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Protein

T-cell surface antigen CD2

Gene

CD2

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

CD2 interacts with lymphocyte function-associated antigen (LFA-3) to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface antigen CD2
Alternative name(s):
CD_antigen: CD2
Gene namesi
Name:CD2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 205ExtracellularSequence analysisAdd BLAST181
Transmembranei206 – 230HelicalSequence analysisAdd BLAST25
Topological domaini231 – 347CytoplasmicSequence analysisAdd BLAST117

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001459925 – 347T-cell surface antigen CD2Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi134 ↔ 199By similarity
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi141 ↔ 182By similarity
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP37998.
PRIDEiP37998.

Expressioni

Tissue specificityi

Expressed in spleen and thymus.

Interactioni

Subunit structurei

Interacts with PSTPIP1.By similarity

Protein-protein interaction databases

MINTiMINT-1769693.
STRINGi9796.ENSECAP00000017053.

Structurei

3D structure databases

ProteinModelPortaliP37998.
SMRiP37998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 123Ig-like V-typeAdd BLAST99
Domaini124 – 199Ig-like C2-typeAdd BLAST76
Repeati283 – 28917
Repeati290 – 29627
Repeati297 – 30337

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni283 – 3033 X 7 AA tandem repeats of H-R-P-[QL]-[AVP]-P-GAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi277 – 340Pro-richAdd BLAST64

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW98. Eukaryota.
ENOG410Y7BE. LUCA.
GeneTreeiENSGT00390000009232.
HOGENOMiHOG000276890.
HOVERGENiHBG000262.
InParanoidiP37998.
KOiK06449.
OMAiGTQVHQQ.
OrthoDBiEOG091G0M7A.
TreeFamiTF335971.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR015632. CD2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF05790. C2-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01870. CD2ANTIGEN.
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLACKLLAS FLLIFFFSSK GAVSKKNITI LGALERDINL DIPAFQMSEH
60 70 80 90 100
VEDIQWSKGK TKIAKFKNGS MTFQKDKTYE VLKNGTLKIK HLERIHEGTY
110 120 130 140 150
KVDAYDSDGK NVLEETFHLS LLEMVSKPNI SWSCTNTTLT CEVTKGTDFE
160 170 180 190 200
LKLYLNGRMI QKSPRKVIVY KRASNQIASF KCTANNTVSE ESSSVVIRCT
210 220 230 240 250
EKGLDIYLIS GICGGGIILF VFLALLIFYI SKRKKQNSRR NDEELEIRAH
260 270 280 290 300
KVISEERGRK PHQIPGSTPL NPAASQPPPP PSHRPQAPGH RPQVPGHRPL
310 320 330 340
PPGHRVQHQQ QKRPAPTPGT QAHQQKGPPL PRPRVQPKPP RGATENS
Length:347
Mass (Da):38,864
Last modified:October 1, 1994 - v1
Checksum:i0529606A2783D5E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69884 mRNA. Translation: CAA49511.1.
PIRiS41638.
RefSeqiNP_001078903.1. NM_001085434.1.
UniGeneiEca.2146.

Genome annotation databases

EnsembliENSECAT00000020758; ENSECAP00000017053; ENSECAG00000019437.
GeneIDi100034205.
KEGGiecb:100034205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69884 mRNA. Translation: CAA49511.1.
PIRiS41638.
RefSeqiNP_001078903.1. NM_001085434.1.
UniGeneiEca.2146.

3D structure databases

ProteinModelPortaliP37998.
SMRiP37998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1769693.
STRINGi9796.ENSECAP00000017053.

Proteomic databases

PaxDbiP37998.
PRIDEiP37998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000020758; ENSECAP00000017053; ENSECAG00000019437.
GeneIDi100034205.
KEGGiecb:100034205.

Organism-specific databases

CTDi914.

Phylogenomic databases

eggNOGiENOG410IW98. Eukaryota.
ENOG410Y7BE. LUCA.
GeneTreeiENSGT00390000009232.
HOGENOMiHOG000276890.
HOVERGENiHBG000262.
InParanoidiP37998.
KOiK06449.
OMAiGTQVHQQ.
OrthoDBiEOG091G0M7A.
TreeFamiTF335971.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR015632. CD2.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR008424. Ig_C2-set.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF05790. C2-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01870. CD2ANTIGEN.
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCD2_HORSE
AccessioniPrimary (citable) accession number: P37998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.