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P37893

- AMPN_CAUCR

UniProt

P37893 - AMPN_CAUCR

Protein

Aminopeptidase N

Gene

pepN

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei124 – 1241SubstrateBy similarity
    Metal bindingi299 – 2991Zinc; catalyticPROSITE-ProRule annotation
    Active sitei300 – 3001Proton acceptorPROSITE-ProRule annotation
    Metal bindingi303 – 3031Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi322 – 3221Zinc; catalyticPROSITE-ProRule annotation
    Sitei383 – 3831Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. metallopeptidase activity Source: UniProtKB-KW
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciCAULO:CC2481-MONOMER.

    Protein family/group databases

    MEROPSiM01.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminopeptidase N (EC:3.4.11.2)
    Alternative name(s):
    Alpha-aminoacylpeptide hydrolase
    Gene namesi
    Name:pepN
    Ordered Locus Names:CC_2481
    OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
    Taxonomic identifieri190650 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001816: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Aminopeptidase NPRO_0000095068Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP37893.
    SMRiP37893. Positions 11-862.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni263 – 2675Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the peptidase M1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0308.
    HOGENOMiHOG000257670.
    KOiK01256.
    OMAiRWDAAQM.
    OrthoDBiEOG693GJ0.

    Family and domain databases

    Gene3Di1.25.50.10. 1 hit.
    InterProiIPR001930. Peptidase_M1.
    IPR014782. Peptidase_M1_N.
    IPR012779. Peptidase_M1_pepN.
    IPR024601. Peptidase_M1_pepN_C.
    [Graphical view]
    PANTHERiPTHR11533. PTHR11533. 1 hit.
    PfamiPF11940. DUF3458. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view]
    PRINTSiPR00756. ALADIPTASE.
    TIGRFAMsiTIGR02414. pepN_proteo. 1 hit.
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P37893-1 [UniParc]FASTAAdd to Basket

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    MRTDTPQAVN LADYRPFPFA IETTRLVFDL HPTRTRVSAE LSVRRTGGKN    50
    EPLVLNGERL KLVSIAIDGR PLAAGEYGVD AERLTIAEAP DAFVLTTEVE 100
    IDPSSNKALM GLYMSGGRFC TQCEAEGFRT ITYFPDRPDV LSRYSVRIEA 150
    DGKFPHLLSN GNPVASGSLD GGRHFAEWSD PFPKPSYLFA LVAGDLDVLA 200
    DKFITMSGRE VALRVFVDPG QASRAAYALD SLKRAMKWDE EAFGREYDLD 250
    LFMIVAVRDF NFGAMENKGL NIFNSSLLLA DPQTATDLDY ERIEAVVAHE 300
    YFHNWTGNRI TCRDWFQLCL KEGFTVFRDQ GLSADMRGAA VQRIKDVRAL 350
    RARQFAEDAG PLAHPVRPSS YLKIDNFYTA TIYEKGAEII RMLKAILGAP 400
    AFRKGCDLYF QRHDGEATTV EAFIACFAEA SGRDLSGFFG WYEQAGTPSV 450
    TIETAYDAAA GALTLTLTQS TSPTPGQPDK KPLPIPIAIG LLAADGRVLR 500
    DTEIVLLDQA QMTVRWDSIP EPPVLSALRG FSAPVNLSTD ARPSDRYVLF 550
    GSDTDLFNRW EAGQTLARDL ILTRAAGAPD EVGEERYADA LGRALVDDAA 600
    EPAFKALLLA LPSEPDLALM FEAADPAALH AARDHLRTRI AVHLGDLLRR 650
    LHGEMQINGE FSSDAAAAGR RALRNACAEA LSADPHAENL ARLLGHFGAA 700
    RNMTDMIGGL YPMVAMGGVP REKALESFHH AWRTEPLVLD KWFAVQGRDP 750
    NPDALERVIA LTQHPDFEPT NPNRLRALVS TFANFNPARF HDPSGAGYAF 800
    LADEILKVDA FNPMTAARLV EPLGGWRRYK PELGDLMRAQ LERIVAHPNL 850
    SKNVLELASK ALG 863
    Length:863
    Mass (Da):94,880
    Last modified:April 27, 2001 - v2
    Checksum:iF04BCE19C6A5F7BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK24452.1.
    M91449 Genomic DNA. Translation: AAA23051.1.
    PIRiH87556.
    S27532.
    RefSeqiNP_421284.1. NC_002696.2.

    Genome annotation databases

    EnsemblBacteriaiAAK24452; AAK24452; CC_2481.
    GeneIDi944052.
    KEGGiccr:CC_2481.
    PATRICi21301996. VBICauCre124313_2499.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005673 Genomic DNA. Translation: AAK24452.1 .
    M91449 Genomic DNA. Translation: AAA23051.1 .
    PIRi H87556.
    S27532.
    RefSeqi NP_421284.1. NC_002696.2.

    3D structure databases

    ProteinModelPortali P37893.
    SMRi P37893. Positions 11-862.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M01.005.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK24452 ; AAK24452 ; CC_2481 .
    GeneIDi 944052.
    KEGGi ccr:CC_2481.
    PATRICi 21301996. VBICauCre124313_2499.

    Phylogenomic databases

    eggNOGi COG0308.
    HOGENOMi HOG000257670.
    KOi K01256.
    OMAi RWDAAQM.
    OrthoDBi EOG693GJ0.

    Enzyme and pathway databases

    BioCyci CAULO:CC2481-MONOMER.

    Family and domain databases

    Gene3Di 1.25.50.10. 1 hit.
    InterProi IPR001930. Peptidase_M1.
    IPR014782. Peptidase_M1_N.
    IPR012779. Peptidase_M1_pepN.
    IPR024601. Peptidase_M1_pepN_C.
    [Graphical view ]
    PANTHERi PTHR11533. PTHR11533. 1 hit.
    Pfami PF11940. DUF3458. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view ]
    PRINTSi PR00756. ALADIPTASE.
    TIGRFAMsi TIGR02414. pepN_proteo. 1 hit.
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19089 / CB15.
    2. "A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus."
      Wang S.P., Sharma P.L., Schoenlein P.V., Ely B.
      Proc. Natl. Acad. Sci. U.S.A. 90:630-634(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 725-863.
      Strain: ATCC 19089 / CB15.

    Entry informationi

    Entry nameiAMPN_CAUCR
    AccessioniPrimary (citable) accession number: P37893
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3