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P37893

- AMPN_CAUCR

UniProt

P37893 - AMPN_CAUCR

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Protein

Aminopeptidase N

Gene

pepN

Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241SubstrateBy similarity
Metal bindingi299 – 2991Zinc; catalyticPROSITE-ProRule annotation
Active sitei300 – 3001Proton acceptorPROSITE-ProRule annotation
Metal bindingi303 – 3031Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi322 – 3221Zinc; catalyticPROSITE-ProRule annotation
Sitei383 – 3831Transition state stabilizerBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. metallopeptidase activity Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciCAULO:CC2481-MONOMER.

Protein family/group databases

MEROPSiM01.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminopeptidase N (EC:3.4.11.2)
Alternative name(s):
Alpha-aminoacylpeptide hydrolase
Gene namesi
Name:pepN
Ordered Locus Names:CC_2481
OrganismiCaulobacter crescentus (strain ATCC 19089 / CB15)
Taxonomic identifieri190650 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001816: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Aminopeptidase NPRO_0000095068Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP37893.
SMRiP37893. Positions 11-862.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni263 – 2675Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Phylogenomic databases

eggNOGiCOG0308.
HOGENOMiHOG000257670.
KOiK01256.
OMAiRWDAAQM.
OrthoDBiEOG693GJ0.

Family and domain databases

Gene3Di1.25.50.10. 1 hit.
InterProiIPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
IPR012779. Peptidase_M1_pepN.
IPR024601. Peptidase_M1_pepN_C.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11940. DUF3458. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
TIGRFAMsiTIGR02414. pepN_proteo. 1 hit.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37893-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTDTPQAVN LADYRPFPFA IETTRLVFDL HPTRTRVSAE LSVRRTGGKN
60 70 80 90 100
EPLVLNGERL KLVSIAIDGR PLAAGEYGVD AERLTIAEAP DAFVLTTEVE
110 120 130 140 150
IDPSSNKALM GLYMSGGRFC TQCEAEGFRT ITYFPDRPDV LSRYSVRIEA
160 170 180 190 200
DGKFPHLLSN GNPVASGSLD GGRHFAEWSD PFPKPSYLFA LVAGDLDVLA
210 220 230 240 250
DKFITMSGRE VALRVFVDPG QASRAAYALD SLKRAMKWDE EAFGREYDLD
260 270 280 290 300
LFMIVAVRDF NFGAMENKGL NIFNSSLLLA DPQTATDLDY ERIEAVVAHE
310 320 330 340 350
YFHNWTGNRI TCRDWFQLCL KEGFTVFRDQ GLSADMRGAA VQRIKDVRAL
360 370 380 390 400
RARQFAEDAG PLAHPVRPSS YLKIDNFYTA TIYEKGAEII RMLKAILGAP
410 420 430 440 450
AFRKGCDLYF QRHDGEATTV EAFIACFAEA SGRDLSGFFG WYEQAGTPSV
460 470 480 490 500
TIETAYDAAA GALTLTLTQS TSPTPGQPDK KPLPIPIAIG LLAADGRVLR
510 520 530 540 550
DTEIVLLDQA QMTVRWDSIP EPPVLSALRG FSAPVNLSTD ARPSDRYVLF
560 570 580 590 600
GSDTDLFNRW EAGQTLARDL ILTRAAGAPD EVGEERYADA LGRALVDDAA
610 620 630 640 650
EPAFKALLLA LPSEPDLALM FEAADPAALH AARDHLRTRI AVHLGDLLRR
660 670 680 690 700
LHGEMQINGE FSSDAAAAGR RALRNACAEA LSADPHAENL ARLLGHFGAA
710 720 730 740 750
RNMTDMIGGL YPMVAMGGVP REKALESFHH AWRTEPLVLD KWFAVQGRDP
760 770 780 790 800
NPDALERVIA LTQHPDFEPT NPNRLRALVS TFANFNPARF HDPSGAGYAF
810 820 830 840 850
LADEILKVDA FNPMTAARLV EPLGGWRRYK PELGDLMRAQ LERIVAHPNL
860
SKNVLELASK ALG
Length:863
Mass (Da):94,880
Last modified:April 27, 2001 - v2
Checksum:iF04BCE19C6A5F7BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK24452.1.
M91449 Genomic DNA. Translation: AAA23051.1.
PIRiH87556.
S27532.
RefSeqiNP_421284.1. NC_002696.2.

Genome annotation databases

EnsemblBacteriaiAAK24452; AAK24452; CC_2481.
GeneIDi944052.
KEGGiccr:CC_2481.
PATRICi21301996. VBICauCre124313_2499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005673 Genomic DNA. Translation: AAK24452.1 .
M91449 Genomic DNA. Translation: AAA23051.1 .
PIRi H87556.
S27532.
RefSeqi NP_421284.1. NC_002696.2.

3D structure databases

ProteinModelPortali P37893.
SMRi P37893. Positions 11-862.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M01.005.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK24452 ; AAK24452 ; CC_2481 .
GeneIDi 944052.
KEGGi ccr:CC_2481.
PATRICi 21301996. VBICauCre124313_2499.

Phylogenomic databases

eggNOGi COG0308.
HOGENOMi HOG000257670.
KOi K01256.
OMAi RWDAAQM.
OrthoDBi EOG693GJ0.

Enzyme and pathway databases

BioCyci CAULO:CC2481-MONOMER.

Family and domain databases

Gene3Di 1.25.50.10. 1 hit.
InterProi IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
IPR012779. Peptidase_M1_pepN.
IPR024601. Peptidase_M1_pepN_C.
[Graphical view ]
PANTHERi PTHR11533. PTHR11533. 1 hit.
Pfami PF11940. DUF3458. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view ]
PRINTSi PR00756. ALADIPTASE.
TIGRFAMsi TIGR02414. pepN_proteo. 1 hit.
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19089 / CB15.
  2. "A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus."
    Wang S.P., Sharma P.L., Schoenlein P.V., Ely B.
    Proc. Natl. Acad. Sci. U.S.A. 90:630-634(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 725-863.
    Strain: ATCC 19089 / CB15.

Entry informationi

Entry nameiAMPN_CAUCR
AccessioniPrimary (citable) accession number: P37893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 27, 2001
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3