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P37893

- AMPN_CAUCR

UniProt

P37893 - AMPN_CAUCR

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Protein
Aminopeptidase N
Gene
pepN, CC_2481
Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241Substrate By similarity
Metal bindingi299 – 2991Zinc; catalytic By similarity
Active sitei300 – 3001Proton acceptor By similarity
Metal bindingi303 – 3031Zinc; catalytic By similarity
Metal bindingi322 – 3221Zinc; catalytic By similarity
Sitei383 – 3831Transition state stabilizer By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. metallopeptidase activity Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCAULO:CC2481-MONOMER.

Protein family/group databases

MEROPSiM01.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminopeptidase N (EC:3.4.11.2)
Alternative name(s):
Alpha-aminoacylpeptide hydrolase
Gene namesi
Name:pepN
Ordered Locus Names:CC_2481
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Aminopeptidase N
PRO_0000095068Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP37893.
SMRiP37893. Positions 11-862.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni263 – 2675Substrate binding By similarity

Sequence similaritiesi

Belongs to the peptidase M1 family.

Phylogenomic databases

eggNOGiCOG0308.
HOGENOMiHOG000257670.
KOiK01256.
OMAiRWDAAQM.
OrthoDBiEOG693GJ0.

Family and domain databases

Gene3Di1.25.50.10. 1 hit.
InterProiIPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
IPR012779. Peptidase_M1_pepN.
IPR024601. Peptidase_M1_pepN_C.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11940. DUF3458. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
TIGRFAMsiTIGR02414. pepN_proteo. 1 hit.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37893-1 [UniParc]FASTAAdd to Basket

« Hide

MRTDTPQAVN LADYRPFPFA IETTRLVFDL HPTRTRVSAE LSVRRTGGKN    50
EPLVLNGERL KLVSIAIDGR PLAAGEYGVD AERLTIAEAP DAFVLTTEVE 100
IDPSSNKALM GLYMSGGRFC TQCEAEGFRT ITYFPDRPDV LSRYSVRIEA 150
DGKFPHLLSN GNPVASGSLD GGRHFAEWSD PFPKPSYLFA LVAGDLDVLA 200
DKFITMSGRE VALRVFVDPG QASRAAYALD SLKRAMKWDE EAFGREYDLD 250
LFMIVAVRDF NFGAMENKGL NIFNSSLLLA DPQTATDLDY ERIEAVVAHE 300
YFHNWTGNRI TCRDWFQLCL KEGFTVFRDQ GLSADMRGAA VQRIKDVRAL 350
RARQFAEDAG PLAHPVRPSS YLKIDNFYTA TIYEKGAEII RMLKAILGAP 400
AFRKGCDLYF QRHDGEATTV EAFIACFAEA SGRDLSGFFG WYEQAGTPSV 450
TIETAYDAAA GALTLTLTQS TSPTPGQPDK KPLPIPIAIG LLAADGRVLR 500
DTEIVLLDQA QMTVRWDSIP EPPVLSALRG FSAPVNLSTD ARPSDRYVLF 550
GSDTDLFNRW EAGQTLARDL ILTRAAGAPD EVGEERYADA LGRALVDDAA 600
EPAFKALLLA LPSEPDLALM FEAADPAALH AARDHLRTRI AVHLGDLLRR 650
LHGEMQINGE FSSDAAAAGR RALRNACAEA LSADPHAENL ARLLGHFGAA 700
RNMTDMIGGL YPMVAMGGVP REKALESFHH AWRTEPLVLD KWFAVQGRDP 750
NPDALERVIA LTQHPDFEPT NPNRLRALVS TFANFNPARF HDPSGAGYAF 800
LADEILKVDA FNPMTAARLV EPLGGWRRYK PELGDLMRAQ LERIVAHPNL 850
SKNVLELASK ALG 863
Length:863
Mass (Da):94,880
Last modified:April 27, 2001 - v2
Checksum:iF04BCE19C6A5F7BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK24452.1.
M91449 Genomic DNA. Translation: AAA23051.1.
PIRiH87556.
S27532.
RefSeqiNP_421284.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK24452; AAK24452; CC_2481.
GeneIDi944052.
KEGGiccr:CC_2481.
PATRICi21301996. VBICauCre124313_2499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005673 Genomic DNA. Translation: AAK24452.1 .
M91449 Genomic DNA. Translation: AAA23051.1 .
PIRi H87556.
S27532.
RefSeqi NP_421284.1. NC_002696.2.

3D structure databases

ProteinModelPortali P37893.
SMRi P37893. Positions 11-862.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M01.005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK24452 ; AAK24452 ; CC_2481 .
GeneIDi 944052.
KEGGi ccr:CC_2481.
PATRICi 21301996. VBICauCre124313_2499.

Phylogenomic databases

eggNOGi COG0308.
HOGENOMi HOG000257670.
KOi K01256.
OMAi RWDAAQM.
OrthoDBi EOG693GJ0.

Enzyme and pathway databases

BioCyci CAULO:CC2481-MONOMER.

Family and domain databases

Gene3Di 1.25.50.10. 1 hit.
InterProi IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
IPR012779. Peptidase_M1_pepN.
IPR024601. Peptidase_M1_pepN_C.
[Graphical view ]
PANTHERi PTHR11533. PTHR11533. 1 hit.
Pfami PF11940. DUF3458. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view ]
PRINTSi PR00756. ALADIPTASE.
TIGRFAMsi TIGR02414. pepN_proteo. 1 hit.
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.
  2. "A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus."
    Wang S.P., Sharma P.L., Schoenlein P.V., Ely B.
    Proc. Natl. Acad. Sci. U.S.A. 90:630-634(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 725-863.
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiAMPN_CAUCR
AccessioniPrimary (citable) accession number: P37893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 27, 2001
Last modified: June 11, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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