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P37908

- YFJD_ECOLI

UniProt

P37908 - YFJD_ECOLI

Protein

UPF0053 inner membrane protein YfjD

Gene

yfjD

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 5 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro
    2. flavin adenine dinucleotide binding Source: InterPro
    3. oxidoreductase activity, acting on CH-OH group of donors Source: InterPro

    Enzyme and pathway databases

    BioCyciEcoCyc:G7356-MONOMER.
    ECOL316407:JW5415-MONOMER.
    RETL1328306-WGS:GSTH-3906-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0053 inner membrane protein YfjD
    Gene namesi
    Name:yfjD
    Synonyms:ypjE
    Ordered Locus Names:b4461, JW5415
    ORF Names:b2612/b2613
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG12442. yfjD.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428UPF0053 inner membrane protein YfjDPRO_0000088357Add
    BLAST

    Proteomic databases

    PRIDEiP37908.

    Expressioni

    Gene expression databases

    GenevestigatoriP37908.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-12070N.
    IntActiP37908. 2 interactions.
    MINTiMINT-1274766.
    STRINGi511145.b4461.

    Structurei

    3D structure databases

    ProteinModelPortaliP37908.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33CytoplasmicSequence Analysis
    Topological domaini25 – 6440PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini86 – 916CytoplasmicSequence Analysis
    Topological domaini113 – 12917PeriplasmicSequence AnalysisAdd
    BLAST
    Topological domaini151 – 428278CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 183175DUF21Add
    BLAST
    Domaini208 – 27063CBS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini272 – 33261CBS 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UPF0053 family.Curated
    Contains 2 CBS domains.PROSITE-ProRule annotation
    Contains 1 DUF21 domain.Curated

    Keywords - Domaini

    CBS domain, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4536.
    HOGENOMiHOG000062298.
    OMAiMRMVGIK.
    OrthoDBiEOG60W7V4.
    PhylomeDBiP37908.

    Family and domain databases

    Gene3Di3.30.465.10. 1 hit.
    InterProiIPR000644. CBS_dom.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR002550. DUF21.
    IPR016166. FAD-bd_2.
    IPR005170. Transptr-assoc_dom.
    [Graphical view]
    PfamiPF00571. CBS. 1 hit.
    PF03471. CorC_HlyC. 1 hit.
    PF01595. DUF21. 1 hit.
    [Graphical view]
    SMARTiSM00116. CBS. 1 hit.
    SM01091. CorC_HlyC. 1 hit.
    [Graphical view]
    SUPFAMiSSF56176. SSF56176. 1 hit.
    PROSITEiPS51371. CBS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37908-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHISTTTLI IILIIMVVIS AYFSGSETGM MTLNRYRLRH MAKQGNRSAK    50
    RVEKLLRKPD RLISLVLIGN NLVNILASAL GTIVGMRLYG DAGVAIATGV 100
    LTFVVLVFAE VLPKTIAALY PEKVAYPSSF LLAPLQILMM PLVWLLNAIT 150
    RMLMRMMGIK TDIVVSGSLS KEELRTIVHE SRSQISRRNQ DMLLSVLDLE 200
    KMTVDDIMVP RSEIIGIDIN DDWKSILRQL SHSPHGRIVL YRDSLDDAIS 250
    MLRVREAWRL MSEKKEFTKE TMLRAADEIY FVPEGTPLST QLVKFQRNKK 300
    KVGLVVNEYG DIQGLVTVED ILEEIVGDFT TSMSPTLAEE VTPQNDGSVI 350
    IDGTANVREI NKAFNWHLPE DDARTVNGVI LEALEEIPVA GTRVRIGEYD 400
    IDILDVQDNM IKQVKVFPVK PLRESVAE 428
    Length:428
    Mass (Da):48,044
    Last modified:July 10, 2007 - v5
    Checksum:i38456865EDBCB151
    GO

    Sequence cautioni

    The sequence X07863 differs from that shown. Reason: Frameshift at positions 326, 331 and 348.
    The sequence BAA16497.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAT48144.3.
    AP009048 Genomic DNA. Translation: BAA16497.2. Different initiation.
    X07863 Genomic DNA. No translation available.
    RefSeqiYP_026171.3. NC_000913.3.
    YP_490835.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAT48144; AAT48144; b4461.
    BAA16497; BAA16497; BAA16497.
    GeneIDi12931626.
    2847739.
    KEGGiecj:Y75_p2560.
    eco:b4461.
    PATRICi32120623. VBIEscCol129921_2710.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00096 Genomic DNA. Translation: AAT48144.3 .
    AP009048 Genomic DNA. Translation: BAA16497.2 . Different initiation.
    X07863 Genomic DNA. No translation available.
    RefSeqi YP_026171.3. NC_000913.3.
    YP_490835.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P37908.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-12070N.
    IntActi P37908. 2 interactions.
    MINTi MINT-1274766.
    STRINGi 511145.b4461.

    Proteomic databases

    PRIDEi P37908.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAT48144 ; AAT48144 ; b4461 .
    BAA16497 ; BAA16497 ; BAA16497 .
    GeneIDi 12931626.
    2847739.
    KEGGi ecj:Y75_p2560.
    eco:b4461.
    PATRICi 32120623. VBIEscCol129921_2710.

    Organism-specific databases

    EchoBASEi EB2336.
    EcoGenei EG12442. yfjD.

    Phylogenomic databases

    eggNOGi COG4536.
    HOGENOMi HOG000062298.
    OMAi MRMVGIK.
    OrthoDBi EOG60W7V4.
    PhylomeDBi P37908.

    Enzyme and pathway databases

    BioCyci EcoCyc:G7356-MONOMER.
    ECOL316407:JW5415-MONOMER.
    RETL1328306-WGS:GSTH-3906-MONOMER.

    Miscellaneous databases

    PROi P37908.

    Gene expression databases

    Genevestigatori P37908.

    Family and domain databases

    Gene3Di 3.30.465.10. 1 hit.
    InterProi IPR000644. CBS_dom.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR002550. DUF21.
    IPR016166. FAD-bd_2.
    IPR005170. Transptr-assoc_dom.
    [Graphical view ]
    Pfami PF00571. CBS. 1 hit.
    PF03471. CorC_HlyC. 1 hit.
    PF01595. DUF21. 1 hit.
    [Graphical view ]
    SMARTi SM00116. CBS. 1 hit.
    SM01091. CorC_HlyC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56176. SSF56176. 1 hit.
    PROSITEi PS51371. CBS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
      Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
      , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
      DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: SEQUENCE REVISION.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "Sequence analysis and transcriptional regulation of the Escherichia coli grpE gene, encoding a heat shock protein."
      Lipinska B., King J., Ang D., Georgopoulos C.
      Nucleic Acids Res. 16:7545-7562(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 322-428.
      Strain: B178.
    6. Rudd K.E.
      Unpublished observations (AUG-1994)
      Cited for: IDENTIFICATION.
    7. "Global topology analysis of the Escherichia coli inner membrane proteome."
      Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
      Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiYFJD_ECOLI
    AccessioniPrimary (citable) accession number: P37908
    Secondary accession number(s): P76600
    , P76601, P77009, Q6BF70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 121 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3