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Protein

DNA-directed RNA polymerase subunit beta'

Gene

rpoC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processAntibiotic resistance, Transcription

Enzyme and pathway databases

BioCyciBSUB:BSU01080-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit beta'UniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit beta'UniRule annotation
Alternative name(s):
RNA polymerase subunit beta'UniRule annotation
Transcriptase subunit beta'UniRule annotation
Gene namesi
Name:rpoCUniRule annotation
Synonyms:lpm, std
Ordered Locus Names:BSU01080
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000677071 – 1199DNA-directed RNA polymerase subunit beta'Add BLAST1199

Proteomic databases

PaxDbiP37871
PRIDEiP37871

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Binary interactionsi

Show more details

Protein-protein interaction databases

DIPiDIP-49022N
IntActiP37871, 7 interactors
MINTiP37871
STRINGi224308.Bsubs1_010100000560

Structurei

3D structure databases

ProteinModelPortaliP37871
SMRiP37871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D27 Bacteria
COG0086 LUCA
HOGENOMiHOG000218387
InParanoidiP37871
KOiK03046
OMAiYFAAYMI
PhylomeDBiP37871

Family and domain databases

Gene3Di1.10.132.30, 1 hit
HAMAPiMF_01322 RNApol_bact_RpoC, 1 hit
InterProiView protein in InterPro
IPR012754 DNA-dir_RpoC_beta_prime
IPR000722 RNA_pol_asu
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR038120 Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 2 hits
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663 RPOLA_N, 1 hit
TIGRFAMsiTIGR02386 rpoC_TIGR, 1 hit

Sequencei

Sequence statusi: Complete.

P37871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDVNNFEYM NIGLASPDKI RSWSFGEVKK PETINYRTLK PEKDGLFCER
60 70 80 90 100
IFGPTKDWEC HCGKYKRVRY KGVVCDRCGV EVTRAKVRRE RMGHIELAAP
110 120 130 140 150
VSHIWYFKGI PSRMGLVLDM SPRALEEVIY FASYVVTDPA NTPLEKKQLL
160 170 180 190 200
SEKEYRAYLD KYGNKFQASM GAEAIHKLLQ DIDLVKEVDM LKEELKTSQG
210 220 230 240 250
QRRTRAIKRL EVLEAFRNSG NKPSWMILDV LPVIPPELRP MVQLDGGRFA
260 270 280 290 300
TSDLNDLYRR VINRNNRLKR LLDLGAPSII VQNEKRMLQE AVDALIDNGR
310 320 330 340 350
RGRPVTGPGN RPLKSLSHML KGKQGRFRQN LLGKRVDYSG RSVIVVGPHL
360 370 380 390 400
KMYQCGLPKE MALELFKPFV MKELVEKGLA HNIKSAKRKI ERVQPEVWDV
410 420 430 440 450
LESVIKEHPV LLNRAPTLHR LGIQAFEPTL VEGRAIRLHP LVCTAYNADF
460 470 480 490 500
DGDQMAVHVP LSAEAQAEAR ILMLAAQNIL NPKDGKPVVT PSQDMVLGNY
510 520 530 540 550
YLTLERAGAV GEGMVFKNTD EALLAYQNGY VHLHTRVAVA ANSLKNVTFT
560 570 580 590 600
EEQRSKLLIT TVGKLVFNEI LPESFPYMNE PTKSNIEEKT PDRFFLEKGA
610 620 630 640 650
DVKAVIAQQP INAPFKKGIL GKIIAEIFKR FHITETSKML DRMKNLGFKY
660 670 680 690 700
STKAGITVGV SDIVVLDDKQ EILEEAQSKV DNVMKQFRRG LITEEERYER
710 720 730 740 750
VISIWSAAKD VIQGKLMKSL DELNPIYMMS DSGARGNASN FTQLAGMRGL
760 770 780 790 800
MANPAGRIIE LPIKSSFREG LTVLEYFIST HGARKGLADT ALKTADSGYL
810 820 830 840 850
TRRLVDVAQD VIIRETDCGT DRGILAKPLK EGTETIERLE ERLIGRFARK
860 870 880 890 900
QVKHPETGEV LVNENELIDE DKALEIVEAG IEEVWIRSAF TCNTPHGVCK
910 920 930 940 950
RCYGRNLATG SDVEVGEAVG IIAAQSIGEP GTQLTMRTFH TGGVAGDDIT
960 970 980 990 1000
QGLPRIQELF EARNPKGQAT ITEIDGTVVE INEVRDKQQE IVVQGAVETR
1010 1020 1030 1040 1050
SYTAPYNSRL KVAEGDKITR GQVLTEGSID PKELLKVTDL TTVQEYLLHE
1060 1070 1080 1090 1100
VQKVYRMQGV EIGDKHVEVM VRQMLRKVRV IDAGDTDVLP GTLLDIHQFT
1110 1120 1130 1140 1150
EANKKVLLEG NRPATGRPVL LGITKASLET DSFLSAASFQ ETTRVLTDAA
1160 1170 1180 1190
IKGKRDELLG LKENVIIGKL VPAGTGMMKY RKVKPVSNVQ PTDDMVPVE
Length:1,199
Mass (Da):134,252
Last modified:June 16, 2009 - v4
Checksum:i33263510698FC12B
GO

Sequence cautioni

The sequence AAB59112 differs from that shown. Reason: Frameshift at positions 888 and 994.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti781H → P in BAA10999 (PubMed:8969501).Curated1
Sequence conflicti1026E → G in BAA10999 (PubMed:8969501).Curated1
Sequence conflicti1173A → G in BAA10999 (PubMed:8969501).Curated1
Sequence conflicti1176G → A in BAA10999 (PubMed:8969501).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti796D → G in streptolydigan resistant alleles stl6/stl445. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43593 Genomic DNA Translation: AAB59112.1 Frameshift.
AL009126 Genomic DNA Translation: CAB11884.2
L24376 Genomic DNA Translation: AAB00973.1
D64127 Genomic DNA Translation: BAA10999.1
PIRiG69698
RefSeqiNP_387989.2, NC_000964.3
WP_004399688.1, NZ_JNCM01000029.1

Genome annotation databases

EnsemblBacteriaiCAB11884; CAB11884; BSU01080
GeneIDi935977
KEGGibsu:BSU01080
PATRICifig|224308.179.peg.111

Similar proteinsi

Entry informationi

Entry nameiRPOC_BACSU
AccessioniPrimary (citable) accession number: P37871
Secondary accession number(s): P70978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: June 16, 2009
Last modified: March 28, 2018
This is version 124 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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