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Protein

Multicystatin

Gene
N/A
Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably has a role in the plant's defense system.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5Reactive siteBy similarity1
Sitei99Reactive siteBy similarity1
Sitei194Reactive siteBy similarity1
Sitei288Reactive siteBy similarity1
Sitei383Reactive siteBy similarity1
Sitei477Reactive siteBy similarity1
Sitei571Reactive siteBy similarity1
Sitei665Reactive siteBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.015.

Names & Taxonomyi

Protein namesi
Recommended name:
Multicystatin
Short name:
MC
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071591 – 756MulticystatinAdd BLAST756

Proteomic databases

PRIDEiP37842.

Expressioni

Tissue specificityi

Expressed abundantly in tuber and leaf.

Inductioni

By wounding.

Structurei

Secondary structure

1756
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi110 – 127Combined sources18
Beta strandi131 – 157Combined sources27
Turni158 – 160Combined sources3
Beta strandi161 – 172Combined sources12
Helixi173 – 175Combined sources3
Beta strandi177 – 185Combined sources9
Helixi394 – 411Combined sources18
Beta strandi416 – 424Combined sources9
Beta strandi426 – 443Combined sources18
Beta strandi445 – 455Combined sources11
Turni456 – 459Combined sources4
Beta strandi460 – 473Combined sources14
Helixi488 – 504Combined sources17
Beta strandi510 – 535Combined sources26
Beta strandi538 – 549Combined sources12
Helixi550 – 552Combined sources3
Beta strandi554 – 565Combined sources12
Helixi582 – 599Combined sources18
Beta strandi604 – 629Combined sources26
Beta strandi632 – 643Combined sources12
Helixi644 – 646Combined sources3
Beta strandi648 – 658Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W9PX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N100-186[»]
2W9QX-ray2.50A100-186[»]
4LZIX-ray2.20A380-660[»]
ProteinModelPortaliP37842.
SMRiP37842.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37842.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 96Cystatin 1Add BLAST94
Domaini97 – 191Cystatin 2Add BLAST95
Domaini192 – 285Cystatin 3Add BLAST94
Domaini286 – 380Cystatin 4Add BLAST95
Domaini381 – 474Cystatin 5Add BLAST94
Domaini475 – 568Cystatin 6Add BLAST94
Domaini569 – 662Cystatin 7Add BLAST94
Domaini663 – 756Cystatin 8Add BLAST94

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 52Secondary area of contactBy similarity5
Motifi142 – 146Secondary area of contactBy similarity5
Motifi237 – 241Secondary area of contactBy similarity5
Motifi331 – 335Secondary area of contactBy similarity5
Motifi426 – 430Secondary area of contactBy similarity5
Motifi520 – 524Secondary area of contactBy similarity5
Motifi614 – 618Secondary area of contactBy similarity5
Motifi708 – 712Secondary area of contactBy similarity5

Sequence similaritiesi

Contains 8 cystatin domains.Curated

Keywords - Domaini

Repeat

Family and domain databases

CDDicd00042. CY. 8 hits.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 2 hits.
PfamiPF00031. Cystatin. 8 hits.
[Graphical view]
SMARTiSM00043. CY. 8 hits.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVGGLVDV PFENKVEFDD LARFAVQDYN QKNDSSLEFK KVLNVKQQIV
60 70 80 90 100
AGIMYYITFE ATEGGNKKEY EAKILLRKWE DLKKVVGFKL VGDDSTMPGG
110 120 130 140 150
IVNVPNPNNT KFQELARFAI QDYNKKQNAH LEFVENLNVK EQVVAGIMYY
160 170 180 190 200
ITLAATDDAG KKKIYKAKIW VKEWEDFKKV VEFKLVGDDI AKLGGITDVP
210 220 230 240 250
FPNNPEFQDL ARFAIQVYNK KENVHLEFVE NLNVKQQVVA GMMYYITLAA
260 270 280 290 300
IDAGKKKIYE TKIWVKEWED FKKVVEFKLV GDDSAKTGGI INVPNPNSPE
310 320 330 340 350
FQDLARFAVQ DYNNTQNAHL EFVENLNVKE QLVSGMMYYI TLAATDAGNK
360 370 380 390 400
KEYEAKIWVK EWEDFKKVID FKLVGNDSAK KLGGFTEVPF PNSPEFQDLT
410 420 430 440 450
RFAVHQYNKD QNAHLEFVEN LNVKKQVVAG MLYYITFAAT DGGKKKIYET
460 470 480 490 500
KIWVKVWENF KKVVEFKLVG DDSAKLGGII NVPFPNNPEF QDLARFAVQD
510 520 530 540 550
YNKKENAHLE FVENLNVKEQ LVAGMLYYIT LVAIDAGKKK IYEAKIWVKE
560 570 580 590 600
WENFKKVIEF KLIGDDSAII GGFTDVPFPN NPEFQDLARF AVQDYNKKEN
610 620 630 640 650
AHLEYVENLN VKEQLVAGMI YYITLVATDA GKKKIYEAKI WVKEWEDFKK
660 670 680 690 700
VVEFKLVGDD SAKPGGIIIV PFPNSPEFQD LARFAVQDFN KKENGHLEFV
710 720 730 740 750
ENLNVKEQVV AGMMYYITLA ATDARKKEIY ETKILVKEWE NFKEVQEFKL

VGDATK
Length:756
Mass (Da):86,786
Last modified:October 1, 1994 - v1
Checksum:i5F48D05CA921CD84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16450 Genomic DNA. Translation: AAA16120.1.
PIRiS40305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16450 Genomic DNA. Translation: AAA16120.1.
PIRiS40305.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W9PX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N100-186[»]
2W9QX-ray2.50A100-186[»]
4LZIX-ray2.20A380-660[»]
ProteinModelPortaliP37842.
SMRiP37842.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI25.015.

Proteomic databases

PRIDEiP37842.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP37842.

Family and domain databases

CDDicd00042. CY. 8 hits.
InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 2 hits.
PfamiPF00031. Cystatin. 8 hits.
[Graphical view]
SMARTiSM00043. CY. 8 hits.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTM_SOLTU
AccessioniPrimary (citable) accession number: P37842
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.