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Protein

Guanine nucleotide-binding protein subunit gamma-1

Gene

Ggamma1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.1 Publication

GO - Molecular functioni

GO - Biological processi

  • apical protein localization Source: FlyBase
  • asymmetric neuroblast division Source: FlyBase
  • cell adhesion involved in heart morphogenesis Source: FlyBase
  • convergent extension involved in gastrulation Source: FlyBase
  • dorsal closure Source: FlyBase
  • embryonic heart tube development Source: FlyBase
  • establishment or maintenance of cytoskeleton polarity involved in gastrulation Source: FlyBase
  • G-protein coupled receptor signaling pathway Source: FlyBase
  • heart process Source: FlyBase
  • mesectoderm development Source: FlyBase
  • proboscis extension reflex Source: FlyBase
  • regulation of gastrulation Source: FlyBase
  • regulation of myosin II filament organization Source: FlyBase

Keywordsi

Molecular functionTransducer

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gamma-1
Gene namesi
Name:Ggamma1
Synonyms:G1
ORF Names:CG8261
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0004921. Ggamma1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126771 – 67Guanine nucleotide-binding protein subunit gamma-1Add BLAST67
PropeptideiPRO_000001267868 – 70Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67Cysteine methyl esterBy similarity1
Lipidationi67S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP38040.
PRIDEiP38040.

Expressioni

Tissue specificityi

Predominantly expressed in the central nervous system.1 Publication

Gene expression databases

BgeeiFBgn0004921.
GenevisibleiP38040. DM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

BioGridi61721. 5 interactors.
STRINGi7227.FBpp0087728.

Structurei

3D structure databases

ProteinModelPortaliP38040.
SMRiP38040.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00650000094727.
InParanoidiP38040.
OMAiCSEHARN.
OrthoDBiEOG091G17J0.
PhylomeDBiP38040.

Family and domain databases

CDDicd00068. GGL. 1 hit.
InterProiView protein in InterPro
IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiView protein in Pfam
PF00631. G-gamma. 1 hit.
SMARTiView protein in SMART
SM00224. GGL. 1 hit.
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiView protein in PROSITE
PS50058. G_PROTEIN_GAMMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38040-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVMSSSLQQ QRVVVEQLRR EAAIDRQTIS ESCAKMMKYI TEHEQEDYLL
60 70
TGFTSQKVNP FREKSSCTVL
Length:70
Mass (Da):8,130
Last modified:October 1, 1994 - v1
Checksum:i1CD46E3BBF8FE4F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85042 mRNA. Translation: AAA28570.1.
AE013599 Genomic DNA. Translation: AAF59030.1.
AE013599 Genomic DNA. Translation: AAM71087.1.
AY118489 mRNA. Translation: AAM49858.1.
PIRiA42155.
RefSeqiNP_523662.1. NM_078938.3.
NP_724718.1. NM_165631.2.
NP_724719.1. NM_165632.2.
UniGeneiDm.2812.

Genome annotation databases

EnsemblMetazoaiFBtr0088645; FBpp0087726; FBgn0004921.
FBtr0088646; FBpp0087727; FBgn0004921.
FBtr0088647; FBpp0087728; FBgn0004921.
GeneIDi35881.
KEGGidme:Dmel_CG8261.

Similar proteinsi

Entry informationi

Entry nameiGBG1_DROME
AccessioniPrimary (citable) accession number: P38040
Secondary accession number(s): A4UZ90, Q540Y8, Q9V4Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 27, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families