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P37893 (AMPN_CAUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aminopeptidase N

EC=3.4.11.2
Alternative name(s):
Alpha-aminoacylpeptide hydrolase
Gene names
Name:pepN
Ordered Locus Names:CC_2481
OrganismCaulobacter crescentus (strain ATCC 19089 / CB15) [Reference proteome] [HAMAP]
Taxonomic identifier190650 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length863 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.

Catalytic activity

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Sequence similarities

Belongs to the peptidase M1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 863863Aminopeptidase N
PRO_0000095068

Regions

Region263 – 2675Substrate binding By similarity

Sites

Active site3001Proton acceptor By similarity
Metal binding2991Zinc; catalytic By similarity
Metal binding3031Zinc; catalytic By similarity
Metal binding3221Zinc; catalytic By similarity
Binding site1241Substrate By similarity
Site3831Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P37893 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: F04BCE19C6A5F7BD

FASTA86394,880
        10         20         30         40         50         60 
MRTDTPQAVN LADYRPFPFA IETTRLVFDL HPTRTRVSAE LSVRRTGGKN EPLVLNGERL 

        70         80         90        100        110        120 
KLVSIAIDGR PLAAGEYGVD AERLTIAEAP DAFVLTTEVE IDPSSNKALM GLYMSGGRFC 

       130        140        150        160        170        180 
TQCEAEGFRT ITYFPDRPDV LSRYSVRIEA DGKFPHLLSN GNPVASGSLD GGRHFAEWSD 

       190        200        210        220        230        240 
PFPKPSYLFA LVAGDLDVLA DKFITMSGRE VALRVFVDPG QASRAAYALD SLKRAMKWDE 

       250        260        270        280        290        300 
EAFGREYDLD LFMIVAVRDF NFGAMENKGL NIFNSSLLLA DPQTATDLDY ERIEAVVAHE 

       310        320        330        340        350        360 
YFHNWTGNRI TCRDWFQLCL KEGFTVFRDQ GLSADMRGAA VQRIKDVRAL RARQFAEDAG 

       370        380        390        400        410        420 
PLAHPVRPSS YLKIDNFYTA TIYEKGAEII RMLKAILGAP AFRKGCDLYF QRHDGEATTV 

       430        440        450        460        470        480 
EAFIACFAEA SGRDLSGFFG WYEQAGTPSV TIETAYDAAA GALTLTLTQS TSPTPGQPDK 

       490        500        510        520        530        540 
KPLPIPIAIG LLAADGRVLR DTEIVLLDQA QMTVRWDSIP EPPVLSALRG FSAPVNLSTD 

       550        560        570        580        590        600 
ARPSDRYVLF GSDTDLFNRW EAGQTLARDL ILTRAAGAPD EVGEERYADA LGRALVDDAA 

       610        620        630        640        650        660 
EPAFKALLLA LPSEPDLALM FEAADPAALH AARDHLRTRI AVHLGDLLRR LHGEMQINGE 

       670        680        690        700        710        720 
FSSDAAAAGR RALRNACAEA LSADPHAENL ARLLGHFGAA RNMTDMIGGL YPMVAMGGVP 

       730        740        750        760        770        780 
REKALESFHH AWRTEPLVLD KWFAVQGRDP NPDALERVIA LTQHPDFEPT NPNRLRALVS 

       790        800        810        820        830        840 
TFANFNPARF HDPSGAGYAF LADEILKVDA FNPMTAARLV EPLGGWRRYK PELGDLMRAQ 

       850        860 
LERIVAHPNL SKNVLELASK ALG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005673 Genomic DNA. Translation: AAK24452.1.
M91449 Genomic DNA. Translation: AAA23051.1.
PIRH87556.
S27532.
RefSeqNP_421284.1. NC_002696.2.

3D structure databases

ProteinModelPortalP37893.
SMRP37893. Positions 11-862.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSM01.005.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK24452; AAK24452; CC_2481.
GeneID944052.
KEGGccr:CC_2481.
PATRIC21301996. VBICauCre124313_2499.

Phylogenomic databases

eggNOGCOG0308.
HOGENOMHOG000257670.
KOK01256.
OMARWDAAQM.
OrthoDBEOG693GJ0.

Enzyme and pathway databases

BioCycCAULO:CC2481-MONOMER.

Family and domain databases

Gene3D1.25.50.10. 1 hit.
InterProIPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
IPR012779. Peptidase_M1_pepN.
IPR024601. Peptidase_M1_pepN_C.
[Graphical view]
PANTHERPTHR11533. PTHR11533. 1 hit.
PfamPF11940. DUF3458. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSPR00756. ALADIPTASE.
TIGRFAMsTIGR02414. pepN_proteo. 1 hit.
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPN_CAUCR
AccessionPrimary (citable) accession number: P37893
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 27, 2001
Last modified: June 11, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries