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P37898

- AAP1_YEAST

UniProt

P37898 - AAP1_YEAST

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Protein
Alanine/arginine aminopeptidase
Gene
AAP1, YHR047C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Positive effector of glycogen accumulation. May be involved in nutrient-sensing.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321Substrate By similarity
Metal bindingi300 – 3001Zinc; catalytic By similarity
Active sitei301 – 3011Proton acceptor By similarity
Metal bindingi304 – 3041Zinc; catalytic By similarity
Metal bindingi323 – 3231Zinc; catalytic By similarity
Sitei386 – 3861Transition state stabilizer By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: SGD
  2. metallopeptidase activity Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycogen metabolic process Source: SGD
  2. proteolysis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31102-MONOMER.
ReactomeiREACT_189060. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiM01.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine/arginine aminopeptidase (EC:3.4.11.-)
Gene namesi
Name:AAP1
Ordered Locus Names:YHR047C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHR047c.
SGDiS000001089. AAP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Alanine/arginine aminopeptidase
PRO_0000095105Add
BLAST

Proteomic databases

MaxQBiP37898.
PaxDbiP37898.
PeptideAtlasiP37898.
PRIDEiP37898.

Expressioni

Gene expression databases

GenevestigatoriP37898.

Interactioni

Protein-protein interaction databases

BioGridi36479. 16 interactions.
DIPiDIP-6698N.
IntActiP37898. 8 interactions.
MINTiMINT-2786533.
STRINGi4932.YHR047C.

Structurei

3D structure databases

ProteinModelPortaliP37898.
SMRiP37898. Positions 6-849.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni264 – 2685Substrate binding By similarity

Sequence similaritiesi

Belongs to the peptidase M1 family.

Phylogenomic databases

eggNOGiCOG0308.
GeneTreeiENSGT00740000114965.
HOGENOMiHOG000106482.
OMAiVIQHELA.
OrthoDBiEOG75TMMT.

Family and domain databases

InterProiIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37898-1 [UniParc]FASTAAdd to Basket

« Hide

MSREVLPNNV TPLHYDITLE PNFRAFTFEG SLKIDLQIND HSINSVQINY    50
LEIDFHSARI EGVNAIEVNK NENQQKATLV FPNGTFENLG PSAKLEIIFS 100
GILNDQMAGF YRAKYTDKVT GETKYMATTQ MEATDARRAF PCFDEPNLKA 150
TFAVTLVSES FLTHLSNMDV RNETIKEGKK YTTFNTTPKM STYLVAFIVA 200
DLRYVESNNF RIPVRVYSTP GDEKFGQFAA NLAARTLRFF EDTFNIEYPL 250
PKMDMVAVHE FSAGAMENWG LVTYRVIDLL LDIENSSLDR IQRVAEVIQH 300
ELAHQWFGNL VTMDWWEGLW LNEGFATWMS WYSCNKFQPE WKVWEQYVTD 350
NLQRALNLDS LRSSHPIEVP VNNADEINQI FDAISYSKGS SLLRMISKWL 400
GEETFIKGVS QYLNKFKYGN AKTGDLWDAL ADASGKDVCS VMNIWTKRVG 450
FPVLSVKEHK NKITLTQHRY LSTGDVKEEE DTTIYPILLA LKDSTGIDNT 500
LVLNEKSATF ELKNEEFFKI NGDQSGIFIT SYSDERWAKL SKQANLLSVE 550
DRVGLVADAK ALSASGYTST TNFLNLISNW KNEDSFVVWE QIINSLSALK 600
STWVFEPEDI LNALDKFTLD LVLNKLSELG WNIGEDDSFA IQRLKVTLFS 650
AACTSGNEKM QSIAVEMFEE YANGNKQAIP ALFKAVVFNT VARLGGENNY 700
EKIFNIYQNP VSSEEKIIAL RALGRFEDKE LLERTLSYLL DGTVLNQDFY 750
IPMQGIRVHK KGIERLWAWM QEHWDEIAKR LQPGSPVLGG VLTLGLTNFT 800
SFEALEKISA FYSRKVTKGF DQTLAQALDT IRSKAQWVSR DREIVATYLR 850
EHEYDQ 856
Length:856
Mass (Da):97,663
Last modified:February 1, 1995 - v2
Checksum:i0209F9E0298DF9DB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti550 – 56920Missing1 Publication
Add
BLAST
Sequence conflicti646 – 6461V → E1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12542 Genomic DNA. No translation available.
U00062 Genomic DNA. Translation: AAB68919.1.
BK006934 Genomic DNA. Translation: DAA06739.1.
PIRiS46750.
RefSeqiNP_011913.1. NM_001179177.1.

Genome annotation databases

EnsemblFungiiYHR047C; YHR047C; YHR047C.
GeneIDi856443.
KEGGisce:YHR047C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12542 Genomic DNA. No translation available.
U00062 Genomic DNA. Translation: AAB68919.1 .
BK006934 Genomic DNA. Translation: DAA06739.1 .
PIRi S46750.
RefSeqi NP_011913.1. NM_001179177.1.

3D structure databases

ProteinModelPortali P37898.
SMRi P37898. Positions 6-849.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36479. 16 interactions.
DIPi DIP-6698N.
IntActi P37898. 8 interactions.
MINTi MINT-2786533.
STRINGi 4932.YHR047C.

Protein family/group databases

MEROPSi M01.007.

Proteomic databases

MaxQBi P37898.
PaxDbi P37898.
PeptideAtlasi P37898.
PRIDEi P37898.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHR047C ; YHR047C ; YHR047C .
GeneIDi 856443.
KEGGi sce:YHR047C.

Organism-specific databases

CYGDi YHR047c.
SGDi S000001089. AAP1.

Phylogenomic databases

eggNOGi COG0308.
GeneTreei ENSGT00740000114965.
HOGENOMi HOG000106482.
OMAi VIQHELA.
OrthoDBi EOG75TMMT.

Enzyme and pathway databases

BioCyci YEAST:G3O-31102-MONOMER.
Reactomei REACT_189060. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi 982057.

Gene expression databases

Genevestigatori P37898.

Family and domain databases

InterProi IPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view ]
PANTHERi PTHR11533. PTHR11533. 1 hit.
Pfami PF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view ]
PRINTSi PR00756. ALADIPTASE.
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of AAP1. A gene encoding an alanine/arginine aminopeptidase in yeast."
    Caprioglio D.R., Padilla C., Werner-Washburne M.
    J. Biol. Chem. 268:14310-14315(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 107-652.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAAP1_YEAST
AccessioniPrimary (citable) accession number: P37898
Secondary accession number(s): D3DKZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: February 1, 1995
Last modified: September 3, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 77000 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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