cysteine methyl esterBy similarity
Lipidationi67 – 671S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP38040.
PRIDEiP38040.

Expressioni

Tissue specificityi

Predominantly expressed in the central nervous system.1 Publication

Gene expression databases

BgeeiP38040.
GenevisibleiP38040. DM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi61721. 2 interactions.
STRINGi7227.FBpp0087728.

Structurei

3D structure databases

ProteinModelPortaliP38040.
SMRiP38040. Positions 7-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00650000094727.
InParanoidiP38040.
OMAiCSEHARN.
OrthoDBiEOG7H1JP7.
PhylomeDBiP38040.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVMSSSLQQ QRVVVEQLRR EAAIDRQTIS ESCAKMMKYI TEHEQEDYLL
60 70
TGFTSQKVNP FREKSSCTVL
Length:70
Mass (Da):8,130
Last modified:October 1, 1994 - v1
Checksum:i1CD46E3BBF8FE4F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85042 mRNA. Translation: AAA28570.1.
AE013599 Genomic DNA. Translation: AAF59030.1.
AE013599 Genomic DNA. Translation: AAM71087.1.
AY118489 mRNA. Translation: AAM49858.1.
PIRiA42155.
RefSeqiNP_523662.1. NM_078938.3.
NP_724718.1. NM_165631.2.
NP_724719.1. NM_165632.2.
UniGeneiDm.2812.

Genome annotation databases

EnsemblMetazoaiFBtr0088645; FBpp0087726; FBgn0004921.
FBtr0088646; FBpp0087727; FBgn0004921.
FBtr0088647; FBpp0087728; FBgn0004921.
GeneIDi35881.
KEGGidme:Dmel_CG8261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85042 mRNA. Translation: AAA28570.1.
AE013599 Genomic DNA. Translation: AAF59030.1.
AE013599 Genomic DNA. Translation: AAM71087.1.
AY118489 mRNA. Translation: AAM49858.1.
PIRiA42155.
RefSeqiNP_523662.1. NM_078938.3.
NP_724718.1. NM_165631.2.
NP_724719.1. NM_165632.2.
UniGeneiDm.2812.

3D structure databases

ProteinModelPortaliP38040.
SMRiP38040. Positions 7-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61721. 2 interactions.
STRINGi7227.FBpp0087728.

Proteomic databases

PaxDbiP38040.
PRIDEiP38040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088645; FBpp0087726; FBgn0004921.
FBtr0088646; FBpp0087727; FBgn0004921.
FBtr0088647; FBpp0087728; FBgn0004921.
GeneIDi35881.
KEGGidme:Dmel_CG8261.

Organism-specific databases

CTDi35881.
FlyBaseiFBgn0004921. Ggamma1.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00650000094727.
InParanoidiP38040.
OMAiCSEHARN.
OrthoDBiEOG7H1JP7.
PhylomeDBiP38040.

Miscellaneous databases

ChiTaRSiGgamma1. fly.
GenomeRNAii35881.
PROiP38040.

Gene expression databases

BgeeiP38040.
GenevisibleiP38040. DM.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila G protein gamma subunit gene (D-G gamma 1) produces three developmentally regulated transcripts and is predominantly expressed in the central nervous system."
    Ray K., Ganguly R.
    J. Biol. Chem. 267:6086-6092(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiGBG1_DROME
AccessioniPrimary (citable) accession number: P38040
Secondary accession number(s): A4UZ90, Q540Y8, Q9V4Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 6, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.