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P37932

- PMIP_SCHCO

UniProt

P37932 - PMIP_SCHCO

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Protein
Mitochondrial intermediate peptidase
Gene
OCT1, MEP, MIP
Organism
Schizophyllum commune (Split gill fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi558 – 5581Zinc; catalytic By similarity
Active sitei559 – 5591 By similarity
Metal bindingi562 – 5621Zinc; catalytic By similarity
Metal bindingi565 – 5651Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:MEP, MIP
OrganismiSchizophyllum commune (Split gill fungus)
Taxonomic identifieri5334 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesSchizophyllaceaeSchizophyllum

Subcellular locationi

Mitochondrion matrix 1 Publication

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828Mitochondrion Reviewed prediction
Add
BLAST
Chaini29 – 775747Mitochondrial intermediate peptidase
PRO_0000028581Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP37932.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37932-1 [UniParc]FASTAAdd to Basket

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MIARPARDVL SSATKKQFRF RGCLAARHEP YHTSTSRAGQ VAILPATTDD    50
KTLVSVFDSP RSNAKLSAFA TTGLFNHSTV THPRALNSIA QGTLIRAHVL 100
TNRILRAKES REELFKVVKN LDRLSDMLCS VIDLCELVRN SHPDRAWVEA 150
ANDAYEGLCQ TMNELNTHVG LYDVLKIVLS DPEIVKSLSP EAYRTAMIFW 200
NDFEKSAINL PAKEREEFVA LSSEIISLGR MFLEETTAAR PPAKIPPSDL 250
AGLKDKGMGV RLQLQAQFTQ RDLHVYPGSL QAQMIMRSAP AEEARRRVYI 300
ASHSSTPEQI ELLERMLSTR ARLARLVGRE SFAAMALDDK MAKNPTNVAR 350
FLDSLMDRSR PYARRALRNL SMRKQEHLHT PPFPTIQAWD RDYYCPPEPP 400
APPIPLPRLT FGTVLMGLSR LFRHLYGIHL RPVKPIAGEV WHSDVHKLEV 450
VDEERGVIGL IYADVFARRG KASGAAHYTV RCSRRTDDDD VQGDNDELTR 500
MYPDLIKQSE EFEAVGRGPI PGLPGTYQQP LVVLLCEFAR PSLGAAVLEW 550
HEVMTLFHEM GHAMHSMIGR TEYQNVSGTR CPTDFVELPS ILMEHFLNSR 600
QVLSLFHADS TSSSSQPIGN HDEDPCHSID TYAQIMLAAL DQIYHSPAAL 650
QPGFDSTRKL ARLHDEKGLI PYVPGTSFQT QFGHLFGYGA TYYSYLFDRA 700
IASRVWKDVF SSSPLSRETG ERYKQEVLRY GGGKDPWEMV SALLKAPELA 750
SGDAEAMATV GRWKIEDEVG LPGRH 775
Length:775
Mass (Da):86,915
Last modified:October 1, 1996 - v2
Checksum:i875772B6D9560C55
GO

Sequence cautioni

The sequence AAB01366.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti572 – 5721E → G in strain: UVM 9-4.
Natural varianti651 – 6511Q → E in strain: UVM 9-1 and CBS 340.81 / UVM 4-40.
Natural varianti659 – 6591K → E in strain: UVM 9-1 and CBS 340.81 / UVM 4-40.
Natural varianti729 – 7291R → Q in strain: UVM 9-1.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861T → D1 Publication
Sequence conflicti621 – 6222HD → QH in AAB01366. 1 Publication
Sequence conflicti621 – 6222HD → QH in AAB01368. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43072 Genomic DNA. Translation: AAA93531.1.
M97179 Genomic DNA. Translation: AAB01366.1. Different initiation.
M97180 Genomic DNA. Translation: AAB01368.1.
M97181 Genomic DNA. Translation: AAB01371.1.
PIRiE37271.
F37271.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43072 Genomic DNA. Translation: AAA93531.1 .
M97179 Genomic DNA. Translation: AAB01366.1 . Different initiation.
M97180 Genomic DNA. Translation: AAB01368.1 .
M97181 Genomic DNA. Translation: AAB01371.1 .
PIRi E37271.
F37271.

3D structure databases

ProteinModelPortali P37932.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mammalian mitochondrial intermediate peptidase: structure/function analysis of a new homologue from Schizophyllum commune and relationship to thimet oligopeptidases."
    Isaya G., Sakati W.R., Rollins R.A., Shen G.P., Hanson L.C., Ullrich R.C., Novotny C.P.
    Genomics 28:450-461(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
    Strain: 1-71.
  2. "The A alpha mating locus of Schizophyllum commune encodes two dissimilar multiallelic homeodomain proteins."
    Stankis M.M., Specht C.A., Yang H., Giasson L., Ullrich R.C., Novotny C.P.
    Proc. Natl. Acad. Sci. U.S.A. 89:7169-7173(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 486-775.
    Strain: ATCC 44201 / CBS 340.81 / UVM 4-40 / 4-40, UVM 9-1 and UVM 9-4.

Entry informationi

Entry nameiPMIP_SCHCO
AccessioniPrimary (citable) accession number: P37932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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