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Protein

Ribonuclease PH

Gene

rph

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.By similarity

Catalytic activityi

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease PH (EC:2.7.7.56)
Short name:
RNase PH
Alternative name(s):
tRNA nucleotidyltransferase
Gene namesi
Name:rph
Synonyms:rnpH, rphA
Ordered Locus Names:ML1174
ORF Names:B1549_C1_182
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Ribonuclease PHPRO_0000139910Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1174.

Structurei

3D structure databases

ProteinModelPortaliP37939.
SMRiP37939. Positions 4-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.Curated

Phylogenomic databases

eggNOGiENOG4105ED0. Bacteria.
COG0689. LUCA.
HOGENOMiHOG000229516.
KOiK00989.
OMAiKGKGQGW.
OrthoDBiPOG091H03ML.

Family and domain databases

CDDicd11362. RNase_PH_bact. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00564. RNase_PH. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR01966. RNasePH. 1 hit.
PROSITEiPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTRADGRLD DELRAVVITR GFTEHPAGSV LIEFGHTKVM CTASPTEGVP
60 70 80 90 100
RWRKGSGKGW LTAEYAMLPS ATHTRSERES VKGRLSGRTQ EISRLIGRSL
110 120 130 140 150
RACIDLAALG ENTIAVDCDV LQADGGTRTA AVTGAYVALA DAVTYLSAAG
160 170 180 190 200
RLLDPRPLSC AIAAVSVGVV DGRIRVDLSY EEDSRAEVDM NVIATDTGTL
210 220 230 240 250
VEIQGTGEGA TFPRSTLDKL LDMALGACDK LFVAQRDALA LPYQGMSPEG

PPPPKAFGS
Length:259
Mass (Da):27,365
Last modified:October 1, 1994 - v1
Checksum:iA258C5C054D17A59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00014 Genomic DNA. Translation: AAA50880.1.
AL583921 Genomic DNA. Translation: CAC31555.1.
PIRiS72788.
RefSeqiNP_301856.1. NC_002677.1.
WP_010908180.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31555; CAC31555; CAC31555.
GeneIDi910272.
KEGGimle:ML1174.
PATRICi18054380. VBIMycLep78757_2131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00014 Genomic DNA. Translation: AAA50880.1.
AL583921 Genomic DNA. Translation: CAC31555.1.
PIRiS72788.
RefSeqiNP_301856.1. NC_002677.1.
WP_010908180.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP37939.
SMRiP37939. Positions 4-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1174.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31555; CAC31555; CAC31555.
GeneIDi910272.
KEGGimle:ML1174.
PATRICi18054380. VBIMycLep78757_2131.

Organism-specific databases

LepromaiML1174.

Phylogenomic databases

eggNOGiENOG4105ED0. Bacteria.
COG0689. LUCA.
HOGENOMiHOG000229516.
KOiK00989.
OMAiKGKGQGW.
OrthoDBiPOG091H03ML.

Family and domain databases

CDDicd11362. RNase_PH_bact. 1 hit.
Gene3Di3.30.230.70. 1 hit.
HAMAPiMF_00564. RNase_PH. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR002381. RNase_PH_bac-type.
IPR018336. RNase_PH_CS.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
TIGRFAMsiTIGR01966. RNasePH. 1 hit.
PROSITEiPS01277. RIBONUCLEASE_PH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNPH_MYCLE
AccessioniPrimary (citable) accession number: P37939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.