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P37898

- AAP1_YEAST

UniProt

P37898 - AAP1_YEAST

Protein

Alanine/arginine aminopeptidase

Gene

AAP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Positive effector of glycogen accumulation. May be involved in nutrient-sensing.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei132 – 1321SubstrateBy similarity
    Metal bindingi300 – 3001Zinc; catalyticPROSITE-ProRule annotation
    Active sitei301 – 3011Proton acceptorPROSITE-ProRule annotation
    Metal bindingi304 – 3041Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi323 – 3231Zinc; catalyticPROSITE-ProRule annotation
    Sitei386 – 3861Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: SGD
    2. metallopeptidase activity Source: UniProtKB-KW
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glycogen metabolic process Source: SGD
    2. proteolysis Source: SGD

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31102-MONOMER.
    ReactomeiREACT_189060. Antigen processing: Ubiquitination & Proteasome degradation.

    Protein family/group databases

    MEROPSiM01.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine/arginine aminopeptidase (EC:3.4.11.-)
    Gene namesi
    Name:AAP1
    Ordered Locus Names:YHR047C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHR047c.
    SGDiS000001089. AAP1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 856856Alanine/arginine aminopeptidasePRO_0000095105Add
    BLAST

    Proteomic databases

    MaxQBiP37898.
    PaxDbiP37898.
    PeptideAtlasiP37898.
    PRIDEiP37898.

    Expressioni

    Gene expression databases

    GenevestigatoriP37898.

    Interactioni

    Protein-protein interaction databases

    BioGridi36479. 16 interactions.
    DIPiDIP-6698N.
    IntActiP37898. 8 interactions.
    MINTiMINT-2786533.
    STRINGi4932.YHR047C.

    Structurei

    3D structure databases

    ProteinModelPortaliP37898.
    SMRiP37898. Positions 6-849.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni264 – 2685Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the peptidase M1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0308.
    GeneTreeiENSGT00740000114965.
    HOGENOMiHOG000106482.
    OMAiVIQHELA.
    OrthoDBiEOG75TMMT.

    Family and domain databases

    InterProiIPR024571. ERAP1-like_C_dom.
    IPR001930. Peptidase_M1.
    IPR014782. Peptidase_M1_N.
    [Graphical view]
    PANTHERiPTHR11533. PTHR11533. 1 hit.
    PfamiPF11838. ERAP1_C. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view]
    PRINTSiPR00756. ALADIPTASE.
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37898-1 [UniParc]FASTAAdd to Basket

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    MSREVLPNNV TPLHYDITLE PNFRAFTFEG SLKIDLQIND HSINSVQINY    50
    LEIDFHSARI EGVNAIEVNK NENQQKATLV FPNGTFENLG PSAKLEIIFS 100
    GILNDQMAGF YRAKYTDKVT GETKYMATTQ MEATDARRAF PCFDEPNLKA 150
    TFAVTLVSES FLTHLSNMDV RNETIKEGKK YTTFNTTPKM STYLVAFIVA 200
    DLRYVESNNF RIPVRVYSTP GDEKFGQFAA NLAARTLRFF EDTFNIEYPL 250
    PKMDMVAVHE FSAGAMENWG LVTYRVIDLL LDIENSSLDR IQRVAEVIQH 300
    ELAHQWFGNL VTMDWWEGLW LNEGFATWMS WYSCNKFQPE WKVWEQYVTD 350
    NLQRALNLDS LRSSHPIEVP VNNADEINQI FDAISYSKGS SLLRMISKWL 400
    GEETFIKGVS QYLNKFKYGN AKTGDLWDAL ADASGKDVCS VMNIWTKRVG 450
    FPVLSVKEHK NKITLTQHRY LSTGDVKEEE DTTIYPILLA LKDSTGIDNT 500
    LVLNEKSATF ELKNEEFFKI NGDQSGIFIT SYSDERWAKL SKQANLLSVE 550
    DRVGLVADAK ALSASGYTST TNFLNLISNW KNEDSFVVWE QIINSLSALK 600
    STWVFEPEDI LNALDKFTLD LVLNKLSELG WNIGEDDSFA IQRLKVTLFS 650
    AACTSGNEKM QSIAVEMFEE YANGNKQAIP ALFKAVVFNT VARLGGENNY 700
    EKIFNIYQNP VSSEEKIIAL RALGRFEDKE LLERTLSYLL DGTVLNQDFY 750
    IPMQGIRVHK KGIERLWAWM QEHWDEIAKR LQPGSPVLGG VLTLGLTNFT 800
    SFEALEKISA FYSRKVTKGF DQTLAQALDT IRSKAQWVSR DREIVATYLR 850
    EHEYDQ 856
    Length:856
    Mass (Da):97,663
    Last modified:February 1, 1995 - v2
    Checksum:i0209F9E0298DF9DB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti550 – 56920Missing(PubMed:8091229)CuratedAdd
    BLAST
    Sequence conflicti646 – 6461V → E(PubMed:8091229)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12542 Genomic DNA. No translation available.
    U00062 Genomic DNA. Translation: AAB68919.1.
    BK006934 Genomic DNA. Translation: DAA06739.1.
    PIRiS46750.
    RefSeqiNP_011913.1. NM_001179177.1.

    Genome annotation databases

    EnsemblFungiiYHR047C; YHR047C; YHR047C.
    GeneIDi856443.
    KEGGisce:YHR047C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12542 Genomic DNA. No translation available.
    U00062 Genomic DNA. Translation: AAB68919.1 .
    BK006934 Genomic DNA. Translation: DAA06739.1 .
    PIRi S46750.
    RefSeqi NP_011913.1. NM_001179177.1.

    3D structure databases

    ProteinModelPortali P37898.
    SMRi P37898. Positions 6-849.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36479. 16 interactions.
    DIPi DIP-6698N.
    IntActi P37898. 8 interactions.
    MINTi MINT-2786533.
    STRINGi 4932.YHR047C.

    Protein family/group databases

    MEROPSi M01.007.

    Proteomic databases

    MaxQBi P37898.
    PaxDbi P37898.
    PeptideAtlasi P37898.
    PRIDEi P37898.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHR047C ; YHR047C ; YHR047C .
    GeneIDi 856443.
    KEGGi sce:YHR047C.

    Organism-specific databases

    CYGDi YHR047c.
    SGDi S000001089. AAP1.

    Phylogenomic databases

    eggNOGi COG0308.
    GeneTreei ENSGT00740000114965.
    HOGENOMi HOG000106482.
    OMAi VIQHELA.
    OrthoDBi EOG75TMMT.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31102-MONOMER.
    Reactomei REACT_189060. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    NextBioi 982057.

    Gene expression databases

    Genevestigatori P37898.

    Family and domain databases

    InterProi IPR024571. ERAP1-like_C_dom.
    IPR001930. Peptidase_M1.
    IPR014782. Peptidase_M1_N.
    [Graphical view ]
    PANTHERi PTHR11533. PTHR11533. 1 hit.
    Pfami PF11838. ERAP1_C. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view ]
    PRINTSi PR00756. ALADIPTASE.
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of AAP1. A gene encoding an alanine/arginine aminopeptidase in yeast."
      Caprioglio D.R., Padilla C., Werner-Washburne M.
      J. Biol. Chem. 268:14310-14315(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 107-652.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAAP1_YEAST
    AccessioniPrimary (citable) accession number: P37898
    Secondary accession number(s): D3DKZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 77000 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3