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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92NADP; via carbonyl oxygenBy similarity1
Binding sitei144SubstrateBy similarity1
Active sitei157Proton acceptorPROSITE-ProRule annotation1
Binding sitei190NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 17NADPBy similarity4
Nucleotide bindingi65 – 66NADPBy similarity2
Nucleotide bindingi157 – 161NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNADP

Enzyme and pathway databases

BioCyciCTRA272561:G1G18-251-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:CT_237
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546711 – 2483-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST248

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP38004
SMRiP38004
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHR Bacteria
ENOG410XNW1 LUCA
InParanoidiP38004
KOiK00059
OMAiGSRNIRC

Family and domain databases

InterProiView protein in InterPro
IPR011284 3oxo_ACP_reduc
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01830 3oxo_ACP_reduc, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P38004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLLVNKTA IVTGGSRGIG FSIAKLFAEQ GANVQIWGIN GEAGQAAAQT
60 70 80 90 100
LSEQTGRQVS FALVDVSKND MVSAQVQNFL AEYNTIDVIV NNAGITRDAL
110 120 130 140 150
LMRMSEEEWS SVINTNLGSI YNVCSAVIRP MIKARSGAII NISSIVGLRG
160 170 180 190 200
SPGQTNYAAA KAGIIGFSKA LSKEVGSKNI RVNCIAPGFI DTDMTKSLND
210 220 230 240
NLKNEWLKGV PLGRVGMPEE IAKAALFLAS DGSSYITGQV LSVDGGMA
Length:248
Mass (Da):26,020
Last modified:January 23, 2007 - v3
Checksum:i508A1F3CD64F4EDE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3G → T in AAC67830 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001273 Genomic DNA Translation: AAC67830.1
PIRiF71538
RefSeqiNP_219742.1, NC_000117.1
WP_009871584.1, NC_000117.1

Genome annotation databases

EnsemblBacteriaiAAC67830; AAC67830; CT_237
GeneIDi35556445
884887
KEGGictr:CT_237
PATRICifig|272561.5.peg.254

Similar proteinsi

Entry informationi

Entry nameiFABG_CHLTR
AccessioniPrimary (citable) accession number: P38004
Secondary accession number(s): O84240
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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