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Protein

Interleukin-2

Gene

IL2

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:IL2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001548321 – 149Interleukin-2Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi78 ↔ 121By similarity
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP37997
PRIDEiP37997

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000013353

Structurei

3D structure databases

ProteinModelPortaliP37997
SMRiP37997
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
HOGENOMiHOG000048727
HOVERGENiHBG007496
InParanoidiP37997
KOiK05429

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRMQLLSCI ALTLAVLANS APTSSSKRET QQQLKQLQMD LKLLLEGVNN
60 70 80 90 100
NKNPKLSKIL TFKINMPKKA TELKHLQCLE EELKPLEEML KNFLSKDIKE
110 120 130 140
LMSNINVTVL GLKGSETRFT CEYDNETETI VEFLNKWITF CQSIISTLT
Length:149
Mass (Da):17,086
Last modified:November 1, 1995 - v2
Checksum:i051BB8C47A0114FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → K in CAA49190 (PubMed:8116217).Curated1
Sequence conflicti8S → A in CAA49190 (PubMed:8116217).Curated1
Sequence conflicti59I → M in CAA49190 (PubMed:8116217).Curated1
Sequence conflicti125N → D in CAA49190 (PubMed:8116217).Curated1
Sequence conflicti128E → G in CAA49190 (PubMed:8116217).Curated1
Sequence conflicti145I → F in CAA49190 (PubMed:8116217).Curated1
Sequence conflicti148L → M in CAA49190 (PubMed:8116217).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69393 mRNA Translation: CAA49190.1
L06009 mRNA Translation: AAA20134.1
PIRiS31391
RefSeqiNP_001078902.1, NM_001085433.2
UniGeneiEca.12635

Genome annotation databases

GeneIDi100034204
KEGGiecb:100034204

Similar proteinsi

Entry informationi

Entry nameiIL2_HORSE
AccessioniPrimary (citable) accession number: P37997
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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