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P37932

- PMIP_SCHCO

UniProt

P37932 - PMIP_SCHCO

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Schizophyllum commune (Split gill fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi558 – 5581Zinc; catalyticPROSITE-ProRule annotation
    Active sitei559 – 5591PROSITE-ProRule annotation
    Metal bindingi562 – 5621Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi565 – 5651Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    Synonyms:MEP, MIP
    OrganismiSchizophyllum commune (Split gill fungus)
    Taxonomic identifieri5334 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesSchizophyllaceaeSchizophyllum

    Subcellular locationi

    Mitochondrion matrix 1 Publication

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
    BLAST
    Chaini29 – 775747Mitochondrial intermediate peptidasePRO_0000028581Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP37932.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P37932-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIARPARDVL SSATKKQFRF RGCLAARHEP YHTSTSRAGQ VAILPATTDD    50
    KTLVSVFDSP RSNAKLSAFA TTGLFNHSTV THPRALNSIA QGTLIRAHVL 100
    TNRILRAKES REELFKVVKN LDRLSDMLCS VIDLCELVRN SHPDRAWVEA 150
    ANDAYEGLCQ TMNELNTHVG LYDVLKIVLS DPEIVKSLSP EAYRTAMIFW 200
    NDFEKSAINL PAKEREEFVA LSSEIISLGR MFLEETTAAR PPAKIPPSDL 250
    AGLKDKGMGV RLQLQAQFTQ RDLHVYPGSL QAQMIMRSAP AEEARRRVYI 300
    ASHSSTPEQI ELLERMLSTR ARLARLVGRE SFAAMALDDK MAKNPTNVAR 350
    FLDSLMDRSR PYARRALRNL SMRKQEHLHT PPFPTIQAWD RDYYCPPEPP 400
    APPIPLPRLT FGTVLMGLSR LFRHLYGIHL RPVKPIAGEV WHSDVHKLEV 450
    VDEERGVIGL IYADVFARRG KASGAAHYTV RCSRRTDDDD VQGDNDELTR 500
    MYPDLIKQSE EFEAVGRGPI PGLPGTYQQP LVVLLCEFAR PSLGAAVLEW 550
    HEVMTLFHEM GHAMHSMIGR TEYQNVSGTR CPTDFVELPS ILMEHFLNSR 600
    QVLSLFHADS TSSSSQPIGN HDEDPCHSID TYAQIMLAAL DQIYHSPAAL 650
    QPGFDSTRKL ARLHDEKGLI PYVPGTSFQT QFGHLFGYGA TYYSYLFDRA 700
    IASRVWKDVF SSSPLSRETG ERYKQEVLRY GGGKDPWEMV SALLKAPELA 750
    SGDAEAMATV GRWKIEDEVG LPGRH 775
    Length:775
    Mass (Da):86,915
    Last modified:October 1, 1996 - v2
    Checksum:i875772B6D9560C55
    GO

    Sequence cautioni

    The sequence AAB01366.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti486 – 4861T → D(PubMed:1353886)Curated
    Sequence conflicti621 – 6222HD → QH in AAB01366. (PubMed:1353886)Curated
    Sequence conflicti621 – 6222HD → QH in AAB01368. (PubMed:1353886)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti572 – 5721E → G in strain: UVM 9-4.
    Natural varianti651 – 6511Q → E in strain: UVM 9-1 and CBS 340.81 / UVM 4-40.
    Natural varianti659 – 6591K → E in strain: UVM 9-1 and CBS 340.81 / UVM 4-40.
    Natural varianti729 – 7291R → Q in strain: UVM 9-1.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43072 Genomic DNA. Translation: AAA93531.1.
    M97179 Genomic DNA. Translation: AAB01366.1. Different initiation.
    M97180 Genomic DNA. Translation: AAB01368.1.
    M97181 Genomic DNA. Translation: AAB01371.1.
    PIRiE37271.
    F37271.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43072 Genomic DNA. Translation: AAA93531.1 .
    M97179 Genomic DNA. Translation: AAB01366.1 . Different initiation.
    M97180 Genomic DNA. Translation: AAB01368.1 .
    M97181 Genomic DNA. Translation: AAB01371.1 .
    PIRi E37271.
    F37271.

    3D structure databases

    ProteinModelPortali P37932.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian mitochondrial intermediate peptidase: structure/function analysis of a new homologue from Schizophyllum commune and relationship to thimet oligopeptidases."
      Isaya G., Sakati W.R., Rollins R.A., Shen G.P., Hanson L.C., Ullrich R.C., Novotny C.P.
      Genomics 28:450-461(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION.
      Strain: 1-71.
    2. "The A alpha mating locus of Schizophyllum commune encodes two dissimilar multiallelic homeodomain proteins."
      Stankis M.M., Specht C.A., Yang H., Giasson L., Ullrich R.C., Novotny C.P.
      Proc. Natl. Acad. Sci. U.S.A. 89:7169-7173(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 486-775.
      Strain: ATCC 44201 / CBS 340.81 / UVM 4-40 / 4-40, UVM 9-1 and UVM 9-4.

    Entry informationi

    Entry nameiPMIP_SCHCO
    AccessioniPrimary (citable) accession number: P37932
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3