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Protein

Protein FimH

Gene

fimH

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Seems to be a mannose-binding adhesin (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciSENT99287:GCTI-550-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FimH
Gene namesi
Name:fimH
Ordered Locus Names:STM0547
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 335313Protein FimHPRO_0000009213Add
BLAST

Proteomic databases

PaxDbiP37925.
PRIDEiP37925.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM0547.

Structurei

3D structure databases

ProteinModelPortaliP37925.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108M66. Bacteria.
ENOG410ZUTT. LUCA.
HOGENOMiHOG000267835.
KOiK07350.
OMAiQMPFGVQ.
OrthoDBiEOG69GZHZ.
PhylomeDBiP37925.

Family and domain databases

InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIYSALLLA GTALFFTHPA LATVCRNSNG TATDIFYDLS DVFTSGNNQP
60 70 80 90 100
GQVVTLPEKS GWVGVNATCP AGTTVNYTYR SYVSELPVQS TEGNFKYLKL
110 120 130 140 150
NDYLLGAMSI TDSVAGVFYP PRNYILMGVD YNVSQQKPFG VQDSKLVFKL
160 170 180 190 200
KVIRPFINMV TIPRQTMFTV YVTTSTGDAL STPVYTISYS GKVEVPQNCE
210 220 230 240 250
VNAGQVVEFD FGDIGASLFS QAGAGNRPQG VTPQTKTIAI KCTNVAAQAY
260 270 280 290 300
LSMRLEAEKA SGQAMVSDNP DLGFVVANSN GTPLTPNNLS SKIPFHLDDN
310 320 330
AAARVGIRAW PISVTGIKPA EGPFTARGYL RVDYD
Length:335
Mass (Da):36,102
Last modified:January 23, 2002 - v2
Checksum:i31EE8222C041D61D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611G → A in AAA75420 (Ref. 1) Curated
Sequence conflicti118 – 1181F → S in AAA75420 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19338 Genomic DNA. Translation: AAA75420.1.
AE006468 Genomic DNA. Translation: AAL19501.1.
RefSeqiNP_459542.1. NC_003197.1.
WP_000708653.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19501; AAL19501; STM0547.
GeneIDi1252067.
KEGGistm:STM0547.
PATRICi32379437. VBISalEnt20916_0580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19338 Genomic DNA. Translation: AAA75420.1.
AE006468 Genomic DNA. Translation: AAL19501.1.
RefSeqiNP_459542.1. NC_003197.1.
WP_000708653.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP37925.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM0547.

Proteomic databases

PaxDbiP37925.
PRIDEiP37925.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL19501; AAL19501; STM0547.
GeneIDi1252067.
KEGGistm:STM0547.
PATRICi32379437. VBISalEnt20916_0580.

Phylogenomic databases

eggNOGiENOG4108M66. Bacteria.
ENOG410ZUTT. LUCA.
HOGENOMiHOG000267835.
KOiK07350.
OMAiQMPFGVQ.
OrthoDBiEOG69GZHZ.
PhylomeDBiP37925.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-550-MONOMER.

Family and domain databases

InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Swenson D.L., Clegg S.
    Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiFIMH_SALTY
AccessioniPrimary (citable) accession number: P37925
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2002
Last modified: November 11, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.