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P37986

- G6PD_DICD3

UniProt

P37986 - G6PD_DICD3

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501NADPUniRule annotation
    Binding sitei147 – 1471NADPUniRule annotation
    Binding sitei177 – 1771SubstrateUniRule annotation
    Binding sitei181 – 1811SubstrateUniRule annotation
    Binding sitei215 – 2151SubstrateUniRule annotation
    Binding sitei234 – 2341SubstrateUniRule annotation
    Active sitei239 – 2391Proton acceptorUniRule annotation
    Binding sitei339 – 3391SubstrateUniRule annotation
    Binding sitei344 – 3441SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi92 – 932NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciDDAD198628:GHFQ-2203-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:Dda3937_03574
    OrganismiDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
    Taxonomic identifieri198628 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
    ProteomesiUP000006859: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Glucose-6-phosphate 1-dehydrogenasePRO_0000068121Add
    BLAST

    Proteomic databases

    PRIDEiP37986.

    Structurei

    3D structure databases

    ProteinModelPortaliP37986.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiYCVTAVS.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37986-1 [UniParc]FASTAAdd to Basket

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    MAVTSTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGHIH PETRIIGVGR    50
    AEWDRDAYIK VVREALETFL KEPLDPALWT TLSNRLDFCN LDVEDTEGFK 100
    RLGTMLDQQN RTTINYFAMP PSTFGAICRG LGQAGLNKEP ARVVMEKPLG 150
    TNLASSRVIN NQVAEFFNEC QVYRIDHYLG KETVLNLLAL RFANSLFANN 200
    WDNRTIDHVQ ITVAEEVGIE GRWGYFDQAG QMRDMIQNHL LQILTMIAMS 250
    PPADLSTDRI RDEKVKVLRS LRRIDRSNVH EVTVRGQYTS GFVQGKKVPG 300
    YLEEEGANKT SNTETFVAIR VDIDDWRWSG VPFYLRTGKR LPSKCSEVVV 350
    YFKNPALNLF HDSYQQLPQN KLIIRLQPDE GVEIQILNKI PGLDHKHRLQ 400
    TTKLDLSFSE TFNQQHLADA YERLLLETMR GIQALFVRRD EVEEAWKWVD 450
    SIMDAWAMDN DSPKPYQAGT WGPVASVAMI TRDGRSWNEV E 491
    Length:491
    Mass (Da):56,034
    Last modified:October 1, 1994 - v1
    Checksum:i67BE0D8DCA97D5A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74866 Genomic DNA. Translation: CAA52858.1.
    CP002038 Genomic DNA. Translation: ADM98358.1.
    PIRiS37053.
    RefSeqiYP_003882915.1. NC_014500.1.

    Genome annotation databases

    EnsemblBacteriaiADM98358; ADM98358; Dda3937_03574.
    GeneIDi9733588.
    KEGGiddd:Dda3937_03574.
    PATRICi42316622. VBIDicDad25310_2134.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X74866 Genomic DNA. Translation: CAA52858.1 .
    CP002038 Genomic DNA. Translation: ADM98358.1 .
    PIRi S37053.
    RefSeqi YP_003882915.1. NC_014500.1.

    3D structure databases

    ProteinModelPortali P37986.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P37986.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM98358 ; ADM98358 ; Dda3937_03574 .
    GeneIDi 9733588.
    KEGGi ddd:Dda3937_03574.
    PATRICi 42316622. VBIDicDad25310_2134.

    Phylogenomic databases

    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi YCVTAVS.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci DDAD198628:GHFQ-2203-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of the Erwinia chrysanthemi region containing the kdgA and zwf genes."
      Hugouvieux-Cotte-Pattat N., Robert-Baudouy J.
      Mol. Microbiol. 11:67-75(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 3937.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 3937.

    Entry informationi

    Entry nameiG6PD_DICD3
    AccessioniPrimary (citable) accession number: P37986
    Secondary accession number(s): E0SB89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3