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Protein

Transcriptional regulatory protein RtcR

Gene

rtcR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcriptional repressor of the rtcAB genes. Interacts with sigma-54.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi215 – 2228ATPPROSITE-ProRule annotation
Nucleotide bindingi281 – 29010ATPPROSITE-ProRule annotation
DNA bindingi485 – 50420H-T-H motifSequence analysisAdd
BLAST

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12356-MONOMER.
ECOL316407:JW3385-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein RtcR
Gene namesi
Name:rtcR
Synonyms:yhgB
Ordered Locus Names:b3422, JW3385
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12356. rtcR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Transcriptional regulatory protein RtcRPRO_0000081335Add
BLAST

Proteomic databases

PaxDbiP38035.
PRIDEiP38035.

Interactioni

Protein-protein interaction databases

BioGridi4261191. 13 interactions.
DIPiDIP-10812N.
IntActiP38035. 5 interactions.
STRINGi511145.b3422.

Structurei

3D structure databases

ProteinModelPortaliP38035.
SMRiP38035. Positions 158-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 424239Sigma-54 factor interactionPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 sigma-54 factor interaction domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CYB. Bacteria.
COG4650. LUCA.
HOGENOMiHOG000145396.
InParanoidiP38035.
KOiK14414.
OMAiYLVHITT.
PhylomeDBiP38035.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR009715. RtcR.
IPR017183. Sigma54_dep_tscrpt_act_RtcR.
IPR002078. Sigma_54_int.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
[Graphical view]
PANTHERiPTHR32071:SF14. PTHR32071:SF14. 1 hit.
PfamiPF06956. RtcR. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PIRSFiPIRSF037354. Txn_actvtr_RtcR. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00676. SIGMA54_INTERACT_2. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKTVAFGFV GTVLDYAGRG SQRWSKWRPT LCLCQQESLV IDRLELLHDA
60 70 80 90 100
RSRSLFETLK RDIASVSPET EVVSVEIELH NPWDFEEVYA CLHDFARGYE
110 120 130 140 150
FQPEKEDYLI HITTGTHVAQ ICWFLLAEAR YLPARLIQSS PPRKKEQPRG
160 170 180 190 200
PGEVTIIDLD LSRYNAIASR FAEERQQTLD FLKSGIATRN PHFNRMIEQI
210 220 230 240 250
EKVAIKSRAP ILLNGPTGAG KSFLARRILE LKQARHQFSG AFVEVNCATL
260 270 280 290 300
RGDTAMSTLF GHVKGAFTGA RESREGLLRS ANGGMLFLDE IGELGADEQA
310 320 330 340 350
MLLKAIEEKT FYPFGSDRQV SSDFQLIAGT VRDLRQLVAE GKFREDLYAR
360 370 380 390 400
INLWTFTLPG LRQRQEDIEP NLDYEVERHA SLTGDSVRFN TEARRAWLAF
410 420 430 440 450
ATSPQATWRG NFRELSASVT RMATFATSGR ITLDVVEDEI NRLRYNWQES
460 470 480 490 500
RPSALTALLG AEAENIDLFD RMQLEHVIAI CRQAKSLSAA GRQLFDVSRQ
510 520 530
GKASVNDADR LRKYLARFGL TWEAVQDQHS SS
Length:532
Mass (Da):60,299
Last modified:November 1, 1995 - v2
Checksum:i86351442491E04DD
GO

Sequence cautioni

The sequence X07520 differs from that shown. Reason: Frameshift at positions 386 and 422. Curated
The sequence X07520 differs from that shown. Reason: Erroneous termination at position 511. Translated as Leu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58220.1.
U00096 Genomic DNA. Translation: AAC76447.1.
AP009048 Genomic DNA. Translation: BAE77870.1.
X07520 Genomic DNA. No translation available.
M96795 Genomic DNA. No translation available.
PIRiA65138.
RefSeqiNP_417880.1. NC_000913.3.
WP_001232948.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76447; AAC76447; b3422.
BAE77870; BAE77870; BAE77870.
GeneIDi947928.
KEGGiecj:JW3385.
eco:b3422.
PATRICi32122280. VBIEscCol129921_3517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58220.1.
U00096 Genomic DNA. Translation: AAC76447.1.
AP009048 Genomic DNA. Translation: BAE77870.1.
X07520 Genomic DNA. No translation available.
M96795 Genomic DNA. No translation available.
PIRiA65138.
RefSeqiNP_417880.1. NC_000913.3.
WP_001232948.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP38035.
SMRiP38035. Positions 158-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261191. 13 interactions.
DIPiDIP-10812N.
IntActiP38035. 5 interactions.
STRINGi511145.b3422.

Proteomic databases

PaxDbiP38035.
PRIDEiP38035.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76447; AAC76447; b3422.
BAE77870; BAE77870; BAE77870.
GeneIDi947928.
KEGGiecj:JW3385.
eco:b3422.
PATRICi32122280. VBIEscCol129921_3517.

Organism-specific databases

EchoBASEiEB2259.
EcoGeneiEG12356. rtcR.

Phylogenomic databases

eggNOGiENOG4105CYB. Bacteria.
COG4650. LUCA.
HOGENOMiHOG000145396.
InParanoidiP38035.
KOiK14414.
OMAiYLVHITT.
PhylomeDBiP38035.

Enzyme and pathway databases

BioCyciEcoCyc:EG12356-MONOMER.
ECOL316407:JW3385-MONOMER.

Miscellaneous databases

PROiP38035.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR009715. RtcR.
IPR017183. Sigma54_dep_tscrpt_act_RtcR.
IPR002078. Sigma_54_int.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
[Graphical view]
PANTHERiPTHR32071:SF14. PTHR32071:SF14. 1 hit.
PfamiPF06956. RtcR. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PIRSFiPIRSF037354. Txn_actvtr_RtcR. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00676. SIGMA54_INTERACT_2. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTCR_ECOLI
AccessioniPrimary (citable) accession number: P38035
Secondary accession number(s): Q2M786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.