Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P38004 (FABG_CHLTR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
Ordered Locus Names:CT_237
OrganismChlamydia trachomatis (strain D/UW-3/Cx) [Reference proteome] [HAMAP]
Taxonomic identifier272561 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2482483-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054671

Regions

Nucleotide binding14 – 174NADP By similarity
Nucleotide binding65 – 662NADP By similarity
Nucleotide binding157 – 1615NADP By similarity

Sites

Active site1571Proton acceptor By similarity
Binding site921NADP; via carbonyl oxygen By similarity
Binding site1441Substrate By similarity
Binding site1901NADP; via amide nitrogen and carbonyl oxygen By similarity

Experimental info

Sequence conflict31G → T in AAC67830. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P38004 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 508A1F3CD64F4EDE

FASTA24826,020
        10         20         30         40         50         60 
MSGLLVNKTA IVTGGSRGIG FSIAKLFAEQ GANVQIWGIN GEAGQAAAQT LSEQTGRQVS 

        70         80         90        100        110        120 
FALVDVSKND MVSAQVQNFL AEYNTIDVIV NNAGITRDAL LMRMSEEEWS SVINTNLGSI 

       130        140        150        160        170        180 
YNVCSAVIRP MIKARSGAII NISSIVGLRG SPGQTNYAAA KAGIIGFSKA LSKEVGSKNI 

       190        200        210        220        230        240 
RVNCIAPGFI DTDMTKSLND NLKNEWLKGV PLGRVGMPEE IAKAALFLAS DGSSYITGQV 


LSVDGGMA 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D/UW-3/Cx.
[2]Bini L., Santucci A., Magi B., Marzocchi B., Sanchez-Campillo M., Comanducci M., Christianen G., Birkelund S., Vtretou E., Ratti G., Pallini V.
Submitted (SEP-1994) to UniProtKB
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
Strain: L2/434/Bu.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001273 Genomic DNA. Translation: AAC67830.1.
PIRF71538.
RefSeqNP_219742.1. NC_000117.1.

3D structure databases

ProteinModelPortalP38004.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272561.CT237.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC67830; AAC67830; CT_237.
GeneID884887.
KEGGctr:CT_237.
PATRIC20379991. VBIChlTra43535_0254.

Phylogenomic databases

eggNOGCOG1028.
KOK00059.
OMAMESAMGE.
OrthoDBEOG6N3CR8.
ProtClustDBPRK05653.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_CHLTR
AccessionPrimary (citable) accession number: P38004
Secondary accession number(s): O84240
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways