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Protein

Transcriptional regulatory protein RtcR

Gene

rtcR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Transcriptional repressor of the rtcAB genes. Interacts with sigma-54.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi215 – 222ATPPROSITE-ProRule annotation8
Nucleotide bindingi281 – 290ATPPROSITE-ProRule annotation10
DNA bindingi485 – 504H-T-H motifSequence analysisAdd BLAST20

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: EcoCyc
  • transcription factor binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation, Two-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12356-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein RtcR
Gene namesi
Name:rtcR
Synonyms:yhgB
Ordered Locus Names:b3422, JW3385
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12356 rtcR

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000813351 – 532Transcriptional regulatory protein RtcRAdd BLAST532

Proteomic databases

PaxDbiP38035
PRIDEiP38035

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4261191, 13 interactors
DIPiDIP-10812N
IntActiP38035, 5 interactors
STRINGi316385.ECDH10B_3596

Structurei

3D structure databases

ProteinModelPortaliP38035
SMRiP38035
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 424Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST239

Phylogenomic databases

eggNOGiENOG4105CYB Bacteria
COG4650 LUCA
HOGENOMiHOG000145396
InParanoidiP38035
KOiK14414
OMAiYLVHITT
PhylomeDBiP38035

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR009715 RtcR
IPR017183 Sigma54_dep_tscrpt_act_RtcR
IPR002078 Sigma_54_int
IPR025943 Sigma_54_int_dom_ATP-bd_2
PANTHERiPTHR32071:SF14 PTHR32071:SF14, 1 hit
PfamiView protein in Pfam
PF06956 RtcR, 1 hit
PF00158 Sigma54_activat, 1 hit
PIRSFiPIRSF037354 Txn_actvtr_RtcR, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00676 SIGMA54_INTERACT_2, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit

Sequencei

Sequence statusi: Complete.

P38035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKTVAFGFV GTVLDYAGRG SQRWSKWRPT LCLCQQESLV IDRLELLHDA
60 70 80 90 100
RSRSLFETLK RDIASVSPET EVVSVEIELH NPWDFEEVYA CLHDFARGYE
110 120 130 140 150
FQPEKEDYLI HITTGTHVAQ ICWFLLAEAR YLPARLIQSS PPRKKEQPRG
160 170 180 190 200
PGEVTIIDLD LSRYNAIASR FAEERQQTLD FLKSGIATRN PHFNRMIEQI
210 220 230 240 250
EKVAIKSRAP ILLNGPTGAG KSFLARRILE LKQARHQFSG AFVEVNCATL
260 270 280 290 300
RGDTAMSTLF GHVKGAFTGA RESREGLLRS ANGGMLFLDE IGELGADEQA
310 320 330 340 350
MLLKAIEEKT FYPFGSDRQV SSDFQLIAGT VRDLRQLVAE GKFREDLYAR
360 370 380 390 400
INLWTFTLPG LRQRQEDIEP NLDYEVERHA SLTGDSVRFN TEARRAWLAF
410 420 430 440 450
ATSPQATWRG NFRELSASVT RMATFATSGR ITLDVVEDEI NRLRYNWQES
460 470 480 490 500
RPSALTALLG AEAENIDLFD RMQLEHVIAI CRQAKSLSAA GRQLFDVSRQ
510 520 530
GKASVNDADR LRKYLARFGL TWEAVQDQHS SS
Length:532
Mass (Da):60,299
Last modified:November 1, 1995 - v2
Checksum:i86351442491E04DD
GO

Sequence cautioni

The sequence X07520 differs from that shown. Reason: Frameshift at positions 386 and 422.Curated
The sequence X07520 differs from that shown. Reason: Erroneous termination at position 511. Translated as Leu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58220.1
U00096 Genomic DNA Translation: AAC76447.1
AP009048 Genomic DNA Translation: BAE77870.1
X07520 Genomic DNA No translation available.
M96795 Genomic DNA No translation available.
PIRiA65138
RefSeqiNP_417880.1, NC_000913.3
WP_001232948.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76447; AAC76447; b3422
BAE77870; BAE77870; BAE77870
GeneIDi947928
KEGGiecj:JW3385
eco:b3422
PATRICifig|1411691.4.peg.3307

Similar proteinsi

Entry informationi

Entry nameiRTCR_ECOLI
AccessioniPrimary (citable) accession number: P38035
Secondary accession number(s): Q2M786
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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