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P37986

- G6PD_DICD3

UniProt

P37986 - G6PD_DICD3

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501NADPUniRule annotation
Binding sitei147 – 1471NADPUniRule annotation
Binding sitei177 – 1771SubstrateUniRule annotation
Binding sitei181 – 1811SubstrateUniRule annotation
Binding sitei215 – 2151SubstrateUniRule annotation
Binding sitei234 – 2341SubstrateUniRule annotation
Active sitei239 – 2391Proton acceptorUniRule annotation
Binding sitei339 – 3391SubstrateUniRule annotation
Binding sitei344 – 3441SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi92 – 932NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciDDAD198628:GHFQ-2203-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:Dda3937_03574
OrganismiDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Taxonomic identifieri198628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
ProteomesiUP000006859: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Glucose-6-phosphate 1-dehydrogenasePRO_0000068121Add
BLAST

Proteomic databases

PRIDEiP37986.

Structurei

3D structure databases

ProteinModelPortaliP37986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000046191.
KOiK00036.
OMAiYCVTAVS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37986-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVTSTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGHIH PETRIIGVGR
60 70 80 90 100
AEWDRDAYIK VVREALETFL KEPLDPALWT TLSNRLDFCN LDVEDTEGFK
110 120 130 140 150
RLGTMLDQQN RTTINYFAMP PSTFGAICRG LGQAGLNKEP ARVVMEKPLG
160 170 180 190 200
TNLASSRVIN NQVAEFFNEC QVYRIDHYLG KETVLNLLAL RFANSLFANN
210 220 230 240 250
WDNRTIDHVQ ITVAEEVGIE GRWGYFDQAG QMRDMIQNHL LQILTMIAMS
260 270 280 290 300
PPADLSTDRI RDEKVKVLRS LRRIDRSNVH EVTVRGQYTS GFVQGKKVPG
310 320 330 340 350
YLEEEGANKT SNTETFVAIR VDIDDWRWSG VPFYLRTGKR LPSKCSEVVV
360 370 380 390 400
YFKNPALNLF HDSYQQLPQN KLIIRLQPDE GVEIQILNKI PGLDHKHRLQ
410 420 430 440 450
TTKLDLSFSE TFNQQHLADA YERLLLETMR GIQALFVRRD EVEEAWKWVD
460 470 480 490
SIMDAWAMDN DSPKPYQAGT WGPVASVAMI TRDGRSWNEV E
Length:491
Mass (Da):56,034
Last modified:October 1, 1994 - v1
Checksum:i67BE0D8DCA97D5A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74866 Genomic DNA. Translation: CAA52858.1.
CP002038 Genomic DNA. Translation: ADM98358.1.
PIRiS37053.
RefSeqiYP_003882915.1. NC_014500.1.

Genome annotation databases

EnsemblBacteriaiADM98358; ADM98358; Dda3937_03574.
GeneIDi9733588.
KEGGiddd:Dda3937_03574.
PATRICi42316622. VBIDicDad25310_2134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74866 Genomic DNA. Translation: CAA52858.1 .
CP002038 Genomic DNA. Translation: ADM98358.1 .
PIRi S37053.
RefSeqi YP_003882915.1. NC_014500.1.

3D structure databases

ProteinModelPortali P37986.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P37986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM98358 ; ADM98358 ; Dda3937_03574 .
GeneIDi 9733588.
KEGGi ddd:Dda3937_03574.
PATRICi 42316622. VBIDicDad25310_2134.

Phylogenomic databases

HOGENOMi HOG000046191.
KOi K00036.
OMAi YCVTAVS.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci DDAD198628:GHFQ-2203-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of the Erwinia chrysanthemi region containing the kdgA and zwf genes."
    Hugouvieux-Cotte-Pattat N., Robert-Baudouy J.
    Mol. Microbiol. 11:67-75(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3937.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3937.

Entry informationi

Entry nameiG6PD_DICD3
AccessioniPrimary (citable) accession number: P37986
Secondary accession number(s): E0SB89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3