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Reviewed, UniProtKB/Swiss-Prot P37877 (ACKA_BACSU)

Last modified November 3, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase
Gene names
Name: ackA
Ordered Locus Names: BSU29470
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Involved in the secretion of excess carbohydrate. Catalyzes interconversion of acetate and acetyl phosphate and appears to favor the formation of acetate. HAMAP MF_00020

Catalytic activity

ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020

ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020

Enzyme regulation

Induced by glucose excess, the induction may be mediated by ccpA transcriptional regulator. HAMAP MF_00020

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the acetokinase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processorganic acid metabolic process

Inferred from electronic annotation. Source: InterPro

phosphorylation

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Acetate kinase HAMAP MF_00020
PRO_0000107534

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Sequences

Sequence LengthMass (Da)Tools
P37877-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 14471DE476D43F59

FASTA39543,137
        10         20         30         40         50         60 
MSKIIAINAG SSSLKFQLFE MPSETVLTKG LVERIGIADS VFTISVNGEK NTEVTDIPDH 

        70         80         90        100        110        120 
AVAVKMLLNK LTEFGIIKDL NEIDGIGHRV VHGGEKFSDS VLLTDETIKE IEDISELAPL 

       130        140        150        160        170        180 
HNPANIVGIK AFKEVLPNVP AVAVFDTAFH QTMPEQSYLY SLPYEYYEKF GIRKYGFHGT 

       190        200        210        220        230        240 
SHKYVTERAA ELLGRPLKDL RLISCHLGNG ASIAAVEGGK SIDTSMGFTP LAGVAMGTRS 

       250        260        270        280        290        300 
GNIDPALIPY IMEKTGQTAD EVLNTLNKKS GLLGISGFSS DLRDIVEATK EGNERAETAL 

       310        320        330        340        350        360 
EVFASRIHKY IGSYAARMSG VDAIIFTAGI GENSVEVRER VLRGLEFMGV YWDPALNNVR 

       370        380        390 
GEEAFISYPH SPVKVMIIPT DEEVMIARDV VRLAK

« Hide

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References

« Hide 'large scale' references
[1]"Regulation of the Bacillus subtilis acetate kinase gene by CcpA."
Grundy F.J., Waters D.A., Allen S.H.G., Henkin T.M.
J. Bacteriol. 175:7348-7355(1993) [PubMed: 8226682] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"Sequencing and functional annotation of the Bacillus subtilis genes in the 200 kb rrnB-dnaB region."
Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.
Microbiology 143:3431-3441(1997) [PubMed: 9387221] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

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Cross-references

Sequence databases

L17320 Unassigned DNA. Translation: AAC36857.1.
AF008220 Genomic DNA. Translation: AAC00318.1.
AL009126 Genomic DNA. Translation: CAB14925.1.
PIRB49935.
RefSeqNP_390825.1.

3D structure databases

HSSPHSSP built from PDB template 1G99 based on UniProtKB P38502.
ModBaseSearch...

Genome annotation databases

GeneID937347.
GenomeReviewsGene locus BSU29470 in contig AL009126_GR.
KEGGbsu:BSU29470.
NMPDRfig|224308.1.peg.2950.

Organism-specific databases

SubtiListBG10813. ackA. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMP37877.
OMASSDFRDV.

Enzyme and pathway databases

BioCycBSUB224308:BSU2943-MON.
BRENDA2.7.2.1. 150.

Family and domain databases

HAMAPMF_00020.
[Tree]
InterProIPR000890. Acetate/butyrate_kinase.
IPR004372. AckA.
[Graphical view]
PANTHERPTHR21060. Acetate_kin. 1 hit.
PTHR21060:SF11. AckA. 1 hit.
PfamPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSPR00471. ACETATEKNASE.
TIGRFAMsTIGR00016. ackA. 1 hit.
PROSITEPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameACKA_BACSU
AccessionPrimary (citable) accession number: P37877
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 3, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents