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P37871

- RPOC_BACSU

UniProt

P37871 - RPOC_BACSU

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Protein
DNA-directed RNA polymerase subunit beta'
Gene
rpoC, lpm, std, BSU01080
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP
  3. protein binding Source: IntAct

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance, Transcription

Enzyme and pathway databases

BioCyciBSUB:BSU01080-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit beta' (EC:2.7.7.6)
Short name:
RNAP subunit beta'
Alternative name(s):
RNA polymerase subunit beta'
Transcriptase subunit beta'
Gene namesi
Name:rpoC
Synonyms:lpm, std
Ordered Locus Names:BSU01080
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU01080. [Micado]

Subcellular locationi

GO - Cellular componenti

  1. DNA-directed RNA polymerase complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11991199DNA-directed RNA polymerase subunit beta'UniRule annotation
PRO_0000067707Add
BLAST

Proteomic databases

PaxDbiP37871.
PRIDEiP37871.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
spxAO316022EBI-5244361,EBI-5248631

Protein-protein interaction databases

DIPiDIP-49022N.
IntActiP37871. 5 interactions.
MINTiMINT-8364832.
STRINGi224308.BSU01080.

Structurei

3D structure databases

ProteinModelPortaliP37871.
SMRiP37871. Positions 5-1197.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0086.
HOGENOMiHOG000218387.
KOiK03046.
OrthoDBiEOG6M9DS6.
PhylomeDBiP37871.

Family and domain databases

HAMAPiMF_01322. RNApol_bact_RpoC.
MF_01323. RNApol_bact_RpoC1.
InterProiIPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02386. rpoC_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

P37871-1 [UniParc]FASTAAdd to Basket

« Hide

MLDVNNFEYM NIGLASPDKI RSWSFGEVKK PETINYRTLK PEKDGLFCER     50
IFGPTKDWEC HCGKYKRVRY KGVVCDRCGV EVTRAKVRRE RMGHIELAAP 100
VSHIWYFKGI PSRMGLVLDM SPRALEEVIY FASYVVTDPA NTPLEKKQLL 150
SEKEYRAYLD KYGNKFQASM GAEAIHKLLQ DIDLVKEVDM LKEELKTSQG 200
QRRTRAIKRL EVLEAFRNSG NKPSWMILDV LPVIPPELRP MVQLDGGRFA 250
TSDLNDLYRR VINRNNRLKR LLDLGAPSII VQNEKRMLQE AVDALIDNGR 300
RGRPVTGPGN RPLKSLSHML KGKQGRFRQN LLGKRVDYSG RSVIVVGPHL 350
KMYQCGLPKE MALELFKPFV MKELVEKGLA HNIKSAKRKI ERVQPEVWDV 400
LESVIKEHPV LLNRAPTLHR LGIQAFEPTL VEGRAIRLHP LVCTAYNADF 450
DGDQMAVHVP LSAEAQAEAR ILMLAAQNIL NPKDGKPVVT PSQDMVLGNY 500
YLTLERAGAV GEGMVFKNTD EALLAYQNGY VHLHTRVAVA ANSLKNVTFT 550
EEQRSKLLIT TVGKLVFNEI LPESFPYMNE PTKSNIEEKT PDRFFLEKGA 600
DVKAVIAQQP INAPFKKGIL GKIIAEIFKR FHITETSKML DRMKNLGFKY 650
STKAGITVGV SDIVVLDDKQ EILEEAQSKV DNVMKQFRRG LITEEERYER 700
VISIWSAAKD VIQGKLMKSL DELNPIYMMS DSGARGNASN FTQLAGMRGL 750
MANPAGRIIE LPIKSSFREG LTVLEYFIST HGARKGLADT ALKTADSGYL 800
TRRLVDVAQD VIIRETDCGT DRGILAKPLK EGTETIERLE ERLIGRFARK 850
QVKHPETGEV LVNENELIDE DKALEIVEAG IEEVWIRSAF TCNTPHGVCK 900
RCYGRNLATG SDVEVGEAVG IIAAQSIGEP GTQLTMRTFH TGGVAGDDIT 950
QGLPRIQELF EARNPKGQAT ITEIDGTVVE INEVRDKQQE IVVQGAVETR 1000
SYTAPYNSRL KVAEGDKITR GQVLTEGSID PKELLKVTDL TTVQEYLLHE 1050
VQKVYRMQGV EIGDKHVEVM VRQMLRKVRV IDAGDTDVLP GTLLDIHQFT 1100
EANKKVLLEG NRPATGRPVL LGITKASLET DSFLSAASFQ ETTRVLTDAA 1150
IKGKRDELLG LKENVIIGKL VPAGTGMMKY RKVKPVSNVQ PTDDMVPVE 1199
Length:1,199
Mass (Da):134,252
Last modified:June 16, 2009 - v4
Checksum:i33263510698FC12B
GO

Sequence cautioni

The sequence AAB59112.1 differs from that shown. Reason: Frameshift at positions 888 and 994.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti796 – 7961D → G in streptolydigan resistant alleles stl6/stl445.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti781 – 7811H → P in BAA10999. 1 Publication
Sequence conflicti1026 – 10261E → G in BAA10999. 1 Publication
Sequence conflicti1173 – 11731A → G in BAA10999. 1 Publication
Sequence conflicti1176 – 11761G → A in BAA10999. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43593 Genomic DNA. Translation: AAB59112.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB11884.2.
L24376 Genomic DNA. Translation: AAB00973.1.
D64127 Genomic DNA. Translation: BAA10999.1.
PIRiG69698.
RefSeqiNP_387989.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB11884; CAB11884; BSU01080.
GeneIDi935977.
KEGGibsu:BSU01080.
PATRICi18971725. VBIBacSub10457_0111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43593 Genomic DNA. Translation: AAB59112.1 . Frameshift.
AL009126 Genomic DNA. Translation: CAB11884.2 .
L24376 Genomic DNA. Translation: AAB00973.1 .
D64127 Genomic DNA. Translation: BAA10999.1 .
PIRi G69698.
RefSeqi NP_387989.2. NC_000964.3.

3D structure databases

ProteinModelPortali P37871.
SMRi P37871. Positions 5-1197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-49022N.
IntActi P37871. 5 interactions.
MINTi MINT-8364832.
STRINGi 224308.BSU01080.

Proteomic databases

PaxDbi P37871.
PRIDEi P37871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB11884 ; CAB11884 ; BSU01080 .
GeneIDi 935977.
KEGGi bsu:BSU01080.
PATRICi 18971725. VBIBacSub10457_0111.

Organism-specific databases

GenoListi BSU01080. [Micado ]

Phylogenomic databases

eggNOGi COG0086.
HOGENOMi HOG000218387.
KOi K03046.
OrthoDBi EOG6M9DS6.
PhylomeDBi P37871.

Enzyme and pathway databases

BioCyci BSUB:BSU01080-MONOMER.

Family and domain databases

HAMAPi MF_01322. RNApol_bact_RpoC.
MF_01323. RNApol_bact_RpoC1.
InterProi IPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view ]
Pfami PF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view ]
SMARTi SM00663. RPOLA_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02386. rpoC_TIGR. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Streptolydigin resistance can be conferred by alterations to either the beta or beta' subunits of Bacillus subtilis RNA polymerase."
    Yang X., Price C.W.
    J. Biol. Chem. 270:23930-23933(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], STREPTOLYDIGAN RESISTANCE.
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 1026; 1173 AND 1176.
  4. "Genetic and transcriptional organization of the region encoding the beta subunit of Bacillus subtilis RNA polymerase."
    Boor K.J., Duncan M.L., Price C.W.
    J. Biol. Chem. 270:20329-20336(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-466.
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  5. "Sequence analysis of a 50 kb region between spo0H and rrnH on the Bacillus subtilis chromosome."
    Yasumoto K., Liu H., Jeong S.M., Ohashi Y., Kakinuma S., Tanaka K., Kawamura F., Yoshikawa H., Takahashi H.
    Microbiology 142:3039-3046(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 453-1199.
    Strain: 168.

Entry informationi

Entry nameiRPOC_BACSU
AccessioniPrimary (citable) accession number: P37871
Secondary accession number(s): P70978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi