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P37898 (AAP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine/arginine aminopeptidase

EC=3.4.11.-
Gene names
Name:AAP1
Ordered Locus Names:YHR047C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length856 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Positive effector of glycogen accumulation. May be involved in nutrient-sensing.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Miscellaneous

Present with 77000 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the peptidase M1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 856856Alanine/arginine aminopeptidase
PRO_0000095105

Regions

Region264 – 2685Substrate binding By similarity

Sites

Active site3011Proton acceptor By similarity
Metal binding3001Zinc; catalytic By similarity
Metal binding3041Zinc; catalytic By similarity
Metal binding3231Zinc; catalytic By similarity
Binding site1321Substrate By similarity
Site3861Transition state stabilizer By similarity

Experimental info

Sequence conflict550 – 56920Missing Ref.2
Sequence conflict6461V → E Ref.2

Sequences

Sequence LengthMass (Da)Tools
P37898 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 0209F9E0298DF9DB

FASTA85697,663
        10         20         30         40         50         60 
MSREVLPNNV TPLHYDITLE PNFRAFTFEG SLKIDLQIND HSINSVQINY LEIDFHSARI 

        70         80         90        100        110        120 
EGVNAIEVNK NENQQKATLV FPNGTFENLG PSAKLEIIFS GILNDQMAGF YRAKYTDKVT 

       130        140        150        160        170        180 
GETKYMATTQ MEATDARRAF PCFDEPNLKA TFAVTLVSES FLTHLSNMDV RNETIKEGKK 

       190        200        210        220        230        240 
YTTFNTTPKM STYLVAFIVA DLRYVESNNF RIPVRVYSTP GDEKFGQFAA NLAARTLRFF 

       250        260        270        280        290        300 
EDTFNIEYPL PKMDMVAVHE FSAGAMENWG LVTYRVIDLL LDIENSSLDR IQRVAEVIQH 

       310        320        330        340        350        360 
ELAHQWFGNL VTMDWWEGLW LNEGFATWMS WYSCNKFQPE WKVWEQYVTD NLQRALNLDS 

       370        380        390        400        410        420 
LRSSHPIEVP VNNADEINQI FDAISYSKGS SLLRMISKWL GEETFIKGVS QYLNKFKYGN 

       430        440        450        460        470        480 
AKTGDLWDAL ADASGKDVCS VMNIWTKRVG FPVLSVKEHK NKITLTQHRY LSTGDVKEEE 

       490        500        510        520        530        540 
DTTIYPILLA LKDSTGIDNT LVLNEKSATF ELKNEEFFKI NGDQSGIFIT SYSDERWAKL 

       550        560        570        580        590        600 
SKQANLLSVE DRVGLVADAK ALSASGYTST TNFLNLISNW KNEDSFVVWE QIINSLSALK 

       610        620        630        640        650        660 
STWVFEPEDI LNALDKFTLD LVLNKLSELG WNIGEDDSFA IQRLKVTLFS AACTSGNEKM 

       670        680        690        700        710        720 
QSIAVEMFEE YANGNKQAIP ALFKAVVFNT VARLGGENNY EKIFNIYQNP VSSEEKIIAL 

       730        740        750        760        770        780 
RALGRFEDKE LLERTLSYLL DGTVLNQDFY IPMQGIRVHK KGIERLWAWM QEHWDEIAKR 

       790        800        810        820        830        840 
LQPGSPVLGG VLTLGLTNFT SFEALEKISA FYSRKVTKGF DQTLAQALDT IRSKAQWVSR 

       850 
DREIVATYLR EHEYDQ 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of AAP1. A gene encoding an alanine/arginine aminopeptidase in yeast."
Caprioglio D.R., Padilla C., Werner-Washburne M.
J. Biol. Chem. 268:14310-14315(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 107-652.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L12542 Genomic DNA. No translation available.
U00062 Genomic DNA. Translation: AAB68919.1.
BK006934 Genomic DNA. Translation: DAA06739.1.
PIRS46750.
RefSeqNP_011913.1. NM_001179177.1.

3D structure databases

ProteinModelPortalP37898.
SMRP37898. Positions 6-849.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36479. 16 interactions.
DIPDIP-6698N.
IntActP37898. 8 interactions.
MINTMINT-2786533.
STRING4932.YHR047C.

Protein family/group databases

MEROPSM01.007.

Proteomic databases

MaxQBP37898.
PaxDbP37898.
PeptideAtlasP37898.
PRIDEP37898.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHR047C; YHR047C; YHR047C.
GeneID856443.
KEGGsce:YHR047C.

Organism-specific databases

CYGDYHR047c.
SGDS000001089. AAP1.

Phylogenomic databases

eggNOGCOG0308.
GeneTreeENSGT00740000114965.
HOGENOMHOG000106482.
OMAVIQHELA.
OrthoDBEOG75TMMT.

Enzyme and pathway databases

BioCycYEAST:G3O-31102-MONOMER.

Gene expression databases

GenevestigatorP37898.

Family and domain databases

InterProIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERPTHR11533. PTHR11533. 1 hit.
PfamPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSPR00756. ALADIPTASE.
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982057.

Entry information

Entry nameAAP1_YEAST
AccessionPrimary (citable) accession number: P37898
Secondary accession number(s): D3DKZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1995
Last modified: May 14, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries