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P37986 (G6PD_DICD3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:Dda3937_03574
OrganismDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) [Complete proteome] [HAMAP]
Taxonomic identifier198628 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglucose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Glucose-6-phosphate 1-dehydrogenase
PRO_0000068121

Sites

Active site2391Proton acceptor By similarity
Binding site181NADP By similarity
Binding site501NADP By similarity
Binding site1771Substrate By similarity
Binding site1811Substrate By similarity
Binding site3441Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P37986 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 67BE0D8DCA97D5A6

FASTA49156,034
        10         20         30         40         50         60 
MAVTSTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGHIH PETRIIGVGR AEWDRDAYIK 

        70         80         90        100        110        120 
VVREALETFL KEPLDPALWT TLSNRLDFCN LDVEDTEGFK RLGTMLDQQN RTTINYFAMP 

       130        140        150        160        170        180 
PSTFGAICRG LGQAGLNKEP ARVVMEKPLG TNLASSRVIN NQVAEFFNEC QVYRIDHYLG 

       190        200        210        220        230        240 
KETVLNLLAL RFANSLFANN WDNRTIDHVQ ITVAEEVGIE GRWGYFDQAG QMRDMIQNHL 

       250        260        270        280        290        300 
LQILTMIAMS PPADLSTDRI RDEKVKVLRS LRRIDRSNVH EVTVRGQYTS GFVQGKKVPG 

       310        320        330        340        350        360 
YLEEEGANKT SNTETFVAIR VDIDDWRWSG VPFYLRTGKR LPSKCSEVVV YFKNPALNLF 

       370        380        390        400        410        420 
HDSYQQLPQN KLIIRLQPDE GVEIQILNKI PGLDHKHRLQ TTKLDLSFSE TFNQQHLADA 

       430        440        450        460        470        480 
YERLLLETMR GIQALFVRRD EVEEAWKWVD SIMDAWAMDN DSPKPYQAGT WGPVASVAMI 

       490 
TRDGRSWNEV E 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of the Erwinia chrysanthemi region containing the kdgA and zwf genes."
Hugouvieux-Cotte-Pattat N., Robert-Baudouy J.
Mol. Microbiol. 11:67-75(1994) [PubMed: 8145647] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 3937.
[2]"Complete genome sequence of Dickeya dadantii 3937."
International Erwinia Consortium
Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 3937.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74866 Genomic DNA. Translation: CAA52858.1.
CP002038 Genomic DNA. Translation: ADM98358.1.
PIRS37053.
RefSeqYP_003882915.1. NC_014500.1.

3D structure databases

ProteinModelPortalP37986.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9733588.
GenomeReviewsGene locus Dda3937_03574 in contig CP002038_GR.
KEGGddd:Dda3937_03574.
PATRIC42316622. VBIDicDad25310_2134.

Organism-specific databases

CMRSearch...

Family and domain databases

InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00036.
PANTHERPTHR23429. G6PDH. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. Zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_DICD3
AccessionPrimary (citable) accession number: P37986
Secondary accession number(s): E0SB89
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families