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Protein

Multicystatin

Gene
N/A
Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably has a role in the plant's defense system.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei5 – 51Reactive siteBy similarity
Sitei99 – 991Reactive siteBy similarity
Sitei194 – 1941Reactive siteBy similarity
Sitei288 – 2881Reactive siteBy similarity
Sitei383 – 3831Reactive siteBy similarity
Sitei477 – 4771Reactive siteBy similarity
Sitei571 – 5711Reactive siteBy similarity
Sitei665 – 6651Reactive siteBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.015.

Names & Taxonomyi

Protein namesi
Recommended name:
Multicystatin
Short name:
MC
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 756756MulticystatinPRO_0000207159Add
BLAST

Expressioni

Tissue specificityi

Expressed abundantly in tuber and leaf.

Inductioni

By wounding.

Structurei

Secondary structure

1
756
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi110 – 12718Combined sources
Beta strandi131 – 15727Combined sources
Turni158 – 1603Combined sources
Beta strandi161 – 17212Combined sources
Helixi173 – 1753Combined sources
Beta strandi177 – 1859Combined sources
Helixi394 – 41118Combined sources
Beta strandi416 – 4249Combined sources
Beta strandi426 – 44318Combined sources
Beta strandi445 – 45511Combined sources
Turni456 – 4594Combined sources
Beta strandi460 – 47314Combined sources
Helixi488 – 50417Combined sources
Beta strandi510 – 53526Combined sources
Beta strandi538 – 54912Combined sources
Helixi550 – 5523Combined sources
Beta strandi554 – 56512Combined sources
Helixi582 – 59918Combined sources
Beta strandi604 – 62926Combined sources
Beta strandi632 – 64312Combined sources
Helixi644 – 6463Combined sources
Beta strandi648 – 65811Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2W9PX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N100-186[»]
2W9QX-ray2.50A100-186[»]
4LZIX-ray2.20A380-660[»]
ProteinModelPortaliP37842.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37842.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 9694Cystatin 1Add
BLAST
Domaini97 – 19195Cystatin 2Add
BLAST
Domaini192 – 28594Cystatin 3Add
BLAST
Domaini286 – 38095Cystatin 4Add
BLAST
Domaini381 – 47494Cystatin 5Add
BLAST
Domaini475 – 56894Cystatin 6Add
BLAST
Domaini569 – 66294Cystatin 7Add
BLAST
Domaini663 – 75694Cystatin 8Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 525Secondary area of contactBy similarity
Motifi142 – 1465Secondary area of contactBy similarity
Motifi237 – 2415Secondary area of contactBy similarity
Motifi331 – 3355Secondary area of contactBy similarity
Motifi426 – 4305Secondary area of contactBy similarity
Motifi520 – 5245Secondary area of contactBy similarity
Motifi614 – 6185Secondary area of contactBy similarity
Motifi708 – 7125Secondary area of contactBy similarity

Sequence similaritiesi

Contains 8 cystatin domains.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR020381. Prot_inh_cystat_cons-reg.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 2 hits.
PfamiPF00031. Cystatin. 8 hits.
[Graphical view]
ProDomiPD001231. Prot_inh_cystat_cons-reg. 8 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00043. CY. 8 hits.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P37842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVGGLVDV PFENKVEFDD LARFAVQDYN QKNDSSLEFK KVLNVKQQIV
60 70 80 90 100
AGIMYYITFE ATEGGNKKEY EAKILLRKWE DLKKVVGFKL VGDDSTMPGG
110 120 130 140 150
IVNVPNPNNT KFQELARFAI QDYNKKQNAH LEFVENLNVK EQVVAGIMYY
160 170 180 190 200
ITLAATDDAG KKKIYKAKIW VKEWEDFKKV VEFKLVGDDI AKLGGITDVP
210 220 230 240 250
FPNNPEFQDL ARFAIQVYNK KENVHLEFVE NLNVKQQVVA GMMYYITLAA
260 270 280 290 300
IDAGKKKIYE TKIWVKEWED FKKVVEFKLV GDDSAKTGGI INVPNPNSPE
310 320 330 340 350
FQDLARFAVQ DYNNTQNAHL EFVENLNVKE QLVSGMMYYI TLAATDAGNK
360 370 380 390 400
KEYEAKIWVK EWEDFKKVID FKLVGNDSAK KLGGFTEVPF PNSPEFQDLT
410 420 430 440 450
RFAVHQYNKD QNAHLEFVEN LNVKKQVVAG MLYYITFAAT DGGKKKIYET
460 470 480 490 500
KIWVKVWENF KKVVEFKLVG DDSAKLGGII NVPFPNNPEF QDLARFAVQD
510 520 530 540 550
YNKKENAHLE FVENLNVKEQ LVAGMLYYIT LVAIDAGKKK IYEAKIWVKE
560 570 580 590 600
WENFKKVIEF KLIGDDSAII GGFTDVPFPN NPEFQDLARF AVQDYNKKEN
610 620 630 640 650
AHLEYVENLN VKEQLVAGMI YYITLVATDA GKKKIYEAKI WVKEWEDFKK
660 670 680 690 700
VVEFKLVGDD SAKPGGIIIV PFPNSPEFQD LARFAVQDFN KKENGHLEFV
710 720 730 740 750
ENLNVKEQVV AGMMYYITLA ATDARKKEIY ETKILVKEWE NFKEVQEFKL

VGDATK
Length:756
Mass (Da):86,786
Last modified:October 1, 1994 - v1
Checksum:i5F48D05CA921CD84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16450 Genomic DNA. Translation: AAA16120.1.
PIRiS40305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16450 Genomic DNA. Translation: AAA16120.1.
PIRiS40305.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2W9PX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N100-186[»]
2W9QX-ray2.50A100-186[»]
4LZIX-ray2.20A380-660[»]
ProteinModelPortaliP37842.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI25.015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP37842.

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR020381. Prot_inh_cystat_cons-reg.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 2 hits.
PfamiPF00031. Cystatin. 8 hits.
[Graphical view]
ProDomiPD001231. Prot_inh_cystat_cons-reg. 8 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00043. CY. 8 hits.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a genomic sequence coding for potato multicystatin, an eight-domain cysteine proteinase inhibitor."
    Waldron C., Wegrich L.M., Merlo P.A., Walsh T.A.
    Plant Mol. Biol. 23:801-812(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Superior.

Entry informationi

Entry nameiCYTM_SOLTU
AccessioniPrimary (citable) accession number: P37842
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.