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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathway: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (ybhE), 6-phosphogluconolactonase (ybhE)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501NADPUniRule annotation
Binding sitei147 – 1471NADPUniRule annotation
Binding sitei177 – 1771SubstrateUniRule annotation
Binding sitei181 – 1811SubstrateUniRule annotation
Binding sitei215 – 2151SubstrateUniRule annotation
Binding sitei234 – 2341SubstrateUniRule annotation
Active sitei239 – 2391Proton acceptorUniRule annotation
Binding sitei339 – 3391SubstrateUniRule annotation
Binding sitei344 – 3441SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi92 – 932NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciDDAD198628:GHFQ-2203-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:Dda3937_03574
OrganismiDickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Taxonomic identifieri198628 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
ProteomesiUP000006859 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Glucose-6-phosphate 1-dehydrogenasePRO_0000068121Add
BLAST

Proteomic databases

PRIDEiP37986.

Interactioni

Protein-protein interaction databases

STRINGi198628.Dda3937_03574.

Structurei

3D structure databases

ProteinModelPortaliP37986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000046191.
OMAiHNLQTTK.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTSTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGHIH PETRIIGVGR
60 70 80 90 100
AEWDRDAYIK VVREALETFL KEPLDPALWT TLSNRLDFCN LDVEDTEGFK
110 120 130 140 150
RLGTMLDQQN RTTINYFAMP PSTFGAICRG LGQAGLNKEP ARVVMEKPLG
160 170 180 190 200
TNLASSRVIN NQVAEFFNEC QVYRIDHYLG KETVLNLLAL RFANSLFANN
210 220 230 240 250
WDNRTIDHVQ ITVAEEVGIE GRWGYFDQAG QMRDMIQNHL LQILTMIAMS
260 270 280 290 300
PPADLSTDRI RDEKVKVLRS LRRIDRSNVH EVTVRGQYTS GFVQGKKVPG
310 320 330 340 350
YLEEEGANKT SNTETFVAIR VDIDDWRWSG VPFYLRTGKR LPSKCSEVVV
360 370 380 390 400
YFKNPALNLF HDSYQQLPQN KLIIRLQPDE GVEIQILNKI PGLDHKHRLQ
410 420 430 440 450
TTKLDLSFSE TFNQQHLADA YERLLLETMR GIQALFVRRD EVEEAWKWVD
460 470 480 490
SIMDAWAMDN DSPKPYQAGT WGPVASVAMI TRDGRSWNEV E
Length:491
Mass (Da):56,034
Last modified:October 1, 1994 - v1
Checksum:i67BE0D8DCA97D5A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74866 Genomic DNA. Translation: CAA52858.1.
CP002038 Genomic DNA. Translation: ADM98358.1.
PIRiS37053.
RefSeqiWP_013317812.1. NC_014500.1.

Genome annotation databases

EnsemblBacteriaiADM98358; ADM98358; Dda3937_03574.
GeneIDi9733588.
PATRICi42316622. VBIDicDad25310_2134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74866 Genomic DNA. Translation: CAA52858.1.
CP002038 Genomic DNA. Translation: ADM98358.1.
PIRiS37053.
RefSeqiWP_013317812.1. NC_014500.1.

3D structure databases

ProteinModelPortaliP37986.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198628.Dda3937_03574.

Proteomic databases

PRIDEiP37986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADM98358; ADM98358; Dda3937_03574.
GeneIDi9733588.
PATRICi42316622. VBIDicDad25310_2134.

Phylogenomic databases

HOGENOMiHOG000046191.
OMAiHNLQTTK.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
BioCyciDDAD198628:GHFQ-2203-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of the Erwinia chrysanthemi region containing the kdgA and zwf genes."
    Hugouvieux-Cotte-Pattat N., Robert-Baudouy J.
    Mol. Microbiol. 11:67-75(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3937.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3937.

Entry informationi

Entry nameiG6PD_DICD3
AccessioniPrimary (citable) accession number: P37986
Secondary accession number(s): E0SB89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.