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Protein

RNA polymerase sigma-F factor

Gene

sigF

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is required for normal spore maturation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi254 – 273H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Sigma factor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma-F factor
Gene namesi
Name:sigF
Synonyms:rpoX
Ordered Locus Names:SCO4035
ORF Names:2SCD60.01c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000939801 – 287RNA polymerase sigma-F factorAdd BLAST287

Interactioni

Protein-protein interaction databases

IntActiP37971. 1 interactor.
STRINGi100226.SCO4035.

Structurei

3D structure databases

ProteinModelPortaliP37971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi91 – 104Polymerase core bindingAdd BLAST14

Sequence similaritiesi

Belongs to the sigma-70 factor family. SigB subfamily.Curated

Phylogenomic databases

eggNOGiENOG4108N6D. Bacteria.
COG1191. LUCA.
HOGENOMiHOG000270270.
InParanoidiP37971.
KOiK03090.
OMAiRSANRIE.
OrthoDBiPOG091H09IG.
PhylomeDBiP37971.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR014322. RNA_pol_sigma-B/F/G.
IPR000943. RNA_pol_sigma70.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02980. SigBFG. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASTAPQAP PAPPAQAQAQ APAQAQEAPA PQRSRGADTR ALTQVLFGEL
60 70 80 90 100
KGLAPGTPEH DRVRAALIEA NLPLVRYAAA RFRSRNEPME DVVQVGTIGL
110 120 130 140 150
INAIDRFDPE RGVQFPTFAM PTVVGEIKRY FRDNVRTVHV PRRLHELWVQ
160 170 180 190 200
VNSATEDLTT AFGRSPTTAE IAERLRITEE EVLSCIEAGR SYHATSLEAA
210 220 230 240 250
QEGDGLPGLL DRLGYEDPAL DGVEHRDLVR HLLVQLPERE QRILLLRYYS
260 270 280
NLTQSQISAE LGVSQMHVSR LLARSFQRLR SANRIDA
Length:287
Mass (Da):31,788
Last modified:October 1, 1994 - v1
Checksum:i89F3E15B57437AE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11648 Genomic DNA. Translation: AAA93052.1.
AL939118 Genomic DNA. Translation: CAC32306.1.
PIRiS69774.
RefSeqiNP_628217.1. NC_003888.3.
WP_011029398.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAC32306; CAC32306; CAC32306.
GeneIDi1099471.
KEGGisco:SCO4035.
PATRICi23737840. VBIStrCoe124346_4098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11648 Genomic DNA. Translation: AAA93052.1.
AL939118 Genomic DNA. Translation: CAC32306.1.
PIRiS69774.
RefSeqiNP_628217.1. NC_003888.3.
WP_011029398.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP37971.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP37971. 1 interactor.
STRINGi100226.SCO4035.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC32306; CAC32306; CAC32306.
GeneIDi1099471.
KEGGisco:SCO4035.
PATRICi23737840. VBIStrCoe124346_4098.

Phylogenomic databases

eggNOGiENOG4108N6D. Bacteria.
COG1191. LUCA.
HOGENOMiHOG000270270.
InParanoidiP37971.
KOiK03090.
OMAiRSANRIE.
OrthoDBiPOG091H09IG.
PhylomeDBiP37971.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR014322. RNA_pol_sigma-B/F/G.
IPR000943. RNA_pol_sigma70.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02980. SigBFG. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOF_STRCO
AccessioniPrimary (citable) accession number: P37971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.