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Protein

Arginine utilization regulatory protein RocR

Gene

rocR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of arginine catabolism. Controls the transcription of the two operons rocABC and rocDEF and probably acts by binding to the corresponding upstream activating sequences.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi171 – 1788ATPPROSITE-ProRule annotation
Nucleotide bindingi233 – 24210ATPPROSITE-ProRule annotation
DNA bindingi434 – 45320H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • arginine metabolic process Source: UniProtKB
  • phosphorelay signal transduction system Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Arginine metabolism, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU40350-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine utilization regulatory protein RocR
Gene namesi
Name:rocR
Ordered Locus Names:BSU40350
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene do not grow in presence of arginine as sole nitrogen source.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Arginine utilization regulatory protein RocRPRO_0000081218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 5714-aspartylphosphateBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP38022.

Expressioni

Inductioni

Repressed by RocR itself.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100021766.

Structurei

3D structure databases

ProteinModelPortaliP38022.
SMRiP38022. Positions 135-454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 372230Sigma-54 factor interactionPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PAS (PER-ARNT-SIM) domain.Curated
Contains 1 sigma-54 factor interaction domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108JUB. Bacteria.
COG3829. LUCA.
HOGENOMiHOG000058487.
InParanoidiP38022.
KOiK06714.
OMAiHELECIP.
PhylomeDBiP38022.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR000014. PAS.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF13426. PAS_9. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38022-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKDSEFLTL VFQSILDEID VGLHVVDEHG NTIVYNNKMM QIEDMEKHDV
60 70 80 90 100
LNKNLMDVFM FSKQQDSTLV QALQEGKTIK NVKQSYFNNK GQEITTINHT
110 120 130 140 150
YPIVQDGKIR GAVEIAKDVT KLERLIRENM NKKGSTTYTF DSILGTSPAI
160 170 180 190 200
QDVIENAKRA TRTSSSVLLA GETGTGKELF AQSIHNGSDR SGGPFISQNC
210 220 230 240 250
AALPDSLVES ILFGTKKGAF TGAVDQPGLF EQAHGGTLLL DEINSLNLSL
260 270 280 290 300
QAKLLRALQE RKIRRIGSTK DTPIDVRIIA TMNEDPIDAI AGERMRKDLY
310 320 330 340 350
YRLSVVTLII PPLRERKEDI LLLASEFIQK NNHLFQMNVE HISDDVKQFF
360 370 380 390 400
LSYDWPGNIR ELEHMIEGAM NFMTDEQTIT ASHLPYQYRM KIKPADIPEP
410 420 430 440 450
ETPRHQPAAD LKEKMESFEK YVIENVLRKH GHNISKAAQE LGISRQSLQY
460
RLKKFSHSSN E
Length:461
Mass (Da):52,177
Last modified:August 29, 2003 - v2
Checksum:i58850E485E32C226
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1572NA → KP in AAA19792 (PubMed:8113162).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22006 Unassigned DNA. Translation: AAA19792.1.
D78193 Genomic DNA. Translation: BAA11294.1.
AL009126 Genomic DNA. Translation: CAB16072.1.
PIRiA53370.
RefSeqiNP_391915.1. NC_000964.3.
WP_003244510.1. NZ_JNCM01000034.1.

Genome annotation databases

EnsemblBacteriaiCAB16072; CAB16072; BSU40350.
GeneIDi937769.
KEGGibsu:BSU40350.
PATRICi18980142. VBIBacSub10457_4233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22006 Unassigned DNA. Translation: AAA19792.1.
D78193 Genomic DNA. Translation: BAA11294.1.
AL009126 Genomic DNA. Translation: CAB16072.1.
PIRiA53370.
RefSeqiNP_391915.1. NC_000964.3.
WP_003244510.1. NZ_JNCM01000034.1.

3D structure databases

ProteinModelPortaliP38022.
SMRiP38022. Positions 135-454.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100021766.

Proteomic databases

PaxDbiP38022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB16072; CAB16072; BSU40350.
GeneIDi937769.
KEGGibsu:BSU40350.
PATRICi18980142. VBIBacSub10457_4233.

Phylogenomic databases

eggNOGiENOG4108JUB. Bacteria.
COG3829. LUCA.
HOGENOMiHOG000058487.
InParanoidiP38022.
KOiK06714.
OMAiHELECIP.
PhylomeDBiP38022.

Enzyme and pathway databases

BioCyciBSUB:BSU40350-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR000014. PAS.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
IPR025944. Sigma_54_int_dom_CS.
[Graphical view]
PfamiPF02954. HTH_8. 1 hit.
PF13426. PAS_9. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS00688. SIGMA54_INTERACT_3. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROCR_BACSU
AccessioniPrimary (citable) accession number: P38022
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 29, 2003
Last modified: September 7, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.