P37986 (G6PD_DICD3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate 1-dehydrogenase
Short name=G6PD
EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	Dda3937_03574

Organism

Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) [Complete proteome] [HAMAP]

Taxonomic identifier

198628 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068121
Sites
	Active site	239	1	Proton acceptor By similarity
	Binding site	18	1	NADP By similarity
	Binding site	50	1	NADP By similarity
	Binding site	177	1	Substrate By similarity
	Binding site	181	1	Substrate By similarity
	Binding site	344	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P37986 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 67BE0D8DCA97D5A6	FASTA	491	56,034
	10 20 30 40 50 60 MAVTSTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGHIH PETRIIGVGR AEWDRDAYIK 70 80 90 100 110 120 VVREALETFL KEPLDPALWT TLSNRLDFCN LDVEDTEGFK RLGTMLDQQN RTTINYFAMP 130 140 150 160 170 180 PSTFGAICRG LGQAGLNKEP ARVVMEKPLG TNLASSRVIN NQVAEFFNEC QVYRIDHYLG 190 200 210 220 230 240 KETVLNLLAL RFANSLFANN WDNRTIDHVQ ITVAEEVGIE GRWGYFDQAG QMRDMIQNHL 250 260 270 280 290 300 LQILTMIAMS PPADLSTDRI RDEKVKVLRS LRRIDRSNVH EVTVRGQYTS GFVQGKKVPG 310 320 330 340 350 360 YLEEEGANKT SNTETFVAIR VDIDDWRWSG VPFYLRTGKR LPSKCSEVVV YFKNPALNLF 370 380 390 400 410 420 HDSYQQLPQN KLIIRLQPDE GVEIQILNKI PGLDHKHRLQ TTKLDLSFSE TFNQQHLADA 430 440 450 460 470 480 YERLLLETMR GIQALFVRRD EVEEAWKWVD SIMDAWAMDN DSPKPYQAGT WGPVASVAMI 490 TRDGRSWNEV E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular analysis of the Erwinia chrysanthemi region containing the kdgA and zwf genes." Hugouvieux-Cotte-Pattat N., Robert-Baudouy J. Mol. Microbiol. 11:67-75(1994) [PubMed: 8145647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 3937.
[2]	"Complete genome sequence of Dickeya dadantii 3937." International Erwinia Consortium Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 3937.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74866 Genomic DNA. Translation: CAA52858.1. CP002038 Genomic DNA. Translation: ADM98358.1.
PIR	S37053.
RefSeq	YP_003882915.1. NC_014500.1.
3D structure databases
ProteinModelPortal	P37986.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9733588.
GenomeReviews	Gene locus Dda3937_03574 in contig CP002038_GR.
KEGG	ddd:Dda3937_03574.
PATRIC	42316622. VBIDicDad25310_2134.
Organism-specific databases
CMR	Search...
Family and domain databases
InterPro	IPR001282. G6P_DH. IPR019796. G6P_DH_AS. IPR022675. G6P_DH_C. IPR022674. G6P_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00036.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
TIGRFAMs	TIGR00871. Zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_DICD3

Accession

Primary (citable) accession number: P37986
Secondary accession number(s): E0SB89

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program